Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT03177
[1]
Histone modification H3K9me3 KDM1A METTL3 Direct Enhancement m6A modification STUB1 STUB1 METTL3 Methylation : m6A sites
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
m6A Target E3 ubiquitin-protein ligase CHIP (STUB1)
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Histone modification (HistMod)
Epigenetic Regulator Lysine-specific histone demethylase 1A (KDM1A) ERASER View Details
Regulated Target Histone H3 lysine 9 trimethylation (H3K9me3) View Details
Downstream Gene METTL3 View Details
Crosstalk Relationship Histone modification  →  m6A Enhancement
Crosstalk Mechanism histone modification directly impacts m6A modification through modulating the level of m6A regulator
Crosstalk Summary KDM1A-mediated upregulation of METTL3, which is caused by the abundant Histone H3 lysine 9 trimethylation (H3K9me3), ameliorates Alzheimer's disease via enhancing autophagic clearance of p-Tau through m6A-dependent regulation of E3 ubiquitin-protein ligase CHIP (STUB1).
Responsed Disease Alzheimer disease ICD-11: 8A20
In-vitro Model
SH-SY5Y Neuroblastoma Homo sapiens CVCL_0019
HT22 Normal Mus musculus CVCL_0321
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Lysine-specific histone demethylase 1A (KDM1A) 81 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name IMG-7289 Phase 2 [2]
Synonyms
KQKBMHGOHXOHTD-KKUQBAQOSA-N; UNII-Y2T4ALDEAT; Y2T4ALDEAT; SCHEMBL17984236; Benzamide, N-((1S)-4-(((1R,2S)-2-(4-fluorophenyl)cyclopropyl)amino)-1-((4-methyl-1-piperazinyl)carbonyl)butyl)-4-(1H-1,2,3-triazol-1-yl)-; 1990504-34-1; N-[(2S)-1-(4-(methyl)piperazin-1-yl)-5-[[(1R,2S)-2-(4-fluorophenyl)-cyclopropyl]amino]-1-oxopentan-2-yl]-4-(1H-1,2,3-triazol-1-yl)benzamide
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name Vafidemstat Phase 2 [3]
Synonyms
(1R,2S)-2-(4-(Benzyloxy)phenyl)-N-((5-imino-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl)cyclopropanamine; 1,3,4-Oxadiazole-2-methanamine, 4,5-dihydro-5-imino-N-((1R,2S)-2-(4-(phenylmethoxy)phenyl)cyclopropyl)-; 1,3,4-Oxadiazole-2-methanamine, 5-amino-N-((1R,2S)-2-(4-(phenylmethoxy)phenyl)cyclopropyl)-; 1357362-02-7; 5-((((1R,2S)-2-(4-(benzyloxy)phenyl)cyclopropyl)amino)methyl)-1,3,4-oxadiazol-2-amine; 5-(((trans)-2-(4-(benzyloxy)phenyl)cyclopropylamino)methyl)-1,3,4-oxadiazol-2-amine; 5-[[[(1R,2S)-2-(4-phenylmethoxyphenyl)cyclopropyl]amino]methyl]-1,3,4-oxadiazol-2-amine; A930244; AKOS040742807; BCP29383; BDBM50594947; CHEMBL4802155; CS-0058593; HY-112623; LZ82JLT4UP; MS-25100; ORY 2001; ORY2001; ORY-2001; ORY-2001; SCHEMBL528204; UNII-LZ82JLT4UP; Vafidemstat; Vafidemstat [INN]; XBBRLCXCBCZIOI-DLBZAZTESA-N
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name CC-90011 Phase 2 [4]
Synonyms
UNII-W6F4FRQ5QC; W6F4FRQ5QC; CC90011; 1821307-10-1; CC-90011 besylate; 4-[2-(4-aminopiperidin-1-yl)-5-(3-fluoro-4-methoxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl]-2-fluorobenzonitrile; Pulrodemstat; 4-(2-(4-Aminopiperidin-1-yl)-5-(3-fluoro-4-methoxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-2-fluorobenzonitrile; Pulrodemstat [INN]; CC-90011 Free base; SCHEMBL17222702; GTPL11284; US10023543, Example 7; BDBM283216; US10023543, Example 85; US10023543, Example 86; NSC822744; NSC-822744; compound 11 [PMID: 33034194]; Q67009340; NC1CCN(CC1)C=1N(C(C(=C(N1)C1=CC(=C(C#N)C=C1)F)C1=CC(=C(C=C1)OC)F)=O)C; 4-(2-(4-Amino-piperidin-1-yl)-5-(3-fluoro-4-methoxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-2-fluorobenzonitrile; 4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-methoxy-phenyl)-1- methyl-6-oxo-1,6-dihydro- pyrimidin-4-yl]-2-fluoro- benzonitrile; Benzonitrile, 4-(2-(4-amino-1-piperidinyl)-5-(3-fluoro-4-methoxyphenyl)-1,6-dihydro-1-methyl-6-oxo-4-pyrimidinyl)-2-fluoro-; V0Y
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name ORY-2001 Phase 2 [5]
Synonyms
(1R,2S)-2-(4-(Benzyloxy)phenyl)-N-((5-imino-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl)cyclopropanamine; 1,3,4-Oxadiazole-2-methanamine, 4,5-dihydro-5-imino-N-((1R,2S)-2-(4-(phenylmethoxy)phenyl)cyclopropyl)-; 1,3,4-Oxadiazole-2-methanamine, 5-amino-N-((1R,2S)-2-(4-(phenylmethoxy)phenyl)cyclopropyl)-; 1357362-02-7; 5-((((1R,2S)-2-(4-(benzyloxy)phenyl)cyclopropyl)amino)methyl)-1,3,4-oxadiazol-2-amine; 5-(((trans)-2-(4-(benzyloxy)phenyl)cyclopropylamino)methyl)-1,3,4-oxadiazol-2-amine; 5-[[[(1R,2S)-2-(4-phenylmethoxyphenyl)cyclopropyl]amino]methyl]-1,3,4-oxadiazol-2-amine; A930244; AKOS040742807; BCP29383; BDBM50594947; CHEMBL4802155; CS-0058593; HY-112623; LZ82JLT4UP; MS-25100; ORY 2001; ORY2001; ORY-2001; ORY-2001; SCHEMBL528204; UNII-LZ82JLT4UP; Vafidemstat; Vafidemstat [INN]; XBBRLCXCBCZIOI-DLBZAZTESA-N
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name INCB59872 Phase 1/2 [2]
MOA Inhibitor
External Link
 Compound Name CC-90011 Phase 1 [2]
MOA Inhibitor
External Link
 Compound Name GSK2879552 Phase 1 [6]
MOA Inhibitor
Activity IC50 = 24 nM
External Link
 Compound Name Seclidemstat Phase 1 [7]
Synonyms
UNII-TYH386V3WJ; SP-2577; TYH386V3WJ; 1423715-37-0; SP2577; CHEMBL4297641; SCHEMBL14697017; SCHEMBL14697019; EX-A3574; s6722; BS-15371; HY-103713; CS-0039281; Benzoic acid, 3-((4-methyl-1-piperazinyl)sulfonyl)-, (2E)-2-(1-(5-chloro-2-hydroxyphenyl)ethylidene)hydrazide
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name TAS-1440 Phase 1 [8]
MOA Inhibitor
External Link
 Compound Name PMID27019002-Compound-16 Patented [9]
MOA Inhibitor
Activity IC50 = 2220 nM
External Link
 Compound Name PMID27019002-Compound-41 Patented [9]
MOA Inhibitor
Activity IC50 = 19 nM
External Link
 Compound Name Benzenamine derivative 2 Patented [9]
Synonyms
PMID27019002-Compound-35
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name PMID27019002-Compound-28a Patented [9]
MOA Inhibitor
Activity IC50 < 1000 nM
External Link
 Compound Name Aryl cyclopropylamine derivative 5 Patented [9]
Synonyms
PMID27019002-Compound-25c
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 352000 nM
External Link
 Compound Name Pyrimidine derivative 17 Patented [9]
Synonyms
PMID27019002-Compound-39
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MOA Inhibitor
Activity IC50 < 100 nM
External Link
 Compound Name PMID27019002-Compound-31b Patented [9]
MOA Inhibitor
Activity IC50 = 31380 nM
External Link
 Compound Name Benzenamine derivative 3 Patented [9]
Synonyms
PMID27019002-Compound-35a
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MOA Inhibitor
External Link
 Compound Name Cyclopropylamine derivative 1 Patented [9]
Synonyms
PMID27019002-Compound-23
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MOA Inhibitor
Activity IC50 = 1 to 100 nM
External Link
 Compound Name N6-cyclopropyllydine derivative 1 Patented [9]
Synonyms
PMID27019002-Compound-30
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 10 to 1000 nM
External Link
 Compound Name Tarnylcypromine derivative 1 Patented [9]
Synonyms
PMID27019002-Compound-18
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1300 nM
External Link
 Compound Name Cyclopropylamine derivative 7 Patented [9]
Synonyms
PMID27019002-Compound-29e
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MOA Inhibitor
External Link
 Compound Name Aryl cyclopropylamine derivative 4 Patented [9]
Synonyms
PMID27019002-Compound-25b
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 456000 nM
External Link
 Compound Name PMID27019002-Compound-45 Patented [9]
MOA Inhibitor
External Link
 Compound Name PMID27019002-Compound-13 Patented [9]
MOA Inhibitor
Activity IC50 = 5270 nM
External Link
 Compound Name PMID27019002-Compound-49 Patented [9]
MOA Inhibitor
External Link
 Compound Name Cyclopropylamine derivative 4 Patented [9]
Synonyms
PMID27019002-Compound-29b
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name PMID27019002-Compound-42b Patented [9]
MOA Inhibitor
Activity IC50 > 3000 nM
External Link
 Compound Name PMID27019002-Compound-31a Patented [9]
MOA Inhibitor
Activity IC50 = 39380 nM
External Link
 Compound Name PMID27019002-Compound-43c Patented [9]
MOA Inhibitor
Activity IC50 = 81 nM
External Link
 Compound Name Aryl cyclopropylamine derivative 3 Patented [9]
Synonyms
PMID27019002-Compound-25a
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 173000 nM
External Link
 Compound Name Benzenamine derivative 4 Patented [9]
Synonyms
PMID27019002-Compound-36
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MOA Inhibitor
External Link
 Compound Name Cyclopropylamine derivative 6 Patented [9]
Synonyms
PMID27019002-Compound-29d
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name Pyrimidine derivative 16 Patented [9]
Synonyms
PMID27019002-Compound-38
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name PMID27019002-Compound-28 Patented [9]
MOA Inhibitor
Activity IC50 < 1000 nM
External Link
 Compound Name Heteroaryl-cyclopropylamine derivative 2 Patented [9]
Synonyms
PMID27019002-Compound-22a
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 to 1000 nM
External Link
 Compound Name Cyclopropylamine derivative 5 Patented [9]
Synonyms
PMID27019002-Compound-29c
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name PMID27019002-Compound-43b Patented [9]
MOA Inhibitor
Activity IC50 = 273 nM
External Link
 Compound Name Pyrimidine derivative 18 Patented [9]
Synonyms
PMID27019002-Compound-40
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name Cyclopropylamine derivative 3 Patented [9]
Synonyms
PMID27019002-Compound-29a
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name PMID27019002-Compound-20b Patented [9]
MOA Inhibitor
Activity IC50 = 1 to 100 nM
External Link
 Compound Name PMID27019002-Compound-50 Patented [9]
MOA Inhibitor
External Link
 Compound Name Cyclopropylamine derivative 8 Patented [9]
Synonyms
PMID27019002-Compound-32
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 to 500 nM
External Link
 Compound Name PMID27019002-Compound-43a Patented [9]
MOA Inhibitor
Activity IC50 = 90 nM
External Link
 Compound Name Benzenamine derivative 1 Patented [9]
Synonyms
PMID27019002-Compound-14
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name PMID27019002-Compound-7 Patented [9]
MOA Inhibitor
Activity IC50 = 59 nM
External Link
 Compound Name PMID27019002-Compound-42a Patented [9]
MOA Inhibitor
Activity IC50 > 3000 nM
External Link
 Compound Name PMID27019002-Compound-37a Patented [9]
MOA Inhibitor
Activity IC50 = 11160 nM
External Link
 Compound Name PMID27019002-Compound-44 Patented [9]
MOA Inhibitor
Activity IC50 = 1190 nM
External Link
 Compound Name PMID27019002-Compound-21a Patented [9]
MOA Inhibitor
Activity IC50 = 100 nM
External Link
 Compound Name PMID27019002-Compound-37b Patented [9]
MOA Inhibitor
Activity IC50 = 10540 nM
External Link
 Compound Name Heteroaryl-cyclopropylamine derivative 4 Patented [9]
Synonyms
PMID27019002-Compound-22c
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 nM
External Link
 Compound Name Cyclopropylamine derivative 11 Patented [9]
Synonyms
PMID27019002-Compound-33c
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 180 nM
External Link
 Compound Name PMID25399762-Compound-Table 6-11 Patented [10]
MOA Inhibitor
Activity IC50 < 200 nM
External Link
 Compound Name PMID27019002-Compound-20a Patented [9]
MOA Inhibitor
Activity IC50 = 1 to 100 nM
External Link
 Compound Name Cyclopropylamine derivative 9 Patented [9]
Synonyms
PMID27019002-Compound-33a
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 230 nM
External Link
 Compound Name PMID25399762-Compound-Table 6-13 Patented [10]
MOA Inhibitor
Activity IC50 < 30 nM
External Link
 Compound Name Heteroaryl-cyclopropylamine derivative 3 Patented [9]
Synonyms
PMID27019002-Compound-22b
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 nM
External Link
 Compound Name Cyclopropylamine derivative 13 Patented [9]
Synonyms
PMID27019002-Compound-33e
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 100 nM
External Link
 Compound Name PMID27019002-Compound-21b Patented [9]
MOA Inhibitor
Activity IC50 = 1 to 100 nM
External Link
 Compound Name PMID27019002-Compound-48 Patented [9]
MOA Inhibitor
External Link
 Compound Name PMID25399762-Compound-Table 6-10 Patented [10]
MOA Inhibitor
Activity IC50 < 100 nM
External Link
 Compound Name PMID25399762-Compound-Table 6-12 Patented [10]
MOA Inhibitor
Activity IC50 < 200 nM
External Link
 Compound Name PMID25399762-Compound-Table 6-9 Patented [10]
MOA Inhibitor
Activity IC50 < 20 nM
External Link
 Compound Name PMID25399762-Compound-Table 6-14 Patented [10]
MOA Inhibitor
Activity IC50 < 100 nM
External Link
 Compound Name PMID25399762-Compound-Table 6-15 Patented [10]
MOA Inhibitor
Activity IC50 < 50 nM
External Link
 Compound Name Cyclopropylamine derivative 12 Patented [9]
Synonyms
PMID27019002-Compound-33d
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MOA Inhibitor
Activity IC50 = 210 nM
External Link
 Compound Name PMID27019002-Compound-21c Patented [9]
MOA Inhibitor
Activity IC50 = 1 to 100 nM
External Link
 Compound Name Cyclopropylamine derivative 10 Patented [9]
Synonyms
PMID27019002-Compound-33b
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MOA Inhibitor
Activity IC50 = 240 nM
External Link
 Compound Name PMID27019002-Compound-47 Patented [9]
MOA Inhibitor
External Link
 Compound Name PMID27019002-Compound-17 Patented [9]
MOA Inhibitor
Activity IC50 = 13 nM
External Link
 Compound Name N-(2-phenylcyclopropyl) amino acid derivative 2 Patented [9]
Synonyms
PMID27019002-Compound-19a
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MOA Inhibitor
Activity IC50 = 18 nM
External Link
 Compound Name PMID27019002-Compound-46 Patented [9]
MOA Inhibitor
External Link
 Compound Name Cyclic peptide derivative 1 Patented [9]
Synonyms
PMID27019002-Compound-compound11
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MOA Inhibitor
Activity IC50 = 5000 nM
External Link
 Compound Name Heteroaryl-cyclopropylamine derivative 1 Patented [9]
Synonyms
PMID27019002-Compound-22d
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MOA Inhibitor
Activity EC50 = 8 nM
External Link
 Compound Name N-(2-phenylcyclopropyl) amino acid derivative 3 Patented [9]
Synonyms
PMID27019002-Compound-19b
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MOA Inhibitor
Activity IC50 = 22 nM
External Link
 Compound Name N-(2-phenylcyclopropyl) amino acid derivative 1 Patented [9]
Synonyms
PMID27019002-Compound-19
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MOA Inhibitor
Activity Ki < 1000 nM
External Link
 Compound Name Tarnylcypromine derivative 2 Patented [9]
Synonyms
PMID27019002-Compound-26a-h
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MOA Inhibitor
Activity IC50 = 1100 to 1900 nM
External Link
 Compound Name Tarnylcypromine derivative 3 Patented [9]
Synonyms
PMID27019002-Compound-27a-m
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MOA Inhibitor
Activity IC50 = 1300 to 40000 nM
External Link
 Compound Name OG-L002 Investigative [11]
Synonyms
1357302-64-7; 4'-((1R,2S)-2-aminocyclopropyl)-[1,1'-biphenyl]-3-ol; SCHEMBL6837351; GTPL7023; OGL002; AOB2070; MolPort-035-395-885; BDBM179446; BCP12278; EX-A2117; s7237; 2610AH; ZINC114026926; AKOS027422749; SB19352; BC600435; 4'-((1R,2S)-2-aminocyclopropyl)biphenyl-3-ol; 3-{4-[(1R,2S)-2-aminocyclopropyl]phenyl}phenol; J-006764; US9676701, 4 4'-((trans)-2-aminocyclopropyl)biphenyl-3-ol hydrochloride
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 20 nM
External Link
 Compound Name GSK-LSD1 Investigative [12]
Synonyms
GSK-LSD1 2HCl; 1431368-48-7; N-[(1R,2S)-2-phenylcyclopropyl]piperidin-4-amine; GSK LSD1 Dihydrochloride; GTPL8241; SCHEMBL14880683; BDBM256459; 1431368-48-7(free base); ZINC44675892; AKOS030573682; GSK-LSD1, &gt; NCGC00356416-07; US9487512, 3
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MOA Inhibitor
Activity IC50 = 24 nM
External Link
 Compound Name NCL-1 Investigative [13]
Synonyms
GTPL7024; ZINC94568752
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MOA Inhibitor
External Link
8A20: Alzheimer disease 498 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Rivastigmine Approved [14]
Synonyms
Rivastigmine (transdermal patch)
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External Link
 Compound Name Propentofylline propionate Approved [15]
Synonyms
Hextol (TN)
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External Link
 Compound Name Dihydroergotoxine Approved [16]
Synonyms
Ergotamine, dihydro, methanesulfonate (salt)
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External Link
 Compound Name Galantamine Approved [17]
Synonyms
GNT; Galantamin; Galantamina; Galantaminum; Galanthamine; Galanthaminum; Jilkon; Lycoremin; Lycoremine; Reminyl; Razadyne ER; Galantamina [INN-Spanish]; Galantamine [USAN:INN]; Galantaminum [INN-Latin]; Nivalin (TN); Razadyne (TN); Razadyne ER (TN); Reminyl (TN); Galantamine (USAN/INN); (-)-Galanthamine; (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro(3a,3,2-ef)(2)benzazepin-6-ol
    Click to Show/Hide
External Link
 Compound Name Eicosapentaenoic acid/docosa-hexaenoic acid Approved [18]
Synonyms
Docosahexaenoic acid; Doconexent; Cervonic acid; 6217-54-5; all-cis-DHA; Doconexentum; Doconexento; Doxonexent; (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoic acid; AquaGrow Advantage; all-Z-Docosahexaenoic acid; Martek DHA HM; Ropufa 60; cis-4,7,10,13,16,19-Docosahexaenoic acid; Docosahexaenoate; UNII-ZAD9OKH9JC; (4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic acid; Docosahexaenoic acid (all-Z); CCRIS 7670; all-cis-4,7,10,13,16,19-Docosahexaenoic acid; ZAD9OKH9JC; all-cis-docosa-4,7,10,13,16,19-hexaenoic acid; CHEMBL367149; Espanova (TN)
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External Link
 Compound Name Donepezil Approved [19]
Synonyms
Donepezil (transdermal patch, Alzheimer's disease)
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External Link
 Compound Name Thiazolidinedione Approved [20]
Synonyms
2295-31-0; 1,3-Thiazolidine-2,4-dione; thiazolidine-2,4-dione; 2,4-Dioxothiazolidine; 2,4(3H,5H)-Thiazoledione; USAF EK-5496; Thiazolidindione; UNII-AA68LXK93C; Thiazolidinedione-2,4; NSC 6745; EINECS 218-941-2; BRN 0110700; AA68LXK93C; AI3-61185; CHEBI:50992; NSC6745; ZOBPZXTWZATXDG-UHFFFAOYSA-N; MFCD00005478; 2,4-Thiazolidinedione, 99%; C3H3NO2S; thiazolidine-dione; 2,4-thiazolidindione; 2,5H)-Thiazoledione; PubChem17487
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External Link
 Compound Name Rosiglitazone XR Approved [21]
Synonyms
Avandia; Nyracta; Venvia; Rosiglitazone Maleate [USAN]; Rosiglitazone maleate; BRL 49653C; Avandia (TN); Avandiaadministration for 6-12 weeks; BRL 49653-C; BRL-49653C; SB-206846; SB-210232; Rosiglitazone maleate (JAN/USAN); (+-)-5-(p-(2-(Methyl-2-pyridylamino)ethoxy)benzyl)-2,4-thiazolidinedione maleate (1:1); (+-)-5-[[4-2-(methyl]-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione,(Z)-2-butenedioate (1:1); 2,4-Thiazolidinedione, 5-((4-(2-(methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-, (2Z)-2-butenedioate (1:1); 2,4-Thiazolidinedione, 5-[[4-[2-(methyl-2-pyridinylamino) ethoxy]phenyl]methyl]-, (2Z)-2-butenedioate (1:1); 2,4-Thiazolidinedione,5-((4-(2-(methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-,(2Z)-2-butenedioate; 5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione; 5-{[4-({2-[methyl(pyridin-2-yl)amino]ethyl}oxy)phenyl]methyl}-1,3-thiazolidine-2,4-dione (2Z)-but-2-enedioate
