m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT03079
 [1]
m6A modification ALDOA ALDOA IGF2BP2 : m6A sites Indirect Enhancement Histone modification H3K18la Regulated Regulator Downstream Gene
m6A Modification:
m6A Regulator Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) READER
 Regulator Info 
m6A Target Fructose-bisphosphate aldolase A (ALDOA)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Histone modification (HistMod)
Regulated Target Histone H3 lysine 18 lactylation (H3K18la) View Details
Crosstalk Relationship m6A  →  Histone modification Enhancement
Crosstalk Mechanism m6A modification indirectly regulates histone modification through downstream signaling pathways
Crosstalk Summary IGF2BP2 mediates Histone H3 lysine 18 lactylation (H3K18la) and regulates the expression of Fructose-bisphosphate aldolase A (ALDOA), a key target in the glycolytic metabolic pathway, which in turn regulates HSCs activation.
Responsed Disease Hepatic fibrosis/cirrhosis ICD-11: DB93
 Disease Info 
Cell Process mRNA stability
mRNA translation.
In-vitro Model
LX-2
 N.A. Homo sapiens CVCL_5792
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
DB93: Hepatic fibrosis/cirrhosis 5 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name KB174 Clinical Trial [2]
External Link
TTD: DDNL40
 Compound Name Quinazoline derivative 12 Patented [3]
Synonyms
PMID26936077-Compound-23
    Click to Show/Hide
External Link
CID: 60163336
TTD: D0EC3H
 Compound Name Quinazoline derivative 10 Patented [3]
Synonyms
PMID26936077-Compound-21
    Click to Show/Hide
External Link
CID: 6737869
TTD: D0CM5P
 Compound Name Quinazoline derivative 11 Patented [3]
Synonyms
PMID26936077-Compound-22
    Click to Show/Hide
External Link
CID: 60163203
TTD: D08ZEM
 Compound Name PMID27998201-Compound-5 Patented [4]
External Link
CID: 46202117
TTD: D05OIU
References
Ref 1 The m(6)A reader IGF2BP2 regulates glycolytic metabolism and mediates histone lactylation to enhance hepatic stellate cell activation and liver fibrosis. Cell Death Dis. 2024 Mar 5;15(3):189. doi: 10.1038/s41419-024-06509-9.
Ref 2 ClinicalTrials.gov (NCT03855956) Clinical Food Study to Evaluate the Effect of KB174 on the Gut Microbiome in Subjects With Well-compensated Cirrhosis. U.S. National Institutes of Health.
Ref 3 Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83.
Ref 4 Cathepsin B and L inhibitors: a patent review (2010 - present). Expert Opin Ther Pat. 2017 Jun;27(6):643-656. doi: 10.1080/13543776.2017.1272572. Epub 2016 Dec 23.