General Information of the m6A Regulator (ID: REG00001)
Regulator Name Fat mass and obesity-associated protein (FTO)
Synonyms
Alpha-ketoglutarate-dependent dioxygenase FTO; U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; m6A(m)-demethylase FTO; mRNA N(6)-methyladenosine demethylase FTO; tRNA N1-methyl adenine demethylase FTO; KIAA1752
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Gene Name FTO
Regulator Type WRITER ERASER READER
Regulator Link Click to View Full Information of This Regulator
Full List of Target Gene(s) of This m6A Regulator and Corresponding Potential Drug Response(s)
Alanine/serine/cysteine/threonine transporter 2 (SLC1A5)
Acyclovir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) is a therapeutic target for Acyclovir. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Acyclovir through regulating the expression of Alanine/serine/cysteine/threonine transporter 2 (SLC1A5). [1], [2]
D-serine [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) is a therapeutic target for D-serine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of D-serine through regulating the expression of Alanine/serine/cysteine/threonine transporter 2 (SLC1A5). [1], [3]
Ganciclovir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) is a therapeutic target for Ganciclovir. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ganciclovir through regulating the expression of Alanine/serine/cysteine/threonine transporter 2 (SLC1A5). [1], [2]
Glycine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) is a therapeutic target for Glycine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Glycine through regulating the expression of Alanine/serine/cysteine/threonine transporter 2 (SLC1A5). [1], [4]
L-carnitine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) is a therapeutic target for L-carnitine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-carnitine through regulating the expression of Alanine/serine/cysteine/threonine transporter 2 (SLC1A5). [1], [5]
L-glutamine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) is a therapeutic target for L-glutamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-glutamine through regulating the expression of Alanine/serine/cysteine/threonine transporter 2 (SLC1A5). [1], [6]
Valacyclovir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) is a therapeutic target for Valacyclovir. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Valacyclovir through regulating the expression of Alanine/serine/cysteine/threonine transporter 2 (SLC1A5). [1], [7]
Valganciclovir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) is a therapeutic target for Valganciclovir. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Valganciclovir through regulating the expression of Alanine/serine/cysteine/threonine transporter 2 (SLC1A5). [1], [8]
Nitric oxide [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) is a therapeutic target for Nitric oxide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Nitric oxide through regulating the expression of Alanine/serine/cysteine/threonine transporter 2 (SLC1A5). [1], [9]
L-threonine [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) is a therapeutic target for L-threonine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-threonine through regulating the expression of Alanine/serine/cysteine/threonine transporter 2 (SLC1A5). [1], [3]
benzylserine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) is a therapeutic target for benzylserine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of benzylserine through regulating the expression of Alanine/serine/cysteine/threonine transporter 2 (SLC1A5). [1], [10]
p-nitrophenyl glutamyl anilide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) is a therapeutic target for p-nitrophenyl glutamyl anilide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of p-nitrophenyl glutamyl anilide through regulating the expression of Alanine/serine/cysteine/threonine transporter 2 (SLC1A5). [1], [11]
Apolipoprotein E (APOE)
AEM-28 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apolipoprotein E (APOE) is a therapeutic target for AEM-28. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AEM-28 through regulating the expression of Apolipoprotein E (APOE). [12], [13]
CN-105 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apolipoprotein E (APOE) is a therapeutic target for CN-105. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CN-105 through regulating the expression of Apolipoprotein E (APOE). [12], [14]
Apolipoprotein E [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Apolipoprotein E (APOE) is a therapeutic target for Apolipoprotein E. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Apolipoprotein E through regulating the expression of Apolipoprotein E (APOE). [12], [15]
Apoptosis mediating surface antigen FAS (FAS)
VB-111 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for VB-111. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of VB-111 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [16], [17]
APG-101 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for APG-101. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of APG-101 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [16], [18]
DE-098 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for DE-098. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of DE-098 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [16], [19]
APO-010 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for APO-010. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of APO-010 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [16], [20]
2-aminophenoxazine-3-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for 2-aminophenoxazine-3-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-aminophenoxazine-3-one through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [16], [21]
