m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00261)

Target Name	Fascin (FSCN1)
Synonyms	55 kDa actin-bundling protein; Singed-like protein; p55; FAN1; HSN; SNL Click to Show/Hide
Gene Name	FSCN1
Chromosomal Location	7p22.1
Family	fascin family
Function	Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF. Click to Show/Hide
Gene ID	6624
Uniprot ID	FSCN1_HUMAN
HGNC ID	HGNC:11148
KEGG ID	hsa:6624

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

FSCN1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) [READER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by IGF2BP1*
Cell Line	HepG2 cell line	Homo sapiens
Treatment: siIGF2BP1 HepG2 cells Control: siControl HepG2 cells		GSE161086
Regulation		logFC: 9.48E-01 p-value: 8.70E-06
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	In contrast to the mRNA-decay-promoting function of YTH domain-containing family protein 2, IGF2BPs promote the stability and storage of their target mRNAs (for example, MYC) in an m6A-dependent manner under normal and stress conditions and therefore affect gene expression output. Four representative high confidence targets, including MYC, Fascin (FSCN1), TK1, and MARCKSL1, exhibit strong binding with IGF2BPs around their m6A motifs in control cells. Knocking down of each individual IGF2BPs in Hela (cervical cancer) and HepG2 (liver cancer) cells significantly repressed MYC expression.
Responsed Disease	Hepatocellular carcinoma		ICD-11: 2C12.02	Disease Info
Cell Process	RNA decay
In-vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	HEK293T	Normal	Homo sapiens	CVCL_0063
	HeLa	Endocervical adenocarcinoma	Homo sapiens	CVCL_0030
	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027

Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) [READER]

Regulator Info

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	In contrast to the mRNA-decay-promoting function of YTH domain-containing family protein 2, IGF2BPs promote the stability and storage of their target mRNAs (for example, MYC) in an m6A-dependent manner under normal and stress conditions and therefore affect gene expression output. Four representative high confidence targets, including MYC, Fascin (FSCN1), TK1, and MARCKSL1, exhibit strong binding with IGF2BPs around their m6A motifs in control cells. Knocking down of each individual IGF2BPs in Hela (cervical cancer) and HepG2 (liver cancer) cells significantly repressed MYC expression.
Responsed Disease	Hepatocellular carcinoma		ICD-11: 2C12.02	Disease Info
Cell Process	RNA decay
In-vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	HEK293T	Normal	Homo sapiens	CVCL_0063
	HeLa	Endocervical adenocarcinoma	Homo sapiens	CVCL_0030
	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027

Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) [READER]

Regulator Info

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	In contrast to the mRNA-decay-promoting function of YTH domain-containing family protein 2, IGF2BPs promote the stability and storage of their target mRNAs (for example, MYC) in an m6A-dependent manner under normal and stress conditions and therefore affect gene expression output. Four representative high confidence targets, including MYC, Fascin (FSCN1), TK1, and MARCKSL1, exhibit strong binding with IGF2BPs around their m6A motifs in control cells. Knocking down of each individual IGF2BPs in Hela (cervical cancer) and HepG2 (liver cancer) cells significantly repressed MYC expression.
Responsed Disease	Hepatocellular carcinoma		ICD-11: 2C12.02	Disease Info
Cell Process	RNA decay
In-vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	HEK293T	Normal	Homo sapiens	CVCL_0063
	HeLa	Endocervical adenocarcinoma	Homo sapiens	CVCL_0030
	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027

Liver cancer [ICD-11: 2C12]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	In contrast to the mRNA-decay-promoting function of YTH domain-containing family protein 2, IGF2BPs promote the stability and storage of their target mRNAs (for example, MYC) in an m6A-dependent manner under normal and stress conditions and therefore affect gene expression output. Four representative high confidence targets, including MYC, Fascin (FSCN1), TK1, and MARCKSL1, exhibit strong binding with IGF2BPs around their m6A motifs in control cells. Knocking down of each individual IGF2BPs in Hela (cervical cancer) and HepG2 (liver cancer) cells significantly repressed MYC expression.
Responsed Disease	Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator	Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)		READER	Regulator Info
Cell Process	RNA decay
In-vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	HEK293T	Normal	Homo sapiens	CVCL_0063
	HeLa	Endocervical adenocarcinoma	Homo sapiens	CVCL_0030
	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027

