m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00153)
Target Name Pvt1 oncogene (PVT1)
Synonyms
PVT1; pvt-1 (murine) oncogene homolog, MYC activator; Pvt1 oncogene homolog (mouse); Pvt1 oncogene (non-protein coding); NCRNA00079; LINC00079; onco-lncRNA-100; MIR1204HG; non-protein coding RNA 79; long intergenic non-protein coding RNA 79; MIR1204, MIR1205, MIR1206 and MIR1207 host gene; plasmacytoma variant translocation 1
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Gene Name PVT1
Chromosomal Location 8q24.21
Family MicroRNA non-coding host genes; Long non-coding RNAs with non-systematic symbols
Gene ID 5820
HGNC ID
HGNC:9709
Ensembl Gene ID
ENSG00000249859
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
PVT1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
RNA demethylase ALKBH5 (ALKBH5) [ERASER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by ALKBH5
Cell Line NOMO-1 cell line Homo sapiens
Treatment: shALKBH5 NOMO-1 cells
Control: shNS NOMO-1 cells
 GSE144968
Regulation
logFC: -1.38E+00
p-value: 6.15E-03
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary ALKBH5 decreased the m6A modification of Pvt1 oncogene (PVT1), thus inhibiting the binding of reader protein YTHDF2 in PVT1. ALKBH5-mediated PVT1 upregulation promoted the osteosarcoma cell proliferation in vitro and tumor growth in vivo.
Target Regulation Up regulation
Responsed Disease Osteosarcoma ICD-11: 2B51
 Disease Info 
Cell Process Cell proliferation
Cell migration
Cell invasion
In-vitro Model 143B Osteosarcoma Homo sapiens CVCL_2270
HOS Osteosarcoma Homo sapiens CVCL_0312
SaOS-LM7 Osteosarcoma Homo sapiens CVCL_0515
MG-63 Osteosarcoma Homo sapiens CVCL_0426
NHOst (Normal human osteoblast cells)
SaOS-2 Osteosarcoma Homo sapiens CVCL_0548
U2OS Osteosarcoma Homo sapiens CVCL_0042
In-vivo Model Indicated stable 143B cells were subcutaneously injected into nude mice.
YTH domain-containing family protein 2 (YTHDF2) [READER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by YTHDF2
Cell Line Human umbilical cord blood CD34+ cells Homo sapiens
Treatment: YTHDF2 knockdown UCB CD34+ cells
Control: Wild type UCB CD34+ cells
 GSE107956
Regulation
logFC: 8.15E-01
p-value: 1.40E-05
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary ALKBH5 decreased the m6A modification of Pvt1 oncogene (PVT1), thus inhibiting the binding of reader protein YTHDF2 in PVT1. ALKBH5-mediated PVT1 upregulation promoted the osteosarcoma cell proliferation in vitro and tumor growth in vivo.
Target Regulation Up regulation
Responsed Disease Osteosarcoma ICD-11: 2B51
 Disease Info 
Cell Process Cell proliferation
Cell migration
Cell invasion
In-vitro Model 143B Osteosarcoma Homo sapiens CVCL_2270
HOS Osteosarcoma Homo sapiens CVCL_0312
SaOS-LM7 Osteosarcoma Homo sapiens CVCL_0515
MG-63 Osteosarcoma Homo sapiens CVCL_0426
NHOst (Normal human osteoblast cells)
SaOS-2 Osteosarcoma Homo sapiens CVCL_0548
U2OS Osteosarcoma Homo sapiens CVCL_0042
In-vivo Model Indicated stable 143B cells were subcutaneously injected into nude mice.
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RIP-seq result supporting the interaction between PVT1 and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 1.16E+01 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [2]
Response Summary m6A modification is co-regulated by METTL3 and FTO in cadmium-treated cells. LncRNA-MALAT1, Pvt1 oncogene (PVT1) and m6A modification could be key nodes for cadmium-induced oxidative damage, and highlight their importance as promising preventive and therapeutic targets in cadmium toxicity.
