m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00606)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
ARC
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3 | ||
Cell Line | Embryonic stem cells | Mus musculus |
Treatment: METTL3 knockout ESCs
Control: Wild type ESCs
|
GSE146466 | |
Regulation |
|
logFC: 1.50E+00 p-value: 1.12E-06 |
More Results | Click to View More RNA-seq Results |
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
Response Summary | METTL3 rescues the A-Bete-induced reduction of Nucleolar protein 3 (ARC) expression via YTHDF1-Dependent m6A modification, which suggests an important mechanism of epigenetic alteration in AD. | |||
Target Regulation | Up regulation | |||
Responsed Disease | Alzheimer disease | ICD-11: 8A20 | ||
In-vitro Model | SH-SY5Y | Neuroblastoma | Homo sapiens | CVCL_0019 |
YTH domain-containing family protein 1 (YTHDF1) [READER]
Representative RNA-seq result indicating the expression of this target gene regulated by YTHDF1 | ||
Cell Line | AGS cell line | Homo sapiens |
Treatment: shYTHDF1 AGS
Control: shControl AGS
|
GSE159425 | |
Regulation |
|
logFC: 8.08E-01 p-value: 1.08E-05 |
More Results | Click to View More RNA-seq Results |
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
Response Summary | METTL3 rescues the A-Bete-induced reduction of Nucleolar protein 3 (ARC) expression via YTHDF1-Dependent m6A modification, which suggests an important mechanism of epigenetic alteration in AD. | |||
Target Regulation | Up regulation | |||
Responsed Disease | Alzheimer disease | ICD-11: 8A20 | ||
In-vitro Model | SH-SY5Y | Neuroblastoma | Homo sapiens | CVCL_0019 |
Alzheimer disease [ICD-11: 8A20]
In total 2 item(s) under this disease | ||||
Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
Response Summary | METTL3 rescues the A-Bete-induced reduction of Nucleolar protein 3 (ARC) expression via YTHDF1-Dependent m6A modification, which suggests an important mechanism of epigenetic alteration in AD. | |||
Responsed Disease | Alzheimer disease [ICD-11: 8A20] | |||
Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
Target Regulation | Up regulation | |||
In-vitro Model | SH-SY5Y | Neuroblastoma | Homo sapiens | CVCL_0019 |
Experiment 2 Reporting the m6A-centered Disease Response | [1] | |||
Response Summary | METTL3 rescues the A-Bete-induced reduction of Nucleolar protein 3 (ARC) expression via YTHDF1-Dependent m6A modification, which suggests an important mechanism of epigenetic alteration in AD. | |||
Responsed Disease | Alzheimer disease [ICD-11: 8A20] | |||
Target Regulator | YTH domain-containing family protein 1 (YTHDF1) | READER | ||
Target Regulation | Up regulation | |||
In-vitro Model | SH-SY5Y | Neuroblastoma | Homo sapiens | CVCL_0019 |
References