APG-103 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for APG-103. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of APG-103 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [16], [22]
F61F12 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for F61F12. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of F61F12 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [16], [23]
ISIS 17020 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for ISIS 17020. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 17020 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [16], [24]
Apoptosis regulator Bcl-2 (BCL-2)
MCI-186 [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for MCI-186. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MCI-186 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [26]
Venetoclax [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for Venetoclax. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Venetoclax through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [27]
ABT-263 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for ABT-263. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ABT-263 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [28]
Oblimersen [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for Oblimersen. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Oblimersen through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [29]
RG7601 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for RG7601. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RG7601 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [30]
Thymoquinone [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for Thymoquinone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Thymoquinone through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [31]
APG-1252 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for APG-1252. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of APG-1252 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [32]
APG-2575 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for APG-2575. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of APG-2575 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [33]
AZD0466 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for AZD0466. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AZD0466 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [34]
Beclanorsen [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for Beclanorsen. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Beclanorsen through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [35]
Gossypol [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for Gossypol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Gossypol through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [36]
Obatoclax [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for Obatoclax. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Obatoclax through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [22], [25]
PNT-2258 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for PNT-2258. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PNT-2258 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [37]
AI-850 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for AI-850. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AI-850 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [38]
BCL201 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for BCL201. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BCL201 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [39]
BGB-11417 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for BGB-11417. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BGB-11417 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [40]
BP1002 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for BP1002. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BP1002 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [41]
LP-108 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for LP-108. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LP-108 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [42]
Pc4 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for Pc4. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Pc4 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [43]
VOB560 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for VOB560. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of VOB560 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [44]
2,3,4-trihydroxy-5-isopropyl-N-phenyl-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for 2,3,4-trihydroxy-5-isopropyl-N-phenyl-benzamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2,3,4-trihydroxy-5-isopropyl-N-phenyl-benzamide through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [45]
4,5-dibenzylbenzene-1,2-diol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for 4,5-dibenzylbenzene-1,2-diol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4,5-dibenzylbenzene-1,2-diol through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [46]
5,10-Dioxy-2-phenyl-benzo[g]pteridin-4-ylamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for 5,10-Dioxy-2-phenyl-benzo[g]pteridin-4-ylamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5,10-Dioxy-2-phenyl-benzo[g]pteridin-4-ylamine through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [47]
Apogossypol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for Apogossypol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Apogossypol through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [48]
BP-100-1.02 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for BP-100-1.02. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BP-100-1.02 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [49]
