m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0361)
Name
Abortion
ICD
ICD-11: JA00
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
In total 6 item(s) under this disease
Crosstalk ID: M6ACROT05180
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Interleukin-1 beta (IL1B)
 Target Gene 
Epigenetic Regulator Long noncoding RNA HZ06 (Lnc-HZ06)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship ncRNA → m6A
Drug Benzo[a]pyrene
 Drug Info 
Crosstalk ID: M6ACROT05823
 Crosstalk Info 
m6A Regulator Methyltransferase-like 14 (METTL14)
 Regulator Info 
m6A Target hsa-miR-21-5p
 Target Gene 
Epigenetic Regulator hsa-miR-21-5p
Regulated Target Mothers against decapentaplegic homolog 3 (SMAD3)
Crosstalk relationship m6A → ncRNA
Crosstalk ID: M6ACROT05830
 Crosstalk Info 
m6A Regulator Fat mass and obesity-associated protein (FTO)
 Regulator Info 
m6A Target Maternally expressed 3 (MEG3)
 Target Gene 
Epigenetic Regulator Maternally expressed 3 (MEG3)
Regulated Target Histone-lysine N-methyltransferase EZH2 (EZH2)
Crosstalk relationship m6A → ncRNA
Crosstalk ID: M6ACROT05831
 Crosstalk Info 
m6A Regulator YTH domain-containing protein 1 (YTHDC1)
 Regulator Info 
m6A Target Maternally expressed 3 (MEG3)
 Target Gene 
Epigenetic Regulator Maternally expressed 3 (MEG3)
Regulated Target Histone-lysine N-methyltransferase EZH2 (EZH2)
Crosstalk relationship m6A → ncRNA
Crosstalk ID: M6ACROT05951
 Crosstalk Info 
m6A Regulator Fat mass and obesity-associated protein (FTO)
 Regulator Info 
m6A Target Maternally expressed 3 (MEG3)
 Target Gene 
Epigenetic Regulator Histone-lysine N-methyltransferase EZH2 (EZH2)
Regulated Target Histone H3 lysine 27 trimethylation (H3K27me3)
Crosstalk relationship m6A → Histone modification
Crosstalk ID: M6ACROT05952
 Crosstalk Info 
m6A Regulator YTH domain-containing protein 1 (YTHDC1)
 Regulator Info 
m6A Target Maternally expressed 3 (MEG3)
 Target Gene 
Epigenetic Regulator Histone-lysine N-methyltransferase EZH2 (EZH2)
Regulated Target Histone H3 lysine 27 trimethylation (H3K27me3)
Crosstalk relationship m6A → Histone modification
References
Ref 1 BMS-936564/MDX-1338: a fully human anti-CXCR4 antibody induces apoptosis in vitro and shows antitumor activity in vivo in hematologic malignancies. Clin Cancer Res. 2013 Jan 15;19(2):357-66. doi: 10.1158/1078-0432.CCR-12-2333. Epub 2012 Dec 4.
Ref 2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2019).
Ref 3 The Keap1-Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases. Biophys Rev. 2017 Feb;9(1):41-56. doi: 10.1007/s12551-016-0244-4. Epub 2016 Dec 6.