m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT03159
 [1]
Histone modification H3K9me3 KDM4C Downstream Gene Direct Enhancement m6A modification SNAI1 SNAI1 ALKBH5 Demethylation : m6A sites
m6A Modification:
m6A Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
m6A Target Zinc finger protein SNAI1 (SNAI1)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Histone modification (HistMod)
Epigenetic Regulator Lysine-specific demethylase 4C (KDM4C) ERASER View Details
Regulated Target Histone H3 lysine 9 trimethylation (H3K9me3) View Details
Crosstalk Relationship Histone modification  →  m6A Enhancement
Crosstalk Mechanism histone modification directly impacts m6A modification through modulating the level of m6A regulator
Crosstalk Summary KDM4C decreases Histone H3 lysine 9 trimethylation (H3K9me3) methylation to upregulate ALKBH5 and subsequently inhibits Zinc finger protein SNAI1 (SNAI1), ultimately impeding liver fibrosis.
Responsed Disease Hepatic fibrosis/cirrhosis ICD-11: DB93
 Disease Info 
In-vitro Model
HSC-T6
 N.A. Rattus norvegicus CVCL_0315
In-vivo Model The mice were divided into several groups: (a) NC; (b) liver fibrosis model; (c) sh-NC; (d) sh-snail1; (e) adeno-associated virus (AAV)-NC1; (f) AAV-KDM4C; (g) AAV-KDM4C + AAV-NC2; and (h) AAV-KDM4C + AAV-snail1 groups; there were 10 mice in each group.
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Lysine-specific demethylase 4C (KDM4C) 14 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name Pyrido[1,2-a]indole-1.-carboxylic acid analog 4 Patented [2]
Synonyms
PMID25468267-Compound-37
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MOA Inhibitor
External Link
CID: 66667765
TTD: D02FWO
 Compound Name Pyrido[1,2-a]indole-1.-carboxylic acid analog 1 Patented [2]
Synonyms
PMID25468267-Compound-34
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MOA Inhibitor
Activity IC50 < 500 nM
External Link
CID: 56589666
TTD: D04KUD
 Compound Name PMID25468267-Compound-56 Patented [2]
MOA Inhibitor
Activity IC50 < 1000 nM
External Link
CID: 90093146
TTD: D07CYB
 Compound Name Pyrido[1,2-a]indole-1.-carboxylic acid analog 5 Patented [2]
Synonyms
PMID25468267-Compound-38
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MOA Inhibitor
Activity IC50 < 500 nM
External Link
CID: 56589667
TTD: D0BK5N
 Compound Name PMID25468267-Compound-47 Patented [2]
MOA Inhibitor
External Link
CID: 53392493
TTD: D0L5RA
 Compound Name Pyrido[1,2-a]indole-1.-carboxylic acid analog 7 Patented [2]
Synonyms
PMID25468267-Compound-40
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MOA Inhibitor
External Link
CID: 56643890
TTD: D0Q5IR
 Compound Name Pyrido[1,2-a]indole-1.-carboxylic acid analog 3 Patented [2]
Synonyms
PMID25468267-Compound-36
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MOA Inhibitor
External Link
CID: 66666946
TTD: D0RP4W
 Compound Name Flavonoid derivative 6 Patented [2]
Synonyms
PMID25468267-Compound-1
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MOA Inhibitor
External Link
TTD: D0S8AZ
 Compound Name PMID25468267-Compound-55 Patented [2]
MOA Inhibitor
Activity IC50 < 1000 nM
External Link
TTD: D0U3KT
 Compound Name Pyrido[1,2-a]indole-1.-carboxylic acid analog 2 Patented [2]
Synonyms
PMID25468267-Compound-35
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MOA Inhibitor
External Link
TTD: D0UQ2R
 Compound Name Pyrido[1,2-a]indole-1.-carboxylic acid analog 6 Patented [2]
Synonyms
PMID25468267-Compound-39
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MOA Inhibitor
External Link
CID: 66667268
TTD: D0Z2YB
 Compound Name Hydroxamate analog 1 Patented [2]
Synonyms
PMID25468267-Compound-31
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MOA Inhibitor
Activity IC50 = 1000 nM
External Link
TTD: D0MJ4L
 Compound Name PMID25468267-Compound-46 Patented [2]
MOA Inhibitor
Activity IC50 = 3400 nM
External Link
CID: 53392492
TTD: D09NCT
 Compound Name IOX1 Investigative [3]
Synonyms
5852-78-8; 8-Hydroxyquinoline-5-Carboxylic Acid; 8-Hydroxy-5-quinolinecarboxylic acid; 5-Carboxy-8-hydroxyquinoline; IOX 1; UNII-JM015YQC1C; IOX-1; 5-carboxy-8HQ; 5-Quinolinecarboxylic acid, 8-hydroxy-; JM015YQC1C; CHEMBL1230640; 4bio; 4jht; 8XQ; 4ie4; AC1LA0UV; MLS002729056; GTPL8230; SCHEMBL6068195; KS-00000PPH; CHEBI:93239; CTK1E0142; DTXSID20207236; AOB6499; JGRPKOGHYBAVMW-UHFFFAOYSA-N; MolPort-006-673-354; HMS3653E21; ZINC5933707; BCP16996; s7234; BDBM50396018; 2184AH; IOX1, &gt; AKOS016371793
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 600 nM
External Link
CID: 459617
TTD: D0X5US
DB93: Hepatic fibrosis/cirrhosis 5 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name KB174 Clinical Trial [4]
External Link
TTD: DDNL40
 Compound Name Quinazoline derivative 12 Patented [5]
Synonyms
PMID26936077-Compound-23
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External Link
CID: 60163336
TTD: D0EC3H
 Compound Name Quinazoline derivative 10 Patented [5]
Synonyms
PMID26936077-Compound-21
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External Link
CID: 6737869
TTD: D0CM5P
 Compound Name Quinazoline derivative 11 Patented [5]
Synonyms
PMID26936077-Compound-22
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External Link
CID: 60163203
TTD: D08ZEM
 Compound Name PMID27998201-Compound-5 Patented [6]
External Link
CID: 46202117
TTD: D05OIU
References
Ref 1 KDM4C represses liver fibrosis by regulating H3K9me3 methylation of ALKBH5 and m6A methylation of snail1 mRNA. J Dig Dis. 2024 May;25(5):298-309. doi: 10.1111/1751-2980.13291. Epub 2024 Jun 27.
Ref 2 KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44.
Ref 3 A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. ChemMedChem. 2014 Mar;9(3):566-71. doi: 10.1002/cmdc.201300428. Epub 2014 Feb 6.
Ref 4 ClinicalTrials.gov (NCT03855956) Clinical Food Study to Evaluate the Effect of KB174 on the Gut Microbiome in Subjects With Well-compensated Cirrhosis. U.S. National Institutes of Health.
Ref 5 Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83.
Ref 6 Cathepsin B and L inhibitors: a patent review (2010 - present). Expert Opin Ther Pat. 2017 Jun;27(6):643-656. doi: 10.1080/13543776.2017.1272572. Epub 2016 Dec 23.