modified HA14-1 compounds (cancer) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for modified HA14-1 compounds (cancer). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of modified HA14-1 compounds (cancer) through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [47]
N-phenyl-2,3,4-trihydroxy-5-benzyl-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for N-phenyl-2,3,4-trihydroxy-5-benzyl-benzamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-phenyl-2,3,4-trihydroxy-5-benzyl-benzamide through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [47]
QEDIIRNIARHLAQVGDSMDR [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for QEDIIRNIARHLAQVGDSMDR. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of QEDIIRNIARHLAQVGDSMDR through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [47]
TW-37 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for TW-37. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TW-37 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [50]
WL-276 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for WL-276. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of WL-276 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [51]
ABT-737 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for ABT-737. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ABT-737 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [25], [52]
Aromatase (CYP19A1)
Aminoglutethimide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for Aminoglutethimide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Aminoglutethimide through regulating the expression of Aromatase (CYP19A1). [53], [54]
Anastrozole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for Anastrozole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Anastrozole through regulating the expression of Aromatase (CYP19A1). [53], [55]
Dehydroepiandrosterone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for Dehydroepiandrosterone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Dehydroepiandrosterone through regulating the expression of Aromatase (CYP19A1). [53], [56]
Dihydrotestosterone [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for Dihydrotestosterone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Dihydrotestosterone through regulating the expression of Aromatase (CYP19A1). [53], [57]
Exemestane [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for Exemestane. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Exemestane through regulating the expression of Aromatase (CYP19A1). [53], [58]
FADROZOLE [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for FADROZOLE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of FADROZOLE through regulating the expression of Aromatase (CYP19A1). [53], [59]
Letrozole [Approved]
In total 2 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for Letrozole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Letrozole through regulating the expression of Aromatase (CYP19A1). [53], [60]
Aromatase (CYP19A1) is a therapeutic target for Letrozole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Letrozole through regulating the expression of Aromatase (CYP19A1). [53], [61]
Levomethadyl acetate hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for Levomethadyl acetate hydrochloride. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Levomethadyl acetate hydrochloride through regulating the expression of Aromatase (CYP19A1). [53], [62]
Methadone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for Methadone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Methadone through regulating the expression of Aromatase (CYP19A1). [53], [63]
Nandrolone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for Nandrolone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Nandrolone through regulating the expression of Aromatase (CYP19A1). [53], [64]
Testolactone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for Testolactone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Testolactone through regulating the expression of Aromatase (CYP19A1). [53], [58]
Testosterone cypionate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for Testosterone cypionate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Testosterone cypionate through regulating the expression of Aromatase (CYP19A1). [53], [65]
LIAROZOLE [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for LIAROZOLE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LIAROZOLE through regulating the expression of Aromatase (CYP19A1). [53], [66]
BGS-649 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for BGS-649. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BGS-649 through regulating the expression of Aromatase (CYP19A1). [53], [67]
Coumate [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for Coumate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Coumate through regulating the expression of Aromatase (CYP19A1). [53], [59]
Naringenin [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for Naringenin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Naringenin through regulating the expression of Aromatase (CYP19A1). [53], [68]
(2S)-5,7,2',4'-tetrahydroxyflavanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for (2S)-5,7,2',4'-tetrahydroxyflavanone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (2S)-5,7,2',4'-tetrahydroxyflavanone through regulating the expression of Aromatase (CYP19A1). [53], [69]
(2S)-abyssinone II [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for (2S)-abyssinone II. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (2S)-abyssinone II through regulating the expression of Aromatase (CYP19A1). [53], [69]
(2S)-euchrenone a7 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for (2S)-euchrenone a7. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (2S)-euchrenone a7 through regulating the expression of Aromatase (CYP19A1). [53], [69]