Cervical cancer [ICD-11: 2C77]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	In contrast to the mRNA-decay-promoting function of YTH domain-containing family protein 2, IGF2BPs promote the stability and storage of their target mRNAs (for example, MYC) in an m6A-dependent manner under normal and stress conditions and therefore affect gene expression output. Four representative high confidence targets, including MYC, Fascin (FSCN1), TK1, and MARCKSL1, exhibit strong binding with IGF2BPs around their m6A motifs in control cells. Knocking down of each individual IGF2BPs in Hela (cervical cancer) and HepG2 (liver cancer) cells significantly repressed MYC expression.
Responsed Disease	Cervical cancer [ICD-11: 2C77]
Target Regulator	Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)		READER	Regulator Info
Cell Process	RNA decay
In-vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	HEK293T	Normal	Homo sapiens	CVCL_0063
	HeLa	Endocervical adenocarcinoma	Homo sapiens	CVCL_0030
	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

RNA modification

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT00540		Crosstalk Info
Epigenetic Regulator	Interferon-inducible protein 4 (ADAR1)
Regulated Target	MicroRNA 200b (MIR200B)
Crosstalk relationship	A-to-I → m6A
Crosstalk ID: M6ACROT00541		Crosstalk Info
Epigenetic Regulator	Y-box-binding protein 1 (YBX1)
Regulated Target	MicroRNA 200b (MIR200B)
Crosstalk relationship	m5C → m6A

m6A Regulator: Methyltransferase-like 14 (METTL14)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT00542		Crosstalk Info
Epigenetic Regulator	Interferon-inducible protein 4 (ADAR1)
Regulated Target	MicroRNA 200b (MIR200B)
Crosstalk relationship	A-to-I → m6A
Crosstalk ID: M6ACROT00543		Crosstalk Info
Epigenetic Regulator	Y-box-binding protein 1 (YBX1)
Regulated Target	MicroRNA 200b (MIR200B)
Crosstalk relationship	m5C → m6A

m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT00544		Crosstalk Info
Epigenetic Regulator	Interferon-inducible protein 4 (ADAR1)
Regulated Target	MicroRNA 200b (MIR200B)
Crosstalk relationship	A-to-I → m6A
Crosstalk ID: M6ACROT00545		Crosstalk Info
Epigenetic Regulator	Y-box-binding protein 1 (YBX1)
Regulated Target	MicroRNA 200b (MIR200B)
Crosstalk relationship	m5C → m6A

m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT00546		Crosstalk Info
Epigenetic Regulator	Interferon-inducible protein 4 (ADAR1)
Regulated Target	MicroRNA 200b (MIR200B)
Crosstalk relationship	A-to-I → m6A
Crosstalk ID: M6ACROT00547		Crosstalk Info
Epigenetic Regulator	Y-box-binding protein 1 (YBX1)
Regulated Target	MicroRNA 200b (MIR200B)
Crosstalk relationship	m5C → m6A

m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT00548		Crosstalk Info
Epigenetic Regulator	Interferon-inducible protein 4 (ADAR1)
Regulated Target	MicroRNA 200b (MIR200B)
Crosstalk relationship	A-to-I → m6A
Crosstalk ID: M6ACROT00549		Crosstalk Info
Epigenetic Regulator	Y-box-binding protein 1 (YBX1)
Regulated Target	MicroRNA 200b (MIR200B)
Crosstalk relationship	m5C → m6A

DNA modification

m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02195		Crosstalk Info
Epigenetic Regulator	Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target	Protein tyrosine phosphatase non-receptor type 13 (PTPN13)
Crosstalk relationship	DNA modification → m6A
Disease	Liver cancer	Disease Info

Non-coding RNA

m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05013		Crosstalk Info
Epigenetic Regulator	DARS1 antisense RNA 1 (DARS1-AS1)
Regulated Target	Insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3)
Crosstalk relationship	ncRNA → m6A
Disease	Cervical cancer	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00261)

