m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00450
|
[1], [2], [3], [4] | |||
.png)
.png)
 : m6A sites
Indirect
Enhancement
RNA modification
MIR214
MIR214
ADARB1
Methylation
 : modification sites
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | RNA demethylase ALKBH5 (ALKBH5) | ERASER | |||
| m6A Target | Pvt1 oncogene (PVT1) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I) | ||||
| Epigenetic Regulator | Double-stranded RNA-specific editase 1 (ADARB1) | WRITER | View Details | ||
| Regulated Target | MicroRNA 214 (MIR214) | View Details | |||
| Crosstalk Relationship | m6A → A-to-I | Enhancement | |||
| Crosstalk Mechanism | m6A modification indirectly impacts RNA modification through downstream signaling pathways | ||||
| Crosstalk Summary | ALKBH5 interacts with Pvt1 oncogene (PVT1), increasing its m6A level and promoting its physical interaction with MicroRNA 214 (MIR214), which was regulated by ADARB1-mediated A-to-I modification. | ||||
In-vitro Model |
MG-63 | Osteosarcoma | Homo sapiens | CVCL_0426 | |
| U2OS | Osteosarcoma | Homo sapiens | CVCL_0042 | ||
| 143B | Osteosarcoma | Homo sapiens | CVCL_2270 | ||
| Huh-7 | Adult hepatocellular carcinoma | Homo sapiens | CVCL_0336 | ||
References