1-(1-Benzyl-2-biphenyl-4-yl-ethyl)-1H-imidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 1-(1-Benzyl-2-biphenyl-4-yl-ethyl)-1H-imidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-(1-Benzyl-2-biphenyl-4-yl-ethyl)-1H-imidazole through regulating the expression of Aromatase (CYP19A1). [53], [70]
1-(2-(benzo[b]thiophen-4-yl)ethyl)-1H-imidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 1-(2-(benzo[b]thiophen-4-yl)ethyl)-1H-imidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-(2-(benzo[b]thiophen-4-yl)ethyl)-1H-imidazole through regulating the expression of Aromatase (CYP19A1). [53], [71]
1-(2-phenoxybenzyl)-1H-imidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 1-(2-phenoxybenzyl)-1H-imidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-(2-phenoxybenzyl)-1H-imidazole through regulating the expression of Aromatase (CYP19A1). [53], [72]
1-(3-(4-fluorophenyl)propyl)-1H-imidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 1-(3-(4-fluorophenyl)propyl)-1H-imidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-(3-(4-fluorophenyl)propyl)-1H-imidazole through regulating the expression of Aromatase (CYP19A1). [53], [59]
1-(3-Methoxy-naphthalen-2-yl)-1H-imidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 1-(3-Methoxy-naphthalen-2-yl)-1H-imidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-(3-Methoxy-naphthalen-2-yl)-1H-imidazole through regulating the expression of Aromatase (CYP19A1). [53], [73]
1-(4-Aminophenyl)-2-(1H-imidazol-1-yl)ethanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 1-(4-Aminophenyl)-2-(1H-imidazol-1-yl)ethanone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-(4-Aminophenyl)-2-(1H-imidazol-1-yl)ethanone through regulating the expression of Aromatase (CYP19A1). [53], [71]
1-(4-Cyanobenzyl)-5-methyl-1H-imidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 1-(4-Cyanobenzyl)-5-methyl-1H-imidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-(4-Cyanobenzyl)-5-methyl-1H-imidazole through regulating the expression of Aromatase (CYP19A1). [53], [74]
1-(4-nitro-2-phenoxybenzyl)-1H-imidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 1-(4-nitro-2-phenoxybenzyl)-1H-imidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-(4-nitro-2-phenoxybenzyl)-1H-imidazole through regulating the expression of Aromatase (CYP19A1). [53], [72]
1-(4-Nitro-2-phenylsulfanylbenzyl)-1H-imidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 1-(4-Nitro-2-phenylsulfanylbenzyl)-1H-imidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-(4-Nitro-2-phenylsulfanylbenzyl)-1H-imidazole through regulating the expression of Aromatase (CYP19A1). [53], [72]
1-(7-Methoxy-2-phenyl-chroman-4-yl)-1H-imidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 1-(7-Methoxy-2-phenyl-chroman-4-yl)-1H-imidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-(7-Methoxy-2-phenyl-chroman-4-yl)-1H-imidazole through regulating the expression of Aromatase (CYP19A1). [53], [75]
1-(9-phenyl-9H-fluoren-9-yl)-1H-1,2,4-triazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 1-(9-phenyl-9H-fluoren-9-yl)-1H-1,2,4-triazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-(9-phenyl-9H-fluoren-9-yl)-1H-1,2,4-triazole through regulating the expression of Aromatase (CYP19A1). [53], [76]
1-(9-Phenyl-9H-fluoren-9-yl)1H-imidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 1-(9-Phenyl-9H-fluoren-9-yl)1H-imidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-(9-Phenyl-9H-fluoren-9-yl)1H-imidazole through regulating the expression of Aromatase (CYP19A1). [53], [71]
1-(9H-fluoren-9-yl)-1H-imidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 1-(9H-fluoren-9-yl)-1H-imidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-(9H-fluoren-9-yl)-1H-imidazole through regulating the expression of Aromatase (CYP19A1). [53], [59]
1-(biphenyl-3-ylmethyl)-1H-1,2,4-triazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 1-(biphenyl-3-ylmethyl)-1H-1,2,4-triazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-(biphenyl-3-ylmethyl)-1H-1,2,4-triazole through regulating the expression of Aromatase (CYP19A1). [53], [77]
1-Bromo-4-imidazol-1-ylmethyl-xanthen-9-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 1-Bromo-4-imidazol-1-ylmethyl-xanthen-9-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-Bromo-4-imidazol-1-ylmethyl-xanthen-9-one through regulating the expression of Aromatase (CYP19A1). [53], [71]
1-Ethyl-5-(imidazol-1-yl-phenyl-methyl)-1H-indole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 1-Ethyl-5-(imidazol-1-yl-phenyl-methyl)-1H-indole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-Ethyl-5-(imidazol-1-yl-phenyl-methyl)-1H-indole through regulating the expression of Aromatase (CYP19A1). [53], [78]
1-Imidazol-1-ylmethyl-4-nitro-xanthen-9-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 1-Imidazol-1-ylmethyl-4-nitro-xanthen-9-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-Imidazol-1-ylmethyl-4-nitro-xanthen-9-one through regulating the expression of Aromatase (CYP19A1). [53], [79]
1-Imidazol-1-ylmethylxanthen-9-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 1-Imidazol-1-ylmethylxanthen-9-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-Imidazol-1-ylmethylxanthen-9-one through regulating the expression of Aromatase (CYP19A1). [53], [72]
1-Naphthalen-2-yl-1H-imidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 1-Naphthalen-2-yl-1H-imidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-Naphthalen-2-yl-1H-imidazole through regulating the expression of Aromatase (CYP19A1). [53], [80]
1-[(7-Fluoronaphth-2-yl)methyl]-1H-imidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 1-[(7-Fluoronaphth-2-yl)methyl]-1H-imidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-[(7-Fluoronaphth-2-yl)methyl]-1H-imidazole through regulating the expression of Aromatase (CYP19A1). [53], [59]
