m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05777
|
[1] | |||
m6A modification
MIR21
MIR21
HNRNPC
 : m6A sites
Direct
Enhancement
Non-coding RNA
MIR21
Regulated Target
lncRNA miRNA circRNA
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) | READER | |||
| m6A Target | microRNA 21 (MIR21) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | MicroRNA 21 (MIR21) | microRNA | View Details | ||
| Crosstalk Relationship | m6A → ncRNA | Enhancement | |||
| Crosstalk Mechanism | m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA | ||||
| Crosstalk Summary | The levels of pri-miR-21, pre-miR-21, and mature microRNA 21 (MIR21) decreased after hnRNPC silencing. HNRNPC interacts with the MIR21. | ||||
| Cell Process | Cell migratory | ||||
| Cell invasion | |||||
| Cell proliferation | |||||
| Cell apoptosis. | |||||
In-vitro Model |
T98G | Glioblastoma | Homo sapiens | CVCL_0556 | |