m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00593
 [1], [2], [3], [4], [5], [6]
RNA modification GAS5 GAS5 YBX1 : modification sites Indirect Enhancement m6A modification MIR21 MIR21 HNRNPC : m6A sites
m6A Modification:
m6A Regulator Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) READER
 Regulator Info 
m6A Target microRNA 21 (MIR21)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> 5-methylcytidine (m5C)
Epigenetic Regulator Y-box-binding protein 1 (YBX1) READER View Details
Regulated Target Growth arrest specific 5 (GAS5) View Details
Crosstalk Relationship m5C  →  m6A Enhancement
Crosstalk Mechanism RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary YBX1 interacts with Growth arrest specific 5 (GAS5), reading its m5C sites and promoting its physical interaction with microRNA 21 (MIR21), which was regulated by HNRNPC-mediated m6A modification.
In-vitro Model
 HGC-27 Gastric carcinoma Homo sapiens CVCL_1279
T98G Glioblastoma Homo sapiens CVCL_0556
References
Ref 1 lncRNA GAS5 enhances G1 cell cycle arrest via binding to YBX1 to regulate p21 expression in stomach cancer. Sci Rep. 2015 May 11;5:10159. doi: 10.1038/srep10159.
Ref 2 Long noncoding RNA GAS5 induces abdominal aortic aneurysm formation by promoting smooth muscle apoptosis. Theranostics. 2019 Jul 28;9(19):5558-5576. doi: 10.7150/thno.34463. eCollection 2019.
Ref 3 Heterogeneous nuclear ribonucleoprotein C1/C2 controls the metastatic potential of glioblastoma by regulating PDCD4. Mol Cell Biol. 2012 Oct;32(20):4237-44. doi: 10.1128/MCB.00443-12. Epub 2012 Aug 20.
Ref 4 lncRNA GAS5 acts as a ceRNA for miR-21 in suppressing PDGF-bb-induced proliferation and migration in vascular smooth muscle cells. J Cell Biochem. 2019 Sep;120(9):15233-15240. doi: 10.1002/jcb.28789. Epub 2019 May 8.
Ref 5 Long Noncoding RNA GAS5 Acts As A Tumor Suppressor In Laryngeal Squamous Cell Carcinoma Via miR-21. Cancer Manag Res. 2019 Sep 17;11:8487-8498. doi: 10.2147/CMAR.S213690. eCollection 2019.
Ref 6 GAS5/miR-21 Axis as a Potential Target to Rescue ZCL-082-Induced Autophagy of Female Germline Stem Cells In?Vitro. Mol Ther Nucleic Acids. 2019 Sep 6;17:436-447. doi: 10.1016/j.omtn.2019.06.012. Epub 2019 Jun 28.