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External Link
 Compound Name GV-971 Approved in China [22]
External Link
 Compound Name Tacrine Approved [23]
Synonyms
Cognex; Romotal; Tacrina; Tacrinal; Tacrinum; Tenakrin; Tetrahydroaminacrine; Tetrahydroaminoacridine; Tetrahydroaminocrin; Tetrahydroaminocrine; Tha; Tacrine hydrochloride; BBL001044; CS 12602; Cognex (TN); Tacrina [INN-Spanish]; Tacrinal (TN); Tacrine (INN); Tacrine [INN:BAN]; Tacrinum [INN-Latin]; 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE; 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE (SEE ALSO 1684-40-8); 1,2,3,4-Tetrahydro-9-acridineamine; 1,2,3,4-Tetrahydro-acridin-9-ylamine; 1,2,3,4-Tetrahydroaminoacridine; 1,2,3,4-tetrahydroacridin-9-amine; 5-Amino-6,7,8,9-tetrahydroacridine (European); 9-AMINOTETRAHYDROACRIDINE; 9-Acridinamine, 1,2,3,4-tetrahydro-(9CI); 9-Amino-1,2,3,4-Tetrahydroacridine Hydrate Hydrochloride Hydrate; 9-amino-1,2,3,4-tetrahydroacridine
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External Link
 Compound Name Lemborexant Phase 2 [24]
Synonyms
E2006
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External Link
 Compound Name Pexidartinib Approved [25]
Synonyms
PLX-3397
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External Link
 Compound Name F18-florbetaben Approved [26]
External Link
 Compound Name Colostrinin Approved [15]
Synonyms
Colostrinin (TN)
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External Link
 Compound Name Huperzine A Approved [15]
Synonyms
Fordine; ( inverted exclamation markA)-Huperazine A; ( inverted exclamation markA)-Huperzine A; C15H18N2O; 5,9-Methanocycloocta(b)pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-; rac-huperzine A; NCGC00159362-02; SCHEMBL679315; SCHEMBL1047469; CHEMBL394259; CHEBI:91724; MolPort-003-941-680
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External Link
 Compound Name Lecanemab Approved [27]
External Link
 Compound Name F18-flutemetamol Approved [28]
External Link
 Compound Name Ergoloid mesylate Approved [29]
Synonyms
Alkergot; Circanol; Gerimal; Hydergin; Ischelium; Redergin; Trigot; Dihydroergotoxin Mesilat; Dihydroergotoxinmesylate; Dihydroergotoxin methanesulfonate; Dihydroergotoxine methanesulfonate; Dihydroergotoxine methanesulphonate; Ergoloid Mesylates [USAN]; Hydergine LC; Hydrogenated Ergot Alkaloids; Alkergot (TN); Cicanol (TN); Deapril-ST; Gerimal (TN); Hydergina (TN); Hydergine (TN); Niloric (TN); Redergin (TN); Redizork (TN)
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External Link
 Compound Name Immune globulin Approved [30]
External Link
 Compound Name Memantine Approved [31]
Synonyms
Memantine ER; Namenda XR; Memantine (extended release); Memantine (extended release), Forest
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External Link
 Compound Name Aducanumab Approved [32]
External Link
 Compound Name Nirogacestat Phase 2 [33]
Synonyms
Nirogacestat; 1290543-63-3; PF-3084014; UNII-QZ62892OFJ; 865773-15-5; PF 3084014; PF-03084014 (PF-3084014); QZ62892OFJ; Z-3181; PF03084014; Nirogacestat [USAN]; Nirogacestat (USAN/INN); GTPL7746; SCHEMBL13184754; CHEMBL1770916; EX-A855; DTXSID60235679; MolPort-039-193-852; (2S)-2-[[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]amino]-N-[1-[1-(2,2-dimethylpropylamino)-2-methylpropan-2-yl]imidazol-4-yl]pentanamide; ZINC38217837; s8018; AKOS030526383; SB16726; DB12005; CS-1689; NCGC00378713-01
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External Link
 Compound Name 18F-AV-1451 Phase 4 [34]
Synonyms
Tau imaging agent)
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External Link
 Compound Name NE3107 Phase 3 [35]
External Link
 Compound Name Guanfacine Phase 3 [36]
Synonyms
(2,6-dichlorophenylacetyl)-guanidine; [(2,6-dichlorophenyl)acetyl]guanidine; [(2,6-Dichlorophenyl)acetyl]guanidine hydrochloride; 29110-47-2; 30OMY4G3MK; A902647; A918619; AB01563079_01; AKOS030255657; AKOS030526130; BCP09647; BDBM81984; Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-; BPBio1_000415; BRD-K32830106-003-03-0; BRD-K32830106-003-11-3; BSPBio_000377; C02AC02; C07037; CAS_29110-47-2; CAS-29110-48-3; CCG-204609; CHEBI:5558; CHEMBL862; D08031; DB01018; DTXCID7026944; DTXSID9046944; EINECS 249-442-8; EN300-243924; Estulic; Estulic (Salt/Mix); Estulic (TN); FT-0669067; FT-0669068; GTPL522; Guanfacina; Guanfacina (INN-Spanish); Guanfacina [INN-Spanish]; GUANFACINE; Guanfacine (INN); Guanfacine [INN:BAN]; GUANFACINE [INN]; GUANFACINE [MI]; GUANFACINE [VANDF]; GUANFACINE [WHO-DD]; Guanfacine HCl; Guanfacine hydrochloride (Salt/Mix); Guanfacinum; Guanfacinum (INN-Latin); Guanfacinum [INN-Latin]; HY-17416A; J-017394; L000286; L013430; LON 798 (Salt/Mix); Lopac0_000519; Lopac-G-1043; MRF-0000019; N-(Diaminomethyliden)-2-(2,6-dichlorophenyl)acetamid; N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide; N-amidino-2-(2,6-dichlorophenyl)acetamide; N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide; NCGC00015469-01; NCGC00015469-02; NCGC00015469-03; NCGC00015469-04; NCGC00015469-05; NCGC00015469-06; NCGC00015469-07; NCGC00024950-01; NCGC00024950-02; NCGC00024950-03; NSC 759121; NSC_3519; NSC-759121; Prestwick0_000339; Prestwick1_000339; Prestwick2_000339; Prestwick3_000339; Q5613599; RASPBERRYKETONEGLUCOSIDE; SCHEMBL35094; SDCCGSBI-0050502.P002; SPBio_002298; Tenex (Salt/Mix); Tocris-1030; UNII-30OMY4G3MK
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External Link
 Compound Name BPDO-1603 Phase 3 [37]
External Link
 Compound Name TRx0237 Phase 3 [38]
Synonyms
951131-15-0; UNII-E79ZM68IOZ; E79ZM68IOZ; Leucomethylene Blue dihydrobromide; TRX0237 dihydrobromide; TRX 0237 dihydrobromide; TRX-0237 dihydrobromide; TRx0237(LMTX); TRX-0237 2HBr; Leukomethylene Blue dihydrobromide; Hydromethylthionine HBr(TRX0237); BCP24159; EX-A4299; Reduced methylene Blue dihydrobromide; N3,N3,N7,N7-Tetramethyl-10H-phenothiazine-3,7-diamine dihydrobromide; Leucomethylene Blue 2HBr;TRX0237 dihydrobromide;TRX 0237 dihydrobromide;TRX-0237 dihydrobromide
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External Link
 Compound Name AXS-05 Phase 2/3 [39]
External Link
 Compound Name Remternetug Phase 3 [40]
Synonyms
LY3372993
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External Link
 Compound Name Donanemab Phase 3 [41]
External Link
 Compound Name AR1001 Phase 3 [42]
Synonyms
(-)-methylbenzylamine; (+)-2-Methylbutylp-aminocinnamate; 103-67-3; 7KN7F4X49E; AI3-26793; AKOS000119094; AR1001; Benzenemethanamine, N-methyl-; benzyl methyl amine; benzyl methylamine; Benzyl(methyl)amine; BENZYLAMINE, N-METHYL; Benzylamine, N-methyl-; Benzylmethylamine; benzyl-methylamine; Benzyl-methyl-amine; Benzylmethyl-d3-amine; BRD-K44558320-003-01-7; CHEMBL1338; CS-W007426; DTXSID9048439; EC 203-133-4; EINECS 203-133-4; EN300-18191; F2190-0316; FT-0631560; HNMeBzl; HY-W007426; InChI=1/C8H11N/c1-9-7-8-5-3-2-4-6-8/h2-6,9H,7H2,1H; KBio2_001842; KBio2_004410; KBio2_006978; KBioGR_002247; KBioSS_001842; M0164; methyl benzylamine; Methyl(phenylmethyl)amine; methyl-benzyl amine; Methylbenzylamine; Methylbenzylamine, N-; methylbezylamine; MFCD00008289; MLS004773900; N-(Phenylmethyl)methylamine; N-benzyl methyl amine; N-benzyl methylamine; N-benzylmethanamine; N-benzyl-methyl amine; N-Benzylmethylamine; N-benzyl-methylamine; N-Benzylmethylamine, 97%; N-Benzyl-N-methylamine; N-benzyl-N-methyl-amine; NCGC00166047-01; N-methyl benzyl amine; N-methyl benzylamine; N-methyl -benzylamine; N-Methyl(phenyl)methanamine; N-methyl-1-phenylmethanamine; N-methyl-1-phenyl-methanamine; N-methylbenzenemethanamine; N-methyl-benzenemethanamine; N-methylbenzyl amine; N-methyl-benzyl amine; N-METHYLBENZYLAMINE; N-methyl-benzylamine; N-methyl-N-(phenylmethyl)amine; N-methyl-N-benzyl amine; N-methyl-N-benzylamine; N-Methy-N-benzylamine; NSC 8059; NSC8059; NSC-8059; omega-Methylaminotoluene; Q23978278; Racemic methylbenzyl amine; SCHEMBL2271; SDCCGMLS-0066901.P001; SMR000112361; Spectrum_001362; Spectrum4_001764; Spectrum5_000347; STR02536; UNII-7KN7F4X49E; W-108843; Z57327124
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External Link
 Compound Name GV-971 Phase 3 [43]
Synonyms
sodium oligomannate
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External Link
 Compound Name AVP-786 Phase 3 [39]
External Link
 Compound Name NI-101 Phase 3 [44]
Synonyms
BART; Ch12F6A; MAb (AD), Neurimmune/Biogen Idec; Monoclonal antibodies (Alzheimer! s disease), Neurimmune Therapeutics/Biogen Idec; Anti-beta amyloid mAbs (Alzheimer! s disease), Neurimmune Therapeutics/Biogen Idec
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External Link
 Compound Name AC-1204 Phase 3 [24]
Synonyms
isoindoline hydrochloride; 32372-82-0; 2,3-Dihydroisoindole hydrochloride; 2,3-dihydro-1H-isoindole hydrochloride; 2,3-Dihydro-1H-isoindole HCl; Isoindoline HCl salt; 1H-Isoindole, 2,3-dihydro-, hydrochloride; Isoindoline hydrochloride, 97%; Isoindolinehydrochloride; Isoindoline, HCl; ISOINDOLINE HCL; AC1Q38WR; dihydroisoindole hydrochloride; KSC491I3F; AMBZ0192; SCHEMBL4702076; CTK3J1432; DTXSID50487241; MolPort-003-986-749; NOVIRODZMIZUPA-UHFFFAOYSA-N; BH168; CS-D1516; ACT08858; ACN-S003258; KS-000001RA
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External Link
 Compound Name Lanabecestat Phase 3 [24]
Synonyms
1383982-64-6; UNII-X8SPJ492VF; X8SPJ492VF; LY3314814; Lanabecestat [USAN]; Lanabecestat (USAN); SCHEMBL9947930; GTPL7789; SCHEMBL9947926; CHEMBL3261045; SCHEMBL10249890; CHEMBL3989948; CHEMBL3349234; BDBM41542; BDBM41537; MolPort-044-560-403; BDBM136733; EX-A1471; s8193; ZINC95576075; BDBM50012629; US8865911, 20a Isomer 1; CS-7494; Lanabecestat(AZD3293,LY-3314814); HY-100740; LY 3314814; D10946; US8865911, 122; US8865911, 114; 4-methoxy-5'-methyl-6'-(5-(prop-1-yn-1-yl)pyridin-3-yl)-3'H-dispiro(cyclohexane
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External Link
 Compound Name Davunetide Phase 3 [45]
Synonyms
NAP; AL-108; AL-208; Davunetide (intranasal spray), Allon; NAPVSIPQ eight amino acid peptide (intranasal spray), Allon; Davunetide (intravenous-infused), Allon Therapeutics; NAP eight amino acid peptide (neuroprotection/cognitive impairment), Allon; NAPVSIPQ eight amino acid peptide (neuroprotection/cognitive impairment), Allon; Central nervous system therapeutic (Alzheimer's disease/schizophrenia), Allon; Central nervous system therapeutic (post-cardiac artery bypass graft/mild cognitive impairment), Allon; NAPVSIPQ eight amino acid peptide (intravenous-infused/subcutaneous depot formulation), Allon Therapeutics; Davunetide (iv/sc, Alzheimer's disease), Allon Therapeutics
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External Link
 Compound Name SB-742457 Phase 3 [46]
Synonyms
GSK 742457; SB 742457; GSK-742457; 3-(benzenesulfonyl)-8-piperazin-1-yl-quinoline
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External Link
 Compound Name Crenezumab Phase 3 [24]
Synonyms
MABT5102A; RG7412
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External Link
 Compound Name verubecestat Phase 3 [47]
Synonyms
example 25 (US8940748)
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External Link
 Compound Name Gantenerumab Phase 3 [48]
Synonyms
RG1450
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External Link
 Compound Name PF-4494700 Phase 3 [24]
Synonyms
PF-04494700; TTP-488; TTP-488); Alzheimers therapy, TransTech/Pfizer; Diabetic nephropathy therapy, Transtech/Pfizer; Alzheimer'streatment, TransTech/Pfizer; Alzheimer's therapy (RAGE), Transtech/Pfizer
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External Link
 Compound Name acelarin Phase 2 [49]
Synonyms
NUC-1031
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External Link
 Compound Name AMG 386 Phase 3 [50]
Synonyms
7440-23-5; Natrium; Sodium-23; Sodio; Sodium metal; Sodio [Spanish]; Sodium (liquid alloy); UNII-9NEZ333N27; HSDB 687; EINECS 231-132-9; UN1428; UNII-23J3BHR95O; Sodium, dry stick; 9NEZ333N27; MFCD00085307; Sodium, 998%, oiled sticks, wrapped in aluminium foil; monosodium; sodium atom; mono sodium; mono-sodium; Sodium, CP; SodiuR4733m hydride, CP; AC1NSENP; ACMC-1BKTZ; Sodium, ACS reagent, dry; 11Na; EC 231-132-9; AC1Q1W6R; SODIUM, LARGE PIECES; Sodium hydride, dry, 95%; NAH 80; HSDB 745; CTK2H7876; CHEBI:26708; Oravescent fentanyl; R3487; PT-15; R4930
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External Link
 Compound Name SI-657 Phase 3 [51]
Synonyms
AC1L9R2T; 6-[3-acetamido-2-[6-[3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
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External Link
 Compound Name EVP-6124 Phase 3 [52]
Synonyms
Encenicline; 550999-75-2; UNII-5FI5376A0X; EVP6124; EVP 6124; CHEMBL2151572; (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide; 5FI5376A0X; C16H17ClN2OS; 550999-74-1; Encenicline [USAN:INN]; FRM-6124; Encenicline (USAN/INN); SCHEMBL744767; GTPL6926; SSRDSYXGYPJKRR-ZDUSSCGKSA-N; ZINC95579362; BDBM50393255; 3662AH; AKOS027322165; DB11726; CS-0933; MT-4666; Benzo(b)thiophene-2-carboxamide, N-(3R)-1-azabicyclo(2.2.2)oct-3-yl-7-chloro-; NCGC00378871-01; HY-15430; W-5978; D10626
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External Link
 Compound Name ALZT-OP1 Phase 3 [24]
Synonyms
ALZT-OP1a+ALZT-OP1b; cromolyn + ibuprofen
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External Link
 Compound Name MIM-D3 Phase 3 [53]
Synonyms
TrkA agonist (ocular disease/Alzheimer's disease), Mimetogen
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External Link
 Compound Name LCS 16 Phase 3 [54]
External Link
 Compound Name Bapineuzumab Phase 3 [55]
Synonyms
AAB-001; Monoclonal antibody (Alzheimer's disease), Elan/Pfizer; Monoclonal antibody (Alzheimer's disease), Elan/Wyeth; Monoclonal antibody (Alzheimer's disease), Wyeth/Elan
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External Link
 Compound Name Tirapazamine Phase 3 [56]
Synonyms
TPZ; Tirazone; SR-259075; SR-4233; SR-4317; SR-4330; SR-4482; Win-59075
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External Link
 Compound Name AV 133 Phase 3 [57]
External Link
 Compound Name Tramiprosate Phase 3 [58]
Synonyms
Alzhemed; Cerebril; Homotaurine; Vivimind; LU-02659; NC-531; NC-758; Tramiprosate (stroke), Neurochem; Tramiprosate (Alzheimer's disease), Neurochem; 3APS
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External Link
 Compound Name E-2609 Phase 3 [24]
Synonyms
Beta secretase inhibitor (Alzheimer's disease), Eisai
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External Link
 Compound Name (-)-Phenserine Phase 3 [59]
Synonyms
CHEMBL54727; SCHEMBL5464366; BDBM10622; (3aS)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyrrolo[2,3-b]indol-5-yl N-phenylcarbamate
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External Link
 Compound Name ARC029 Phase 3 [60]
Synonyms
Nilvadipine; 75530-68-6; Escor; Nivadil; Nivadipine; FR-34235; Nilvadipinum [Latin]; Nilvadipino [Spanish]; FR 34235; FK 235; Nilvadipine [USAN:INN:JAN]; Nilvadipine (ARC029); FK-235; F-102362; BRN 3572609; F 102,362; CL-287389; CL 287,389; FAIIFDPAEUKBEP-UHFFFAOYSA-N; C19H19N3O6; NCGC00167435-01; 5-Isopropyl 3-methyl 2-cyano-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate; 3,5-Pyridinedicarboxylic acid, 2-cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-methyl 5-(1-methylethyl) ester; Nilvadipino
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External Link
 Compound Name Eltoprazine Phase 2 [24]
Synonyms
Piperazine derivative (ADHD), PsychoGenics/ReqMed Company; 5-HT1A/5-HT1B agonist and 5-HT2C antagonist (ADHD), PsychoGenics/ReqMed Company
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External Link
 Compound Name LMT-X Phase 3 [61]
Synonyms
Second-generation tau aggregation inhibitor (Alzheimer's disease); Second-generation tau aggregation inhibitor (Alzheimer's disease), TauRx
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External Link
 Compound Name INM-176 Phase 3 [62]
Synonyms
WIN-026; Win-025; Alzheimer's therapeutic, Whanin Pharmaceuticals; KR-WAP-026; Anti-beta amyloid/AChE inhibitor (Alzheimer's), WhanIn; Anti-beta amyloid/acetylcholinesterase inhibitor (Alzheimer's), WhanIn
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External Link
 Compound Name Xaliproden Phase 3 [63]
Synonyms
Xaliproden (USAN); 1,2,3,6-tetrahydro-1-(2-(2-naphthalenyl)ethyl)-4-(3-(trifluoromethyl)phenyl)-pyridine; 1,2,3,6-tetrahydro-1-(2-(2-naphthyl)ethyl)-4-(alpha,alpha,alpha-trifluoro-m-tolyl)pyridine; 1-(2-(2-Naphthyl)ethyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine; 1-(2-naphthalen-2-ylethyl)-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-pyridine; 1-[2-(2-naphthyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine
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External Link
 Compound Name Tamibarotene Phase 3 [64]
Synonyms
Tamibarotene (oral, Alzheimer's disease)
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External Link
 Compound Name Immune globulin + albumin Phase 3 [24]
External Link
 Compound Name Solanezumab Phase 3 [65]
External Link
 Compound Name E2814 Phase 2/3 [66]
External Link
 Compound Name CAD106 Phase 2/3 [67]
External Link
 Compound Name Icosapent ethyl Phase 2/3 [68]
Synonyms
(5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoic acid ethyl ester; (5Z,8Z,11Z,14Z,17Z)-Eicosapetaenoic acid ethyl ester; (all-Z)-5,8,11,14,17-Eicosapentaenoic acid ethyl ester; 5,8,11,14,17-eicosapentaenoic acid, ethyl ester, (5Z,8Z,11Z,14Z,17Z)-; 5,8,11,14,17-Eicosapentaenoic acid, ethyl ester, (all-Z)-; 5-8-11-14-17-all cis-eicosapentaenoic acid ethyl ester; 5Z,8Z,11Z,14Z,17Z-Eicosapentaenoic acid, ethyl ester; 6GC8A4PAYH; 73310-10-8; 86227-47-6; 86227-47-6 for all ''Z'' compound, 73310-10-8 for ''undefined'' compound; AB01563352_01; AC-33765; AKOS025295847; all cis-5,8,11,14,17-Eicosapentaenoic Acid Ethyl Ester; all-cis-ethyl 5,8,11,14,17-icosapentaenoate; AMR 101; AMR101; AMR-101; BS-48985; CCG-213714; CHEBI:80366; CHEBI:84883; CHEMBL2095209; cis-5,8,11,14,17-Eicosapentaenoic acid ethyl ester; cis-5,8,11,14,17-Eicosapentaenoic acidethyl ester; cis-Eicosapentaenoic acid ethyl ester; CS-5304; D01892; DB08887; DTXSID601018686; E0442; E0853; E-EPA; Eicosapentaenoic acid (ethyl ester); Eicosapentaenoic acid ethyl ester; EICOSAPENTAENOIC ACID ETHYL ESTER (MART.); EICOSAPENTAENOIC ACID ETHYL ESTER (USP-RS); EICOSAPENTAENOIC ACID ETHYL ESTER [MART.]; EICOSAPENTAENOIC ACID ETHYL ESTER [MI]; EICOSAPENTAENOIC ACID ETHYL ESTER [USP-RS]; EICOSAPENTAENOIC ACID ETHYL ESTER [WHO-DD]; Eicosapentaenoic acid, ethyl ester; Eicosapentaenoicacidethylester; EICOSAPENTAENOICACIDETHYLESTER(EPAEE)(SG); EN300-25951782; EPA ethyl ester; Epadel; Epadel S; Epadel S (TN); EPA-E; Ethyl (5Z,8Z,11Z,14Z,17Z)-eicosa-5,8,11,14,17-pentaenoate; ethyl (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate; ethyl (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate; ethyl (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate; Ethyl (all cis)-5,8,11,14,17-icosapentaenoate; Ethyl all cis-5,8,11,14,17-Eicosapentaenoate; Ethyl all cis-5,8,11,14,17-Icosapentaenoate; ethyl all-cis-5,8,11,14,17-icosapentaenoate; Ethyl all-cis-5,8,11,14,17-icosapentaenoic acid; ethyl eicosapentaenoate; Ethyl eicosapentaenoic acid; Ethyl EPA; Ethyl ester(all-Z)-5,8,11,14,17-Eicosapentaenoic acid; Ethyl icosapent; ethyl icosapentaenoate; ethyl icosapentate; Ethyl icosapentate (JP17); Ethyl icosapentate [JAN]; Ethyl icosapentate, JAN; ethyl-eicosapentaenoic acid; ethyl-EPA; GTPL7441; HMS2094K19; HY-B0747; ICOSAPENT ETHYL; Icosapent ethyl (USAN); ICOSAPENT ETHYL [ORANGE BOOK]; Icosapent ethyl [USAN]; ICOSAPENT ETHYL [VANDF]; Icosapent ethyl ester; LMFA07010877; MFCD00673476; MND 21; NSC 759597; NSC759597; NSC-759597; Pharmakon1600-01300030; Q5404453; s6466; SBI-0206684.P002; SCHEMBL123305; SR-05000002595; SR-05000002595-1; Timnodonic acid ethyl ester; UNII-6GC8A4PAYH; Vascepa; Vascepa (TN); Vazkepa
