m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00290)
Target Name Interferon beta (IFNB1)
Synonyms
IFN-beta; Fibroblast interferon; IFB; IFNB
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Gene Name IFNB1
Chromosomal Location 9p21.3
Family alpha/beta interferon family
Function
Has antiviral, antibacterial and anticancer activities.
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Gene ID 3456
Uniprot ID
IFNB_HUMAN
HGNC ID
HGNC:5434
Ensembl Gene ID
ENSG00000171855
KEGG ID
hsa:3456
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
IFNB1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 14 (METTL14) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL14
Cell Line Neural progenitor cell line Mus musculus
Treatment: METTL14 knockout NPCs
Control: Wild type NPCs
 GSE158985
Regulation
logFC: 7.66E-01
p-value: 2.22E-04
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Responses to nonmicrobial dsDNA in uninfected cells, which shape host immunity and contribute to autoimmune disease, are regulated by enzymes controlling m6A epitranscriptomic changes. While METTL14 depletion reduced virus reproduction and stimulated dsDNA- or HCMV-induced Interferon beta (IFNB1) mRNA accumulation, ALKBH5 depletion had the opposite effect.
Target Regulation Down regulation
Responsed Disease Unspecified viral infection ICD-11: 1D9Z
 Disease Info 
Pathway Response Cellular senescence hsa04218
Cell Process Metabolic reprogramming
Stress responses
Aging
In-vitro Model BSC40 Normal Chlorocebus pygerythrus CVCL_3656
HCMV AD169GFP (Human cytomegalovirus)
NHDF (Primary Normal Human Dermal Fibroblasts)
Vero Normal Chlorocebus sabaeus CVCL_0059
RNA demethylase ALKBH5 (ALKBH5) [ERASER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by ALKBH5
Cell Line Peritoneal macrophages Mus musculus
Treatment: ALKBH5-/- peritoneal macrophages
Control: Wild type peritoneal macrophages
 GSE127739
Regulation
logFC: -6.45E-01
p-value: 8.14E-03
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Responses to nonmicrobial dsDNA in uninfected cells, which shape host immunity and contribute to autoimmune disease, are regulated by enzymes controlling m6A epitranscriptomic changes. While METTL14 depletion reduced virus reproduction and stimulated dsDNA- or HCMV-induced Interferon beta (IFNB1) mRNA accumulation, ALKBH5 depletion had the opposite effect.
Target Regulation Up regulation
Responsed Disease Unspecified viral infection ICD-11: 1D9Z
 Disease Info 
Pathway Response Cellular senescence hsa04218
Cell Process Metabolic reprogramming
Stress responses
Aging
In-vitro Model BSC40 Normal Chlorocebus pygerythrus CVCL_3656
HCMV AD169GFP (Human cytomegalovirus)
NHDF (Primary Normal Human Dermal Fibroblasts)
Vero Normal Chlorocebus sabaeus CVCL_0059
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [2]
Response Summary Overexpression of HNRNPC can promote the proliferation of PC12 cells, inhibit their apoptosis, and inhibit the expression of inflammatory factors Interferon beta (IFNB1), IL-6, and TNF-Alpha, suggesting that HNRNPC can cause PD by inhibiting the proliferation of dopaminergic nerve cells, promoting their apoptosis, and causing immune inflammation.
Target Regulation Down regulation
Responsed Disease Parkinson disease ICD-11: 8A00
 Disease Info 
Cell Process Immune inflammation
Cell apoptosis
In-vitro Model PC12 Rat adrenal gland pheochromocytoma Rattus norvegicus CVCL_0481
Cytomegaloviral disease [ICD-11: 1DB2]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Responses to nonmicrobial dsDNA in uninfected cells, which shape host immunity and contribute to autoimmune disease, are regulated by enzymes controlling m6A epitranscriptomic changes. While METTL14 depletion reduced virus reproduction and stimulated dsDNA- or HCMV-induced Interferon beta (IFNB1) mRNA accumulation, ALKBH5 depletion had the opposite effect.
