m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0078)
Name
Innate immunity
ICD
ICD-11: 4A00
Full List of Target Gene(s) of This m6A-centered Disease Response
Interferon beta (IFNB1)
 Target Info 
In total 2 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary Responses to nonmicrobial dsDNA in uninfected cells, which shape host immunity and contribute to autoimmune disease, are regulated by enzymes controlling m6A epitranscriptomic changes. While METTL14 depletion reduced virus reproduction and stimulated dsDNA- or HCMV-induced Interferon beta (IFNB1) mRNA accumulation, ALKBH5 depletion had the opposite effect.
Responsed Disease Innate immunity [ICD-11: 4A00]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Down regulation
Pathway Response Cellular senescence hsa04218
Cell Process Metabolic reprogramming
Stress responses
Aging
In-vitro Model BSC40 Normal Chlorocebus pygerythrus CVCL_3656
HCMV AD169GFP (Human cytomegalovirus)
NHDF (Primary Normal Human Dermal Fibroblasts)
Vero Normal Chlorocebus sabaeus CVCL_0059
Experiment 2 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary Responses to nonmicrobial dsDNA in uninfected cells, which shape host immunity and contribute to autoimmune disease, are regulated by enzymes controlling m6A epitranscriptomic changes. While METTL14 depletion reduced virus reproduction and stimulated dsDNA- or HCMV-induced Interferon beta (IFNB1) mRNA accumulation, ALKBH5 depletion had the opposite effect.
Responsed Disease Innate immunity [ICD-11: 4A00]
Target Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Cellular senescence hsa04218
Cell Process Metabolic reprogramming
Stress responses
Aging
In-vitro Model BSC40 Normal Chlorocebus pygerythrus CVCL_3656
HCMV AD169GFP (Human cytomegalovirus)
NHDF (Primary Normal Human Dermal Fibroblasts)
Vero Normal Chlorocebus sabaeus CVCL_0059
References
Ref 1 RNA m(6) A modification enzymes shape innate responses to DNA by regulating interferon Beta. Genes Dev. 2018 Dec 1;32(23-24):1472-1484. doi: 10.1101/gad.319475.118. Epub 2018 Nov 21.