m6A-centered Drug Response Information
General Information of the Drug (ID: M6ADRUG0194)
| Name |
Docetaxel
|
||||
|---|---|---|---|---|---|
| Synonyms |
EmDOC; TXL; Taxotere; Docetaxel anhydrous; ANX-514; Docetaxel (INN); Docetaxel, Trihydrate; RP-56976; SDP-014; Taxotere (TN); Taxotere(R); XRP-6976L; Docetaxel 114977-28-5; N-debenzoyl-N-Boc-10-deacetyl taxol; N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel; N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol; (2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate; 4-(acetyloxy)-13alpha-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7beta,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate
Click to Show/Hide
|
||||
| Structure |
 |
||||
|
3D MOL
|
|||||
| Formula |
C43H53NO14
|
||||
| InChI |
1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
|
||||
| InChIKey |
ZDZOTLJHXYCWBA-VCVYQWHSSA-N
|
||||
| PubChem CID | |||||
| TTD Drug ID | |||||
| DrugBank ID | |||||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Drug
| In total 7 item(s) under this drug | ||
| Crosstalk ID: M6ACROT02014 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Semaphorin-3F (SEMA3F) | |
| Epigenetic Regulator | DNA (cytosine-5)-methyltransferase 1 (DNMT1) | |
| Regulated Target | Semaphorin-3F (SEMA3F) | |
| Crosstalk relationship | m6A → DNA modification | |
| Disease | Prostate cancer | |
| Crosstalk ID: M6ACROT02015 | ||
| m6A Regulator | RNA-binding motif protein 15 (RBM15) | |
| m6A Target | Semaphorin-3F (SEMA3F) | |
| Epigenetic Regulator | DNA (cytosine-5)-methyltransferase 1 (DNMT1) | |
| Regulated Target | Semaphorin-3F (SEMA3F) | |
| Crosstalk relationship | m6A → DNA modification | |
| Disease | Prostate cancer | |
| Crosstalk ID: M6ACROT02016 | ||
| m6A Regulator | Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) | |
| m6A Target | Semaphorin-3F (SEMA3F) | |
| Epigenetic Regulator | DNA (cytosine-5)-methyltransferase 1 (DNMT1) | |
| Regulated Target | Semaphorin-3F (SEMA3F) | |
| Crosstalk relationship | m6A → DNA modification | |
| Disease | Prostate cancer | |
| Crosstalk ID: M6ACROT02017 | ||
| m6A Regulator | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) | |
| m6A Target | Semaphorin-3F (SEMA3F) | |
| Epigenetic Regulator | DNA (cytosine-5)-methyltransferase 1 (DNMT1) | |
| Regulated Target | Semaphorin-3F (SEMA3F) | |
| Crosstalk relationship | m6A → DNA modification | |
| Disease | Prostate cancer | |
| Crosstalk ID: M6ACROT02018 | ||
| m6A Regulator | YTH domain-containing family protein 2 (YTHDF2) | |
| m6A Target | Semaphorin-3F (SEMA3F) | |
| Epigenetic Regulator | DNA (cytosine-5)-methyltransferase 1 (DNMT1) | |
| Regulated Target | Semaphorin-3F (SEMA3F) | |
| Crosstalk relationship | m6A → DNA modification | |
| Disease | Prostate cancer | |
| Crosstalk ID: M6ACROT05167 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | long intergenic non-protein coding RNA 662 (LINC00662) | |
| Epigenetic Regulator | hsa-miR-186-5p | |
| Regulated Target | Methyltransferase-like protein 3 (METTL3) | |
| Crosstalk relationship | ncRNA → m6A | |
| Disease | Triple-negative breast cancer | |
| Crosstalk ID: M6ACROT05168 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | long intergenic non-protein coding RNA 662 (LINC00662) | |
| Epigenetic Regulator | Long intergenic non-protein coding RNA 662 (LINC00662) | |
| Regulated Target | hsa-miR-186-5p | |
| Crosstalk relationship | ncRNA → m6A | |
| Disease | Triple-negative breast cancer | |