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External Link
 Compound Name Fosgonimeton Phase 2/3 [69]
Synonyms
2093305-05-4; AKOS040757261; ATH-1017; ATH-1017 FREE ACID; CHEMBL5095419; CS-0204081; dihydrogen 4-[(2S)-3-({(2S,3S)-1-[(6-amino-6-oxohexyl)amino]-3-methyl-1-oxopentan-2-yl}amino)-2-hexanamido-3-oxopropyl]phenyl phosphate; Fosgonimeton; Fosgonimeton [INN]; Fosgonimeton [USAN:INN]; Fosgonimeton [USAN]; H91OA9858J; HY-132814; L-Isoleucinamide, O-(phosphono-kappaO)-N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-; L-Isoleucinamide, O-(phosphono-kappaO)-N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-,; NDX-1017; NDX-1017 FREE ACID; UNII-H91OA9858J; WHO 11782
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External Link
 Compound Name Ginkgo biloba Phase 2/3 [70]
External Link
 Compound Name Atuzaginstat Phase 2/3 [71]
Synonyms
2211981-76-7; Atuzaginstat; Atuzaginstat [INN]; AtuzaginstatCOR388; BDBM453275; CHEMBL5095230; COR388; COR-388; Cyclopentanecarboxamide, N-((1S)-5-amino-1-(2-(2,3,6-trifluorophenoxy)acetyl)pentyl)-; DGN7ROZ8EN; EX-A6081; N-((3S)-7-Amino-2-oxo-1-(2,3,6- trifluorophenoxy)heptan-3-yl)cyclopentanecarboxamide; N-[(3S)-7-amino-2-oxo-1-(2,3,6-trifluorophenoxy)heptan-3-yl]cyclopentanecarboxamide; SCHEMBL19972758; UNII-DGN7ROZ8EN; US10730826, Compound 1a-non-racemic; US10730826, Compound 1a-racemic
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External Link
 Compound Name JNJ-54861911 Phase 2/3 [72]
External Link
 Compound Name Plasminogen Phase 2/3 [73]
External Link
 Compound Name CAD-106 Phase 2/3 [74]
Synonyms
Amilomotide; Alzheimers disease vaccine, Cytos/Novartis; Immunodrug vaccines (Alzheimers disease), Cytos/Novartis; Beta amyloid 1-6 peptide/Qbeta virus-like particle conjugate (Alzheimer's disease), Cytos/Novartis
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External Link
 Compound Name AMG520 Phase 2/3 [47]
Synonyms
CNP520
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External Link
 Compound Name SI-614 Phase 2/3 [75]
Synonyms
Modified Hyaluronate
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External Link
 Compound Name AZD3293 Phase 2/3 [76]
Synonyms
CHEMBL2152914; SCHEMBL9948518; SCHEMBL9948271; SCHEMBL18562845; BDBM50393099
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External Link
 Compound Name ABvac40 Phase 2 [77]
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 Compound Name AL002 Phase 2 [78]
External Link
 Compound Name MLC901 Phase 2 [79]
Synonyms
NeuroAiD
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External Link
 Compound Name ABBV-916 Phase 2 [80]
External Link
 Compound Name TB006 Phase 2 [81]
External Link
 Compound Name LY3372689 Phase 2 [82]
Synonyms
2241514-56-5; Acetamide, N-(4-fluoro-5-(((2S,4S)-2-methyl-4-((5-methyl-1,2,4-oxadiazol-3-yl)methoxy)-1-piperidinyl)methyl)-2-thiazolyl)-; CHEMBL5095251; CS-0433932; EX-A6549; GLXC-25705; GTPL11953; HY-144681; LY3372689; LY-3372689; MS-26295; N-(4-Fluoro-5-(((2S,4S)-2-methyl-4-((5-methyl-1,2,4-oxadiazol-3-yl)methoxy)piperidin-1-yl)methyl)thiazol-2-yl)acetamide; N-[4-fluoro-5-[[(2S,4S)-2-methyl-4-[(5-methyl-1,2,4-oxadiazol-3-yl)methoxy]piperidin-1-yl]methyl]-1,3-thiazol-2-yl]acetamide; SCHEMBL20421995; U0SGP6ZX2V; UNII-U0SGP6ZX2V
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External Link
 Compound Name MP-101 Phase 2 [83]
External Link
 Compound Name DHP1401 Phase 2 [84]
External Link
 Compound Name CY6463 Phase 2 [85]
Synonyms
2201048-82-8; 8-(2-Fluorobenzyl)-6-(3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl)imidazo(1,2-a)pyrazine; 8-[(2-fluorophenyl)methyl]-6-[5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl]imidazo[1,2-a]pyrazine; 8-[(2-fluorophenyl)methyl]-6-[5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl]imidazo[1,2-a]pyrazine; AKOS040757400; CS-0376702; CY6463; CY-6463; EX-A7620; GTKNNCQKFKGSHR-UHFFFAOYSA-N; H7KEN3O8AI; HY-145607; Imidazo(1,2-a)pyrazine, 8-((2-fluorophenyl)methyl)-6-(5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl)-; Imidazo[1,2-a]pyrazine, 8-[(2-fluorophenyl)methyl]-6-[5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl]-; IW-6463; MS-25746; SCHEMBL19922804; UNII-H7KEN3O8AI; Zagociguat; Zagociguat [INN]; ZAGOCIGUAT [USAN]
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External Link
 Compound Name ID1201 Phase 2 [86]
External Link
 Compound Name Benfotiamine Phase 2 [87]
Synonyms
(3Z)-4-{N-[(4-amino-2-methylpyrimidin-5-yl)methyl]carbonylamino}-3-(phenylcarb onylthio)pent-3-enyl dihydrogen phosphate; (Z)-S-(2-(N-((4-amino-2-methylpyrimidin-5-yl)methyl)formamido)-5-(phosphonooxy)pent-2-en-3-yl) benzothioate; {[(3Z)-4-{N-[(4-amino-2-methylpyrimidin-5-yl)methyl]formamido}-3-[(Z)-benzoylsulfanyl]pent-3-en-1-yl]oxy}phosphonic acid; 22457-89-2; 22457-89-2 (free acid); 775256-41-2; AC-8280; AKOS015920320; Benfotamine; Benfotiamina; benfotiamine; Benfotiamine (JAN/INN); Benfotiaminum; Benphothiamine; Benzoylthiamine monophosphate; Betivina; Biotamin (TN); BPBio1_000757; BSPBio_000687; CAS-22457-89-2; CCG-220654; CHEBI:41039; CHEMBL4303665; D01255; DB11748; DTXCID1025433; DTXSID3045433; EN300-21694383; HMS1570C09; HMS2097C09; HMS3714C09; MFCD00057343; N-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide S-benzoate O-phosphate; NCGC00016764-01; NCGC00016764-04; NCGC00179477-01; Prestwick_68; Prestwick2_000654; Prestwick3_000654; S-(2-(N-((4-Amino-2-methylpyrimidin-5-yl)methyl)formamido)-5-(phosphonooxy)pent-2-en-3-yl)benzothioa; S-[(Z)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-phosphonooxypent-2-en-3-yl] benzenecarbothioate; s-[2-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-5-(phosphonooxy)pent-2-en-3-yl] benzenecarbothioate; s-{(1z)-2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl](formyl)amino]-1-[2-(phosphonooxy)ethyl]-1-propenyl} benzenecarbothioate; S-{(1Z)-2-[[(4-Amino-2-methyl-5-pyrimidinyl)methyl](formyl)amino]-1-[2-(phosphonooxy)ethyl]-1-propenyl} benzenecarbothioate, AldrichCPR; S-Benzoylthiamine monophosphate; S-Benzoylthiamine O-monophosphate; S-Benzoylthiamine-O-monophosphate; SCHEMBL188070; SCHEMBL19184708; SR-01000872627; SR-01000872627-1; SR-01000872627-2; Tox21_110597; Tox21_110597_1
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External Link
 Compound Name ORY-2001 Phase 2 [88]
Synonyms
(1R,2S)-2-(4-(Benzyloxy)phenyl)-N-((5-imino-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl)cyclopropanamine; 1,3,4-Oxadiazole-2-methanamine, 4,5-dihydro-5-imino-N-((1R,2S)-2-(4-(phenylmethoxy)phenyl)cyclopropyl)-; 1,3,4-Oxadiazole-2-methanamine, 5-amino-N-((1R,2S)-2-(4-(phenylmethoxy)phenyl)cyclopropyl)-; 1357362-02-7; 5-((((1R,2S)-2-(4-(benzyloxy)phenyl)cyclopropyl)amino)methyl)-1,3,4-oxadiazol-2-amine; 5-(((trans)-2-(4-(benzyloxy)phenyl)cyclopropylamino)methyl)-1,3,4-oxadiazol-2-amine; 5-[[[(1R,2S)-2-(4-phenylmethoxyphenyl)cyclopropyl]amino]methyl]-1,3,4-oxadiazol-2-amine; A930244; AKOS040742807; BCP29383; BDBM50594947; CHEMBL4802155; CS-0058593; HY-112623; LZ82JLT4UP; MS-25100; ORY 2001; ORY2001; ORY-2001; ORY-2001; SCHEMBL528204; UNII-LZ82JLT4UP; Vafidemstat; Vafidemstat [INN]; XBBRLCXCBCZIOI-DLBZAZTESA-N
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External Link
 Compound Name Bepranemab Phase 2 [89]
Synonyms
RG6416
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External Link
 Compound Name JNJ-63733657 Phase 2 [90]
External Link
 Compound Name SAGE-718 Phase 2 [91]
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 Compound Name APH-1105 Phase 2 [92]
External Link
 Compound Name Nuplazid Phase 2 [93]
Synonyms
Pimavanserin tartrate; UNII-NA83F1SJSR; 706782-28-7; ACP 103; ACP-103; 706782-28-7 (tartrate); NA83F1SJSR; Pimavanserin tartrate [USAN]; Bis(1-(4-Fluorobenzyl)-1-(1-methylpiperidin-4-yl)-3-(4-(2-methylpropoxy)benzyl)urea) (2R,3R)-2,3-dihydroxybutanedioate; Pimavanserin tartrate (USAN); 1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methylpiperidin-4-yl)urea, ((2R,3R)-2,3-dihydroxysuccinate) (2:1); Nuplazide (TN); pimavanserin hemitartrate; DTXSID50220958; CHEBI:133014; HMS3886L06; HY-14557A; Pimavanserin Dihydroxysuccinate(2:1); AKOS027327334; CCG-270608; CS-7954; 1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methylpiperidin-4-yl)urea (2R,3R)-2,3-dihydroxysuccinate; AC-29901; AS-56699; N-(4-Fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1); Urea, N-((4-fluorophenyl)methyl)-N-(1-methyl-4-piperidinyl)-N'-((4-(2-methylpropoxy)phenyl)methyl)-, (2R,3R)-2,3-dihydroxybutanedioate (2:1); D08969; Q27284759; bis(4-{[(4-fluorophenyl)methyl]({[4-(2-methylpropoxy)phenyl]methyl}carbamoyl)amino}-1-methylpiperidin-1-ium) (2R,3R)-2,3-dihydroxybutanedioate; bis{N-[(4-fluorophenyl)methyl]-N-(1-methylpiperidin-4-yl)-N'-{[4-(2-methylpropoxy)phenyl]methyl}urea} (2R,3R)-2,3-dihydroxybutanedioate
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External Link
 Compound Name MK-1942 Phase 2 [94]
External Link
 Compound Name Bryostatin-1 Phase 2 [95]
Synonyms
(1S-(1R*,3R*,5Z,7S*,8E,11R*,12R*(2E,4E),13E,15R*,17S*(S*),21S*,23S*,25R*))-25-(Acetyloxy)-1,11,21-trihydroxy-17-(1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo(21.3.1.13,7.111,15)nonacos-8-en-12-yl 2,4-octadienoate; (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1(3,7).1(11,15)]nonacos-8-en-12-yl (2E,4E)-octa-2,4-dienoate; (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E, 4E)-2,4-octadienoic acid ester; [(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-acetyloxy-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl] (2E,4E)-octa-2,4-dienoate; 2,4-Octadienoic acid, (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-((1R)-1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo(21.3.1.13,7.111,15)nonacos-8-en-12-yl ester, (2E,4E)-; 2,4-Octadienoic acid, 25-(acetyloxy)-1,11,21-trihydroxy-17-(1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo(21.3.1.13,7.111,15)nonacos-8-en-12-yl ester, (1S-(1R*,3R*,5Z,7S*,8E,11R*,12R*(2E,4E),13E,15R*,17S*(S*),21S*,23S*,25R*))-; 37O2X55Y9E; 83314-01-6; BDBM50258529; BMY-45618; BRN 4349157; BRYOSTATIN; Bryostatin 1; Bryostatin 1 - CAS 83314-01-6; BRYOSTATIN 1 [MI]; BRYOSTATIN 1 [WHO-DD]; Bryostatin 1, >=99%, solid; Bryostatin-1; CHEBI:88353; CHEMBL449158; CS-0025440; DTXSID8046876; HY-105231; MFCD00893832; MJQUEDHRCUIRLF-TVIXENOKSA-N; NSC 339555; NSC-339555; Q27095907; SCHEMBL182960; UNII-37O2X55Y9E
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External Link
 Compound Name AADvac-1 Phase 2 [96]
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 Compound Name Semorinemab Phase 2 [97]
Synonyms
RO7105705
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External Link
 Compound Name NLY01 Phase 2 [98]
External Link
 Compound Name PTI-125 Phase 2 [99]
Synonyms
UNII-6NV440YIO0; 6NV440YIO0; PTI-910; Simufilam; Simufilam [USAN]; SCHEMBL12627054; C0105M; WHO 11778; 1-benzyl-8-methyl-1,4,8-triazaspiro(4.5)decan-2-one; 1,4,8-Triazaspiro(4.5)decan-2-one, 8-methyl-1-(phenylmethyl)-; 1224591-33-6
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External Link
 Compound Name AD-35 Phase 2 [100]
Synonyms
1531586-58-9; 6'-(2-(1-(Pyridin-2-ylmethyl)piperidin-4-yl)ethyl)spiro[cyClopropane-1,5'-[1,3]dioxolo[4,5-f]isoindol]-7'(6'H)-one; AD-35; BDBM231544; CHEMBL3949886; GLXC-15057; IND-120499; SCHEMBL15598869; starbld0021420; US9346818, I-29; US9346818, I-33; US9346818, I-35
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External Link
 Compound Name Vafidemstat Phase 2 [88]
Synonyms
(1R,2S)-2-(4-(Benzyloxy)phenyl)-N-((5-imino-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl)cyclopropanamine; 1,3,4-Oxadiazole-2-methanamine, 4,5-dihydro-5-imino-N-((1R,2S)-2-(4-(phenylmethoxy)phenyl)cyclopropyl)-; 1,3,4-Oxadiazole-2-methanamine, 5-amino-N-((1R,2S)-2-(4-(phenylmethoxy)phenyl)cyclopropyl)-; 1357362-02-7; 5-((((1R,2S)-2-(4-(benzyloxy)phenyl)cyclopropyl)amino)methyl)-1,3,4-oxadiazol-2-amine; 5-(((trans)-2-(4-(benzyloxy)phenyl)cyclopropylamino)methyl)-1,3,4-oxadiazol-2-amine; 5-[[[(1R,2S)-2-(4-phenylmethoxyphenyl)cyclopropyl]amino]methyl]-1,3,4-oxadiazol-2-amine; A930244; AKOS040742807; BCP29383; BDBM50594947; CHEMBL4802155; CS-0058593; HY-112623; LZ82JLT4UP; MS-25100; ORY 2001; ORY2001; ORY-2001; ORY-2001; SCHEMBL528204; UNII-LZ82JLT4UP; Vafidemstat; Vafidemstat [INN]; XBBRLCXCBCZIOI-DLBZAZTESA-N
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 Compound Name T3D-959 Phase 2 [101]
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 Compound Name RPh201 Phase 2 [102]
External Link
 Compound Name Trontinemab Phase 2 [103]
Synonyms
RG6102
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External Link
 Compound Name TPI-287 Phase 1 [104]
Synonyms
849213-15-6; (1S,2S,4S,7S,7aR,7a1S,10aS,11aR,13aS,13bR)-1-(benzoyloxy)-4-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-5-methylhexanoyl)oxy)-2-hydroxy-5,7a1,14,14-tetramethyl-9-vinyl-2,3,4,7,7a,7a1,10a,11,11a,13,13a,13b-dodecahydro-1H-8,10,12-trioxa-2,6-methanocyclobuta[b]cyclodeca[de]naphthalene-7,13a-diyl diacetate; TPI 287; SCHEMBL10000720; DTXSID50233967; Q27273546
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External Link
 Compound Name MW150 Phase 2 [105]
Synonyms
1628502-91-9; 3GF; 6-(4-methyl-1-piperazinyl)-3-(2-naphthalenyl)-4-(4-pyridinyl)-pyridazine; 6-(4-Methyl-piperazin-1-yl)-(2-naphthalen-2-yl)-4-pyridin-4-ylpyridazine; 6-(4-Methylpiperazin-1-Yl)-3-(Naphthalen-2-Yl)-4-(Pyridin-4-Yl)pyridazine; 6-(4-methylpiperazin-1-yl)-3-naphthalen-2-yl-4-pyridin-4-ylpyridazine; AKOS040758765; BDBM50537600; CHEMBL4129018; CIIVUDIZZJLXCN-UHFFFAOYSA-N; compound 11 [PMID: 30978288]; compound 27 [WO2014145485A2]; compound 8 [PMID: 25676389]; CS-0069509; EPZ68T461K; EX-A3206A; GTPL10524; HY-120111; MS-26255; MW 150; MW01-18-150SRM; MW150; MW-150; NSC785340; NSC-785340; Pyridazine, 6-(4-methyl-1-piperazinyl)-3-(2-naphthalenyl)-4-(4-pyridinyl)-; Q27453797; SCHEMBL16061104; UNII-EPZ68T461K
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External Link
 Compound Name NP001 Phase 1 [24]
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 Compound Name Nuedexta Phase 2 [24]
External Link
 Compound Name SUVN-502 Phase 2 [24]
Synonyms
SVN-502; 5-HT 6 receptor antagonist (Alzheimer's disease), Suven; 5-HT 6 receptor antagonist (cognitive/memory disorder), Suven
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External Link
 Compound Name S-38093 Phase 2 [106]
Synonyms
S-41150; S-38471-1; S-750-1; Histamine H3 antagonists (sleep/cognitive disorders), Servier
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 Compound Name LY3202626 Phase 2 [24]
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 Compound Name AN-1792 Phase 2 [107]
Synonyms
Betabloc; AIP-001
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 Compound Name BI-409306 Phase 2 [24]
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 Compound Name Methanesulfonyl fluoride Phase 2 [108]
Synonyms
Fluoride; Methanesulfonyl fluoride (oral, Alzheimer's disease/cognitive disorder)
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External Link
 Compound Name NIC5-15 Phase 2 [109]
Synonyms
D-Pinitol; Pinitol; 10284-63-6; 3-O-Methyl-D-chiro-inositol; (+)-Pinitol; D-(+)-Pinitol; Inzitol; Methylinositol; Sennitol; 1-D-4-O-METHYL-MYO-INOSITOL; Pinit; D-ononitol; Ononitol; 1D-4-O-Methyl-myo-inositol; 1D-3-O-methyl-chiro-inositol; D-chiro-Inositol, 3-O-methyl-; 4-O-Methyl-myo-inositol; UNII-TF9HZN9T0M; UNII-A998ME07KR; 5D-5-O-Methyl-chiro-inositol; 6090-97-7; (1r,2s,4s,5s)-6-methoxycyclohexane-1,2,3,4,5-pentol; TF9HZN9T0M; 484-68-4; Matezit; Sennit; CHEMBL493737; A998ME07KR; CHEBI:28548; DSCFFEYYQKSRSV-KLJZZCKASA-N; NSC 43336
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External Link
 Compound Name SAM-531 Phase 2 [110]
Synonyms
PF-05212365; PF-5212365; WAY-262531; 5-HT6 receptor antagonist (Alzheimer's disease, schizophrenia), Pfizer
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External Link
 Compound Name IMD-1041 Phase 2 [111]
Synonyms
IMD-1041 (oral, COPD/interstitial cystis/type 2 diabetics/chronic inflammatory disease/metabolic syndrome/AD), IMMD
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 Compound Name GSK933776A Phase 2 [112]
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 Compound Name LY3002813 Phase 2 [113]
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 Compound Name AD02 vaccine Phase 2 [114]
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 Compound Name E2027 Phase 1 [24]
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 Compound Name TTP-448 Phase 2 [115]
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 Compound Name CPC-201 Phase 2 [116]
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 Compound Name UE-2343 Phase 2 [24]
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 Compound Name EVP-0962 Phase 2 [117]
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 Compound Name R-phenserine Phase 2 [118]
Synonyms
Posiphen (TN)
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External Link
 Compound Name FK-962 Phase 2 [119]
Synonyms
FK-960 analog, Fujisawa
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External Link
 Compound Name SAR-110894 Phase 2 [120]
Synonyms
SAR-110894D
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External Link
 Compound Name UB-311 Phase 2 [121]
External Link
 Compound Name ABT-288 Phase 2 [122]
Synonyms
UNII-5MEI1M3NHH; 5MEI1M3NHH; ABT 288; GNIRITULTPTAQWKNQAVFIVSAN; SCHEMBL2406947; ABT288; GTPL6927; GNIRITULTPTAQW-KNQAVFIVSA-N; 948845-91-8; J3.497.401B; 2-[4'-(3aR,6aR)-(5-Methylhexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)-1,1'-biphenyl-4-yl]pyridazin-3(2H)-one; 2-{4'-[(3aR,6aR)-5-Methylhexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl]-1,1-biphenyl-4-yl}pyridazin-3(2H)-one; 2-[4'-(3aR,6aR)-(5-methylhexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)-1,1'-biphenyl-4-yl ]pyridazin-3(2H)-one; (3aR, 6aR)-2-[4'-(5-Methyl-hexahydro-pyrrolo[3,4
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 Compound Name Oleoyl-estrone Phase 2 [24]
Synonyms
Anti-obesity hormone-based therapy, Manhattan
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 Compound Name CERE-110 Phase 2 [123]