10-EPI-8-DEOXY-CUMAMBRIN B [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 10-EPI-8-DEOXY-CUMAMBRIN B. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 10-EPI-8-DEOXY-CUMAMBRIN B through regulating the expression of Aromatase (CYP19A1). [53], [81]
11BETA,13-DIHYDRO-10-EPI-8-DEOXYCUMAM-BRIN B [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 11BETA,13-DIHYDRO-10-EPI-8-DEOXYCUMAM-BRIN B. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 11BETA,13-DIHYDRO-10-EPI-8-DEOXYCUMAM-BRIN B through regulating the expression of Aromatase (CYP19A1). [53], [59]
2,3,4-Trimethoxy-4'-amino-trans-stilbene [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 2,3,4-Trimethoxy-4'-amino-trans-stilbene. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2,3,4-Trimethoxy-4'-amino-trans-stilbene through regulating the expression of Aromatase (CYP19A1). [53], [82]
2,3,5-Trimethoxy-4'-amino-trans-stilbene [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 2,3,5-Trimethoxy-4'-amino-trans-stilbene. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2,3,5-Trimethoxy-4'-amino-trans-stilbene through regulating the expression of Aromatase (CYP19A1). [53], [82]
2,3-Dimethoxy-4'-amino-trans-stilbene [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 2,3-Dimethoxy-4'-amino-trans-stilbene. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2,3-Dimethoxy-4'-amino-trans-stilbene through regulating the expression of Aromatase (CYP19A1). [53], [82]
2,4-Dimethoxy-3'-amino-trans-stilbene [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 2,4-Dimethoxy-3'-amino-trans-stilbene. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2,4-Dimethoxy-3'-amino-trans-stilbene through regulating the expression of Aromatase (CYP19A1). [53], [82]
2,4-Dimethoxy-4'-amino-trans-stilbene [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 2,4-Dimethoxy-4'-amino-trans-stilbene. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2,4-Dimethoxy-4'-amino-trans-stilbene through regulating the expression of Aromatase (CYP19A1). [53], [82]
2,5-Dimethoxy-4'-amino-trans-stilbene [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 2,5-Dimethoxy-4'-amino-trans-stilbene. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2,5-Dimethoxy-4'-amino-trans-stilbene through regulating the expression of Aromatase (CYP19A1). [53], [82]
2-(1H-Imidazol-1-yl)-1-(4-nitrophenyl)ethanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 2-(1H-Imidazol-1-yl)-1-(4-nitrophenyl)ethanone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-(1H-Imidazol-1-yl)-1-(4-nitrophenyl)ethanone through regulating the expression of Aromatase (CYP19A1). [53], [82]
2-(3-hydroxyphenyl)-7-methoxychroman-4-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 2-(3-hydroxyphenyl)-7-methoxychroman-4-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-(3-hydroxyphenyl)-7-methoxychroman-4-one through regulating the expression of Aromatase (CYP19A1). [53], [71]
2-(4-hydroxyphenyl)-7-methoxychroman-4-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 2-(4-hydroxyphenyl)-7-methoxychroman-4-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-(4-hydroxyphenyl)-7-methoxychroman-4-one through regulating the expression of Aromatase (CYP19A1). [53], [83]
2-Imidazol-1-yl-7-methoxy-3-phenyl-chromen-4-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 2-Imidazol-1-yl-7-methoxy-3-phenyl-chromen-4-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-Imidazol-1-yl-7-methoxy-3-phenyl-chromen-4-one through regulating the expression of Aromatase (CYP19A1). [53], [77]
2-Imidazol-1-ylmethylxanthen-9-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 2-Imidazol-1-ylmethylxanthen-9-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-Imidazol-1-ylmethylxanthen-9-one through regulating the expression of Aromatase (CYP19A1). [53], [84]
2-phenyl-2,3-dihydrobenzo[h]chromen-4-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 2-phenyl-2,3-dihydrobenzo[h]chromen-4-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-phenyl-2,3-dihydrobenzo[h]chromen-4-one through regulating the expression of Aromatase (CYP19A1). [53], [85]
2-Phenyl-3-pyridin-4-ylmethylene-chroman-4-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 2-Phenyl-3-pyridin-4-ylmethylene-chroman-4-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-Phenyl-3-pyridin-4-ylmethylene-chroman-4-one through regulating the expression of Aromatase (CYP19A1). [53], [83]
2-Phenyl-4-[1,2,4]triazol-1-yl-chroman-7-ol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 2-Phenyl-4-[1,2,4]triazol-1-yl-chroman-7-ol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-Phenyl-4-[1,2,4]triazol-1-yl-chroman-7-ol through regulating the expression of Aromatase (CYP19A1). [53], [59]
3,4'-(Ethane-1,2-diyl)dibenzenamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3,4'-(Ethane-1,2-diyl)dibenzenamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,4'-(Ethane-1,2-diyl)dibenzenamine through regulating the expression of Aromatase (CYP19A1). [53], [82]
3,4,5-Trimethoxy-3'-amino-trans-stilbene [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3,4,5-Trimethoxy-3'-amino-trans-stilbene. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,4,5-Trimethoxy-3'-amino-trans-stilbene through regulating the expression of Aromatase (CYP19A1). [53], [82]
3,4,5-Trimethoxy-4'-amino-trans-stilbene [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3,4,5-Trimethoxy-4'-amino-trans-stilbene. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,4,5-Trimethoxy-4'-amino-trans-stilbene through regulating the expression of Aromatase (CYP19A1). [53], [82]
3,4-bis(3,4-dimethoxyphenyl)furan-2(5H)-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3,4-bis(3,4-dimethoxyphenyl)furan-2(5H)-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,4-bis(3,4-dimethoxyphenyl)furan-2(5H)-one through regulating the expression of Aromatase (CYP19A1). [53], [59]
