m6A-centered Drug Response Information
General Information of the Drug (ID: M6ADRUG0214)
| Name |
SETDB1-TTD-IN-1
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| Synonyms |
SETDB1-TTD-IN-1, 2755823-12-0, (R,R)-59, 2-[[(3~{R},5~{R})-1-methyl-5-(4-phenylmethoxyphenyl)piperidin-3-yl]amino]-3-prop-2-enyl-5~{H}-pyrrolo[3,2-d]pyrimidin-4-one, 3-Allyl-2-(((3R,5R)-5-(4-(benzyloxy)phenyl)-1-methylpiperidin-3-yl)amino)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, GLXC-26047, SETDB1-TTD-IN-(R,R)-59, AKOS040759958, MS-28686, HY-141539, CS-0179804, G18254, 2-[[(3R,5R)-1-methyl-5-(4-phenylmethoxyphenyl)piperidin-3-yl]amino]-3-prop-2-enyl-5H-pyrrolo[3,2-d]pyrimidin-4-one, CYH-260, 3-allyl-2-(((3R,5R)-5-(4-(benzyloxy)phenyl)-1-methylpiperidin-3-yl)amino)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, G09
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| Structure |
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3D MOL
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| Formula |
C28H31N5O2
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| InChI |
InChI=1S/C28H31N5O2/c1-3-15-33-27(34)26-25(13-14-29-26)31-28(33)30-23-16-22(17-32(2)18-23)21-9-11-24(12-10-21)35-19-20-7-5-4-6-8-20/h3-14,22-23,29H,1,15-19H2,2H3,(H,30,31)/t22-,23+/m0/s1
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| InChIKey |
NBDJDKAXIGWAIM-XZOQPEGZSA-N
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| PubChem CID | |||||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Drug
| In total 7 item(s) under this drug | ||
| Crosstalk ID: M6ACROT03095 | ||
| m6A Regulator | Wilms tumor 1-associating protein (WTAP) | |
| m6A Target | NACHT, LRR and PYD domains-containing protein 3 (NLRP3) | |
| Epigenetic Regulator | Histone acetyltransferase p300 (P300) | |
| Regulated Target | Histone H3 lysine 27 acetylation (H3K27ac) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Diabetic nephropathy | |
| Crosstalk ID: M6ACROT03173 | ||
| m6A Regulator | RNA-binding motif protein 15 (RBM15) | |
| m6A Target | C-X-C motif chemokine 11 (CXCL11) | |
| Epigenetic Regulator | Histone acetyltransferase p300 (P300) | |
| Regulated Target | Histone H3 lysine 27 acetylation (H3K27ac) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Renal cell carcinoma of kidney | |
| Crosstalk ID: M6ACROT03174 | ||
| m6A Regulator | RNA-binding motif protein 15 (RBM15) | |
| m6A Target | C-X-C motif chemokine 11 (CXCL11) | |
| Epigenetic Regulator | Histone acetyltransferase p300 (P300) | |
| Regulated Target | Histone H3 lysine 9 acetylation (H3K9Ac) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Renal cell carcinoma of kidney | |
| Crosstalk ID: M6ACROT03175 | ||
| m6A Regulator | RNA-binding motif protein 15 (RBM15) | |
| m6A Target | C-X-C motif chemokine 11 (CXCL11) | |
| Epigenetic Regulator | CREB-binding protein (CREBBP) | |
| Regulated Target | Histone H3 lysine 27 acetylation (H3K27ac) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Renal cell carcinoma of kidney | |
| Crosstalk ID: M6ACROT03176 | ||
| m6A Regulator | RNA-binding motif protein 15 (RBM15) | |
| m6A Target | C-X-C motif chemokine 11 (CXCL11) | |
| Epigenetic Regulator | CREB-binding protein (CREBBP) | |
| Regulated Target | Histone H3 lysine 9 acetylation (H3K9Ac) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Renal cell carcinoma of kidney | |
| Crosstalk ID: M6ACROT03353 | ||
| m6A Regulator | Wilms tumor 1-associating protein (WTAP) | |
| m6A Target | Dickkopf-related protein 3 (DKK3) | |
| Epigenetic Regulator | Histone acetyltransferase p300 (P300) | |
| Regulated Target | Histone H3 lysine 27 acetylation (H3K27ac) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Diabetic nephropathy | |
| Crosstalk ID: M6ACROT03354 | ||
| m6A Regulator | YTH domain-containing family protein 1 (YTHDF1) | |
| m6A Target | Dickkopf-related protein 3 (DKK3) | |
| Epigenetic Regulator | Histone acetyltransferase p300 (P300) | |
| Regulated Target | Histone H3 lysine 27 acetylation (H3K27ac) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Diabetic nephropathy | |