Fascin (FSCN1)

Adenosine-to-Inosine editing (A-to-I)

In total 2 m6A sequence/site(s) in this target gene
mod ID: A2ISITE001858		Click to Show/Hide the Full List
mod site	chr7:5598576-5598577:+		[2]
Sequence	AAGCGCCCTGCTTATTTGCAAGGCTGTGTGAGGACGAGCCC
Transcript ID List	ENST00000444748.5; ENST00000447103.5; ENST00000382361.8; ENST00000405801.2
External Link	RMBase: RNA-editing_site_120825
mod ID: A2ISITE001859		Click to Show/Hide the Full List
mod site	chr7:5601718-5601719:+		[3]
Sequence	ATGTGGTGGTGTGTGCCTGTAGTCTCAGCTATTTGGGAGGC
Transcript ID List	ENST00000447103.5; rmsk_2152929; ENST00000405801.2; ENST00000382361.8; ENST00000444748.5
External Link	RMBase: RNA-editing_site_120826

2'-O-Methylation (2'-O-Me)

In total 3 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000429		Click to Show/Hide the Full List
mod site	chr7:5605449-5605450:+		[4]
Sequence	GCCTCGGCGGAAACCGTGGACCCCGCCTCGCTCTGGGAGTA
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000382361.8; ENST00000473330.1
External Link	RMBase: Nm_site_6038
mod ID: 2OMSITE000430		Click to Show/Hide the Full List
mod site	chr7:5605450-5605451:+		[4]
Sequence	CCTCGGCGGAAACCGTGGACCCCGCCTCGCTCTGGGAGTAC
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000382361.8; ENST00000473330.1
External Link	RMBase: Nm_site_6039
mod ID: 2OMSITE000431		Click to Show/Hide the Full List
mod site	chr7:5605793-5605794:+		[4]
Sequence	TCAGACGGCTCTGAGCCTTATTTCTCTGGAAGCGGCTAAGG
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000382361.8; ENST00000473330.1
External Link	RMBase: Nm_site_6040

5-methylcytidine (m5C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE004077		Click to Show/Hide the Full List
mod site	chr7:5605350-5605351:+		[5]
Sequence	ACTCCTGTGGACTTCTTCTTCGAGTTCTGCGACTATAACAA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000382361.8; ENST00000473330.1
External Link	RMBase: m5C_site_39011

N6-methyladenosine (m6A)