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 Compound Name HSRx-888 Phase 2 [24]
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 Compound Name AVN 322 Phase 1 [124]
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 Compound Name Nefiracetam Phase 2 [125]
Synonyms
Motiva (TN)
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External Link
 Compound Name JOT106 Phase 2 [47]
External Link
 Compound Name BPN14770 Phase 2 [126]
Synonyms
KRRGWHSEDYQKDQ-UHFFFAOYSA-N; SCHEMBL15659026; 2-(4-((2-(3-Chlorophenyl)-6-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acetamide
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External Link
 Compound Name BIIB092 Phase 2 [24]
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 Compound Name AZD-5213 Phase 2 [127]
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 Compound Name ABBV-8E12 Phase 2 [128]
Synonyms
C2N-8E12
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External Link
 Compound Name LymPro Phase 2 [129]
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 Compound Name AQW-051 Phase 2 [130]
Synonyms
669770-29-0; (R)-3-((6-(p-Tolyl)pyridin-3-yl)oxy)quinuclidine; AQW051; NPDLTEZXGWRMLQ-IBGZPJMESA-N; UNII-JQH481R778; SCHEMBL1459285; GTPL7371; SCHEMBL19522679; JQH481R778; ZINC3942685; AKOS030628482; SB17130; AS-35273; (R)-3-(6-p-tolyl-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane
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 Compound Name CX-717 Preclinical [131]
Synonyms
CX-1763; CX-546; CX-614; CX-727; CX-729; CX-743; CX-815; S-40929; First generation AMPA receptor modulators, Cortex/University of California; First-generation AMPAKINE compounds, University of California/Cortex
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 Compound Name PF-05212377 Phase 2 [132]
Synonyms
SAM-760
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 Compound Name CT1812 Phase 2 [133]
Synonyms
Elayta
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External Link
 Compound Name LY2886721 Phase 2 [134]
Synonyms
1262036-50-9; LY-2886721; UNII-2CQ62IWB67; LY 2886721; 2CQ62IWB67; N-(3-((4aS,7aS)-2-amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide; CHEMBL2396989; N-{3-[(4as,7as)-2-Amino-4a,5-Dihydro-4h-Furo[3,4-D][1,3]thiazin-7a(7h)-Yl]-4-Fluorophenyl}-5-Fluoropyridine-2-Carboxamide; n-(3-((4as,7as)-2-amino-4a,5-dihydro-4h-furo(3,4-d)(1,3)thiazin-7a(7h)-yl)-4-fluorophenyl)-5-fluoro-2-pyridinecarboxamide; NIDRNVHMMDAAIK-YPMLDQLKSA-N; MLS006011070; SCHEMBL966802; GTPL6475
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External Link
 Compound Name CSTC1 Phase 2 [24]
Synonyms
BAC; D-Bacillosamine; Bacillosamine; D-Bac; 2,4-Diamino-2,4,6-Trideoxy-D-Glucopyranose; 2,4-Diamino-2,4,6-Trideoxy-Glucose; 2,4,6-Trideoxy-2,4-Diamino-Glucose; 2,4-Diamino-2,4,6-Trideoxy-D-Glucose; 2,4,6-Trideoxy-2,4-Diamino-D-Glucose; 2,4,6-Trideoxy-2,4-Diamino-Glucopyranose; 2,4-Diamino-2,4,6-Trideoxy-Glucopyranose; 2,4-Diamino-2,4,6-Trideoxy-Glucopyranoside; 2,4,6-Trideoxy-2,4-Diamino-Glucopyranoside; 2,4,6-Trideoxy-2,4-Diamino-D-Glucopyranose; 2,4,6-Trideoxy-2,4-Diamino-D-Glucopyranoside; 2,4-Diamino-2,4,6-Trideoxy-D-Gluc
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External Link
 Compound Name T-817MA Phase 2 [135]
Synonyms
Edonerpic maleate; UNII-0LB9F7I5P3; 0LB9F7I5P3; 519187-97-4; T-817; T-817 maleate; SCHEMBL48064; RLUCYBFCLXANSO-BTJKTKAUSA-N; HY-17631A; DC10762; CS-8069; J2.179.155E; 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol maleate; 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol maleate; 1-(3-(2-(Benzo(b)thiophene-5-yl)ethoxy)propyl)azetidine-3-ol maleate; 1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)-3-azetidinol maleate; 3-Azetidinol, 1-(3-(2-benzo(b)thien-5-ylethoxy)propyl)-, (2Z)-2-butenedioate (1:
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External Link
 Compound Name KPAX002 Phase 2 [24]
External Link
 Compound Name Bryostatin-1 Phase 2 [24]
Synonyms
Bryostatin 1; 83314-01-6
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External Link
 Compound Name MIQ-001 Phase 2 [136]
Synonyms
M-IQ 001; Fatty acid metabolism inhibitor (Alzheimer's disease), Meta-IQ
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External Link
 Compound Name Basmisanil Phase 2 [137]
Synonyms
1159600-41-5; UNII-788PET5SUA; 788PET5SUA; (1,1-Dioxidothiomorpholino)(6-((3-(4-fluorophenyl)-5-methylisoxazol-4-yl)methoxy)pyridin-3-yl)methanone; Basmisanil [INN]; Basmisanil [USAN:INN]; Basmisani; Basmisanil(RG1662); Basmisanil (USAN/INN); SCHEMBL2685527; CHEMBL3681419; MolPort-044-561-818; VCGRFBXVSFAGGA-UHFFFAOYSA-N; BDBM133427; EX-A1272; AKOS032947142; ZINC145814743; DB11877; CS-6046; HY-16716; (1,1-Dioxo-4-thiomorpholinyl)(6-((3-(4-fluorophenyl)-5-methylisoxazol-4-yl)methoxy)pyridin-3-yl)metha
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External Link
 Compound Name Ladostigil Phase 2 [138]
Synonyms
Ladostigil tartrate; Alzheimer disease therapeutics, Teva; TV-3219; TV-3279; TV-3326
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External Link
 Compound Name NDD-094 Phase 2 [139]
Synonyms
NDD-094A; SDZ-NDD-094
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External Link
 Compound Name Ponezumab Phase 2 [140]
Synonyms
Neurological disease and injury therapeutics, Pfizer; PF-04360365; PF-4360365; RI-1014; RI-1219; RI-409; RN-1219
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External Link
 Compound Name ORM-12741 Phase 2 [141]
Synonyms
Alpha 2c adrenoceptor antagonist (neurological diseases), Orion; Alpha 2c adrenoceptor antagonist (psychiatric disorders), Orion
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External Link
 Compound Name PF-4447943 Phase 2 [142]
Synonyms
BCP16255
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External Link
 Compound Name DCB-AD1 Phase 2 [143]
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 Compound Name ABT-126 Phase 2 [144]
External Link
 Compound Name AZD4694 Phase 2 [145]
External Link
 Compound Name GSK239512 Phase 2 [146]
Synonyms
720691-69-0; GSK-239512; 1-(6-((3-CYCLOBUTYL-2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPIN-7-YL)OXY)PYRIDIN-3-YL)PYRROLIDIN-2-ONE; UNII-4I7U5C459M; CHEMBL3092650; 4I7U5C459M; YFRBKEVUUCQYOW-UHFFFAOYSA-N; SCHEMBL167578; MolPort-035-776-189; ZINC3961802; BDBM50444496; AKOS025291102; SB16754; KS-0000063Q; AS-42474; AK171368; 2-Pyrrolidinone, 1-(6-((3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy)-3-pyridinyl)-; J3.497.402K
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External Link
 Compound Name ALZ-801 Phase 2 [24]
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 Compound Name SYN-120 Phase 2 [147]
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 Compound Name VI-1121 Phase 2 [148]
External Link
 Compound Name TPI 287 Phase 1 [47]
Synonyms
FDTAUJJRHBRHIJ-BBGIBMRQSA-N; 849213-15-6; SCHEMBL19374618; Hexanoic acid, 3-(((1,1-dimethylethoxy)carbonyl)amino)-2-hydroxy-5-methyl-, (1S,2S,4S,7S,7aR,10aS,11aR,13aS,13bR,13cS)-7,13a-bis(acetyloxy)-1-(benzoyloxy)-9-ethenyl-1,3,4,7,7a,10a,11,11a,13,13a,13b,13c-dodecahydro-2-hydroxy-5,13c,14,14-tetramethyl-2,6-methano-2H-cyclodec(de)oxeto(3,2-g)(1,3)benzodioxin-4-yl ester, (2R,3S)-
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External Link
 Compound Name ST-101 Phase 2 [149]
Synonyms
ST 101 [French]; 7-Chloro-1,3-dihydro-5-phenyl-1-trimethylgermyl-2H-1,4-benzodiazepin-2-one; Trimethyl germyl-1, chloro-7, dihydro-1-3, phenyl-5 2H benzodiazepine-1-4 one-2 [French]; 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-phenyl-1-trimethylgermyl-; AC1O4GHW; ST 101; LS-34275; Trimethyl germyl-1, chloro-7, dihydro-1-3, phenyl-5 2H benzodiazepine-1-4 one-2
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 Compound Name EVT302 Phase 2 [24]
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 Compound Name DM-99 Phase 2 [150]
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 Compound Name RP5063 Phase 1 [39]
External Link
 Compound Name ABT-384 Phase 2 [151]
Synonyms
UNII-R5TH77F919; CHEMBL222670; ABT 384; R5TH77F919; SCHEMBL231595; GTPL7357; ABT384; SCHEMBL20457214; BDBM50195291; DB12501; 868623-40-9; 4-{2-methyl-2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-propionylamino}-adamantane-1-carboxylic acid amide
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External Link
 Compound Name PRX-3140 Phase 2 [152]
External Link
 Compound Name Myo-inositol Phase 2 [39]
Synonyms
Scyllo-inositol; inositol; Muco-Inositol; epi-Inositol; i-Inositol; meso-Inositol; Allo-inositol; 87-89-8; 1D-Chiro-inositol; 1L-Chiro-inositol; 488-59-5; Scyllitol; 643-12-9; D-(+)-chiro-Inositol; cis-Inositol; mesoinositol; Quercinitol; Myoinosite; Dambose; Cyclohexane-1,2,3,4,5,6-hexaol; Neo-inositol; Meat sugar; 6917-35-7; Phaseomannite; Inositina; Cocositol; D-chiro-Inositol; Inositene; Inosital; Iso-inositol; cyclohexane-1,2,3,4,5,6-hexol; Phaseomannitol; Cyclohexitol; Mesoinosit; Scyllite; Mesoinosite; Inosite
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External Link
 Compound Name CHF-5074 Phase 2 [153]
Synonyms
CHF 5074; CHF5074; 749269-83-8; Itanapraced; UNII-C35RF1MWQZ; GHF-5074; C35RF1MWQZ; CHEMBL196945; 1-(3',4'-dichloro-2-fluoro(1,1'-biphenyl)-4-yl)cyclopropanecarboxylic acid; 1-[4-(3,4-dichlorophenyl)-3-fluorophenyl]cyclopropane-1-carboxylic acid; 1-(3',4'-Dichloro-2-Fluorobiphenyl-4-Yl)cyclopropanecarboxylic Acid; H50; SCHEMBL407631; GTPL7339; DTXSID30225901; AOB5325; LIYLTQQDABRNRX-UHFFFAOYSA-N; ZINC3986651; EX-A1963; BDBM50172482; AKOS026750398; SB16945; CS-5022; NCGC00408905-01; AS-16850; HY-14399; BC600569; FT-0708261
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External Link
 Compound Name FRM-0962 Phase 2 [154]
External Link
 Compound Name MK-7622 Phase 2 [155]
Synonyms
M1 receptor modulator; 1227923-29-6; MK7622; MK 7622; 3-[(1S,2S)-2-Hydroxycyclohexyl]-6-[(6-methyl-3-pyridinyl)methyl]benzo[h]quinazolin-4(3H)-one; SCHEMBL2399084; EX-A804; JUVQLZBJFOGEEO-GOTSBHOMSA-N; BCP27739; ZINC95930184; AKOS028113668; DB12897; CS-5442; HY-15618; Benzo(H)quinazolin-4(3H)-one, 3-((1S,2S)-2-hydroxycyclohexyl)-6-((6-methyl-3-pyridinyl)methyl)-; AS-35236; KB-145903; J-690076; UNII-57R7D1Q49R component JUVQLZBJFOGEEO-GOTSBHOMSA-N
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External Link
 Compound Name RG1577 Phase 2 [156]
External Link
 Compound Name VX-745 Phase 2 [24]
Synonyms
5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-one; 209410-46-8; Neflamapimod; VX 745; VX745; VRT-031745; UNII-TYL52QM320; TYL52QM320; CHEBI:90528; 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one; 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one; Neflamapimod (USAN); Neflamapimod [USAN]; AK-44905; C19H9Cl2F2N3OS; 5-(2,6-Dichlorophenyl)-2-[(2,4-Difluorophenyl)sulfanyl]-6h-Pyrimido[1,6-B]pyridazin-6-One; VX745, VX-745; 5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido(1,6-b)pyridazin-6-one; Vertex 745 (VX745)
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External Link
 Compound Name BMS-708163 Phase 2 [157]
Synonyms
Avagacestat
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External Link
 Compound Name Tau-binding PET tracer Phase 2 [158]
Synonyms
T-777; T-807; T-808; Tau-binding PET tracer (Alzheimer disease); Tau-binding PET tracer (Alzheimer disease), Siemens
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External Link
 Compound Name MK-0752 Phase 2 [159]
Synonyms
471905-41-6; MK0752; UNII-9JD9B4S53T; MK 0752; cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid; 9JD9B4S53T; 3-((1r,4s)-4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid; 3-(cis-4-((4-Chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid; 3-((1r,4s)-4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid; 952578-68-6; cc-14; C21H21ClF2O4S; MLS006011072; SCHEMBL756249; SCHEMBL756248; SCHEMBL756247; CHEMBL3392635
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External Link
 Compound Name GM-602 Phase 2 [160]
Synonyms
Alirinetide; UNII-6BK9OEG8CC; 6BK9OEG8CC; 725715-18-4; GM-603; GM-605; GM-604; GM-607; GM-609; GM-606; L-Arginine, L-phenylalanyl-L-seryl-L-arginyl-L-tyrosyl-L-alanyl-; (2S)-2-(((2S)-2-(((2S)-2-(((2S)-2-(((2S)-2-(((2S)-2-Amino-3-phenyl-propanoyl)amino)-3-hydroxy-propanoyl)amino)-5-guanidino-pentanoyl)amino)-3-(4-hydroxyphenyl)propanoyl)amino)propanoyl)amino)-5-guanidino-pentanoic acid
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External Link
 Compound Name HF-0220 Phase 2 [161]
Synonyms
Cytoprotective steroid (Alzheimer's disease), Newron; Prostaglandin D synthase stimulator (Alzheimer's disease), Newron; Prostaglandin J2 synthesis stimulator (Alzheimer's disease), Newron; Cytoprotective steroid (Alzheimer's disease), Hunter-Fleming; Prostaglandin D synthase stimulator (Alzheimer's disease), Hunter-Fleming; Prostaglandin J2 synthesis stimulator (Alzheimer's disease), Hunter-Fleming
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External Link
 Compound Name Mibampator Phase 2 [162]
Synonyms
LY-450108; LY-451395; AMPA agonists (Alzheimer's Disease), Lilly; AMPA receptor agonist (agitation in Alzheimer's Disease), Eli Lilly
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External Link
 Compound Name AVN 101 Phase 2 [163]
External Link
 Compound Name Coluracetam Phase 2 [164]
Synonyms
BCI-540; MKC-231; High-affinity choline uptake facilitator (CNS disorders), Mitsubishi; Neurons growth promoting compound (major depressive disorder/anxiety), BrainCells; High-affinity choline uptake facilitator (depression/ anxiety), BrainCells
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External Link
 Compound Name AZD-1446 Phase 2 [165]
Synonyms
TC-6683; Alpha-4 beta-2 neuronal nicotinic receptor modulator (oral, cognitive disorder), Targacept/AstraZeneca
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External Link
 Compound Name AUS-131 Phase 2 [24]
External Link
 Compound Name TD-8954 Phase 1/2 [166]
Synonyms
UNII-35F0Y2W16Q; CHEMBL2402904; 35F0Y2W16Q; 916075-84-8; compound 18 [PMID 23756062]; SCHEMBL390795; GTPL8426; BDBM50436989; SB17471; DB12725; 1-Piperidinecarboxylic acid, 4-((4-((((2-(1-methylethyl)-1H-benzimidazol-7-yl)carbonyl)amino)methyl)-1-piperidinyl)methyl)-, methyl ester; methyl 4-[[4-[[(2-propan-2-yl1H-benzimidazole-4-carbonyl)amino]methyl]piperidin-1-yl]methyl]piperidine-1-carboxylate
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External Link
 Compound Name Vanutide cridificar Phase 2 [167]
Synonyms
ACC-001
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 Compound Name RG6100 Phase 2 [168]
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 Compound Name Mitoglitazone Phase 2 [24]
Synonyms
MSDC-0160; Mitoglitazone (TN)
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External Link
 Compound Name PBT-2 Phase 2 [169]
Synonyms
AD/HD therapy, Prana; Alzheimers/Huntingtons disease therapy (chelating agent), Prana
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External Link
 Compound Name Neu-P11 Phase 2 [24]
Synonyms
Piromelatine; UNII-S3UN2146K9; 946846-83-9; S3UN2146K9; Piromelatine [INN]; NEU-P-11; SCHEMBL8235551; DTXSID90241566; N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)-4-oxo-4H-pyran-2-carboxamide; 4H-Pyran-2-carboxamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-4-oxo-; SB19819
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External Link
 Compound Name ICA-17043 Phase 2 [170]
Synonyms
Senicapoc; 289656-45-7; 2,2-bis(4-fluorophenyl)-2-phenylacetamide; UNII-TS6G201A6Q; TS6G201A6Q; 2,2-BIS(4-FLUOROPHENYL)-2-PHENYL-ACETAMIDE; AK-79332; Senicapoc (USAN); Bis(4-fluorophenyl)phenylacetamide; Senicapoc [USAN:INN]; ICA 17043; C20H15F2NO; PubChem19381; 4-Fluoro-alpha-(4-fluorophenyl)-alpha-phenylbenzeneacetamide; AC1Q4NLN; AC1L50IL; CHEMBL405821; SCHEMBL1443805; GTPL2331; CTK4G2492; DTXSID60276906; SCTZUZTYRMOMKT-UHFFFAOYSA-N; MolPort-019-996-128; BCP14507; ACT06676; ZINC3816408; KS-00000XJ3; BBL102413; STL556215
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External Link
 Compound Name MIB-626 Phase 1/2 [171]
External Link
 Compound Name Xanamem Phase 1/2 [172]
Synonyms
(5-(1H-Pyrazol-4-yl)thiophen-3-yl)((1R,3r,5S)-3-hydroxy-3-(pyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone; [(1S,5R)-3-hydroxy-3-pyrimidin-2-yl-8-azabicyclo[3.2.1]octan-8-yl]-[5-(1H-pyrazol-4-yl)thiophen-3-yl]methanone; 1346013-80-6; compound 4 [PMID: 28012176]; GLXC-26582; GTPL12037; SCHEMBL23207782; SCHEMBL23798797; starbld0030988; UE2343; UE-2343; Xanamem
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 Compound Name VGH-AD1 Phase 1/2 [173]
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 Compound Name GB301 Phase 1/2 [174]
External Link
 Compound Name LM11A-31 Phase 1/2 [175]
Synonyms
N-[2-(Morpholin-4-yl)ethyl]-L-isoleucinamide; 1243259-19-9; (2S,3S)-2-amino-3-methyl-N-(2-morpholin-4-ylethyl)pentanamide; 102562-74-3; SCHEMBL1723692; DTXSID50595097; ZINC4239960; (2s,3s)-2-amino-3-methyl-N-(2-morpholinoethyl) pentanamide; (2S,3S)-2-amino-3-methyl-N-(2-morpholinoethyl)-pentanamide; (2S,3S)-2-Amino-3-methyl-N-(2-morpholinoethyl)pentanamide
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External Link
 Compound Name LX1001 Phase 1/2 [176]
Synonyms
AAVrh.10hAPOE2
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External Link
 Compound Name VAC20121 Phase 1/2 [177]
Synonyms
ACI-35
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External Link
 Compound Name AL 001 Phase 1/2 [178]
Synonyms
Latozinemab
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External Link
 Compound Name T3D-959 Phase 1/2 [179]
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 Compound Name AstroStem Phase 1/2 [24]
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 Compound Name EB-101 Phase 1/2 [180]
Synonyms
Beta amyloid vaccine (Alzheimer's disease), Atlas Pharmaceuticals
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External Link
 Compound Name IONIS-MAPTRx Phase 1/2 [47]
External Link
 Compound Name ACI-24 Phase 1/2 [181]
Synonyms
Beta amyloid vaccine (liposomal/SupraAntigen, Alzheimer's disease/Down syndrome), AC Immune
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External Link
 Compound Name RVX-208 Phase 1/2 [182]
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 Compound Name VLP norovirus bivalent vaccine Phase 1/2 [183]
Synonyms
VLP norovirus bivalent vaccine (intranasal, norovirus-induced gastroenteritis)
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External Link
 Compound Name APH-0703 Phase 1/2 [184]
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 Compound Name LM11A-31 Phase 1/2 [24]
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 Compound Name BIIB080 Phase 1/2 [24]
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 Compound Name BIL010t Phase 1/2 [170]
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 Compound Name MK-2461 Phase 1/2 [185]
Synonyms
MK 2461
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External Link
 Compound Name PF-06648671 Phase 1 [186]
Synonyms
