Name	Parkinson disease
ICD	ICD-11: 8A00

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[1]
Response Summary	Decreased m6A in dopaminergic cells by overexpressing a nucleic acid demethylase, FTO, or by m6A inhibitor. m6A reduction could induce the expression of Glutamate receptor ionotropic, NMDA 1 (NMDAR1/GRIN1), and elevate oxidative stress and Ca2+ influx, resulting in dopaminergic neuron apoptosis. m6A modification plays a vital role in the death of dopaminergic neuron, which provides a novel view of mRNA methylation to understand the epigenetic regulation of Parkinson's disease.
Responsed Disease	Parkinson disease [ICD-11: 8A00]
Target Regulator	Fat mass and obesity-associated protein (FTO)		ERASER	Regulator Info
Target Regulation	Up regulation
In-vitro Model	HEK293T	Normal	Homo sapiens	CVCL_0063
	PC-12	Lung papillary adenocarcinoma	Homo sapiens	CVCL_S979
	SH-SY5Y	Neuroblastoma	Homo sapiens	CVCL_0019
In-vivo Model	Two weeks after the stereotaxic surgery, all the animals were intraperitoneally injected with apomorphine at a dose of 0.5 mg/kg to induce the contralateral rotations. Ten minutes after the injection, a video was used to record the rotations of each rat for 20 min. Only those 6-OHDA induced rats showing robust contralateral turning (>7 turns/min) that were injected with 6-OHDA were used in subsequent experiments.

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[2]
Response Summary	Overexpression of HNRNPC can promote the proliferation of PC12 cells, inhibit their apoptosis, and inhibit the expression of inflammatory factors Interferon beta (IFNB1), IL-6, and TNF-Alpha, suggesting that HNRNPC can cause PD by inhibiting the proliferation of dopaminergic nerve cells, promoting their apoptosis, and causing immune inflammation.
Responsed Disease	Parkinson disease [ICD-11: 8A00]
Target Regulator	Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)		READER	Regulator Info
Target Regulation	Down regulation
Cell Process	Immune inflammation
	Cell apoptosis
In-vitro Model	PC12	Rat adrenal gland pheochromocytoma	Rattus norvegicus	CVCL_0481

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[3]
Response Summary	Paraquat (PQ) is a ubiquitously applied herbicide. Long-term PQ exposure with low dose has been reported to induce abnormal expression of long non-coding RNAs (lncRNAs) in brain nerve cells, which could further lead to Parkinson's disease (PD). Tow specific m6A modified lncRNAs were identified: Lnc_CDC5L and lncRNA STAT3, which could influence downstream autophagy related biological function.
Responsed Disease	Parkinson disease [ICD-11: 8A00]
Pathway Response	Autophagy			hsa04140
Cell Process	Cell autophagy
In-vitro Model	Neuro-2a	Mouse neuroblastoma	Mus musculus	CVCL_0470

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[3]
Response Summary	Paraquat (PQ) is a ubiquitously applied herbicide. Long-term PQ exposure with low dose has been reported to induce abnormal expression of long non-coding RNAs (lncRNAs) in brain nerve cells, which could further lead to Parkinson's disease (PD). Tow specific m6A modified lncRNAs were identified: lncRNA CDC5L and Lnc_STAT3, which could influence downstream autophagy related biological function.
Responsed Disease	Parkinson disease [ICD-11: 8A00]
Pathway Response	Autophagy			hsa04140
Cell Process	Cell autophagy
In-vitro Model	Neuro-2a	Mouse neuroblastoma	Mus musculus	CVCL_0470

Ref 1	Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death. ACS Chem Neurosci. 2019 May 15;10(5):2355-2363. doi: 10.1021/acschemneuro.8b00657. Epub 2019 Mar 14.
Ref 2	Influence of N6-Methyladenosine Modification Gene HNRNPC on Cell Phenotype in Parkinson's Disease. Parkinsons Dis. 2021 Dec 20;2021:9919129. doi: 10.1155/2021/9919129. eCollection 2021.
Ref 3	Paraquat-induced oxidative stress regulates N6-methyladenosine (m(6)A) modification of long noncoding RNAs in Neuro-2a cells. Ecotoxicol Environ Saf. 2022 Jun 1;237:113503. doi: 10.1016/j.ecoenv.2022.113503. Epub 2022 Apr 19.