In total 44 m6A sequence/site(s) in this target gene
mod ID: M6ASITE078559		Click to Show/Hide the Full List
mod site	chr7:5592856-5592857:+		[6]
Sequence	GTGCGGGCCGCGGCAGCCGAACAAAGGAGCAGGGGCGCCGC
Motif Score	2.951386905
Cell/Tissue List	HeLa; hESC-HEK293T; HepG2; A549; GSC-11; NB4
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000382361.8
External Link	RMBase: m6A_site_747070
mod ID: M6ASITE078560		Click to Show/Hide the Full List
mod site	chr7:5592884-5592885:+		[6]
Sequence	GCAGGGGCGCCGCCGCAGGGACCCGCCACCCACCTCCCGGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; MM6; HEK293T; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000382361.8
External Link	RMBase: m6A_site_747071
mod ID: M6ASITE078561		Click to Show/Hide the Full List
mod site	chr7:5592997-5592998:+		[7]
Sequence	CGGCCTCATCAACTGCGGCAACAAGTACCTGACGGCCGAGG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000382361.8
External Link	RMBase: m6A_site_747072
mod ID: M6ASITE078562		Click to Show/Hide the Full List
mod site	chr7:5593153-5593154:+		[6]
Sequence	GGGCCGCTACCTGGCGGCGGACAAGGACGGCAACGTGACCT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; hESC-HEK293T; A549; MM6; Jurkat; GSC-11; endometrial; NB4
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000382361.8
External Link	RMBase: m6A_site_747073
mod ID: M6ASITE078563		Click to Show/Hide the Full List
mod site	chr7:5593285-5593286:+		[6]
Sequence	CTACTTCGGCGGCACCGAGGACCGCCTGTCCTGCTTCGCGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; A549; Jurkat; GSC-11; HEK293T; endometrial; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000382361.8
External Link	RMBase: m6A_site_747074
mod ID: M6ASITE078564		Click to Show/Hide the Full List
mod site	chr7:5593339-5593340:+		[7]
Sequence	CGCCGAGAAGTGGAGCGTGCACATCGCCATGCACCCTCAGG
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000382361.8
External Link	RMBase: m6A_site_747075
mod ID: M6ASITE078565		Click to Show/Hide the Full List
mod site	chr7:5593432-5593433:+		[6]
Sequence	GGCCGACGAGATCGCCGTGGACCGCGACGTGCCCTGGGGCG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; GSC-11; HEK293T; endometrial; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000382361.8
External Link	RMBase: m6A_site_747076
mod ID: M6ASITE078566		Click to Show/Hide the Full List
mod site	chr7:5593483-5593484:+		[6]
Sequence	CATCACCCTCGCCTTCCAGGACCAGCGCTACAGCGTGCAGA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; Jurkat; GSC-11; HEK293T; endometrial; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000382361.8
External Link	RMBase: m6A_site_747077
mod ID: M6ASITE078567		Click to Show/Hide the Full List
mod site	chr7:5593503-5593504:+		[6]
Sequence	ACCAGCGCTACAGCGTGCAGACCGCCGACCACCGCTTCCTG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; Jurkat; GSC-11; HEK293T; endometrial; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000382361.8
External Link	RMBase: m6A_site_747078
mod ID: M6ASITE078568		Click to Show/Hide the Full List
mod site	chr7:5593570-5593571:+		[7]
Sequence	CCCCGAGCCGGCCACTGGCTACACGCTGGAGTTCCGCTCCG
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000382361.8
External Link	RMBase: m6A_site_747079
mod ID: M6ASITE078569		Click to Show/Hide the Full List
mod site	chr7:5594782-5594783:+		[6]
Sequence	GCTTCAGCGCGAGCCGGGAGACCCCAGGCCAGCTCCCTCGG
Motif Score	2.876744048
Cell/Tissue List	HeLa; GSC-11
Seq Type List	m6A-seq
Transcript ID List	ENST00000447103.5; ENST00000405801.2; ENST00000444748.5; ENST00000382361.8
External Link	RMBase: m6A_site_747080
mod ID: M6ASITE078570		Click to Show/Hide the Full List
mod site	chr7:5594824-5594825:+		[6]
Sequence	AAGCCCCTACCCTCTGGTGAACCCATCCCCTAGGGCGCTCG
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000382361.8; ENST00000444748.5; ENST00000447103.5; ENST00000405801.2
External Link	RMBase: m6A_site_747081
mod ID: M6ASITE078571		Click to Show/Hide the Full List
mod site	chr7:5594851-5594852:+		[6]