1587727-31-8; 2-[(1S)-1-[(2S,5R)-5-[4-Chloro-5-fluoro-2-(trifluoromethyl)phenyl]tetrahydro-2-furanyl]ethyl]-3,4-dihydro-7-(4-methyl-1H-imidazol-1-yl)-2H-pyrido[1,2-a]pyrazine-1,6-dione; CHEMBL3951810; SCHEMBL15611304; BDBM193081; HY-120789; CS-0079177; US9193726, 69; Q29213634; 2-[(1S)-1-[(2S,5R)-5-[4-chloro-5-fluoro-2-(trifluoromethyl)phenyl]oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione
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External Link
 Compound Name AD101 Phase 1 [187]
Synonyms
(2,4-dimethyl-3-pyridyl)-[4-methyl-4-[(3S)-3-methyl-4-[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]piperazin-1-yl]-1-piperidyl]methanone; (2,4-Dimethylpyridin-3-yl)(4-methyl-4-((S)-3-methyl-4-((S)-1-(4-(trifluoromethyl)phenyl)ethyl)piperazin-1-yl)piperidin-1-yl)methanone; (2,4-Dimethyl-pyridin-3-yl)-(4-methyl-4-{(S)-3-methyl-4-[(S)-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazin-1-yl}-piperidin-1-yl)-methanone; (2,4-Dimethyl-pyridin-3-yl)-(4-methyl-4-{3-methyl-4-[1-(4-trifluoromethyl-phenyl)-ethyl]-piperazin-1-yl}-piperidin-1-yl)-methanone; (2,4-dimethylpyridin-3-yl)-[4-methyl-4-[(3S)-3-methyl-4-[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]piperazin-1-yl]piperidin-1-yl]methanone; 306293-36-7; AD101; BDBM50104946; CHEMBL113436; DTKUANPECHGGBY-UNMCSNQZSA-N; PD084304; Piperazine, 4-[1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4-methyl-4-piperidinyl]-2-methyl-1-[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]-, (2S)-; SCHEMBL4453513
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External Link
 Compound Name IGCAD1 Phase 1 [188]
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 Compound Name AVN-322 Phase 1 [189]
Synonyms
1194574-68-9; N,7-dimethyl-3-(phenylsulfonyl)-6,7,8,9-tetrahydropyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-2-amine hydrochloride; SB17475
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External Link
 Compound Name J147 Phase 1 [190]
Synonyms
(E)-N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N'-(3-methoxybenzylidene)acetohydrazide; 1146963-51-0; 1807913-16-1; 2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide; A894156; AC-35232; Acetic acid, 2,2,2-trifluoro-, (2E)-1-(2,4-dimethylphenyl)-2-((3-methoxyphenyl)methylene)hydrazide; Acetic acid, 2,2,2-trifluoro-, 1-(2,4-dimethylphenyl)-2-((3-methoxyphenyl)methylene)hydrazide; Acetic acid, 2,2,2-trifluoro-, 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide; AKOS024458485; AS-16718; CCG-268030; CHEBI:192601; CHEMBL2387144; CS-3688; DB13957; DTXSID501045787; EX-A2235; HMS3886O17; HY-13779; HYMZAYGFKNNHDN-SSDVNMTOSA-N; j147; J-147; MFCD25976644; N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N-((E)-(3-methoxyphenyl)methylideneamino)acetamide; N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N'-(3-methoxybenzylidene)acetohydrazide; N-(2,4-DIMETHYLPHENYL)-2,2,2-TRIFLUORO-N'-[(1E)-(3-METHOXYPHENYL)METHYLIDENE]ACETOHYDRAZIDE; N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N'-[(3-methoxyphenyl)methylidene]acetohydrazide; N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N'-[(E)-(3-methoxyphenyl)methylene]acetohydrazide; N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N'-[(E)-(3-methoxyphenyl)methylidene]acetohydrazide; N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]acetamide; N-(2,4-dimethylphenyl)-2,2,2-triluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]acetamide; s5269; SCHEMBL12995834; SCHEMBL21294999; UNII-Z41H3C5BT9; Z41H3C5BT9
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 Compound Name RG6289 Phase 1 [191]
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 Compound Name ASN51 Phase 1 [192]
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 Compound Name E2511 Phase 1 [193]
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 Compound Name SHR-1707 Phase 1 [194]
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 Compound Name Lu AF87908 Phase 1 [195]
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 Compound Name APNmAb005 Phase 1 [196]
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 Compound Name APH-1104 Phase 1 [197]
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 Compound Name DNL919 Phase 1 [198]
Synonyms
TAK-920
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 Compound Name PRX-005 Phase 1 [199]
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 Compound Name NTRX-07 Phase 1 [200]
Synonyms
MDA7
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 Compound Name AAV-hTERT Phase 1 [201]
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 Compound Name DNL104 Phase 1 [202]
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 Compound Name DNL747 Phase 1 [203]
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 Compound Name BEY2153 Phase 1 [204]
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 Compound Name REM0046127 Phase 1 [205]
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 Compound Name ACU193 Phase 1 [206]
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 Compound Name Protollin Phase 1 [207]
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 Compound Name BMS-984923 Phase 1 [208]
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 Compound Name ALN-APP Phase 1 [209]
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 Compound Name MK-4334 Phase 1 [210]
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 Compound Name NNI-362 Phase 1 [211]
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 Compound Name COR588 Phase 1 [212]
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 Compound Name AL003 Phase 1 [213]
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 Compound Name LY3372993 Phase 1 [214]
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 Compound Name MER5101 Phase 1 [24]
External Link
 Compound Name BMS-984923 Phase 1 [215]
Synonyms
(4R,5R)-5-(2-Chlorophenyl)-4-(5-(phenylethynyl)pyridin-3-yl)oxazolidin-2-one; (4R,5R)-5-(2-chlorophenyl)-4-[5-(2-phenylethynyl)pyridin-3-yl]-1,3-oxazolidin-2-one; 1375752-78-5; 2-Oxazolidinone, 5-(2-chlorophenyl)-4-(5-(2-phenylethynyl)-3-pyridinyl)-, (4R,5R)-; 3I1803DK5Z; AKOS040756698; BDBM50536712; BMS984923; BMS-984923; CHEMBL4571075; CS-0087012; HY-122559; SCHEMBL4541143; UNII-3I1803DK5Z
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 Compound Name BIIB113 Phase 1 [216]
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 Compound Name 11C-6-Me-BTA-1 Phase 1 [217]
Synonyms
Carbon-11-6-Me-BTA-1; 11C-BTA-1
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 Compound Name RVT-104 Phase 1 [24]
External Link
 Compound Name V950 vaccine Phase 1 [218]
External Link
 Compound Name PF-06751979 Phase 1 [47]
Synonyms
ZLZUHACSRMOLLV-RAALSFIWSA-N; 1818339-66-0; UNII-1Y0Y126GUG; 1Y0Y126GUG; US9315520, Example 1; CHEMBL3952064; US9315520, Example 2; US9315520, Comparator 1; SCHEMBL17162186; BDBM223395; HY-112157; CS-0043501; US9315520, 1; N-(2-((4aR,6S,8aR)-2-Amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano(3,4-d)(1,3)thiazin-8a-yl)thiazol-4-yl)-5-(difluoromethoxy)pyridine-2-carboxamide; N-{2-[(4aR,6S,8aR)-2-Amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-1,3-thiazol-4-yl}-5-(difluoromethoxy)pyridine-2-carb
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 Compound Name BMS-932481 Phase 1 [115]
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 Compound Name ABT-354 Phase 1 [219]
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 Compound Name Affitope AD-01 Phase 1 [220]
Synonyms
AD-01; Amyloid beta 40-42 peptide vaccine (sc, Alzheimer's), AFFiRiS
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 Compound Name PTI-125 Phase 1 [24]
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 Compound Name CPC-212 Phase 1 [24]
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 Compound Name COR-388 Phase 1 [24]
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 Compound Name BIIB076 Phase 1 [24]
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 Compound Name CPC-250 Phase 1 [24]
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 Compound Name ACI-35 Phase 1 [221]
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 Compound Name PU-AD Phase 1 [24]
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 Compound Name BMS-241027 Phase 1 [222]
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 Compound Name AD03 vaccine Phase 1 [223]
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 Compound Name 11C-AZD-2184 Phase 1 [224]
Synonyms
AZD-2184-[11C]; AZD-2184-[3H]; Tritium-AZD-2184; Beta amyloid modulator (iv PET ligand, AD), AstraZeneca; Carbon-11-AZD-2184; Hydrogen-3-AZD-2184; Beta amyloid modulator (iv PET ligand, Alzheimer's disease), AstraZeneca; 3H-AZD-2184
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 Compound Name GSI-136 Phase 1 [225]
Synonyms
WAY-179642; WAY-208983; WAY-GSI-A; WAY-GSI-B; Gamma-secretase inhibitors (oral, Alzheimer's disease), Wyeth
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 Compound Name 18F-FEDAA-1106 Phase 1 [226]
Synonyms
ZK-6032924; FEDAA-1106-[18F]; Fluorine-18-FEDAA-1106; 18F-labeled PET imaging agent (Alzheimer's disease), Bayer; 18F-labeled PET imaging agent (multiple sclerosis), Bayer
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 Compound Name PF-06648671 Phase 1 [47]
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 Compound Name BCI-632 Phase 1 [227]
Synonyms
LFAGGDAZZKUVKO-JAGWWQSPSA-N; MGS-0039; CHEMBL186453; 569686-87-9; MGS0039; MGS 0039; SCHEMBL234576; GTPL1397; DTXSID40432407; BDBM50151435; (1R,2R,3R,5R,6R)-2-amino-3-[(3,4-dichlorophenyl)methoxy]-6-fluorobicyclo[310]hexane-2,6-dicarboxylic acid; (1r,2r,3r,5r,6r)-2-amino-3-(3,4-dichlorobenzyloxy)6-fluorobicyclo[310] hexane-2,6-dicarboxylic acid; (1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo[310]hexane-2,6-dicarboxylic acid; (1R, 2R, 3R, 5R,
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 Compound Name ARC031 Phase 1 [228]
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 Compound Name RVT-103+RVT-104 Phase 1 [47]
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 Compound Name Exebryl-1 Phase 1 [229]
Synonyms
Exebryl-1 (TN)
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 Compound Name TAu mAb Phase 1 [24]
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 Compound Name PTI-80 Phase 1 [230]
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 Compound Name BAY-1006578 Phase 1 [231]
Synonyms
Diagnostic PET imaging agent (Alzheimer's disease), Bayer
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 Compound Name RG7129 Phase 1 [232]
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 Compound Name SAR228810 Phase 1 [233]
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 Compound Name GRF6019 Phase 1 [24]
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 Compound Name 123I-MNI-168 Phase 1 [234]
Synonyms
Alzheimer's diagnostic, IND; 123I-SPECT diagnostic (Alzheimer's disease), IND
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 Compound Name LY-2811376 Phase 1 [235]
Synonyms
LY2811376; 1194044-20-6; (S)-4-(2,4-Difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine; LY 2811376; UNII-UR18YJ97SJ; UR18YJ97SJ; CHEMBL2333941; (4s)-4-[2,4-Difluoro-5-(Pyrimidin-5-Yl)phenyl]-4-Methyl-5,6-Dihydro-4h-1,3-Thiazin-2-Amine; (4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-4H-1,3-thiazin-2-amine; J-501480; MJQMRGWYPNIERM-HNNXBMFYSA-N; 4H-1,3-Thiazin-2-amine, 4-(2,4-difluoro-5-(5-pyrimidinyl)phenyl)-5,6-dihydro-4-methyl-, (4S)-; 4H-1,3-Thiazin-2-amine,
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 Compound Name 123I-MNI-330 Phase 1 [236]
External Link
 Compound Name SUVN-D4010 Phase 1 [24]
Synonyms
DWTFBJGTRBMHPG-UHFFFAOYSA-N; UNII-GNQ25KYD72; GNQ25KYD72; 1428862-32-1; SCHEMBL14810657; 1-isopropyl-3-{5-[1-(3-methoxy propyl)piperidin-4-yl]-[1,3,4]oxadiazol-2-yl}-1H-indazole; 1-isopropyl-3-{5-[1-(3-methoxy propyl) piperidin-4-yl]-[1,3,4]oxadiazol-2-yl}-1H-indazole
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 Compound Name Mesenchymal stem cell therapy Phase 1 [24]
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 Compound Name AZD2184 Phase 1 [237]
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 Compound Name ASP-0777 Phase 1 [238]
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 Compound Name NPT088 Phase 1 [24]
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 Compound Name Aleplasinin Phase 1 [239]
Synonyms
PAZ-417; PAI inhibitors (Alzheimers disease), Wyeth; Plasminogen activator inhibitor inhibitors (Alzheimers disease),Wyeth
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 Compound Name MEDI1841 Phase 1 [240]
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 Compound Name E-2212 Phase 1 [241]
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 Compound Name TTP-4000 Phase 1 [242]
Synonyms
Extracellular RAGE domain (diabetic nephropathy), TransTech; Extracellular RAGE domain (Alzheimer's disease), TransTech
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 Compound Name ANVS301 Phase 1 [243]
Synonyms
Bisnormcerysine
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External Link
 Compound Name E2012 Phase 1 [244]
Synonyms
870843-42-8; E 2012; (E)-1-[(1S)-1-(4-FLUOROPHENYL)ETHYL]-3-[3-METHOXY-4-(4-METHYL-1H-IMIDAZOL-1-YL)BENZYLIDENE]PIPERIDIN-2-ONE; E-2012; UNII-3LSD4Y5F0F; 3LSD4Y5F0F; CHEMBL1224151; J-501810; (3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]piperidin-2-one; (e)-1-((1s)-1-(4-fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1h-imidazol-1-yl)benzylidene)piperidin-2-one; PUOAETJYKQITMO-LANLRWRYSA-N
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External Link
 Compound Name NGP 555 Phase 1 [47]
Synonyms
WDEKUGNKKOGFOA-UHFFFAOYSA-N; NGP555; 1304630-27-0; UNII-1XA7T7L527; CHEMBL2151100; SCHEMBL16198584; NGP-455; 1XA7T7L527; HY-108714; CS-0030521; 2-Thiazolamine, N-(5-ethyl-2,4-dimethylphenyl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)-; N-(5-Ethyl-2,4-dimethylphenyl)-4-(3-fluoro-4-(4-methylimidazol-1-yl)phenyl)-1,3-thiazol-2-amine
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 Compound Name AV-965 Phase 1 [245]
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 Compound Name GSK2647544 Phase 1 [246]
Synonyms
GSK-2647544
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 Compound Name NDX-1017 Phase 1 [24]
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 Compound Name GC021109 Phase 1 [24]
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 Compound Name NsG-0202 Phase 1 [247]
Synonyms
ECB-AD; ECT-AD; ECT-NGF; ECT (Alzheimers Disease), NsGene; Encapsulated cell technology (Alzheimers Disease), NsGene; Encapsulated ARPE-19 cells (Alzheimers disease), NsGene
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 Compound Name SGC-1061 Phase 1 [248]
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 Compound Name NBXT-001+Nobilis inhalation device Phase 1 [47]
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 Compound Name Lu AF20513 Phase 1 [24]
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 Compound Name Begacestat Phase 1 [249]
Synonyms
GSI-953; PF-05212362; PF-5212362; WAY-201953; WAY-210953
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 Compound Name BCI-838 Discontinued in Phase 1 [250]
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 Compound Name MK-3328 Phase 1 [251]
Synonyms
UNII-4I12ES557C; MK-3328 F-18; 4I12ES557C; 1201324-21-1; (18F)MK-3328; [18F]MK-3328; CHEMBL2203396; SCHEMBL12268073
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 Compound Name JES-9501 Phase 1 [252]
Synonyms
DHED; Dehydroevodiamine; Dehydroevodiamine hydrochloride
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 Compound Name TAK-071 Phase 1 [24]
Synonyms
WFSARWQASFQZMG-FGZHOGPDSA-N; 1820812-16-5
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 Compound Name ANAVEX 2-73 Phase 1 [24]
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 Compound Name SPI-014 Phase 1 [253]
Synonyms
SPI-1802; SPI-1810; Amyloid beta peptide 1-42 deposition inhibitor (AD), Satori; Gamma-secretase modulators (Alzheimers disease), Satori Pharmaceuticals
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 Compound Name HPP-854 Phase 1 [254]
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 Compound Name JNJ-63733657 Phase 1 [24]
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 Compound Name DSP-8658 Phase 1 [255]
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 Compound Name SOR-C13 Phase 1 [170]
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 Compound Name DWP-09031 Phase 1 [256]
Synonyms
DWJ-301
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 Compound Name AZD2995 Phase 1 [237]
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 Compound Name Palomid-529 Phase 1 [257]
Synonyms
P-529; P-529 (inhaled), Paloma; P-529 (ophthalmic), Paloma; P-529 (oral), Paloma; P-529 (topical), Paloma; P-529 drug eluting stent (cardiovascular disease), Paloma; Palomid-529 (inhaled), Paloma; Palomid-529 (ophthalmic), Paloma; Palomid-529 (oral), Paloma; Palomid-529 (topical), Paloma; Palomid-529 drug eluting stent (cardiovascular disease), Paloma; P-529 (intravitreal/subconjunctival), Paloma; Palomid-529 (intravitreal/subconjunctival), Paloma
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 Compound Name Protexia Phase 1 [258]
Synonyms
RBChE; PEG-rBChE; PEGylated butyrylcholinesterase (recombinant human, nerve agent exposure), PharmAthene
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 Compound Name FGLL Phase 1 [259]
Synonyms
NCAM mimetics (Alzheimer's disease), Enkam
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 Compound Name Posiphen R-phenserine Phase 1 [260]
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 Compound Name Anti-N3pG-Abeta antibody Phase 1 [261]
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 Compound Name CTS-21166 Phase 1 [262]
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 Compound Name MCD-386 Phase 1 [263]
Synonyms
CDD-0102; CDD-0262; CDD-0264; CDD-102; MCD-386 Forte; MCD-386 Transderm; MCD-386CR; MCD-386 Forte/Transderm; Tetrahydropyrimidine muscarinic M1 agonists (Alzeimer's disease), Cognitive Pharmaceuticals; Tetrahydropyrimidine muscarinic M1 agonists (Alzeimer's disease), University of Toledo; Tetrahydropyrimidine muscarinicM1 agonists (Alzheimer's disease), Mithridion; MCD-386 (oral controlled release, CNS disorders), Mithridion; MCD-386 (high dose transdermal, Alzheimer's disease/schizophrenia), Mithridion; MCD-386 (high dose, Alzheimer's disease/schizophrenia), Mithridion; MCD-386 (transdermal, Alzheimer's disease/schizophrenia), Mithridion
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 Compound Name AZD-3839 Phase 1 [264]
Synonyms
GTPL6931; 4b05; (3S)-3-[2-(difluoromethyl)pyridin-4-yl]-7-fluoro-3-[3-(pyrimidin-5-yl)phenyl]-2,3-dihydro-1H-isoindol-1-amine; 32D
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External Link
 Compound Name MEDI1814 Phase 1 [24]
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 Compound Name ABT-957 Phase 1 [265]
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 Compound Name XEL 001HP Phase 1 [266]
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 Compound Name PF-05251749 Phase 1 [47]
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 Compound Name PF-04995274 Phase 1 [267]
Synonyms