Target Regulation Up regulation
Responsed Disease Kidney failure ICD-11: GB6Z
 Disease Info 
In-vitro Model NIT-1 Insulin tumor Mus musculus CVCL_3561
Fat mass and obesity-associated protein (FTO) [ERASER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [2]
Response Summary m6A modification is co-regulated by METTL3 and FTO in cadmium-treated cells. LncRNA-MALAT1, Pvt1 oncogene (PVT1) and m6A modification could be key nodes for cadmium-induced oxidative damage, and highlight their importance as promising preventive and therapeutic targets in cadmium toxicity.
Target Regulation Up regulation
Responsed Disease Kidney failure ICD-11: GB6Z
 Disease Info 
In-vitro Model NIT-1 Insulin tumor Mus musculus CVCL_3561
Osteosarcoma [ICD-11: 2B51]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary ALKBH5 decreased the m6A modification of Pvt1 oncogene (PVT1), thus inhibiting the binding of reader protein YTHDF2 in PVT1. ALKBH5-mediated PVT1 upregulation promoted the osteosarcoma cell proliferation in vitro and tumor growth in vivo.
Responsed Disease Osteosarcoma [ICD-11: 2B51]
Target Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell proliferation
Cell migration
Cell invasion
In-vitro Model 143B Osteosarcoma Homo sapiens CVCL_2270
HOS Osteosarcoma Homo sapiens CVCL_0312
SaOS-LM7 Osteosarcoma Homo sapiens CVCL_0515
MG-63 Osteosarcoma Homo sapiens CVCL_0426
NHOst (Normal human osteoblast cells)
SaOS-2 Osteosarcoma Homo sapiens CVCL_0548
U2OS Osteosarcoma Homo sapiens CVCL_0042
In-vivo Model Indicated stable 143B cells were subcutaneously injected into nude mice.
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary ALKBH5 decreased the m6A modification of Pvt1 oncogene (PVT1), thus inhibiting the binding of reader protein YTHDF2 in PVT1. ALKBH5-mediated PVT1 upregulation promoted the osteosarcoma cell proliferation in vitro and tumor growth in vivo.
Responsed Disease Osteosarcoma [ICD-11: 2B51]
Target Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell proliferation
Cell migration
Cell invasion
In-vitro Model 143B Osteosarcoma Homo sapiens CVCL_2270
HOS Osteosarcoma Homo sapiens CVCL_0312
SaOS-LM7 Osteosarcoma Homo sapiens CVCL_0515
MG-63 Osteosarcoma Homo sapiens CVCL_0426
NHOst (Normal human osteoblast cells)
SaOS-2 Osteosarcoma Homo sapiens CVCL_0548
U2OS Osteosarcoma Homo sapiens CVCL_0042
In-vivo Model Indicated stable 143B cells were subcutaneously injected into nude mice.
Kidney failure [ICD-11: GB6Z]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [2]
Response Summary m6A modification is co-regulated by METTL3 and FTO in cadmium-treated cells. LncRNA-MALAT1, Pvt1 oncogene (PVT1) and m6A modification could be key nodes for cadmium-induced oxidative damage, and highlight their importance as promising preventive and therapeutic targets in cadmium toxicity.
Responsed Disease Kidney failure [ICD-11: GB6Z]
Target Regulator Fat mass and obesity-associated protein (FTO) ERASER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model NIT-1 Insulin tumor Mus musculus CVCL_3561
Experiment 2 Reporting the m6A-centered Disease Response [2]
Response Summary m6A modification is co-regulated by METTL3 and FTO in cadmium-treated cells. LncRNA-MALAT1, Pvt1 oncogene (PVT1) and m6A modification could be key nodes for cadmium-induced oxidative damage, and highlight their importance as promising preventive and therapeutic targets in cadmium toxicity.
Responsed Disease Kidney failure [ICD-11: GB6Z]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model NIT-1 Insulin tumor Mus musculus CVCL_3561
References
Ref 1 ALKBH5-mediated m(6)A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma. Cancer Cell Int. 2020 Jan 30;20:34. doi: 10.1186/s12935-020-1105-6. eCollection 2020.
Ref 2 Changes and relationship of N(6)-methyladenosine modification and long non-coding RNAs in oxidative damage induced by cadmium in pancreatic Beta-cells. Toxicol Lett. 2021 Jun 1;343:56-66. doi: 10.1016/j.toxlet.2021.02.014. Epub 2021 Feb 24.