m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0089)
Name
Alzheimer disease
ICD
ICD-11: 8A20
Full List of Target Gene(s) of This m6A-centered Disease Response
Nucleolar protein 3 (ARC)
 Target Info 
In total 2 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary METTL3 rescues the A-Bete-induced reduction of Nucleolar protein 3 (ARC) expression via YTHDF1-Dependent m6A modification, which suggests an important mechanism of epigenetic alteration in AD.
Responsed Disease Alzheimer disease [ICD-11: 8A20]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model SH-SY5Y Neuroblastoma Homo sapiens CVCL_0019
Experiment 2 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary METTL3 rescues the A-Bete-induced reduction of Nucleolar protein 3 (ARC) expression via YTHDF1-Dependent m6A modification, which suggests an important mechanism of epigenetic alteration in AD.
Responsed Disease Alzheimer disease [ICD-11: 8A20]
Target Regulator YTH domain-containing family protein 1 (YTHDF1) READER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model SH-SY5Y Neuroblastoma Homo sapiens CVCL_0019
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
In total 5 item(s) under this disease
Crosstalk ID: M6ACROT02076
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Cysteine methyltransferase DNMT3A (DNMT3A)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Alpha tubulin acetyltransferase 1 (ATAT1)
Crosstalk relationship m6A → DNA modification
Crosstalk ID: M6ACROT02077
 Crosstalk Info 
m6A Regulator YTH domain-containing family protein 1 (YTHDF1)
 Regulator Info 
m6A Target Cysteine methyltransferase DNMT3A (DNMT3A)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Alpha tubulin acetyltransferase 1 (ATAT1)
Crosstalk relationship m6A → DNA modification
Crosstalk ID: M6ACROT03177
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target E3 ubiquitin-protein ligase CHIP (STUB1)
 Target Gene 
Epigenetic Regulator Lysine-specific histone demethylase 1A (KDM1A)
Regulated Target Histone H3 lysine 9 trimethylation (H3K9me3)
Crosstalk relationship Histone modification → m6A
Crosstalk ID: M6ACROT03530
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Nucleolar protein 3 (ARC)
 Target Gene 
Epigenetic Regulator Lysine-specific histone demethylase 1A (KDM1A)
Regulated Target Histone H3 lysine 9 trimethylation (H3K9me3)
Crosstalk relationship Histone modification → m6A
Crosstalk ID: M6ACROT03531
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Cysteine methyltransferase DNMT3A (DNMT3A)
 Target Gene 
Epigenetic Regulator Lysine-specific histone demethylase 1A (KDM1A)
Regulated Target Histone H3 lysine 9 trimethylation (H3K9me3)
Crosstalk relationship Histone modification → m6A
References
Ref 1 Methyltransferase-Like 3 Rescues the Amyloid-beta protein-Induced Reduction of Activity-Regulated Cytoskeleton Associated Protein Expression via YTHDF1-Dependent N6-Methyladenosine Modification. Front Aging Neurosci. 2022 Apr 25;14:890134. doi: 10.3389/fnagi.2022.890134. eCollection 2022.
Ref 2 A peroxisome proliferator-activated receptor alpha/gamma dual agonist with a unique in vitro profile and potent glucose and lipid effects in rodent models of type 2 diabetes and dyslipidemia. Mol Endocrinol. 2005 Jun;19(6):1593-605. doi: 10.1210/me.2005-0015. Epub 2005 Apr 14.
Ref 3 Phase I and Pharmacokinetic Studies of CYT-6091, a Novel PEGylated Colloidal Gold-rhTNF Nanomedicine. Clin Cancer Res. 2010 December 15; 16(24): 6139-6149.
Ref 4 Clinical pipeline report, company report or official report of Zydus Cadila.