Sequence	CCCTAGGGCGCTCGCCGGGAACAATTGACTGCAACTCGATC
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000447103.5; ENST00000405801.2; ENST00000444748.5; ENST00000382361.8
External Link	RMBase: m6A_site_747082
mod ID: M6ASITE078572		Click to Show/Hide the Full List
mod site	chr7:5602931-5602932:+		[6]
Sequence	GTTGCCCAGGCTGGTCTCAAACTCCTAGACTCAAACAATCC
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000382361.8; ENST00000444748.5; ENST00000447103.5; ENST00000473330.1; ENST00000405801.2
External Link	RMBase: m6A_site_747083
mod ID: M6ASITE078573		Click to Show/Hide the Full List
mod site	chr7:5602939-5602940:+		[6]
Sequence	GGCTGGTCTCAAACTCCTAGACTCAAACAATCCTCCTGCCT
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000473330.1; ENST00000382361.8; ENST00000444748.5; ENST00000405801.2; ENST00000447103.5
External Link	RMBase: m6A_site_747084
mod ID: M6ASITE078574		Click to Show/Hide the Full List
mod site	chr7:5602945-5602946:+		[6]
Sequence	TCTCAAACTCCTAGACTCAAACAATCCTCCTGCCTTGGCCT
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000444748.5; ENST00000405801.2; ENST00000382361.8; ENST00000447103.5; ENST00000473330.1
External Link	RMBase: m6A_site_747085
mod ID: M6ASITE078575		Click to Show/Hide the Full List
mod site	chr7:5603045-5603046:+		[6]
Sequence	CTGGGGAAAGTCATGTGGGAACAGATGTAGCTTGCCTTGGC
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000382361.8; ENST00000473330.1; ENST00000444748.5; ENST00000405801.2; ENST00000447103.5
External Link	RMBase: m6A_site_747086
mod ID: M6ASITE078576		Click to Show/Hide the Full List
mod site	chr7:5603262-5603263:+		[6]
Sequence	CCTCCTCTCTGCAGGTATGGACCTGTCTGCCAATCAGGACG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; A549; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000405801.2; ENST00000473330.1; ENST00000382361.8; ENST00000444748.5; ENST00000447103.5
External Link	RMBase: m6A_site_747087
mod ID: M6ASITE078577		Click to Show/Hide the Full List
mod site	chr7:5603288-5603289:+		[6]
Sequence	CTGCCAATCAGGACGAGGAGACCGACCAGGAGACCTTCCAG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; A549; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000405801.2; ENST00000447103.5; ENST00000473330.1; ENST00000382361.8; ENST00000444748.5
External Link	RMBase: m6A_site_747088
mod ID: M6ASITE078578		Click to Show/Hide the Full List
mod site	chr7:5603300-5603301:+		[6]
Sequence	ACGAGGAGACCGACCAGGAGACCTTCCAGCTGGAGATCGAC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; A549; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000382361.8; ENST00000444748.5; ENST00000447103.5; ENST00000473330.1; ENST00000405801.2
External Link	RMBase: m6A_site_747089
mod ID: M6ASITE078579		Click to Show/Hide the Full List
mod site	chr7:5603325-5603326:+		[7]
Sequence	CCAGCTGGAGATCGACCGCGACACCAAAAAGTGTGCCTTCC
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000447103.5; ENST00000444748.5; ENST00000405801.2; ENST00000382361.8; ENST00000473330.1
External Link	RMBase: m6A_site_747090
mod ID: M6ASITE078580		Click to Show/Hide the Full List
mod site	chr7:5603352-5603353:+		[8]
Sequence	AAAGTGTGCCTTCCGTACCCACACGGGCAAGTACTGGACGC
Motif Score	2.053113095
Cell/Tissue List	HEK293; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000473330.1; ENST00000405801.2; ENST00000444748.5; ENST00000382361.8; ENST00000447103.5
External Link	RMBase: m6A_site_747091
mod ID: M6ASITE078581		Click to Show/Hide the Full List
mod site	chr7:5603515-5603516:+		[7]
Sequence	GAATGCCAGCTGCTACTTTGACATCGAGTGGCGTGACCGGC
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000444748.5; ENST00000447103.5; ENST00000473330.1; ENST00000382361.8; ENST00000405801.2
External Link	RMBase: m6A_site_747092
mod ID: M6ASITE078582		Click to Show/Hide the Full List
mod site	chr7:5603530-5603531:+		[9]
Sequence	CTTTGACATCGAGTGGCGTGACCGGCGCATCACACTGAGGG
Motif Score	2.839113095
Cell/Tissue List	AML
Seq Type List	miCLIP
Transcript ID List	ENST00000447103.5; ENST00000444748.5; ENST00000473330.1; ENST00000382361.8; ENST00000405801.2
