m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00132)
Target Name microRNA 21 (MIR21)
Synonyms
MIR21; MIRN21; hsa-mir-21; MIR-21
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Gene Name MIR21
Chromosomal Location 17q23.1
Family MicroRNAs
Gene ID 406991
HGNC ID
HGNC:31586
miRBase ID
MI0000077
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MIR21 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Browse Disease
RNA demethylase ALKBH5 (ALKBH5) [ERASER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [2]
Response Summary ALKBH5 plays an antitumor role in colorectal cancer by modulating the FOXO3/microRNA 21 (MIR21)/SPRY2 axis, which not only suggests a regulatory effect between ALKBH5 and FOXO3, but also provides a new therapeutic direction for colorectal cancer.
Responsed Disease Colorectal cancer ICD-11: 2B91
 Disease Info 
Pathway Response FoxO signaling pathway hsa04068
In-vitro Model Caco-2 Colon adenocarcinoma Homo sapiens CVCL_0025
FHC Normal Homo sapiens CVCL_3688
HCT 116 Colon carcinoma Homo sapiens CVCL_0291
SW480 Colon adenocarcinoma Homo sapiens CVCL_0546
SW620 Colon adenocarcinoma Homo sapiens CVCL_0547
Colorectal cancer [ICD-11: 2B91]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [2]
Response Summary ALKBH5 plays an antitumor role in colorectal cancer by modulating the FOXO3/microRNA 21 (MIR21)/SPRY2 axis, which not only suggests a regulatory effect between ALKBH5 and FOXO3, but also provides a new therapeutic direction for colorectal cancer.
Responsed Disease Colorectal cancer [ICD-11: 2B91]
Target Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
Pathway Response FoxO signaling pathway hsa04068
In-vitro Model Caco-2 Colon adenocarcinoma Homo sapiens CVCL_0025
FHC Normal Homo sapiens CVCL_3688
HCT 116 Colon carcinoma Homo sapiens CVCL_0291
SW480 Colon adenocarcinoma Homo sapiens CVCL_0546
SW620 Colon adenocarcinoma Homo sapiens CVCL_0547
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
RNA modification
m6A Regulator: Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)
 Regulator Info 
In total 7 item(s) under this m6A regulator
Crosstalk ID: M6ACROT00589
 Crosstalk Info 
Epigenetic Regulator Interferon-inducible protein 4 (ADAR1)
Regulated Target Protein sprouty homolog 2 (SPRY2)
Crosstalk relationship m6A → A-to-I
Crosstalk ID: M6ACROT00591
 Crosstalk Info 
Epigenetic Regulator Double-stranded RNA-specific editase 1 (ADARB1)
Regulated Target Protein sprouty homolog 2 (SPRY2)
Crosstalk relationship m6A → A-to-I
Crosstalk ID: M6ACROT00593
 Crosstalk Info 
Epigenetic Regulator Y-box-binding protein 1 (YBX1)
Regulated Target Growth arrest specific 5 (GAS5)
Crosstalk relationship m5C → m6A
Crosstalk ID: M6ACROT00595
 Crosstalk Info 
Epigenetic Regulator Putative methyltransferase NSUN7 (NSUN7)
Regulated Target Phosphofructokinase, muscle (PFKM)
Crosstalk relationship m6A → m5C
Crosstalk ID: M6ACROT00597
 Crosstalk Info 
Epigenetic Regulator Methylcytosine dioxygenase TET1 (TET1)
Regulated Target Mutated in multiple advanced cancers 1 (PTEN)
Crosstalk relationship m6A → m5C
Crosstalk ID: M6ACROT00599
 Crosstalk Info 
Epigenetic Regulator Methylcytosine dioxygenase TET2 (TET2)
