m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0170)
| Name |
Kidney disorders
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|---|---|---|---|---|---|
| ICD |
ICD-11: GB90
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Full List of Target Gene(s) of This m6A-centered Disease Response
Transcriptional coactivator YAP1 (YAP1)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | YTHDF1 knockdown alleviated the progression of renal fibrosis both in cultured cells induced by transforming growth factor-beta administration and in the UUO mouse model. Transcriptional coactivator YAP1 (YAP1) was accordingly down-regulated when YTHDF1 was inhibited. | |||
| Responsed Disease | Kidney disorders [ICD-11: GB90] | |||
| Target Regulator | YTH domain-containing family protein 1 (YTHDF1) | READER | ||
| Target Regulation | Up regulation | |||
hsa-miR-21-5p
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [2] | |||
| Response Summary | METTL3-m6A-miR-21-5p-SPRY1/ERK/NF-kB axis in obstructive renal fibrosis and provides a deeper understanding of renal fibrosis. | |||
| Responsed Disease | Kidney disorders [ICD-11: GB90] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | NF-kappa B signaling pathway | hsa04064 | ||
| In-vitro Model | HK2 | Normal | Acipenser baerii | CVCL_YE28 |
| In-vivo Model | Each mouse was anaesthetized with inhaled isoflurane, and the left proximal ureter was exposed. Then, the ureter was ligated with 6-0 silk thread and severed. In the sham operation group, the left ureters of mice were exposed, but not ligated or severed. The 3rd, 7th and 14th days after surgery were the time points for killing. At each time point, a total of 10 mice in the UUO group were executed, and a total of 10 mice in the sham group were also executed to serve as controls. | |||
References