m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0017)
| Name |
Hepatic fibrosis/cirrhosis
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|---|---|---|---|---|---|
| ICD |
ICD-11: DB93
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Full List of Target Gene(s) of This m6A-centered Disease Response
Protein patched homolog 1 (PTCH1)
| In total 2 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [2] | |||
| Response Summary | AcSDKP in liver fibrosis via m6A modification and Hedgehog pathway, which helps us to shed light on the molecular mechanism in liver fibrosis progression. WTAP targeted the 3'-UTR of Protein patched homolog 1 (PTCH1) mRNA, and administration of AcSDKP reduced the stability of Ptch1 mRNA. | |||
| Responsed Disease | Hepatic fibrosis [ICD-11: DB93.0] | |||
| Responsed Drug | AcSDKP | Phase 2 | ||
| Target Regulator | Wilms tumor 1-associating protein (WTAP) | WRITER | ||
| Target Regulation | Down regulation | |||
| Pathway Response | Hedgehog signaling pathway | hsa04340 | ||
| Cell Process | Cell apoptosis | |||
| In-vitro Model | HSC (Hematopoietic stem cell) | |||
| In-vivo Model | Male Sprague-Dawley rats (375-400 g) liver fibrosis was induced by subcutaneous injection of carbon tetrachloride (CCl4) and olive oil (a ratio of 2:3) twice per week. | |||
| Experiment 2 Reporting the m6A-centered Disease Response by This Target Gene | [3] | |||
| Response Summary | ALKBH5 mediated Protein patched homolog 1 (PTCH1) activation via a m6A-dependent manner,ALKBH5 ameliorated liver fibrosis and suppressed HSCs activation via triggering PTCH1 activation in a m6A dependent manner. | |||
| Responsed Disease | Hepatic fibrosis [ICD-11: DB93.0] | |||
| Target Regulator | RNA demethylase ALKBH5 (ALKBH5) | ERASER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | Hedgehog signaling pathway | hsa04340 | ||
| In-vitro Model | HSCs (Hepatic stellate cells(HSCs) were purchased from American Type Culture Collections (Manassas, VA)) | |||
| In-vivo Model | Liver fibrosis mice model was induced by intraperitoneal CCl4 injection for 12 weeks. The dose regimen for CCl4 in mice is 1 ml kg-1, diluted to 50% with olive oil twice per week for 12 weeks. Until 11 weeks, mice with liver-specific disruption of ALKBH5 were given hydrodynamic tail-vein injections of LV5-ALKBH5. | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
| In total 8 item(s) under this disease | ||
| Crosstalk ID: M6ACROT02001 | ||
| m6A Regulator | YTH domain-containing family protein 1 (YTHDF1) | |
| m6A Target | Collagen alpha-1 (COL1A1) | |
| Epigenetic Regulator | Cysteine methyltransferase DNMT3A (DNMT3A) | |
| Regulated Target | Suppressor of cytokine signaling 3 (SOCS3) | |
| Crosstalk relationship | DNA modification → m6A | |
| Crosstalk ID: M6ACROT02002 | ||
| m6A Regulator | YTH domain-containing family protein 1 (YTHDF1) | |
| m6A Target | Collagen alpha-2(I) chain (COL1A2) | |
| Epigenetic Regulator | Cysteine methyltransferase DNMT3A (DNMT3A) | |
| Regulated Target | Suppressor of cytokine signaling 3 (SOCS3) | |
| Crosstalk relationship | DNA modification → m6A | |
| Crosstalk ID: M6ACROT02003 | ||
| m6A Regulator | YTH domain-containing family protein 1 (YTHDF1) | |
| m6A Target | Collagen alpha-1 (III) chain (COL3A1) | |
| Epigenetic Regulator | Cysteine methyltransferase DNMT3A (DNMT3A) | |
| Regulated Target | Suppressor of cytokine signaling 3 (SOCS3) | |
| Crosstalk relationship | DNA modification → m6A | |
| Crosstalk ID: M6ACROT02004 | ||
| m6A Regulator | YTH domain-containing family protein 1 (YTHDF1) | |
| m6A Target | Collagen alpha-2(V) chain (COL5A2) | |
| Epigenetic Regulator | Cysteine methyltransferase DNMT3A (DNMT3A) | |
| Regulated Target | Suppressor of cytokine signaling 3 (SOCS3) | |
| Crosstalk relationship | DNA modification → m6A | |
| Crosstalk ID: M6ACROT02005 | ||
| m6A Regulator | YTH domain-containing family protein 1 (YTHDF1) | |
| m6A Target | Collagen alpha-2(VI) chain (COL6A2) | |
| Epigenetic Regulator | Cysteine methyltransferase DNMT3A (DNMT3A) | |
| Regulated Target | Suppressor of cytokine signaling 3 (SOCS3) | |
| Crosstalk relationship | DNA modification → m6A | |
| Crosstalk ID: M6ACROT03079 | ||
| m6A Regulator | Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) | |
| m6A Target | Fructose-bisphosphate aldolase A (ALDOA) | |
| Regulated Target | Histone H3 lysine 18 lactylation (H3K18la) | |
| Crosstalk relationship | m6A → Histone modification | |
| Crosstalk ID: M6ACROT03159 | ||
| m6A Regulator | RNA demethylase ALKBH5 (ALKBH5) | |
| m6A Target | Zinc finger protein SNAI1 (SNAI1) | |
| Epigenetic Regulator | Lysine-specific demethylase 4C (KDM4C) | |
| Regulated Target | Histone H3 lysine 9 trimethylation (H3K9me3) | |
| Crosstalk relationship | Histone modification → m6A | |
| Crosstalk ID: M6ACROT05650 | ||
| m6A Regulator | YTH domain-containing family protein 2 (YTHDF2) | |
| m6A Target | Circ_IRF2 | |
| Epigenetic Regulator | Circ_IRF2 | |
| Regulated Target | hsa-miR-29b-1-5p | |
| Crosstalk relationship | m6A → ncRNA | |
References