Regulated Target Mutated in multiple advanced cancers 1 (PTEN)
Crosstalk relationship m6A → m5C
Crosstalk ID: M6ACROT00601
 Crosstalk Info 
Epigenetic Regulator Methylcytosine dioxygenase TET3 (TET3)
Regulated Target Mutated in multiple advanced cancers 1 (PTEN)
Crosstalk relationship m6A → m5C
m6A Regulator: Methyltransferase-like 3 (METTL3)
 Regulator Info 
In total 7 item(s) under this m6A regulator
Crosstalk ID: M6ACROT00590
 Crosstalk Info 
Epigenetic Regulator Interferon-inducible protein 4 (ADAR1)
Regulated Target Protein sprouty homolog 2 (SPRY2)
Crosstalk relationship m6A → A-to-I
Crosstalk ID: M6ACROT00592
 Crosstalk Info 
Epigenetic Regulator Double-stranded RNA-specific editase 1 (ADARB1)
Regulated Target Protein sprouty homolog 2 (SPRY2)
Crosstalk relationship m6A → A-to-I
Crosstalk ID: M6ACROT00594
 Crosstalk Info 
Epigenetic Regulator Y-box-binding protein 1 (YBX1)
Regulated Target Growth arrest specific 5 (GAS5)
Crosstalk relationship m5C → m6A
Crosstalk ID: M6ACROT00596
 Crosstalk Info 
Epigenetic Regulator Putative methyltransferase NSUN7 (NSUN7)
Regulated Target Phosphofructokinase, muscle (PFKM)
Crosstalk relationship m6A → m5C
Crosstalk ID: M6ACROT00598
 Crosstalk Info 
Epigenetic Regulator Methylcytosine dioxygenase TET1 (TET1)
Regulated Target Mutated in multiple advanced cancers 1 (PTEN)
Crosstalk relationship m6A → m5C
Crosstalk ID: M6ACROT00600
 Crosstalk Info 
Epigenetic Regulator Methylcytosine dioxygenase TET2 (TET2)
Regulated Target Mutated in multiple advanced cancers 1 (PTEN)
Crosstalk relationship m6A → m5C
Crosstalk ID: M6ACROT00602
 Crosstalk Info 
Epigenetic Regulator Methylcytosine dioxygenase TET3 (TET3)
Regulated Target Mutated in multiple advanced cancers 1 (PTEN)
Crosstalk relationship m6A → m5C
Histone modification
m6A Regulator: RNA demethylase ALKBH5 (ALKBH5)
 Regulator Info 
In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03357
 Crosstalk Info 
Epigenetic Regulator Histone deacetylase 2 (HDAC2)
Regulated Target Histone H3 lysine 27 acetylation (H3K27ac)
Crosstalk relationship Histone modification → m6A
Disease Colorectal cancer
 Disease Info 
Crosstalk ID: M6ACROT03453
 Crosstalk Info 
Epigenetic Regulator Histone deacetylase 1 (HDAC1)
Regulated Target Histone H3 lysine 27 acetylation (H3K27ac)
Crosstalk relationship Histone modification → m6A
Disease Colorectal cancer
 Disease Info 
Non-coding RNA
m6A Regulator: RNA demethylase ALKBH5 (ALKBH5)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05538
 Crosstalk Info 
Epigenetic Regulator MicroRNA 21 (MIR21)
Regulated Target Protein sprouty homolog 2 (SPRY2)
Crosstalk relationship m6A → ncRNA
Disease Colorectal cancer
 Disease Info 
m6A Regulator: Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05777
 Crosstalk Info 
Epigenetic Regulator MicroRNA 21 (MIR21)
Crosstalk relationship m6A → ncRNA
References
Ref 1 Terameprocol, a novel site-specific transcription inhibitor with anticancer activity. IDrugs. 2008 Mar;11(3):204-14.
Ref 2 m(6)A demethylase ALKBH5 inhibits cell proliferation and the metastasis of colorectal cancer by regulating the FOXO3/miR-21/SPRY2 axis. Am J Transl Res. 2021 Oct 15;13(10):11209-11222. eCollection 2021.