m6A-centered Drug Response Information
General Information of the Drug (ID: M6ADRUG0210)
| Name |
Simvastatin
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| Synonyms |
Cholestat; Coledis; Colemin; Corolin; Denan; Labistatin; Lipex; Lipovas; Lodales; Medipo; Nivelipol; Pantok; Rendapid; Simovil; Simvastatina; Simvastatine; Simvastatinum; Sinvacor; Sivastin; Synvinolin; Vasotenal; Zocor; Zocord; Simvast CR; Simvastatina [Spanish]; Simvastatine [French]; Simvastatinum [Latin]; MK 0733; MK 733; MK733; TNP00259; DRG-0320; KS-1113; L 644128-000U; MK-0733; MK-733; Simcard (TN); Simlup (TN); Simvacor (TN); Simvastatin & Primycin; Simvastatin, Compactin; Zocor (TN); Simvastatin [USAN:INN:BAN]; Simvastatin (JAN/USP/INN); Zocor, Simlup, Simcard, Simvacor, Simvoget, Zorced, Simvastatin; [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate; Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester; Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester; Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,*aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester; (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate; Butanoic acid, 2,2-dimethyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-ethyl]-1-naphthalenyl ester, [1S-[1 alpha,3 alpha,7 beta,8 beta(2S*,4S*),-8a beta; 2,2-Dimethylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester; 2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
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| Structure |
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3D MOL
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| Formula |
C25H38O5
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| InChI |
1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
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| InChIKey |
RYMZZMVNJRMUDD-HGQWONQESA-N
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Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Drug
| In total 5 item(s) under this drug | ||
| Crosstalk ID: M6ACROT02047 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | |
| Epigenetic Regulator | Cysteine methyltransferase DNMT3A (DNMT3A) | |
| Regulated Target | Secreted frizzled-related protein 2 (SFRP2) | |
| Crosstalk relationship | m6A → DNA modification | |
| Crosstalk ID: M6ACROT02048 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | |
| Epigenetic Regulator | DNA (cytosine-5)-methyltransferase 3B (DNMT3B) | |
| Regulated Target | Secreted frizzled-related protein 2 (SFRP2) | |
| Crosstalk relationship | m6A → DNA modification | |
| Crosstalk ID: M6ACROT02049 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | |
| Epigenetic Regulator | DNA (cytosine-5)-methyltransferase 1 (DNMT1) | |
| Regulated Target | Secreted frizzled-related protein 2 (SFRP2) | |
| Crosstalk relationship | m6A → DNA modification | |
| Crosstalk ID: M6ACROT02050 | ||
| m6A Regulator | Methyltransferase-like 16 (METTL16) | |
| m6A Target | Stearoyl-CoA desaturase (SCD) | |
| Epigenetic Regulator | DNA (cytosine-5)-methyltransferase 1 (DNMT1) | |
| Regulated Target | Methyltransferase 16, RNA N6-adenosine (METTL16) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Papillary Thyroid Cancer | |
| Crosstalk ID: M6ACROT02051 | ||
| m6A Regulator | YTH domain-containing protein 2 (YTHDC2) | |
| m6A Target | Stearoyl-CoA desaturase (SCD) | |
| Epigenetic Regulator | DNA (cytosine-5)-methyltransferase 1 (DNMT1) | |
| Regulated Target | Methyltransferase 16, RNA N6-adenosine (METTL16) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Papillary Thyroid Cancer | |
References