3,4-Dimethoxy-4'-amino-trans-stilbene [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3,4-Dimethoxy-4'-amino-trans-stilbene. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,4-Dimethoxy-4'-amino-trans-stilbene through regulating the expression of Aromatase (CYP19A1). [53], [82]
3,5-Diacetoxy-4'-amino-trans-stilbene [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3,5-Diacetoxy-4'-amino-trans-stilbene. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,5-Diacetoxy-4'-amino-trans-stilbene through regulating the expression of Aromatase (CYP19A1). [53], [82]
3,5-Diamino-4'-amino-trans-stilbene [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3,5-Diamino-4'-amino-trans-stilbene. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,5-Diamino-4'-amino-trans-stilbene through regulating the expression of Aromatase (CYP19A1). [53], [82]
3,5-Dihydroxyl-4'-amino-trans-stilbene [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3,5-Dihydroxyl-4'-amino-trans-stilbene. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,5-Dihydroxyl-4'-amino-trans-stilbene through regulating the expression of Aromatase (CYP19A1). [53], [82]
3,5-Dimethoxy-4'-amino-trans-stilbene [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3,5-Dimethoxy-4'-amino-trans-stilbene. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,5-Dimethoxy-4'-amino-trans-stilbene through regulating the expression of Aromatase (CYP19A1). [53], [82]
3-((1H-imidazol-1-yl)methyl)-9H-xanthen-9-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-((1H-imidazol-1-yl)methyl)-9H-xanthen-9-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-((1H-imidazol-1-yl)methyl)-9H-xanthen-9-one through regulating the expression of Aromatase (CYP19A1). [53], [86]
3-(1-ethyl-3,4-dihydronaphthalen-2-yl)-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(1-ethyl-3,4-dihydronaphthalen-2-yl)-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(1-ethyl-3,4-dihydronaphthalen-2-yl)-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [87]
3-(1-methyl-3,4-dihydronaphthalen-2-yl)-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(1-methyl-3,4-dihydronaphthalen-2-yl)-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(1-methyl-3,4-dihydronaphthalen-2-yl)-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [87]
3-(2,2-Diphenyl-vinyl)-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(2,2-Diphenyl-vinyl)-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(2,2-Diphenyl-vinyl)-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-(3,4-dihydronaphthalen-2-yl)pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(3,4-dihydronaphthalen-2-yl)pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(3,4-dihydronaphthalen-2-yl)pyridine through regulating the expression of Aromatase (CYP19A1). [53], [89]
3-(3-methyl-3,4-dihydronaphthalen-2-yl)pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(3-methyl-3,4-dihydronaphthalen-2-yl)pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(3-methyl-3,4-dihydronaphthalen-2-yl)pyridine through regulating the expression of Aromatase (CYP19A1). [53], [87]
3-(4-Amino-phenyl)-1-methyl-pyrrolidine-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(4-Amino-phenyl)-1-methyl-pyrrolidine-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-Amino-phenyl)-1-methyl-pyrrolidine-2,5-dione through regulating the expression of Aromatase (CYP19A1). [53], [59]
3-(4-Amino-phenyl)-3-butyl-piperidine-2,6-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(4-Amino-phenyl)-3-butyl-piperidine-2,6-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-Amino-phenyl)-3-butyl-piperidine-2,6-dione through regulating the expression of Aromatase (CYP19A1). [53], [90]
3-(4-Amino-phenyl)-3-ethyl-pyrrolidine-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(4-Amino-phenyl)-3-ethyl-pyrrolidine-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-Amino-phenyl)-3-ethyl-pyrrolidine-2,5-dione through regulating the expression of Aromatase (CYP19A1). [53], [91]
3-(4-Amino-phenyl)-3-heptyl-piperidine-2,6-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(4-Amino-phenyl)-3-heptyl-piperidine-2,6-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-Amino-phenyl)-3-heptyl-piperidine-2,6-dione through regulating the expression of Aromatase (CYP19A1). [53], [90]
3-(4-Amino-phenyl)-3-hexyl-piperidine-2,6-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(4-Amino-phenyl)-3-hexyl-piperidine-2,6-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-Amino-phenyl)-3-hexyl-piperidine-2,6-dione through regulating the expression of Aromatase (CYP19A1). [53], [92]
3-(4-Amino-phenyl)-3-methyl-pyrrolidine-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(4-Amino-phenyl)-3-methyl-pyrrolidine-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-Amino-phenyl)-3-methyl-pyrrolidine-2,5-dione through regulating the expression of Aromatase (CYP19A1). [53], [75]
3-(4-Amino-phenyl)-3-pentyl-piperidine-2,6-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(4-Amino-phenyl)-3-pentyl-piperidine-2,6-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-Amino-phenyl)-3-pentyl-piperidine-2,6-dione through regulating the expression of Aromatase (CYP19A1). [53], [90]
3-(4-Amino-phenyl)-3-propyl-piperidine-2,6-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(4-Amino-phenyl)-3-propyl-piperidine-2,6-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-Amino-phenyl)-3-propyl-piperidine-2,6-dione through regulating the expression of Aromatase (CYP19A1). [53], [90]
3-(4-Amino-phenyl)-pyrrolidine-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(4-Amino-phenyl)-pyrrolidine-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-Amino-phenyl)-pyrrolidine-2,5-dione through regulating the expression of Aromatase (CYP19A1). [53], [73]
3-(4-methyl-3,4-dihydronaphthalen-2-yl)pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(4-methyl-3,4-dihydronaphthalen-2-yl)pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-methyl-3,4-dihydronaphthalen-2-yl)pyridine through regulating the expression of Aromatase (CYP19A1). [53], [87]
