m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00596				[1], [2], [3]
m⁶A modification MIR21 MIR21 METTL3 Methylation : m⁶A sites Indirect Enhancement RNA modification PFKM PFKM NSUN7 Methylation : modification sites
m6A Regulator	Methyltransferase-like 3 (METTL3)			WRITER	Regulator Info
m6A Target	microRNA 21 (MIR21)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> 5-methylcytidine (m5C)
Epigenetic Regulator	Putative methyltransferase NSUN7 (NSUN7)			WRITER	View Details
Regulated Target	Phosphofructokinase, muscle (PFKM)				View Details
Crosstalk Relationship	m6A → m5C			Enhancement
Crosstalk Mechanism	m6A modification indirectly impacts RNA modification through downstream signaling pathways
Crosstalk Summary	METTL3 interacts with microRNA 21 (MIR21), increasing its m6A level and promoting its physical interaction with Phosphofructokinase, muscle (PFKM), which was regulated by NSUN7-mediated m5C modification.
In-vitro Model	Hepa 1-6	Hepatocellular carcinoma of the mouse	Mus musculus		CVCL_0327
In-vitro Model	HK2	Normal	Acipenser baerii		CVCL_YE28

References

Ref 1	Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1alpha. Cell Rep. 2016 Jan 26;14(3):479-492. doi: 10.1016/j.celrep.2015.12.043. Epub 2016 Jan 7.
Ref 2	METTL3/N6-methyladenosine/ miR-21-5p promotes obstructive renal fibrosis by regulating inflammation through SPRY1/ERK/NF-KappaB pathway activation. J Cell Mol Med. 2021 Aug;25(16):7660-7674. doi: 10.1111/jcmm.16603. Epub 2021 Jun 24.
Ref 3	Mycobacterium tuberculosis Limits Host Glycolysis and IL-1beta by Restriction of PFK-M via MicroRNA-21. Cell Rep. 2020 Jan 7;30(1):124-136.e4. doi: 10.1016/j.celrep.2019.12.015.