External Link	RMBase: m6A_site_747093
mod ID: M6ASITE078583		Click to Show/Hide the Full List
mod site	chr7:5603541-5603542:+		[7]
Sequence	AGTGGCGTGACCGGCGCATCACACTGAGGGCGTCCAATGGC
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000444748.5; ENST00000405801.2; ENST00000447103.5; ENST00000473330.1; ENST00000382361.8
External Link	RMBase: m6A_site_747094
mod ID: M6ASITE078584		Click to Show/Hide the Full List
mod site	chr7:5603610-5603611:+		[6]
Sequence	AGCTGGCCGCCTCGGTGGAGACAGCAGGTAACACTAAAGCC
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; HEK293; CD4T; peripheral-blood; HEK293T; endometrial; HEC-1-A
Seq Type List	m6A-seq; m6A-REF-seq
Transcript ID List	ENST00000405801.2; ENST00000473330.1; ENST00000444748.5; ENST00000382361.8; ENST00000447103.5
External Link	RMBase: m6A_site_747095
mod ID: M6ASITE078585		Click to Show/Hide the Full List
mod site	chr7:5603865-5603866:+		[6]
Sequence	CCCTCTTTCTGGGACAGGGGACTCAGAGCTCTTCCTCATGA
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; CD4T; peripheral-blood; HEK293T; endometrial; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000405801.2; ENST00000382361.8; ENST00000444748.5; ENST00000473330.1; ENST00000447103.5
External Link	RMBase: m6A_site_747096
mod ID: M6ASITE078586		Click to Show/Hide the Full List
mod site	chr7:5604018-5604019:+		[7]
Sequence	GGAGTTCAACGATGGCGCCTACAACATCAAAGGCAGGTTCT
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000473330.1; ENST00000382361.8
External Link	RMBase: m6A_site_747097
mod ID: M6ASITE078587		Click to Show/Hide the Full List
mod site	chr7:5605328-5605329:+		[8]
Sequence	CGCGGTCACCAGCAGCGGCGACACTCCTGTGGACTTCTTCT
Motif Score	2.865571429
Cell/Tissue List	brain; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000382361.8; ENST00000473330.1
External Link	RMBase: m6A_site_747098
mod ID: M6ASITE078588		Click to Show/Hide the Full List
mod site	chr7:5605340-5605341:+		[6]
Sequence	CAGCGGCGACACTCCTGTGGACTTCTTCTTCGAGTTCTGCG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000382361.8; ENST00000473330.1
External Link	RMBase: m6A_site_747099
mod ID: M6ASITE078589		Click to Show/Hide the Full List
mod site	chr7:5605367-5605368:+		[7]
Sequence	CTTCGAGTTCTGCGACTATAACAAGGTGGCCATCAAGGTGG
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T; AML
Seq Type List	MAZTER-seq; miCLIP
Transcript ID List	ENST00000473330.1; ENST00000382361.8
External Link	RMBase: m6A_site_747100
mod ID: M6ASITE078590		Click to Show/Hide the Full List
mod site	chr7:5605441-5605442:+		[6]
Sequence	TCCTGAAGGCCTCGGCGGAAACCGTGGACCCCGCCTCGCTC
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; A549
Seq Type List	m6A-seq
Transcript ID List	ENST00000473330.1; ENST00000382361.8
External Link	RMBase: m6A_site_747101
mod ID: M6ASITE078591		Click to Show/Hide the Full List
mod site	chr7:5605448-5605449:+		[6]
Sequence	GGCCTCGGCGGAAACCGTGGACCCCGCCTCGCTCTGGGAGT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; A549
Seq Type List	m6A-seq
Transcript ID List	ENST00000382361.8; ENST00000473330.1
External Link	RMBase: m6A_site_747102
mod ID: M6ASITE078592		Click to Show/Hide the Full List
mod site	chr7:5605503-5605504:+		[7]
Sequence	GTCCTTCCCCGCCCCTGCCCACATGGCGGCTCCTGCCAACC
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000382361.8; ENST00000473330.1
External Link	RMBase: m6A_site_747103
mod ID: M6ASITE078593		Click to Show/Hide the Full List
mod site	chr7:5605590-5605591:+		[6]
Sequence	CAAGCCCCCTTGCCTTTCAAACTGGAAACCCCAGAGAAAAC
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; H1A; H1B; hESCs; fibroblasts; A549; LCLs; H1299; MM6; MSC; TIME; iSLK; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000473330.1; ENST00000382361.8
External Link	RMBase: m6A_site_747104
mod ID: M6ASITE078594		Click to Show/Hide the Full List
mod site	chr7:5605597-5605598:+		[6]
Sequence	CCTTGCCTTTCAAACTGGAAACCCCAGAGAAAACGGTGCCC
