m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00349)
Target Name Glutamate receptor ionotropic, NMDA 1 (NMDAR1/GRIN1)
Synonyms
GluN1; Glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NMD-R1; NMDAR1
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Gene Name GRIN1
Chromosomal Location 9q34.3
Family glutamate-gated ion channel (TC 1;A;10;1) family; NR1/GRIN1 subfamily
Function
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition.
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Gene ID 2902
Uniprot ID
NMDZ1_HUMAN
HGNC ID
HGNC:4584
Ensembl Gene ID
ENSG00000176884
KEGG ID
hsa:2902
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
GRIN1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Fat mass and obesity-associated protein (FTO) [ERASER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by FTO
Cell Line UMRC2 cell line Homo sapiens
Treatment: FTO knockdown UMRC2 cells
Control: Wild type UMRC2 cells
 GSE139123
Regulation
logFC: -9.35E-01
p-value: 3.38E-05
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Decreased m6A in dopaminergic cells by overexpressing a nucleic acid demethylase, FTO, or by m6A inhibitor. m6A reduction could induce the expression of Glutamate receptor ionotropic, NMDA 1 (NMDAR1/GRIN1), and elevate oxidative stress and Ca2+ influx, resulting in dopaminergic neuron apoptosis. m6A modification plays a vital role in the death of dopaminergic neuron, which provides a novel view of mRNA methylation to understand the epigenetic regulation of Parkinson's disease.
Target Regulation Up regulation
Responsed Disease Parkinson disease ICD-11: 8A00
 Disease Info 
In-vitro Model HEK293T Normal Homo sapiens CVCL_0063
PC-12 Lung papillary adenocarcinoma Homo sapiens CVCL_S979
SH-SY5Y Neuroblastoma Homo sapiens CVCL_0019
In-vivo Model Two weeks after the stereotaxic surgery, all the animals were intraperitoneally injected with apomorphine at a dose of 0.5 mg/kg to induce the contralateral rotations. Ten minutes after the injection, a video was used to record the rotations of each rat for 20 min. Only those 6-OHDA induced rats showing robust contralateral turning (>7 turns/min) that were injected with 6-OHDA were used in subsequent experiments.
Parkinson disease [ICD-11: 8A00]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Decreased m6A in dopaminergic cells by overexpressing a nucleic acid demethylase, FTO, or by m6A inhibitor. m6A reduction could induce the expression of Glutamate receptor ionotropic, NMDA 1 (NMDAR1/GRIN1), and elevate oxidative stress and Ca2+ influx, resulting in dopaminergic neuron apoptosis. m6A modification plays a vital role in the death of dopaminergic neuron, which provides a novel view of mRNA methylation to understand the epigenetic regulation of Parkinson's disease.
Responsed Disease Parkinson disease [ICD-11: 8A00]
Target Regulator Fat mass and obesity-associated protein (FTO) ERASER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model HEK293T Normal Homo sapiens CVCL_0063
PC-12 Lung papillary adenocarcinoma Homo sapiens CVCL_S979
SH-SY5Y Neuroblastoma Homo sapiens CVCL_0019
In-vivo Model Two weeks after the stereotaxic surgery, all the animals were intraperitoneally injected with apomorphine at a dose of 0.5 mg/kg to induce the contralateral rotations. Ten minutes after the injection, a video was used to record the rotations of each rat for 20 min. Only those 6-OHDA induced rats showing robust contralateral turning (>7 turns/min) that were injected with 6-OHDA were used in subsequent experiments.
References
Ref 1 Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death. ACS Chem Neurosci. 2019 May 15;10(5):2355-2363. doi: 10.1021/acschemneuro.8b00657. Epub 2019 Mar 14.