UNII-XI179PG9LV; PF 04995274; XI179PG9LV; 1331782-27-4; CHEMBL2152922; (R)-4-((4-(((4-(Tetrahydrofuran-3-yloxy)-1,2-benzisoxazol-3-yl)oxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol; PF04995274; compound 2d [PMID: 22974325]; SCHEMBL619629; GTPL9059; WLLOFQROROXOMO-GOSISDBHSA-N; ZINC95577747; BDBM50398598; DB12675; NCGC00386746-01; PF-04995274, &gt; 4-[[4-[[4-[(3R)-oxolan-3-yl]oxy-1,2-benzoxazol-3-yl]oxymethyl]piperidin-1-yl]methyl]oxan-4-ol
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 Compound Name LY3303560 Phase 1 [47]
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 Compound Name AAB-003/PF-05236812 Phase 1 [268]
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 Compound Name GSK2981710 Phase 1 [269]
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 Compound Name ASP3662 Phase 1 [270]
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 Compound Name AAD-2004 Phase 1 [271]
Synonyms
927685-43-6; UNII-11VWK61J69; 11VWK61J69; 2-Hydroxy-5-((4-(trifluoromethyl)phenethyl)amino)benzoic acid; Benzoic acid, 2-hydroxy-5-((2-(4-(trifluoromethyl)phenyl)ethyl)amino)-; Benzoic acid, 2-hydroxy-5-[[2-[4-(trifluoromethyl)phenyl]ethyl]amino]-; UTMVACIBQLDZLP-UHFFFAOYSA-N; SCHEMBL608498; ZINC34885635; AKOS027338686; SB16954; AS-35180; 2-HYDROXY-5-(2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINO)-BENZOIC ACID
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External Link
 Compound Name TT-301 Phase 1 [272]
Synonyms
Minozac; MW01-9-034WH; Anti-neuroinflammatories (Alzheimer's disease), NeuroMedix/Transition Therapeutics
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External Link
 Compound Name methyl 5-[(4-tert-butylbenzoyl)amino]-2H-1,2,4-triazole-3-carboxylate Clinical trial [273]
Synonyms
MLS001003740; SMR000347588; methyl 3-[(4-tert-butylbenzoyl)amino]-1H-1,2,4-triazole-5-carboxylate; AC1M4T6W; Oprea1_530669; Oprea1_180448; GTPL6553; SCHEMBL14688402; CHEMBL1595992; cid_2314952; BDBM33902; CHEBI:109731; HMS2702F21; AB00577675-02; SR-01000028101; SR-01000028101-1; 3-[[(4-tert-butylphenyl)-oxomethyl]amino]-1H-1,2,4-triazole-5-carboxylic acid methyl ester; methyl 3-[(4-tert-butylphenyl)carbonylamino]-1H-1,2,4-triazole-5-carboxylate
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External Link
 Compound Name bimatoprost (free acid form) Clinical trial [274]
Synonyms
17-phenyl-omega-trinor-PGF2alpha
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External Link
 Compound Name JNJ-479655 Clinical trial [275]
Synonyms
1428327-31-4; N-((4-(4-phenylpiperazin-1-yl)tetrahydro-2H-pyran-4-yl)methyl)-2-(phenylthio)nicotinamide; JNJ-47965567; JNJ 47965567; N-{[4-(4-Phenylpiperazin-1-Yl)oxan-4-Yl]methyl}-2-(Phenylsulfanyl)pyridine-3-Carboxamide; P2X Antagonist III; antagonist JNJ47965567; GTPL7538; CHEMBL2338352; MolPort-035-941-198; ZINC95590396; AKOS025142079; JNJ47965567; NCGC00387264-01; J-115; JNJ-47965567, &gt; Z2235332565; N-[[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methyl]-2-phenylsulfanylpyridine-3-carboxamide
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External Link
 Compound Name alpha-ketothiazole analogue 36 Clinical trial [276]
Synonyms
GTPL6549; CHEMBL273653; BDBM12976; (2S)-2-[[(1R)-1-(4-bromophenyl)ethyl]carbamoylamino]-5-(carbamoylamino)-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]pentanamide
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 Compound Name PMID27998201-Compound-22 Patented [277]
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 Compound Name PMID28350212-Compound-20 Patented [278]
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 Compound Name PMID27998201-Compound-2 Patented [277]
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 Compound Name Schiff base compound 2 Patented [279]
Synonyms
PMID29324067-Compound-53
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 Compound Name PMID29334795-Compound-22 Patented [280]
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 Compound Name PMID28350212-Compound-19 Patented [278]
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 Compound Name Thiadiazolyl carboxamide derivative 1 Patented [281]
Synonyms
PMID28270010-Compound-Figure18-1
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 Compound Name Schiff base compound 1 Patented [279]
Synonyms
PMID29324067-Compound-43
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 Compound Name PMID28350212-Compound-18 Patented [278]
External Link
 Compound Name Zanapezil Discontinued in Phase 3 [282]
Synonyms
TAK-147
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External Link
 Compound Name PF-1913539 Discontinued in Phase 3 [283]
Synonyms
Sch-58261; Sch 58261; 160098-96-4; Sch58261; 2-(Furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine; UNII-4309023MAH; CHEMBL17127; 4309023MAH; 7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine; 2-(2-Furanyl)-7-(2-phenylethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine; 5-Amino-7-(2-phenylethyl)-2-(2-furyl)-pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine; [3H]SCH 58261
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External Link
 Compound Name AZD0328 Discontinued in Phase 2 [284]
Synonyms
AR-R23465XX; AZD-0328; Spiro[1-azabicyclo[2.2.2]octane-8,8'-7-oxa-5-azabicyclo[4.3.0]nona-2,4,10-triene]
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External Link
 Compound Name S-18986 Discontinued in Phase 2 [285]
Synonyms
S 18986; UNII-IA262432Y9; 175340-20-2; S18986; IA262432Y9; MNTIJYGEITVWHU-SNVBAGLBSA-N; AC1LCV4Z; S18986-1; SCHEMBL6622911; S 18986-1; GTPL4304; CHEMBL320642; EX-A818; MolPort-023-276-986; (3aS)-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide; ZINC3827020; AKOS024457867; (S)-2,3-dihydro-(3,4)cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide; B5493; (3aS)-5,5Dioxo-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine
    Click to Show/Hide
External Link
 Compound Name AVN 397 Discontinued in Phase 2 [286]
External Link
 Compound Name DPC-543 Discontinued in Phase 2 [287]
External Link
 Compound Name NGD-97-1 Discontinued in Phase 2 [288]
Synonyms
CP-457,920
    Click to Show/Hide
External Link
 Compound Name IPENOXAZONE Discontinued in Phase 2 [289]
Synonyms
MLV-6976; NC-1200; (+)-(4S,5R)-4-(2-Methylpropyl)-3-[3-(perhydroazepin-1-yl)propyl]-5-phenyl-1,3-oxazolidin-2-one
    Click to Show/Hide
External Link
 Compound Name Ispronicline Discontinued in Phase 2 [290]
Synonyms
RJR 1734; TC 01734; AZD-3480; RJR-1734; Ispronicline (INN/USAN); (E)-N-methyl-5-(5-propan-2-yloxypyridin-3-yl)pent-4-en-2-amine
    Click to Show/Hide
External Link
 Compound Name ABT-418 Discontinued in Phase 2 [291]
Synonyms
Abt 418; 147402-53-7; 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole; CHEMBL274525; (S)-3-Methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole; (S)-3-methyl-5-(1-methylpyrrolidin-2-yl)isoxazole; C9H14N2O; Isoxazole, 3-methyl-5-((2S)-1-methyl-2-pyrrolidinyl)-; Isoxazole, 3-methyl-5-(1-methyl-2-pyrrolidinyl)-, (S)-; Isoxazole, 3-methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]-; 3-methyl-5-[(2S)-1-methylpyrrolidin-2-yl]-1,2-oxazole; AC1L3OPH; SCHEMBL194161; DTXSID10163711; ILLGYRJAYAAAEW-QMMMGPOBSA-N; ZINC3786099; BDBM50035398
    Click to Show/Hide
External Link
 Compound Name Talsaclidine fumarate Discontinued in Phase 2 [292]
Synonyms
Wal 2014 FU; Talsaclidine fumarate (USAN); 1-Azabicyclo(2.2.2)octane, 3-(2-propynyloxy)-, (R)-, (E)-2-butenedioate (1:1); 3-(2-Propynyloxy)-1-azabicyclo(2.2.2)octane 2-butenedioate; 3-prop-2-ynoxy-1-azabicyclo[2.2.2]octane
    Click to Show/Hide
External Link
 Compound Name Affitope AD-02 Discontinued in Phase 2 [293]
Synonyms
Alzheimer's disease vaccine 2 (AFFITOPE), AFFiRiS; Alzheimer's disease vaccine 2 (AFFITOPE), GlaxoSmithKline Biologicals
    Click to Show/Hide
External Link
 Compound Name SIB-1553A Discontinued in Phase 2 [294]
Synonyms
191611-89-9; SIB 1553A hydrochloride; SIB 1553A Hyrdrochloride; SIB 1553A HCl; SCHEMBL6333252; SIB 1553A; MolPort-035-765-827; AKOS024458336; LS-104963; J-012387; (+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride; (+-)-4-((2-(1-Methyl-2-pyrrolidinyl)ethyl)thio)phenol hydrochloride; Phenol, 4-((2-(1-methyl-2-pyrrolidinyl)ethyl)thio)-, hydrochloride
    Click to Show/Hide
External Link
 Compound Name VP-025 Discontinued in Phase 1 [295]
Synonyms
Inflammation therapeutics, Vasogen; VP-015
    Click to Show/Hide
External Link
 Compound Name TRx-0037 Discontinued in Phase 1 [296]
External Link
 Compound Name EVT-301 Discontinued in Phase 1 [297]
Synonyms
MAO B inhibitors (Alzheimer's disease), Evotec/Roche; Monoamineoxidase B inhibitors (Alzheimer's disease),Evotec/Roche
    Click to Show/Hide
External Link
 Compound Name AZD-1080 Discontinued in Phase 1 [298]
External Link
 Compound Name PF-05236812 Discontinued in Phase 1 [299]
Synonyms
AAB-003
    Click to Show/Hide
External Link
 Compound Name C-9138 Discontinued in Phase 1 [300]
External Link
 Compound Name SL-25.1188 Discontinued in Phase 1 [301]
External Link
 Compound Name GR-253035 Discontinued in Phase 1 [302]
External Link
 Compound Name TAK-065 Discontinued in Phase 1 [303]
Synonyms
Neuroregeneration enhancer (oral, Alzheimers/Parkinsons disease), Takeda
    Click to Show/Hide
External Link
 Compound Name NP-61 Discontinued in Phase 1 [304]
Synonyms
Dual binding site acetylcholinesterase inhibitor, Neuropharma; NP-00361; NP-0361; AChE inhibitor (Alzheimer's) Neuropharma (Zeltia); AChE inhibitor/beta amyloid secretion inhibitor (oral formulation, Alzheimer's disease), Noscira
    Click to Show/Hide
External Link
 Compound Name ACC-002 Phase 0 [305]
External Link
 Compound Name INP102 Phase 0 [24]
External Link
 Compound Name AAB-002 Phase 0 [306]
External Link
 Compound Name SD1003 Preclinical [307]
External Link
 Compound Name Z-Phe-Ala-diazomethylketone Preclinical [307]
Synonyms
71732-53-1; CHEMBL2179950; carbobenzoxycarbonyl-phenylalanyl-alaninyldiazomethane; ZPAD; Z-FA-DMK; SCHEMBL9364460; SCHEMBL17747846; SCHEMBL17747847; ZINC4899534; BDBM50400264; MFCD00077029; (Z,3S)-1-diazonio-3-[[(2S)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]amino]but-1-en-2-olate; Q27278127; benzyl (S)-1-((S)-4-diazo-3-oxobutan-2-ylamino)-1-oxo-3-phenylpropan-2-ylcarbamate; benzyl N-[(2S)-1-[[(2S)-4-diazo-3-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
    Click to Show/Hide
External Link
 Compound Name SD1002 Preclinical [307]
External Link
 Compound Name TPT-43 Preclinical [308]
External Link
 Compound Name CX-1501 Preclinical [309]
Synonyms
AMPA receptor modulators (ADHD, AD, sleep disorders), Cortex Pharmaceuticals
    Click to Show/Hide
External Link
 Compound Name SPH-1285 Preclinical [310]
Synonyms
Galantamine derivatives, Sanochemia; SPH-1286; SPH-1359
    Click to Show/Hide
External Link
 Compound Name ANAVEX 1-41 Preclinical [311]
External Link
 Compound Name VER-155008 Preclinical [307]
Synonyms
Heat shock protein 70 inhibitor (cancer), Vernalis; Hsp 70 inhibitor (cancer), Vernalis
    Click to Show/Hide
External Link
 Compound Name Pepticlere Preclinical [312]
Synonyms
DP-68; DP-74; Small peptide beta amyloid protein fibril formation inhibitors, Proteotech; Alzheimers disease therapy (nasal spray), ProteTech; Small peptide A-beta protein fibril formation inhibitors, Proteotech; Laminin alpha chain derivatives (Alzheimer's disease), Proteotech; 6-9 mer peptide analogs (Alzheimer's disease), Proteotech
    Click to Show/Hide
External Link
 Compound Name SCH-1359113 Preclinical [313]
Synonyms
SCH-1341030; SCH-1682496; SCH-745966; SCH-747123; SCH-785532; BACE-1 inhibitors (Alzheimer's disease); BACE-1 inhibitors (Alzheimer's disease), Merck & Co; BACE-1 inhibitors (Alzheimer's disease), Schering-Plough; Beta-secretase inhibitors (Alzheimer's disease), Schering-Plough
    Click to Show/Hide
External Link
 Compound Name humanin Preclinical [314]
Synonyms
formyl humanin
    Click to Show/Hide
External Link
 Compound Name CDD-0199-J Preclinical [315]
External Link
 Compound Name Alvameline Terminated [316]
Synonyms
Alvameline maleate; LU-25077; LU-25109; LU-31126; LU-32181; Lu-25109M
    Click to Show/Hide
External Link
 Compound Name Ro-46-5934 Terminated [317]
External Link
 Compound Name IDRA-21 Terminated [318]
Synonyms
IDRA-21 analogs; IDRA-5
    Click to Show/Hide
External Link
 Compound Name BIBN-99 Terminated [319]
Synonyms
Bibn 99; 145301-48-0; AC1L31GK; SCHEMBL194898; DTXSID00162975; N-(3-(1-(2-(8-Chloro-5,6-dihydro-6-oxo-11H-pyrido(2,3-b)(1,4)benzodiazepin-11-yl)-2-oxoethyl)-4-piperidinyl)propyl)-N-ethyl-2,2-dimethylpentanamide; L008252; N-[3-[1-[2-(8-chloro-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepin-11-yl)-2-oxoethyl]piperidin-4-yl]propyl]-N-ethyl-2,2-dimethylpentanamide; Pentanamide, N-(3-(1-(2-(8-chloro-5,6-dihydro-6-oxo-11H-pyrido(2,3-b)(1,4)benzodiazepin-11-yl)-2-oxoethyl)-4-piperidinyl)propyl)-N-ethyl-2,2-dimethyl-
    Click to Show/Hide
External Link
 Compound Name RS-66252 Terminated [320]
External Link
 Compound Name ZK-93426 Terminated [321]
Synonyms
ZK 93426; ZK93426; ZK 93 426; CHEMBL1271047; 89592-45-0; 5-Isopropoxy-4-methyl-beta-carboline-3-carboxylic acid ethyl ester; Ethyl 4-methyl-5-(1-methylethoxy)-9H-pyrido(3,4-b)indole-3-carboxylate; 9H-Pyrido(3,4-b)indole-3-carboxylic acid, 4-methyl-5-(1-methylethoxy)-, ethyl ester; AC1L3GQB; SCHEMBL195334; GTPL4347; CHEBI:93201; ZINC5857864; BDBM50329658; NCGC00161396-01; LS-178094; BRD-K68392338-003-01-2; ethyl 5-isopropoxy-4-methyl-9H-pyrido[3,4-b]indole-3-carboxylate; ethyl 4-methyl-5-propan-2-yloxy-9H-pyrido[5,4-
    Click to Show/Hide
External Link
 Compound Name CEP-427 Terminated [322]
External Link
 Compound Name EHT-1864 Terminated [323]
Synonyms
EHT-0101; EHT-0206; EHT-101; EHT-206; Rac1 inhibitor (Alzheimer's disease/cancer),Exonhit
    Click to Show/Hide
External Link
 Compound Name CI-1002 Terminated [324]
Synonyms
PD-142676
    Click to Show/Hide
External Link
 Compound Name BU-4514N Terminated [325]
Synonyms
BU 4514N; AC1Q6BPU; AC1L4UFU; SCHEMBL194669; 4-[(2-{2-[(5-amino-6-methyltetrahydro-2h-pyran-2-yl)oxy]propyl}-1,3,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)carbonyl]-5-hydroxy-1,2-dihydro-3h-pyrrol-3-one
    Click to Show/Hide
External Link
 Compound Name DNP-004089 Terminated [326]
Synonyms
BACE inhibitors, De Novo; Beta-amyloid converting enzyme inhibitors,De Novo; Beta-secretase inhibitors, De Novo
    Click to Show/Hide
External Link
 Compound Name MF-8615 Terminated [327]
External Link
 Compound Name FR-152558 Terminated [328]
External Link
 Compound Name NS-649 Terminated [329]
External Link
 Compound Name MDL-28170 Terminated [330]
Synonyms
MDL-2170
    Click to Show/Hide
External Link
 Compound Name NS-377 Terminated [331]
External Link
 Compound Name R-1315 Terminated [332]
External Link
 Compound Name L-698544 Terminated [333]
Synonyms
7-Chloro-3-nitro-3,4-dihydroquinolin-2(1H)-one; 147778-05-0; 7-chloro-3-nitro-3,4-dihydro-1H-quinolin-2-one; CHEMBL102574; 2(1H)-Quinolinone,7-chloro-3,4-dihydro-3-nitro-; ACMC-1C9KO; SCHEMBL8271408; CTK4C5567; DTXSID50436916; BDBM50038176; 3697AJ; AKOS024260378; AB06846; AK153524; DB-063735; AX8026622; FT-0703007; Z-7553; CNDQ
    Click to Show/Hide
External Link
 Compound Name GYKI-52466 Terminated [334]
Synonyms
102771-26-6; GYKI 52466; UNII-471V8NZ5X3; GYKI 52466 HCl; CHEMBL275006; CHEBI:79560; 471V8NZ5X3; 1-(p-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride; 4-(8-methyl-9h-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl)aniline; 4-(8-Methyl-9H-1,3-dioxolo(4,5-h)(2,3)benzodiazepin-5-yl)benzenamine; Benzenamine,4-(8-methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)-; Benzenamine, 4-(8-methyl-9H-1,3-dioxolo(4,5-h)(2,3)benzodiazepin-5-yl)-; C17H15N3O2
    Click to Show/Hide
External Link
 Compound Name Nerve growth factor Terminated [335]
Synonyms
Neuleze; Nerve growth factor (recombinant); RhNGF, Genentech; NGF-beta, Genentech; Nerve growth factor (recombinant), Genentech; Nerve growth factor, Mitsubishi/Dompe/Fidia
    Click to Show/Hide
External Link
 Compound Name F-3796 Terminated [336]
External Link
 Compound Name NNC-90-0270 Terminated [337]
Synonyms
Nicotinic ACh agonists, Novo Nordisk
    Click to Show/Hide
External Link
 Compound Name F-14413 Terminated [338]
Synonyms
Alpha-2 adrenoceptor antagonist (Alzheimer's disease), Pierre Fabre
    Click to Show/Hide
External Link
 Compound Name GT-4001 Terminated [339]
External Link
 Compound Name SAN-61 Terminated [340]
Synonyms
SAN-AL-61; Oral beta amyloid inhibitor (Alzheimer's disease), Sanomune
    Click to Show/Hide
External Link
 Compound Name Milacemide Terminated [341]
Synonyms
Glyzac; Glyzan; Milacemide hydrochloride; CP-1552S
    Click to Show/Hide
External Link
 Compound Name Sch-57790 Terminated [342]
Synonyms
CHEMBL73341; SCH57790; GTPL350; SCHEMBL194921; SCH 57790; BDBM50092317; 2-(4-cyclohexylpiperazin-1-yl)-2-[4-(4-methoxyphenyl)sulfinylphenyl]acetonitrile; L018294
    Click to Show/Hide
External Link
 Compound Name MF268 Terminated [343]
Synonyms
MF 268; 154619-51-9; 5-O-[8-(cis-2,6-dimethylmorpholino)octylcarbamoyl]eseroline; (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl {8-[(2R,6S)-2,6-dimethylmorpholin-4-yl]octyl}carbamate; Carbamic acid, (8-(2,6-dimethyl-4-morpholinyl)octyl)-, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-yl ester, (3aS-(3a-alpha,5(2R*,6S*),8a-alpha))-; AC1MINCK; SCHEMBL2405111; CHEBI:43927; LS-49610; [(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-[8-[(2S,6R)-2,6-dimet
    Click to Show/Hide
External Link
 Compound Name Z-4105 Terminated [344]
Synonyms
119737-52-9; Butanoic acid, 4-(((3-methyl-5-isoxazolyl)carbonyl)amino)-; Butanoic acid,4-[[(3-methyl-5-isoxazolyl)carbonyl]amino]-; ACMC-20cew8; AC1Q5P7F; SCHEMBL195378; AC1L4P39; CTK4B1474; 4-[(3-methyl-1,2-oxazole-5-carbonyl)amino]butanoic acid; DTXSID50152568; 4-{[(3-methyl-1,2-oxazol-5-yl)carbonyl]amino}butanoic acid
    Click to Show/Hide
External Link
 Compound Name RU-33965 Terminated [345]
Synonyms
RU 33965; 122321-05-5; AC1L2W1Z; SCHEMBL195494; DTXSID50153570; 6H-Imidazo(1,5-a)(1,4)benzodiazepin-6-one, 3-(cyclopropylcarbonyl)-4,5-dihydro-5-methyl-
    Click to Show/Hide
External Link
 Compound Name RS 86 Terminated [346]
Synonyms
RS-86; UNII-5ASV6M91QU; 5ASV6M91QU; 2-Ethyl-8-methyl-2,8-diazaspiro(4,5)decane-1,3-dione hydrobromide; 2,8-Diazaspiro(4,5)decane-1,3-dione, 2-ethyl-8-methyl-, hydrobromide; 2-ethyl-8-methyl-2,8-diazaspiro[4.5]decane-1,3-dione hydrobromide(1:1); CHEMBL542883; RS-86 hydrobromide; RS 86, hydrobromide; 2-ethyl-8-methyl-2,8-diazaspiro[4,5]decane-1,3-dione hydrobromide; AC1L3EP8; 7524-74-5; C11H18N2O2.HBr; AC1Q23N4; CTK8D5439; 2-Nitrophenyl -D-galactopyranoside; 2-Nitrophenyl; A-D-galactopyranoside
    Click to Show/Hide
External Link
 Compound Name FR-121196 Terminated [347]
Synonyms
FR 121196; 133920-65-7; N-(4-Acetyl-1-piperazinyl)-4-fluorobenzenesulfonamide; PZQKOVUNWPDCCQ-UHFFFAOYSA-N; FR121196; ACMC-20mv5f; AC1L2ZLZ; SCHEMBL195526; CTK4B8875; DTXSID90158423; Piperazine, 1-acetyl-4-(((4-fluorophenyl)sulfonyl)amino)-
    Click to Show/Hide
External Link
 Compound Name AZD-2858 Terminated [348]
Synonyms
