m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05168
 [1]
Non-coding RNA LINC00662 miR-186-5p  lncRNA       miRNA   circRNA Indirect Enhancement m6A modification Linc00662 Linc00662 METTL3 Methylation : m6A sites
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target long intergenic non-protein coding RNA 662 (LINC00662)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator Long intergenic non-protein coding RNA 662 (LINC00662) LncRNA View Details
Regulated Target hsa-miR-186-5p View Details
Crosstalk Relationship ncRNA  →  m6A Enhancement
Crosstalk Mechanism ncRNAs indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary METTL3/Long intergenic non-protein coding RNA 662 (LINC00662)/hsa-miR-186-5p feedback loop regulates docetaxel resistance in triple negative breast cancer
Responsed Disease Triple-negative breast cancer ICD-11: 2C6Z
 Disease Info 
Responsed Drug Docetaxel
 Drug Info 
In-vitro Model
 MDA-MB-231 Breast adenocarcinoma Homo sapiens CVCL_0062
References
Ref 1 METTL3/LINC00662/miR-186-5p feedback loop regulates docetaxel resistance in triple negative breast cancer. Sci Rep. 2022 Oct 6;12(1):16715. doi: 10.1038/s41598-022-20477-0.