Responsed Disease Unspecified viral infection [ICD-11: 1D9Z]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Down regulation
Pathway Response Cellular senescence hsa04218
Cell Process Metabolic reprogramming
Stress responses
Aging
In-vitro Model BSC40 Normal Chlorocebus pygerythrus CVCL_3656
HCMV AD169GFP (Human cytomegalovirus)
NHDF (Primary Normal Human Dermal Fibroblasts)
Vero Normal Chlorocebus sabaeus CVCL_0059
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary Responses to nonmicrobial dsDNA in uninfected cells, which shape host immunity and contribute to autoimmune disease, are regulated by enzymes controlling m6A epitranscriptomic changes. While METTL14 depletion reduced virus reproduction and stimulated dsDNA- or HCMV-induced Interferon beta (IFNB1) mRNA accumulation, ALKBH5 depletion had the opposite effect.
Responsed Disease Unspecified viral infection [ICD-11: 1D9Z]
Target Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Cellular senescence hsa04218
Cell Process Metabolic reprogramming
Stress responses
Aging
In-vitro Model BSC40 Normal Chlorocebus pygerythrus CVCL_3656
HCMV AD169GFP (Human cytomegalovirus)
NHDF (Primary Normal Human Dermal Fibroblasts)
Vero Normal Chlorocebus sabaeus CVCL_0059
Innate immunity [ICD-11: 4A00]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Responses to nonmicrobial dsDNA in uninfected cells, which shape host immunity and contribute to autoimmune disease, are regulated by enzymes controlling m6A epitranscriptomic changes. While METTL14 depletion reduced virus reproduction and stimulated dsDNA- or HCMV-induced Interferon beta (IFNB1) mRNA accumulation, ALKBH5 depletion had the opposite effect.
Responsed Disease Innate immunity [ICD-11: 4A00]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Down regulation
Pathway Response Cellular senescence hsa04218
Cell Process Metabolic reprogramming
Stress responses
Aging
In-vitro Model BSC40 Normal Chlorocebus pygerythrus CVCL_3656
HCMV AD169GFP (Human cytomegalovirus)
NHDF (Primary Normal Human Dermal Fibroblasts)
Vero Normal Chlorocebus sabaeus CVCL_0059
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary Responses to nonmicrobial dsDNA in uninfected cells, which shape host immunity and contribute to autoimmune disease, are regulated by enzymes controlling m6A epitranscriptomic changes. While METTL14 depletion reduced virus reproduction and stimulated dsDNA- or HCMV-induced Interferon beta (IFNB1) mRNA accumulation, ALKBH5 depletion had the opposite effect.
Responsed Disease Innate immunity [ICD-11: 4A00]
Target Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Cellular senescence hsa04218
Cell Process Metabolic reprogramming
Stress responses
Aging
In-vitro Model BSC40 Normal Chlorocebus pygerythrus CVCL_3656
HCMV AD169GFP (Human cytomegalovirus)
NHDF (Primary Normal Human Dermal Fibroblasts)
Vero Normal Chlorocebus sabaeus CVCL_0059
Parkinson disease [ICD-11: 8A00]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [2]
Response Summary Overexpression of HNRNPC can promote the proliferation of PC12 cells, inhibit their apoptosis, and inhibit the expression of inflammatory factors Interferon beta (IFNB1), IL-6, and TNF-Alpha, suggesting that HNRNPC can cause PD by inhibiting the proliferation of dopaminergic nerve cells, promoting their apoptosis, and causing immune inflammation.
Responsed Disease Parkinson disease [ICD-11: 8A00]
Target Regulator Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) READER
 Regulator Info 
Target Regulation Down regulation
Cell Process Immune inflammation
Cell apoptosis
In-vitro Model PC12 Rat adrenal gland pheochromocytoma Rattus norvegicus CVCL_0481
References
Ref 1 RNA m(6) A modification enzymes shape innate responses to DNA by regulating interferon Beta. Genes Dev. 2018 Dec 1;32(23-24):1472-1484. doi: 10.1101/gad.319475.118. Epub 2018 Nov 21.
Ref 2 Influence of N6-Methyladenosine Modification Gene HNRNPC on Cell Phenotype in Parkinson's Disease. Parkinsons Dis. 2021 Dec 20;2021:9919129. doi: 10.1155/2021/9919129. eCollection 2021.