m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0144)
| Name |
Endometriosis
|
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|---|---|---|---|---|---|
| ICD |
ICD-11: GA10
|
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Full List of Target Gene(s) of This m6A-centered Disease Response
microRNA 126 (MIR126)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [4] | |||
| Response Summary | The METTL3/m6A/miR126 pathway, whose inhibition contributes to endometriosis development by enhancing cellular migration and invasion. | |||
| Responsed Disease | Endometriosis [ICD-11: GA10] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| In-vitro Model | HESC (Human endometrial stromal cells) | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
| In total 4 item(s) under this disease | ||
| Crosstalk ID: M6ACROT03081 | ||
| m6A Regulator | RNA demethylase ALKBH5 (ALKBH5) | |
| m6A Target | Histone-lysine N-methyltransferase EZH2 (EZH2) | |
| Epigenetic Regulator | Histone-lysine N-methyltransferase EZH2 (EZH2) | |
| Regulated Target | Histone H3 lysine 27 trimethylation (H3K27me3) | |
| Crosstalk relationship | m6A → Histone modification | |
| Crosstalk ID: M6ACROT03082 | ||
| m6A Regulator | YTH domain-containing family protein 2 (YTHDF2) | |
| m6A Target | Histone-lysine N-methyltransferase EZH2 (EZH2) | |
| Epigenetic Regulator | Histone-lysine N-methyltransferase EZH2 (EZH2) | |
| Regulated Target | Histone H3 lysine 27 trimethylation (H3K27me3) | |
| Crosstalk relationship | m6A → Histone modification | |
| Crosstalk ID: M6ACROT05304 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Wnt inhibitory factor 1 (WIF1) | |
| Epigenetic Regulator | hsa-miR-21-5p | |
| Regulated Target | Methyltransferase-like protein 3 (METTL3) | |
| Crosstalk relationship | ncRNA → m6A | |
| Crosstalk ID: M6ACROT05595 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | microRNA 126 (MIR126) | |
| Epigenetic Regulator | MicroRNA 126 (MIR126) | |
| Crosstalk relationship | m6A → ncRNA | |
References