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; H1A; H1B; hESCs; fibroblasts; A549; LCLs; H1299; MM6; MSC; TIME; iSLK; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000473330.1; ENST00000382361.8
External Link	RMBase: m6A_site_747105
mod ID: M6ASITE078595		Click to Show/Hide the Full List
mod site	chr7:5605637-5605638:+		[6]
Sequence	CCCACCTGTCGCCCCTATGGACTCCCCACTCTCCCCTCCGC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; H1A; H1B; hESCs; fibroblasts; A549; LCLs; H1299; MM6; MSC; TIME; iSLK; AML
Seq Type List	m6A-seq; DART-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000473330.1; ENST00000382361.8
External Link	RMBase: m6A_site_747106
mod ID: M6ASITE078596		Click to Show/Hide the Full List
mod site	chr7:5605908-5605909:+		[7]
Sequence	GCCCCCCAGGAGAGCTGGGCACATGTCCCAAGCCTGTCAGT
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000382361.8; ENST00000473330.1
External Link	RMBase: m6A_site_747107
mod ID: M6ASITE078597		Click to Show/Hide the Full List
mod site	chr7:5605956-5605957:+		[6]
Sequence	CCTGGTGCACTGTCCCCGAAACCCCTGCTTGGGAAGGGAAG
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000473330.1; ENST00000382361.8
External Link	RMBase: m6A_site_747108
mod ID: M6ASITE078598		Click to Show/Hide the Full List
mod site	chr7:5605994-5605995:+		[6]
Sequence	AAGCTGTCGGGTGGGCTAGGACTGACCCTTGTGGTGTTTTT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000382361.8; ENST00000473330.1
External Link	RMBase: m6A_site_747109
mod ID: M6ASITE078599		Click to Show/Hide the Full List
mod site	chr7:5606032-5606033:+		[6]
Sequence	TTTTTGGGTGGTGGCTGGAAACAGCCCCTCTCCCACGTGGC
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000473330.1; ENST00000382361.8
External Link	RMBase: m6A_site_747110
mod ID: M6ASITE078600		Click to Show/Hide the Full List
mod site	chr7:5606219-5606220:+		[10]
Sequence	CTGACTGGAAGCAGAAAATGACCAAATCAGTATTTTTTTTA
Motif Score	2.839113095
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000382361.8; ENST00000473330.1
External Link	RMBase: m6A_site_747111
mod ID: M6ASITE078601		Click to Show/Hide the Full List
mod site	chr7:5606393-5606394:+		[7]
Sequence	GCCCTGGGCCTGGGCTGCCGACACCTGGGCCAGAGCCCCTG
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000382361.8; ENST00000473330.1
External Link	RMBase: m6A_site_747112
mod ID: M6ASITE078602		Click to Show/Hide the Full List
mod site	chr7:5606527-5606528:+		[7]
Sequence	GCCAGCCTCCCCCGTCCCCAACATGCATCTCACTCTGGGTG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000382361.8; ENST00000473330.1
External Link	RMBase: m6A_site_747113

Pseudouridine (Pseudo)

In total 1 m6A sequence/site(s) in this target gene
mod ID: PSESITE000250		Click to Show/Hide the Full List
mod site	chr7:5606282-5606283:+		[11]
Sequence	GTCCCAGGCAAGCCTGGCTGTAGTAGCGAGTGATCTGGCGG
Transcript ID List	ENST00000473330.1; ENST00000382361.8
External Link	RMBase: Pseudo_site_4382

Ref 1	Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat Cell Biol. 2018 Mar;20(3):285-295. doi: 10.1038/s41556-018-0045-z. Epub 2018 Feb 23.
Ref 2	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 3	Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome. Nat Biotechnol. 2012 Feb 12;30(3):253-60. doi: 10.1038/nbt.2122.
Ref 4	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.
Ref 5	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 6	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 7	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 8	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 9	The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nat Med. 2017 Nov;23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18.
Ref 10	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 11	Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome. Nat Chem Biol. 2015 Aug;11(8):592-7. doi: 10.1038/nchembio.1836. Epub 2015 Jun 15.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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