m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00049)
Target Name hsa-miR-21-5p
Synonyms
hsa_miR_21_5p
    Click to Show/Hide
Gene Name hsa-miR-21-5p
miRBase ID
MIMAT0000076
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
hsa-miR-21-5p can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3-m6A-miR-21-5p-SPRY1/ERK/NF-kB axis in obstructive renal fibrosis and provides a deeper understanding of renal fibrosis.
Target Regulation Up regulation
Responsed Disease Kidney disorders ICD-11: GB90
 Disease Info 
Pathway Response NF-kappa B signaling pathway hsa04064
In-vitro Model HK2 Normal Acipenser baerii CVCL_YE28
In-vivo Model Each mouse was anaesthetized with inhaled isoflurane, and the left proximal ureter was exposed. Then, the ureter was ligated with 6-0 silk thread and severed. In the sham operation group, the left ureters of mice were exposed, but not ligated or severed. The 3rd, 7th and 14th days after surgery were the time points for killing. At each time point, a total of 10 mice in the UUO group were executed, and a total of 10 mice in the sham group were also executed to serve as controls.
RNA demethylase ALKBH5 (ALKBH5) [ERASER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [2]
Response Summary In non-small cell lung cancer, m6A marks in mature hsa-miR-21-5p could directly affect its silencing potency towards target genes, which finally impaired its promotion to proliferation and motility. Depletion of the demethylase ALKBH5 altered the m6A abundance of miR-21-5p, thereby changing the expression levels of its target gene.
Responsed Disease Non-small-cell lung carcinoma ICD-11: 2C25.Y
 Disease Info 
In-vitro Model A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
NCI-H1299 Lung large cell carcinoma Homo sapiens CVCL_0060
HEK293-A Normal Homo sapiens CVCL_6910
Lung cancer [ICD-11: 2C25]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [2]
Response Summary In non-small cell lung cancer, m6A marks in mature hsa-miR-21-5p could directly affect its silencing potency towards target genes, which finally impaired its promotion to proliferation and motility. Depletion of the demethylase ALKBH5 altered the m6A abundance of miR-21-5p, thereby changing the expression levels of its target gene.
Responsed Disease Non-small-cell lung carcinoma [ICD-11: 2C25.Y]
Target Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
In-vitro Model A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
NCI-H1299 Lung large cell carcinoma Homo sapiens CVCL_0060
HEK293-A Normal Homo sapiens CVCL_6910
Kidney disorders [ICD-11: GB90]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3-m6A-miR-21-5p-SPRY1/ERK/NF-kB axis in obstructive renal fibrosis and provides a deeper understanding of renal fibrosis.
Responsed Disease Kidney disorders [ICD-11: GB90]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response NF-kappa B signaling pathway hsa04064
In-vitro Model HK2 Normal Acipenser baerii CVCL_YE28
In-vivo Model Each mouse was anaesthetized with inhaled isoflurane, and the left proximal ureter was exposed. Then, the ureter was ligated with 6-0 silk thread and severed. In the sham operation group, the left ureters of mice were exposed, but not ligated or severed. The 3rd, 7th and 14th days after surgery were the time points for killing. At each time point, a total of 10 mice in the UUO group were executed, and a total of 10 mice in the sham group were also executed to serve as controls.
References
Ref 1 METTL3/N6-methyladenosine/ miR-21-5p promotes obstructive renal fibrosis by regulating inflammation through SPRY1/ERK/NF-KappaB pathway activation. J Cell Mol Med. 2021 Aug;25(16):7660-7674. doi: 10.1111/jcmm.16603. Epub 2021 Jun 24.
Ref 2 m(6)A-seq analysis of microRNAs reveals that the N6-methyladenosine modification of miR-21-5p affects its target expression. Arch Biochem Biophys. 2021 Oct 30;711:109023. doi: 10.1016/j.abb.2021.109023. Epub 2021 Sep 1.