3-(5-Bromo-6-methoxy-naphthalen-2-yl)-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(5-Bromo-6-methoxy-naphthalen-2-yl)-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(5-Bromo-6-methoxy-naphthalen-2-yl)-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [80]
3-(5-Chloro-6-methoxy-naphthalen-2-yl)-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(5-Chloro-6-methoxy-naphthalen-2-yl)-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(5-Chloro-6-methoxy-naphthalen-2-yl)-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [59]
3-(6-Ethoxy-naphthalen-2-yl)-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(6-Ethoxy-naphthalen-2-yl)-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(6-Ethoxy-naphthalen-2-yl)-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [80]
3-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine through regulating the expression of Aromatase (CYP19A1). [53], [87]
3-(6-methoxynaphthalen-2-yl)pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(6-methoxynaphthalen-2-yl)pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(6-methoxynaphthalen-2-yl)pyridine through regulating the expression of Aromatase (CYP19A1). [53], [80]
3-(imidazolylmethyl)-4'-methoxyflavone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(imidazolylmethyl)-4'-methoxyflavone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(imidazolylmethyl)-4'-methoxyflavone through regulating the expression of Aromatase (CYP19A1). [53], [89]
3-(imidazolylmethyl)-4'-nitroflavone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(imidazolylmethyl)-4'-nitroflavone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(imidazolylmethyl)-4'-nitroflavone through regulating the expression of Aromatase (CYP19A1). [53], [89]
3-(imidazolylmethyl)-7-methoxy-4'-nitroflavone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(imidazolylmethyl)-7-methoxy-4'-nitroflavone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(imidazolylmethyl)-7-methoxy-4'-nitroflavone through regulating the expression of Aromatase (CYP19A1). [53], [59]
3-(imidazolylmethyl)flavone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(imidazolylmethyl)flavone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(imidazolylmethyl)flavone through regulating the expression of Aromatase (CYP19A1). [53], [89]
3-(naphthalen-2-yl)pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-(naphthalen-2-yl)pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(naphthalen-2-yl)pyridine through regulating the expression of Aromatase (CYP19A1). [53], [77]
3-Amino-4'-amino-trans-stilbene [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-Amino-4'-amino-trans-stilbene. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Amino-4'-amino-trans-stilbene through regulating the expression of Aromatase (CYP19A1). [53], [82]
3-Fluoren-9-ylidenemethyl-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-Fluoren-9-ylidenemethyl-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Fluoren-9-ylidenemethyl-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-Fluoro-4'-(pyridin-4-ylmethyl)biphenyl-4-ol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-Fluoro-4'-(pyridin-4-ylmethyl)biphenyl-4-ol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Fluoro-4'-(pyridin-4-ylmethyl)biphenyl-4-ol through regulating the expression of Aromatase (CYP19A1). [53], [81]
3-Indan-(1E)-ylidenemethyl-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-Indan-(1E)-ylidenemethyl-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Indan-(1E)-ylidenemethyl-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [93]
3-Indan-(1Z)-ylidenemethyl-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-Indan-(1Z)-ylidenemethyl-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Indan-(1Z)-ylidenemethyl-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-Methoxyl-4'-amino-trans-stilbene [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-Methoxyl-4'-amino-trans-stilbene. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Methoxyl-4'-amino-trans-stilbene through regulating the expression of Aromatase (CYP19A1). [53], [82]
3-Nitro-4'-nitro-trans-stilbene [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-Nitro-4'-nitro-trans-stilbene. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Nitro-4'-nitro-trans-stilbene through regulating the expression of Aromatase (CYP19A1). [53], [82]
3-[3-Methyl-indan-(1E)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[3-Methyl-indan-(1E)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[3-Methyl-indan-(1E)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-[3-Methyl-indan-(1Z)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[3-Methyl-indan-(1Z)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[3-Methyl-indan-(1Z)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-[3-Phenyl-indan-(1E)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[3-Phenyl-indan-(1E)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[3-Phenyl-indan-(1E)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-[4-Chloro-indan-(1E)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[4-Chloro-indan-(1E)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[4-Chloro-indan-(1E)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-[4-Chloro-indan-(1Z)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[4-Chloro-indan-(1Z)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[4-Chloro-indan-(1Z)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-[4-Fluoro-indan-(1E)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[4-Fluoro-indan-(1E)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[4-Fluoro-indan-(1E)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-[4-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[4-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[4-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-[4-Methyl-indan-(1E)