AZD2858; 486424-20-8; AZD 2858; CHEMBL2177161; 3-amino-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]-N-pyridin-3-ylpyrazine-2-carboxamide; 3-amino-6-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide; 3-Amino-6-{4-[(4-Methylpiperazin-1-Yl)sulfonyl]phenyl}-N-Pyridin-3-Ylpyrazine-2-Carboxamide; GSK-3 inhibition; 3-amino-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-N-(pyridin-3-yl)pyrazine-2-carboxamide; GTPL8478; SCHEMBL3327702; C21H23N7O3S; EX-A707; AOB6850; MolPort-035-395-808
    Click to Show/Hide
External Link
 Compound Name CEP-431 Terminated [349]
Synonyms
Clipsin inhibitor, Cephalon
    Click to Show/Hide
External Link
 Compound Name NP-7557 Terminated [350]
Synonyms
Alzheimers disease therapy, Nastech; AChEI therapy (intranasal), Nastech
    Click to Show/Hide
External Link
 Compound Name GT-2016 Terminated [351]
Synonyms
GT 2016; CHEMBL14812; 152241-24-2; SCHEMBL3395544; BDBM86490; MolPort-023-276-421; ZINC1537834; PDSP2_001477; PDSP1_001493; AKOS024457088; API0010299; NCGC00371075-01; LS-193753; L009653
    Click to Show/Hide
External Link
 Compound Name A-72055 Terminated [352]
External Link
 Compound Name ABS-301 Terminated [353]
Synonyms
ABS-302; ABS-303; ABS-304; Tacrine analogs, ABS
    Click to Show/Hide
External Link
 Compound Name ZK-91296 Terminated [354]
Synonyms
ZK 91296; 83910-34-3; Ethyl 5-benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylate; 9H-Pyrido(3,4-b)indole-3-carboxylic acid, 4-(methoxymethyl)-5-(phenylmethoxy)-, ethyl ester; WFPXOWCKXUEKCA-UHFFFAOYSA-N; AC1Q64YJ; SCHEMBL8845201; AC1L3X51; zk91296; BDBM85040; PDSP2_001753; ethyl 5-(benzyloxy)-4-(methoxymethyl)-9h-; PDSP1_001770; CAS_123700; NSC_123700; LS-187464; LS-186794; 5-benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylic acid-ethyl ester
    Click to Show/Hide
External Link
 Compound Name BIBN-140 Terminated [355]
Synonyms
Bibn 140; 145301-79-7; SCHEMBL8879830; Pentanamide, N-(3-(1-(2-(10,11-dihydro-11-oxo-5H-dibenzo(b,e)(1,4)diazepin-5-yl)-2-oxoethyl)-4-piperidinyl)propyl)-N-ethyl-2,2-dimethyl-
    Click to Show/Hide
External Link
 Compound Name Bifemelane Terminated [356]
Synonyms
Alnert; Celeport; E-0687; MCI-2016; SON-216
    Click to Show/Hide
External Link
 Compound Name Sibopirdine Terminated [357]
Synonyms
DuP-921; EXP-9121; EXP-921; 5H-Cyclopenta[2,1-b:3,4-b']dipyridine, 5,5-bis(4-pyridinylmethyl)-, monohydrate
    Click to Show/Hide
External Link
 Compound Name Tenilsetam Terminated [358]
Synonyms
CAS-997
    Click to Show/Hide
External Link
 Compound Name AD-0802 Investigative [180]
Synonyms
Humanized monoclonal antibody vaccine (Alzheimers disease), Bioarctic
    Click to Show/Hide
External Link
 Compound Name VK-11 Investigative [180]
Synonyms
Imaging agent (Alzheimer's disease), Prana
    Click to Show/Hide
External Link
 Compound Name AZD-6319 Investigative [359]
Synonyms
Alpha 7 neuronal nicotinic receptor agonist (Alzheimer's disease), AstraZeneca
    Click to Show/Hide
External Link
 Compound Name PD-2015 Investigative [360]
Synonyms
PD-2016; TNF alpha inhibitors (Alzheimers disease); TNF alpha inhibitors (Alzheimers disease), P2D Bioscience
    Click to Show/Hide
External Link
 Compound Name CBNU-06 Investigative [360]
External Link
 Compound Name RAP-310 Investigative [361]
Synonyms
Small stabilized receptor active peptide (Alzheimers disease), RAPID Pharmaceuticals
    Click to Show/Hide
External Link
 Compound Name Tideglusib Phase 2 [362]
External Link
 Compound Name DWJ-209 Investigative [360]
External Link
 Compound Name EVP-4473 Investigative [359]
External Link
 Compound Name ReN-004 Investigative [360]
Synonyms
Stem cell therapy (neurological disorders), ReNeuron
    Click to Show/Hide
External Link
 Compound Name KD-901 Investigative [360]
External Link
 Compound Name NAChR APLs Investigative [360]
Synonyms
NAChR APLs (Alzheimer's disease)
    Click to Show/Hide
External Link
 Compound Name COG-248 Investigative [360]
Synonyms
Apolipoprotein E agonist series (Alzheimer's/Parkinsons disease); Neuroprotectant (Alzheimers/Parkinsons disease), Cognosci; Apolipoprotein E agonist series (Alzheimer's/Parkinsons disease), Cognosci
    Click to Show/Hide
External Link
 Compound Name ELND-007 Investigative [363]
Synonyms
ELN-318463; ELN-318611; ELN-44989; ELN-475513; ELN-475516; ELN-480271; ELN-481090; ELN-481970; ELND-006; Gamma secretase inhibitors (Alzheimer's disease), Elan
    Click to Show/Hide
External Link
 Compound Name BAN-2203 Investigative [180]
Synonyms
Beta amyloid modulator (Alzheimer's disease), BioArctic
    Click to Show/Hide
External Link
 Compound Name Turmeric extracts Investigative [180]
Synonyms
HSS-808; HSS-818; HSS-838; HSS-848; HSS-888; Turmeric extracts (Alzheimer's disease); Turmeric extracts (Alzheimer's disease), HerbalScience
    Click to Show/Hide
External Link
 Compound Name Ginkgo biloba extract Investigative [360]
Synonyms
YY-1224; YY-1824; Ginkgo biloba extract (Parkinson's disease/Alzheimer's disease); Ginkgo biloba extract (Parkinson's disease/Alzheimer's disease), Yuyu Inc
    Click to Show/Hide
External Link
 Compound Name SX-AZD1 Investigative [360]
External Link
 Compound Name AIKb2 Investigative [360]
External Link
 Compound Name NAChR alpha 7 APLs Investigative [360]
Synonyms
NAChR alpha 7 APLs (Alzheimer's disease)
    Click to Show/Hide
External Link
 Compound Name 11A1 Investigative [180]
External Link
 Compound Name Gamma-secretase modulators Investigative [364]
Synonyms
Gamma-secretase modulators (Alzheimer's disease); Gamma-secretase modulators (Alzheimer's disease), F Hoffmann-La Roche
    Click to Show/Hide
External Link
 Compound Name MCD-386/glycopyrrolate Investigative [360]
Synonyms
13283-82-4; (1,1-dimethylpyrrolidin-1-ium-3-yl) 2-cyclopentyl-2-hydroxy-2-phenylacetate; Glycopyrronium (USAN); NCGC00179456-02; Tovanor Breezhaler; zlchem 10; beta-1-Methyl-3-pyrrolidyl-alpha-cyclopentylmandelate methobromide; G00010-Watson-Int; Prestwick2_000746; Prestwick1_000746; Prestwick3_000746; Prestwick0_000746; AC1Q60WT; BSPBio_000732; SCHEMBL133002; SPBio_002671; AC1L1G28; BPBio1_000806; GTPL7459; Pyrrolidinium,
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External Link
 Compound Name HL-026 Investigative [360]
External Link
 Compound Name ESN-XX Investigative [360]
External Link
 Compound Name ETN-001 Investigative [360]
External Link
 Compound Name DBT-1339 Investigative [180]
Synonyms
DBTA-1339; DBTAI-1339; DWJ-501; DWK-1339; Beta-amyloid aggregation inhibitors (Alzheimer's), Digital Biotech; Beta-amyloid deposition inhibitors (Alzheimer's), Digital Biotech; Beta-amyloid aggregation/deposition inhibitors (Alzheimer's), Digital Biotech
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External Link
 Compound Name GRL-11097 Investigative [360]
Synonyms
Memapsin 2 inhibitors (Alzheimers); Memapsin 2 inhibitors (Alzheimers), Purdue University/Astellas
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External Link
 Compound Name KNX-Monoclonal204 Investigative [180]
Synonyms
KNX-Monoclonal205; KNX-Monoclonal205); Passive immunotherapy (Alzheimers disease), Kinexis
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External Link
 Compound Name KMS-88009 Investigative [180]
Synonyms
KMS-88016; KMSB-600; Aminostyrylbenzofuran derivative beta amyloid fibril formation inhibitors (Alzheimer's disease), Korea Institute of Science and Technology/Seoul National University/Hanmi Pharmaceutical
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External Link
 Compound Name NGN-9079 Investigative [360]
Synonyms
Alzheimer's disease therapy, NeuroGeneration
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External Link
 Compound Name PNB-04 Investigative [360]
Synonyms
Alzheimer's disease therapy, PharmaNeuroBoost
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External Link
 Compound Name IMD-4482 Investigative [360]
Synonyms
IMD-4690; PAI-1 inhibitor (oral, Alzheimers disease), IMMD; Plasminogen activator inhibitor-1 inhibitor (oral, Alzheimers disease), Institute of Medicinal Molecular Design
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External Link
 Compound Name Abloid Investigative [180]
Synonyms
Amyloid protein deposition inhibitor (Alzheimer's disease), Virionics
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External Link
 Compound Name Memex Investigative [360]
Synonyms
Nicotinomide adenine dinucleotide (NADH)
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External Link
 Compound Name CDD-0235-J Investigative [360]
External Link
 Compound Name NP-103 Investigative [360]
Synonyms
NP-060103; NP-60103; Glycogen synthase kinase-3 inhibitor (Alzheimer's disease), Neuropharma
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External Link
 Compound Name Leptin Investigative [365]
Synonyms
Leptin (Alzheimer's disease)
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External Link
 Compound Name SP-08 Investigative [180]
Synonyms
SP-008
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External Link
 Compound Name SPI-017 Investigative [360]
Synonyms
SPI-017 (oral, Alzheimer's disease)
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External Link
 Compound Name RECALL-VAX Investigative [180]
Synonyms
RV-01; RV-02; Beta-amyloid fragment-tetanus toxoid prophylactic vaccine (Alzheimer's disease); Beta-amyloid fragment-tetanus toxoid prophylactic vaccine (Alzheimer's disease), Intellect Neuroscience
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External Link
 Compound Name CWF-0804 Investigative [360]
External Link
 Compound Name ACU-0101979 Investigative [180]
Synonyms
HuC091; ACU-5A5; ADDL formation inhibitors, Acumen/Merck; Anti-ADDL antibodies (Alzheimers disease); Anti-ADDL antibodies (Alzheimers disease), Acumen/Merck & Co; Anti-ADDL vaccines (Alzheimers disease), Acumen/Merck & Co
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External Link
 Compound Name Cystatin C Investigative [360]
Synonyms
Cystatin C (Alzheimer's disease)
    Click to Show/Hide
External Link
 Compound Name EDN-OL1 Investigative [180]
Synonyms
Amyloid beta oligonucleotide (Alzheimer's disease/Down syndrome), Edunn
    Click to Show/Hide
External Link
 Compound Name ADepVac Investigative [360]
Synonyms
DNA vaccine (Alzheimer's disease), University of California Irvine; DNA vaccine (TriGrid electroporation, Alzheimers), Ichor/UCI/IMM
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External Link
 Compound Name Anticalin Investigative [180]
Synonyms
Anticalin (Alzheimer's disease)
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External Link
 Compound Name ACI-518 Investigative [360]
Synonyms
AMPA glutamate receptor agonist (Alzheimer's disease), AC Immune
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External Link
 Compound Name SEN-1500 Investigative [180]
Synonyms
SEN-1576; Beta-amyloid aggregation inhibitors (Alzheimer's disease); Beta-amyloid aggregation inhibitors (Alzheimer's disease), Senexis
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External Link
 Compound Name ARN-2966 Investigative [366]
Synonyms
ARN-4261; Abeta aggregation inhibitors (Alzheimer's disease); Abeta aggregation inhibitors (Alzheimer's disease), New York University/Aria Neurosciences
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External Link
 Compound Name AZ-AAV9 Investigative [360]
Synonyms
Alzheimers disease gene therapy, RegenX Biosciences; Adeno-associated virus vector-9 based gene therapy (injectable,AD), RegenX Biosciences
    Click to Show/Hide
External Link
 Compound Name ACI-636 Investigative [180]
Synonyms
Morphomers; ACI-140; Beta amyloid beta sheet formation inhibitor (CNS diseases), AC Immune; Beta-amyloid oligomer inhibitors (Alzheimer's disease), AC Immune
    Click to Show/Hide
External Link
 Compound Name TKP-1001 Investigative [180]
Synonyms
Amyloid-beta modulator (Alzheimer's disease), EUSA Pharma; Amyloid-beta modulator (Alzheimer's disease), Talisker Pharma; Amyloid-beta synthesis modulator (Alzheimer's disease), The Open University
    Click to Show/Hide
External Link
 Compound Name NP-17 Investigative [360]
Synonyms
NP-21; NPM-01; NPM-05 series; NPM-05B1; NPM-05B2; Alpha-secreatse activators (oral, Alzheimer's disease), Noscira
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External Link
 Compound Name ANA-5 Investigative [180]
External Link
 Compound Name NXD-9062 Investigative [360]
External Link
 Compound Name LNK-3186 Investigative [360]
External Link
 Compound Name A-887755 Investigative [180]
External Link
 Compound Name ARC-069 Investigative [180]
Synonyms
Gamma secretase inhibitors (Alzheimer's disease), Archer Pharmaceuticals
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External Link
 Compound Name NNI-AD Investigative [360]
Synonyms
NNI-251; NNI-362; NNI-C; NNI-X01; AD therapy (oral), Neuronascent
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External Link
 Compound Name AZP-2006 Investigative [360]
Synonyms
Amyloid precursor protein modulator (AD), AlzProtect/INSERM/University of Lille II
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External Link
 Compound Name AC-4402 Investigative [360]
Synonyms
GABAA receptor inverse agonist (Alzheimer's disease), Dainippon Sumitomo Pharma
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External Link
 Compound Name GT 1061 Investigative [360]
External Link
 Compound Name LNK-3248 Investigative [360]
External Link
 Compound Name UC-1011 Investigative [367]
Synonyms
UC-2021; UC-2025; GABA A receptor antagonists (Alzheimer's disease); GABA A receptor antagonists (Alzheimer's disease), Umecrine; 3beta-20beta-dihydroxy-5alpha-pregnane; 3beta-20beta-dihydroxy-5alpha-pregnane (Alzheimer's disease), Umecrine
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External Link
 Compound Name F-18 T808 Investigative [360]
External Link
 Compound Name KD-501 Investigative [360]
External Link
 Compound Name Haw-AD-14 Investigative [360]
External Link
 Compound Name CDD-190 Investigative [360]
External Link
 Compound Name 123I-DRM-106 Investigative [180]
Synonyms
DRM-106-[123I]; Iodine-123-DRM-106; SPECT diagnostic (Alzheimer's disease), Fujifilm RI Pharma Co Ltd
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External Link
 Compound Name PN-403 Investigative [360]
External Link
 Compound Name Mimovax Investigative [180]
Synonyms
MV-01; AFFITOPE-based vaccine targeting truncated Abeta40/42 (Alzheimer's disease), AFFiRiS
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External Link
 Compound Name SEL-103 Investigative [360]
External Link
 Compound Name Molecule 22 Investigative [360]
Synonyms
MARK3 inhibitors (Alzheimer's disease); MARK3 inhibitors (Alzheimer's disease), Merck & Co
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External Link
References
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Ref 81 ClinicalTrials.gov (NCT05074498) A Seamless Phase 1b/2a Double-blind, Randomized, Multiple Dose, Multi-center, Sequential Dose-escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of TB006 in Patients With Mild to Severe Alzheimer's Disease. U.S.National Institutes of Health.
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Ref 83 ClinicalTrials.gov (NCT03044249) A Study of MP-101 in Dementia-Related Psychosis and/or Agitation and Aggression. U.S. National Institutes of Health.
Ref 84 ClinicalTrials.gov (NCT03055741) A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase IIb, Clinical Study to Evaluate the Safety and Efficacy of DHP1401 in Patients With Mild-moderate Alzheimer's Disease Treated With Donepezil(DRAMA). U.S.National Institutes of Health.
Ref 85 ClinicalTrials.gov (NCT04798989) A Phase 2a Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CY6463 When Administered to Participants With Alzheimer's Disease and Vascular Pathology. U.S.National Institutes of Health.
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Ref 88 ClinicalTrials.gov (NCT03867253) A Multicentre,Randomised, Double-blind, Placebo-controlled, 3-arm, 24-week Parallel-group Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of ORY-2001 in Patients With Mild-moderate Alzheimer's Disease. U.S.National Institutes of Health.
Ref 89 ClinicalTrials.gov (NCT04867616) A Patient- and Investigator-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Bepranemab (UCB0107) in Study Participants With Prodromal to Mild Alzheimer's Disease (AD), Followed by an Open-Label Extension Period. U.S.National Institutes of Health.
Ref 90 ClinicalTrials.gov (NCT04619420) A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Assess the Efficacy and Safety of JNJ-63733657, an Anti-tau Monoclonal Antibody, in Participants With Early Alzheimer's Disease. U.S.National Institutes of Health.
Ref 91 ClinicalTrials.gov (NCT04602624) An Open-Label Evaluation of the Safety and Tolerability of SAGE-718 in Participants With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease. U.S.National Institutes of Health.
Ref 92 ClinicalTrials.gov (NCT03806478) Safety, Tolerability and Efficacy Assessment of Intranasal Nanoparticles of APH-1105, A Novel Alpha Secretase Modulator For Mild to Moderate Cognitive Impairment Due to Alzheimer's Disease(AD). U.S.National Institutes of Health.
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Ref 95 ClinicalTrials.gov (NCT03560245) A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study Assessing the Safety, Tolerability and Efficacy of Bryostatin in the Treatment of Moderately Severe to Severe Alzheimer's Disease Subjects Not Receiving Memantine Treatment. U.S.National Institutes of Health.
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Ref 98 Clinical pipeline report, company report or official report of Neuraly
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Ref 100 ClinicalTrials.gov (NCT03790982) A Randomized, Double Blind, Placebo Controlled, Parallel-Group 52-week Multicenter Phase II Study to Investigate the Safety, Efficacy and Pharmacokinetics of AD-35 Tablet in Subjects With Mild to Moderate Alzheimer's Disease. U.S.National Institutes of Health.
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Ref 102 ClinicalTrials.gov (NCT03462121) A 6-Month, Double-Blind, Phase 2 Study and 6-Month Open- Label Extension Evaluating the Safety, Tolerability, and Clinical Benefit of RPh201 in Individuals With Alzheimer's Disease With or Without Coexisting Cerebrovascular Disease. U.S.National Institutes of Health.
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Ref 105 ClinicalTrials.gov (NCT05194163) A Phase 2a Study of MW150 Stress Kinase Inhibitor in Mild to Moderate Alzheimer's Disease. U.S.National Institutes of Health.
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Ref 107 ClinicalTrials.gov (NCT00021723) Randomized Safety, Tolerability and Pilot Efficacy of AN-1792 in Alzheimer's Disease. U.S. National Institutes of Health.
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Ref 109 ClinicalTrials.gov (NCT01928420) A Single Site, Randomized, Double-blind, Placebo Controlled Trial of NIC5-15 in Subjects With Alzheimer's Disease. U.S. National Institutes of Health.
Ref 110 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7356).
