m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0118)
| Name |
Kidney failure
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|---|---|---|---|---|---|
| ICD |
ICD-11: GB6Z
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Full List of Target Gene(s) of This m6A-centered Disease Response
Metastasis associated lung adenocarcinoma transcript 1 (MALAT1)
| In total 2 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | m6A modification is co-regulated by METTL3 and FTO in cadmium-treated cells. Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), LncRNA-PVT1 and m6A modification could be key nodes for cadmium-induced oxidative damage, and highlight their importance as promising preventive and therapeutic targets in cadmium toxicity. | |||
| Responsed Disease | Kidney failure [ICD-11: GB6Z] | |||
| Target Regulator | Fat mass and obesity-associated protein (FTO) | ERASER | ||
| Target Regulation | Up regulation | |||
| In-vitro Model | NIT-1 | Insulin tumor | Mus musculus | CVCL_3561 |
| Experiment 2 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | m6A modification is co-regulated by METTL3 and FTO in cadmium-treated cells. Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), LncRNA-PVT1 and m6A modification could be key nodes for cadmium-induced oxidative damage, and highlight their importance as promising preventive and therapeutic targets in cadmium toxicity. | |||
| Responsed Disease | Kidney failure [ICD-11: GB6Z] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| In-vitro Model | NIT-1 | Insulin tumor | Mus musculus | CVCL_3561 |
Pvt1 oncogene (PVT1)
| In total 2 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | m6A modification is co-regulated by METTL3 and FTO in cadmium-treated cells. LncRNA-MALAT1, Pvt1 oncogene (PVT1) and m6A modification could be key nodes for cadmium-induced oxidative damage, and highlight their importance as promising preventive and therapeutic targets in cadmium toxicity. | |||
| Responsed Disease | Kidney failure [ICD-11: GB6Z] | |||
| Target Regulator | Fat mass and obesity-associated protein (FTO) | ERASER | ||
| Target Regulation | Up regulation | |||
| In-vitro Model | NIT-1 | Insulin tumor | Mus musculus | CVCL_3561 |
| Experiment 2 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | m6A modification is co-regulated by METTL3 and FTO in cadmium-treated cells. LncRNA-MALAT1, Pvt1 oncogene (PVT1) and m6A modification could be key nodes for cadmium-induced oxidative damage, and highlight their importance as promising preventive and therapeutic targets in cadmium toxicity. | |||
| Responsed Disease | Kidney failure [ICD-11: GB6Z] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| In-vitro Model | NIT-1 | Insulin tumor | Mus musculus | CVCL_3561 |
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
| In total 4 item(s) under this disease | ||
| Crosstalk ID: M6ACROT05477 | ||
| m6A Regulator | Fat mass and obesity-associated protein (FTO) | |
| m6A Target | Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | |
| Epigenetic Regulator | Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | |
| Crosstalk relationship | m6A → ncRNA | |
| Crosstalk ID: M6ACROT05478 | ||
| m6A Regulator | Fat mass and obesity-associated protein (FTO) | |
| m6A Target | Pvt1 oncogene (PVT1) | |
| Epigenetic Regulator | Pvt1 oncogene (PVT1) | |
| Crosstalk relationship | m6A → ncRNA | |
| Crosstalk ID: M6ACROT05479 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | |
| Epigenetic Regulator | Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | |
| Crosstalk relationship | m6A → ncRNA | |
| Crosstalk ID: M6ACROT05480 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Pvt1 oncogene (PVT1) | |
| Epigenetic Regulator | Pvt1 oncogene (PVT1) | |
| Crosstalk relationship | m6A → ncRNA | |