Ref 111 Inhibition of IKappaB phosphorylation prevents load-induced cardiac dysfunction in mice. Am J Physiol Heart Circ Physiol. 2012 Dec 15;303(12):H1435-45. doi: 10.1152/ajpheart.00290.2012. Epub 2012 Oct 5.
Ref 112 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027328)
Ref 113 ClinicalTrials.gov (NCT03367403) A Study of LY3002813 in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ). U.S. National Institutes of Health.
Ref 114 Clinical pipeline report, company report or official report of Affiris.
Ref 115 Biopharmaceutical Research Companies are Developing Nearly 100 Medicines for Alzheimer's Disease and Other Dementias. Pharmaceutical Research and Manufacturers of America report. 2012.
Ref 116 ClinicalTrials.gov (NCT02185053) A Phase II Study of CPC-201 to Treat Alzheimer's Disease Type Dementia. U.S. National Institutes of Health.
Ref 117 ClinicalTrials.gov (NCT01661673) Safety, Tolerability, Pharmacokinetics of EVP-0962 and Effects of EVP-0962 on Cerebral Spinal Fluid Amyloid Concentrations in Healthy Subjects and in Subjects With Mild Cognitive Impairment or Early Alzheimer's Disease. U.S. National Institutes of Health.
Ref 118 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021506)
Ref 119 ClinicalTrials.gov (NCT00087724) A Randomized Study to Evaluate FK962 in Subjects With Mild to Moderate Alzheimer's Disease. U.S. National Institutes of Health.
Ref 120 ClinicalTrials.gov (NCT01266525) Effect of Different Doses of SAR110894D on Cognition in Patients With Mild to Moderate Alzheimer's Disease on Donepezil. U.S. National Institutes of Health.
Ref 121 ClinicalTrials.gov (NCT02551809) Evaluate the Safety, Tolerability, Immunogenicity and Efficacy of UB-311 in Mild Alzheimer's Disease (AD) Patients.
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Ref 123 ClinicalTrials.gov (NCT00876863) Randomized, Controlled Study Evaluating CERE-110 in Subjects With Mild to Moderate Alzheimer's Disease. U.S. National Institutes of Health.
Ref 124 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031585)
Ref 125 ClinicalTrials.gov (NCT00001933) Nefiracetam in the Treatment of Alzheimer's Disease. U.S. National Institutes of Health.
Ref 126 ClinicalTrials.gov (NCT03817684) Tetra PICASSO AD Trial: Study to Evaluate Effects of BPN14770 in Early Alzheimer's Subjects. U.S. National Institutes of Health.
Ref 127 ClinicalTrials.gov (NCT01548287) A Study of the Safety and Tolerability of AZD5213 Effect on Sleep for Patients With Alzheimer's/Cognitive Impairment. U.S. National Institutes of Health.
Ref 128 ClinicalTrials.gov (NCT03712787) An Extension Study of ABBV-8E12 in Early Alzheimer's Disease (AD). U.S. National Institutes of Health.
Ref 129 Amarantus BioScience Licenses LymPro Alzheimer's Disease Diagnostic Blood Test
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Ref 131 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7842).
Ref 132 ClinicalTrials.gov (NCT01712074) Study Evaluating TheSafety And Efficacy Of PF-05212377 Or Placebo In Subjects With Alzheimer's Disease With Existing Neuropsychiatric Symptoms On Donepezil. U.S. National Institutes of Health.
Ref 133 ClinicalTrials.gov (NCT04735536) Pilot Clinical Study of CT1812 in Mild to Moderate Alzheimer's Disease Using EEG. U.S. National Institutes of Health.
Ref 134 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6475).
Ref 135 ClinicalTrials.gov (NCT02079909) Efficacy and Safety of T-817MA in Patients With Mild to Moderate Alzheimer's Disease (US202). U.S. National Institutes of Health.
Ref 136 Clinical pipeline report, company report or official report of Meta-IQ Aps.
Ref 137 ClinicalTrials.gov (NCT02484703) A Study of RG1662 in Down Syndrome Among Children 6 to 11 Years of Age.
Ref 138 Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr;13(4):483-94.
Ref 139 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006456)
Ref 140 ClinicalTrials.gov (NCT01821118) Study Evaluating the Safety,Tolerability and Efficacy of PF-04360365 in Adults With Probable Cerebral Amyloid Angiopathy. U.S. National Institutes of Health.
Ref 141 ClinicalTrials.gov (NCT02471196) Efficacy of ORM-12741 on Agitation/Aggression Symptoms in Alzheimer's Disease.
Ref 142 ClinicalTrials.gov (NCT00930059) A Study Of PF-04447943 Compared To Placebo In Subjects With Mild To Moderate Alzheimer's Disease. U.S. National Institutes of Health.
Ref 143 ClinicalTrials.gov (NCT00154635) Efficacy and Safety Study of DCB-AD1 in Patients With Mild to Moderate Alzheimer's Disease. U.S. National Institutes of Health.
Ref 144 ClinicalTrials.gov (NCT01655680) A Study to Evaluate ABT-126 for the Treatment of Cognitive Deficits in Schizophrenia. U.S. National Institutes of Health.
Ref 145 ClinicalTrials.gov (NCT00991419) To Compare Positron Emission Tomography (PET) Measurements of Fibrillar Amyloid Burden. U.S. National Institutes of Health.
Ref 146 ClinicalTrials.gov (NCT01772199) Study to Assess Whether GSK239512 Can Remyelinate Lesions in Subjects With Relapsing Remitting Multiple Sclerosis. U.S. National Institutes of Health.
Ref 147 ClinicalTrials.gov (NCT02258152) SYN120 a Dual 5-HT6/5-HT2A Antagonist Proof of Concept Study to Evaluate Its Safety, Tolerability and Efficacy in Parkinson's Disease Dementia (SYNAPSE). U.S. National Institutes of Health.
Ref 148 ClinicalTrials.gov (NCT01428362) VI-1121 for the Treatment Alzheimer's Disease. U.S. National Institutes of Health.
Ref 149 ClinicalTrials.gov (NCT00842673) Preliminary Efficacy and Safety Study of ST101 in Alzheimer's Disease. U.S. National Institutes of Health.
Ref 150 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030024)
Ref 151 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7357).
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Ref 153 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7339).
Ref 154 Clinical pipeline report, company report or official report of Forum pharmaceuticals.
Ref 155 ClinicalTrials.gov (NCT01852110) Efficacy and Safety of MK-7622 as Adjunct Therapy in Participants With Alzheimer's Disease (MK-7622-012). U.S. National Institutes of Health.
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Ref 157 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6489).
Ref 158 ClinicalTrials.gov (NCT02414347) F 18 T807 Tau PET Imaging of Alzheimer's Disease. U.S. National Institutes of Health.
Ref 159 Determination of the gamma-secretase inhibitor MK-0752 in human plasma by online extraction and electrospray tandem mass spectrometry (HTLC-ESI-MS/MS). J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Sep 1;878(25):2348-52.
Ref 160 ClinicalTrials.gov (NCT01221246) Efficacy and Safety Study of GM602 in Patients With Acute Middle Cerebral Artery Ischemic Stroke Within 18 Hours. U.S. National Institutes of Health.
Ref 161 ClinicalTrials.gov (NCT00357357) European Study of HF0220 in Mild to Moderate Alzheimer's Disease Patients. U.S. National Institutes of Health.
Ref 162 ClinicalTrials.gov (NCT00843518) Treatment for Aggression and Agitation in Patients With Alzheimer's Disease. U.S. National Institutes of Health.
Ref 163 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030006)
Ref 164 ClinicalTrials.gov (NCT00621270) Safety and Effectiveness Study of BCI-540 Versus Placebo in the Treatment of Major Depressive Disorder With Concomitant Anxiety. U.S. National Institutes of Health.
Ref 165 ClinicalTrials.gov (NCT01012375) Study to Investigate the Efficacy and Tolerability of AZD1446 in Adult ADHD Patients.. U.S. National Institutes of Health.
Ref 166 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8426).
Ref 167 ClinicalTrials.gov (NCT01284387) Amyloid Imaging And Safety Study Of ACC-001 In Subjects With Mild to Moderate Alzheimer's Disease. U.S. National Institutes of Health.
Ref 168 ClinicalTrials.gov (NCT03289143) A Study to Evaluate the Efficacy and Safety of Semorinemab in Patients With Prodromal to Mild Alzheimer's Disease. U.S. National Institutes of Health.
Ref 169 ClinicalTrials.gov (NCT01590888) Effect of PBT2 in Patients With Early to Mid Stage Huntington Disease. U.S. National Institutes of Health.
Ref 170 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. doi: 10.1038/s41573-019-0013-8.
Ref 171 ClinicalTrials.gov (NCT05040321) A Proof of Concept Trial of a Sirtuin-NAD Activator in Alzheimer's Disease. U.S.National Institutes of Health.
Ref 172 ClinicalTrials.gov (NCT04983368) XanaMIA-DR A Double-Blind, Placebo-Controlled, Dose Ranging Study to Assess the Efficacy, Pharmacodynamics and Safety of Xanamem? in Healthy Elderly Volunteers. U.S.National Institutes of Health.
Ref 173 ClinicalTrials.gov (NCT04249869) The Effect of Traditional Chinese Medicine (VGH-AD1) on Patients With Alzheimer's Disease: A Double-blinded Randomized Placebo-controlled Cross-over Study. U.S.National Institutes of Health.
Ref 174 ClinicalTrials.gov (NCT03865017) A Safety and Tolerability Study of GB301 Given as a Single Intravenous Dose in Subjects With Mild to Moderate Alzheimer's Disease. U.S.National Institutes of Health.
Ref 175 ClinicalTrials.gov (NCT03069014) Study of LM11A-31-BHS in Mild-moderate AD Patients. U.S. National Institutes of Health.
Ref 176 ClinicalTrials.gov (NCT03634007) A 52-Week, Multicenter, Phase 1/2 Open-label Study to Evaluate the Safety of LX1001 in Participants With APOE4 Homozygote Alzheimer's Disease. U.S.National Institutes of Health.
Ref 177 Clinical pipeline report, company report or official report of JOHNSON & JOHNSON
Ref 178 ClinicalTrials.gov (NCT05363293) A Multiple-dose, Steady-state, Double-blind, Ascending Dose, Safety, Tolerability, Pharmacokinetic Study of AL001 in Patients With Mild to Moderate Alzheimer\'s Disease and Healthy Adult Subjects ("MAD Study"). U.S.National Institutes of Health.
Ref 179 ClinicalTrials.gov (NCT02560753) Feasibility Study in Subjects With Mild to Moderate Alzheimer's Disease.
Ref 180 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402).
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Ref 182 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7034).
Ref 183 ClinicalTrials.gov (NCT01609257) Norovirus Bivalent-Vaccine Efficacy Study. U.S. National Institutes of Health.
Ref 184 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030376)
Ref 185 MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33. doi: 10.1158/0008-5472.CAN-09-2541. Epub 2010 Feb 9.
Ref 186 ClinicalTrials.gov (NCT02407353) A Study to Evaluate the Pharmacodynamic Effects of Single Oral Doses of PF-06648671 on beta-Amyloid (Abeta) Concentrations in Cerebrospinal Fluid (CSF). U.S. National Institutes of Health.
Ref 187 ClinicalTrials.gov (NCT01397539) A Randomized, Blinded, Placebo-Controlled Single Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of BIIB037 in Subjects With Mild to Moderate Alzheimer's Disease. U.S.National Institutes of Health.
Ref 188 ClinicalTrials.gov (NCT04749563) A Phase I Randomized Placebo Controlled MAD Study to Evaluate Safety and Tolerability of IGC-AD1 in Subjects With Dementia Due to Alzheimer's Disease. U.S.National Institutes of Health.
Ref 189 5HT6 Antagonists in the Treatment of Alzheimer's Dementia: Current Progress. Neurol Ther. 2018 Jun;7(1):51-58.
Ref 190 ClinicalTrials.gov (NCT03838185) A Phase I, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety, Tolerability and Pharmacokinetics of Single Ascending Oral Doses of J147 in Healthy Young Volunteers and Healthy Elderly Volunteers. U.S.National Institutes of Health.
Ref 191 Clinical pipeline report, company report or official report of Genentch
Ref 192 ClinicalTrials.gov (NCT04759365) A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Oral ASN51 in Healthy Young Adult and Elderly Subjects and Elderly Subjects With Alzheimer's Disease. U.S.National Institutes of Health.
Ref 193 Clinical pipeline report, company report or official report of Eisai
Ref 194 ClinicalTrials.gov (NCT04973189) A Phase 1, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Intravenous Administration of SHR-1707 in Healthy Young Adult and Elderly Subjects. U.S.National Institutes of Health.
Ref 195 ClinicalTrials.gov (NCT04149860) Interventional, Randomized, Double-blind, Placebo-controlled, Single-ascending-dose Study Investigating the Safety, Tolerability, and Pharmacokinetic Properties of Lu AF87908 in Healthy Subjects and Patients With Alzheimer's Disease. U.S.National Institutes of Health.
Ref 196 ClinicalTrials.gov (NCT05344989) A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of APNmAb005 in Healthy Subjects. U.S.National Institutes of Health.
Ref 197 Clinical pipeline report, company report or official report of Aphios
Ref 198 ClinicalTrials.gov (NCT05450549) A Phase 1, Randomized, Placebo-Controlled, Double-Blind, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL919 in Healthy Participants. U.S.National Institutes of Health.
Ref 199 Clinical pipeline report, company report or official report of Prothena
Ref 200 Clinical pipeline report, company report or official report of NeuroTherapia
Ref 201 ClinicalTrials.gov (NCT04133649) Evaluation of Safety and Tolerability of Libella Gene Therapy (LGT) for the Treatment of Aging: AAV- hTERT. U.S.National Institutes of Health.
Ref 202 DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers. Clin Pharmacol Ther. 2020 Feb;107(2):406-414.
Ref 203 ClinicalTrials.gov (NCT03757325) Study to Evaluate DNL747 in Subjects With Alzheimer's Disease. U.S. National Institutes of Health.
Ref 204 ClinicalTrials.gov (NCT04476303) A Randomized, Double-blind, Placebo-controlled, Single and Multiple Ascending Dose Phase I Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of BEY2153 After Oral Administration in Healthy Young and Elderly Male Volunteers. U.S.National Institutes of Health.
Ref 205 ClinicalTrials.gov (NCT04672135) A Phase 1 (First in Human) Randomized, Double-blind, Placebo-controlled SAD, MAD Study With an Adaptive Dose Design to Evaluate the Safety, Tolerability, and Pharmacokinetics of REM0046127 in Healthy Subjects. U.S.National Institutes of Health.
Ref 206 ClinicalTrials.gov (NCT04931459) A Phase 1 Placebo-Controlled, Single- and Multiple-Dose Study of the Safety, Tolerability, and Pharmacokinetics of Intravenous ACU193 in Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease. U.S.National Institutes of Health.
Ref 207 Clinical pipeline report, company report or official report of I-Mab Biopharma
Ref 208 ClinicalTrials.gov (NCT04805983) An Open-Label, Single-Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Receptor Occupancy of BMS-984923. U.S.National Institutes of Health.
Ref 209 ClinicalTrials.gov (NCT05231785) A Randomized, Double-blind, Placebo-controlled Single Ascending Dose and Open-label Multi-dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intrathecally Administered ALN-APP in Adult Patients With Early-onset Alzheimer's Disease (EOAD). U.S.National Institutes of Health.
Ref 210 ClinicalTrials.gov (NCT03740178) A Randomized, Double-Blinded Clinical Trial to Assess the Safety, Tolerability and Pharmacokinetics of MK-4334 in Participants With Alzheimer's Clinical Syndrome on a Stable Dose of Donepezil. U.S.National Institutes of Health.
Ref 211 ClinicalTrials.gov (NCT04074837) Phase1a, Randomized Placebo-controlled, Single and Multiple Dose, Dose-escalation Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Oral NNI-362 in Healthy Aged Volunteers 50 to 72 Years of Age. U.S.National Institutes of Health.
Ref 212 ClinicalTrials.gov (NCT04920903) A Phase 1, Randomized, Double-Blind, Placebo-Controlled, First-in-Human, Single- and Multiple-Ascending Dose Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Oral COR588 in Healthy Adult Subjects. U.S.National Institutes of Health.
Ref 213 ClinicalTrials.gov (NCT03822208) A Phase I Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Single and Multiple Doses of AL003 in Healthy Participants and in Participants With Mild to Moderate Alzheimer's Disease.. U.S.National Institutes of Health.
Ref 214 ClinicalTrials.gov (NCT04451408) A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LY3372993 in Participants With Alzheimer's Disease and Healthy Participants. U.S.National Institutes of Health.
Ref 215 ClinicalTrials.gov (NCT05804383) A Phase 1B Multiple Ascending Dose Study of The Safety and Tolerability of BMS-984923 in Healthy Older Adults and Patients With Alzheimer's Disease. U.S.National Institutes of Health.
Ref 216 ClinicalTrials.gov (NCT05195008) A Phase 1 Randomized, Blinded, Placebo-Controlled, Single- and Multiple-Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics, With an Open-Label Target Occupancy Study of BIIB113 in Healthy Participants. U.S.National Institutes of Health.
Ref 217 List of drugs in development for neurodegenerative diseases: update October 2011. Neurodegener Dis. 2012;9(4):210-83.
Ref 218 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027767)
Ref 219 ClinicalTrials.gov (NCT01908010) Safety, Tolerability, and Pharmacokinetics of ABT-354 in Subjects With Mild-to-Moderate Alzheimer's Disease on Stable Doses of Acetylcholinesterase Inhibitors. U.S. National Institutes of Health.
Ref 220 ClinicalTrials.gov (NCT00495417) Tolerability and Safety of Subcutaneous Administration of Affitope AD01 in Mild to Moderate Alzheimer's Disease. U.S. National Institutes of Health.
Ref 221 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 222 ClinicalTrials.gov (NCT01492374) Study to Evaluate the Safety, Tolerability and the Effect of BMS-241027 on Cerebrospinal Fluid Biomarkers in Subjects With Mild Alzheimer's Disease. U.S. National Institutes of Health.
Ref 223 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033932)
Ref 224 ClinicalTrials.gov (NCT00838877) Positron Emission Tomography (PET) Study With [18F]AZD4694 and [11C]AZD2184, Candidate PET Ligands for A Amyloid. U.S. National Institutes of Health.
Ref 225 ClinicalTrials.gov (NCT00719394) Study Evaluating Safety of GSI 136 in Young and Elderly Japanese Males. U.S. National Institutes of Health.
Ref 226 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031827)
Ref 227 ClinicalTrials.gov (NCT01548703) A Multiple Ascending Dose Study of BCI-838 in Healthy Volunteers. U.S. National Institutes of Health.
Ref 228 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031729)
Ref 229 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 700036191)
Ref 230 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028705)
Ref 231 ClinicalTrials.gov (NCT01153607) Evaluation of the Diagnostic Potential of BAY1006578 in Probable Alzheimers Disease Patients Versus Healthy Volunteers and Radiation Dosimetry of BAY1006578 in Healthy Volunteers. U.S. National Institutes of Health.
Ref 232 ClinicalTrials.gov (NCT01592331) A Pharmacodynamic and Pharmacokinetic Study of RO5508887 in Healthy Volunteers. U.S. National Institutes of Health.
Ref 233 ClinicalTrials.gov (NCT01485302) Single and Repeated Dosing Study to Assess the Safety and the Concentration-time Profile of SAR228810 in Alzheimer's Patients. U.S. National Institutes of Health.
Ref 234 ClinicalTrials.gov (NCT00870519) Brain Imaging Study in Subjects With Alzheimer Disease in Comparison to Healthy Subjects. U.S. National Institutes of Health.
Ref 235 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6936).
Ref 236 ClinicalTrials.gov (NCT00657813) Evaluation of [123I] MNI-330 and SPECT as a Marker of Beta-amyloid Protein Deposition. U.S. National Institutes of Health.
Ref 237 ClinicalTrials.gov (NCT00692705) Positron Emission Tomography (PET) Study With [11C]AZD2995 and [11C]AZD2184, Candidate PET Ligands for Amyloid. U.S. National Institutes of Health.
Ref 238 ClinicalTrials.gov (NCT01406145) A Study of the Safety and Tolerability of ASP0777 in Subjects With Alzheimer's Disease (AD) Taking a Stable Dose of Donepezil. U.S. National Institutes of Health.
Ref 239 ClinicalTrials.gov (NCT00739037) Study Evaluating PAZ-417 in Cerebrospinal Fluid in Subjects With Alzheimer's Disease. U.S. National Institutes of Health.
Ref 240 Biopharmaceutical Research Companies Are Developing More Than 430 Medicines for Top Chronic Diseases Affecting Older Americans. Pharmaceutical Research and Manufacturers of America report. 2014.
Ref 241 ClinicalTrials.gov (NCT01221259) A Randomized, Double-blind, Placebo-controlled, Sequential Ascending, Single-dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2212 in Healthy Subjects. U.S. National Institutes of Health.
Ref 242 ClinicalTrials.gov (NCT01548430) A Safety Study of TTP4000 in Subjects With Alzheimer's Disease. U.S. National Institutes of Health.
Ref 243 Clinical pipeline report, company report or official report of Annovis Bio
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Ref 245 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025412)
Ref 246 ClinicalTrials.gov (NCT01924858) A Positron Emission Tomography (PET) Study to Investigate the Brain Biodistribution of 18F GSK2647544 in Healthy Subjects to Determine Its Ability to Cross the Blood-brain-barrier.. U.S. National Institutes of Health.
Ref 247 ClinicalTrials.gov (NCT01163825) Encapsulated Cell Biodelivery of Nerve Growth Factor to Alzheimer Disease Patients. U.S. National Institutes of Health.
Ref 248 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800036473)
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Ref 250 ClinicalTrials.gov (NCT01546051) A Study of BCI-838 and Several BCI-632 Prodrugs in Healthy Volunteers. U.S. National Institutes of Health.
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