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[4-Methyl-indan-(1E)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[4-Methyl-indan-(1E)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-[4-Methyl-indan-(1Z)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[4-Methyl-indan-(1Z)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[4-Methyl-indan-(1Z)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-[5-Bromo-indan-(1E)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[5-Bromo-indan-(1E)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[5-Bromo-indan-(1E)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-[5-Bromo-indan-(1Z)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[5-Bromo-indan-(1Z)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[5-Bromo-indan-(1Z)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-[5-Chloro-indan-(1E)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[5-Chloro-indan-(1E)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[5-Chloro-indan-(1E)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-[5-Chloro-indan-(1Z)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[5-Chloro-indan-(1Z)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[5-Chloro-indan-(1Z)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-[5-Ethoxy-indan-(1E)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[5-Ethoxy-indan-(1E)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[5-Ethoxy-indan-(1E)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-[5-Ethoxy-indan-(1Z)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[5-Ethoxy-indan-(1Z)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[5-Ethoxy-indan-(1Z)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-[5-Methoxy-indan-(1E)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[5-Methoxy-indan-(1E)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[5-Methoxy-indan-(1E)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-[5-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[5-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[5-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-[6-Methoxy-indan-(1E)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[6-Methoxy-indan-(1E)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[6-Methoxy-indan-(1E)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-[6-Methyl-indan-(1E)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[6-Methyl-indan-(1E)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[6-Methyl-indan-(1E)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
3-[6-Methyl-indan-(1Z)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[6-Methyl-indan-(1Z)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[6-Methyl-indan-(1Z)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [74]
3-[7-Methoxy-indan-(1E)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 3-[7-Methoxy-indan-(1E)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-[7-Methoxy-indan-(1E)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
4'-(Pyridin-4-ylmethyl)biphenyl-3,4-diol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4'-(Pyridin-4-ylmethyl)biphenyl-3,4-diol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4'-(Pyridin-4-ylmethyl)biphenyl-3,4-diol through regulating the expression of Aromatase (CYP19A1). [53], [81]
4'-(Pyridin-4-ylmethyl)biphenyl-3-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4'-(Pyridin-4-ylmethyl)biphenyl-3-amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4'-(Pyridin-4-ylmethyl)biphenyl-3-amine through regulating the expression of Aromatase (CYP19A1). [53], [94]
4'-bromo-3-(imidazolylmethyl)-7-methoxyflavone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4'-bromo-3-(imidazolylmethyl)-7-methoxyflavone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4'-bromo-3-(imidazolylmethyl)-7-methoxyflavone through regulating the expression of Aromatase (CYP19A1). [53], [89]
4'-bromo-3-(imidazolylmethyl)flavone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4'-bromo-3-(imidazolylmethyl)flavone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4'-bromo-3-(imidazolylmethyl)flavone through regulating the expression of Aromatase (CYP19A1). [53], [89]
4'-cyano-3-(imidazolylmethyl)-7-methoxyflavone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4'-cyano-3-(imidazolylmethyl)-7-methoxyflavone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4'-cyano-3-(imidazolylmethyl)-7-methoxyflavone through regulating the expression of Aromatase (CYP19A1). [53], [89]
4'-cyano-3-(imidazolylmethyl)flavone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4'-cyano-3-(imidazolylmethyl)flavone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4'-cyano-3-(imidazolylmethyl)flavone through regulating the expression of Aromatase (CYP19A1). [53], [89]
4-((1H-imidazol-1-yl)methyl)-2H-chromen-2-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-((1H-imidazol-1-yl)methyl)-2H-chromen-2-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-((1H-imidazol-1-yl)methyl)-2H-chromen-2-one through regulating the expression of Aromatase (CYP19A1). [53], [71]
4-((1H-imidazol-1-yl)methyl)benzonitrile [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-((1H-imidazol-1-yl)methyl)benzonitrile. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-((1H-imidazol-1-yl)methyl)benzonitrile through regulating the expression of Aromatase (CYP19A1). [53], [71]
4-(1-Imidazol-1-yl-vinyl)-benzonitrile [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-(1-Imidazol-1-yl-vinyl)-benzonitrile. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(1-Imidazol-1-yl-vinyl)-benzonitrile through regulating the expression of Aromatase (CYP19A1). [53], [86]
4-(2,2-Diphenyl-vinyl)-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-(2,2-Diphenyl-vinyl)-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(2,2-Diphenyl-vinyl)-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
4-(2-(1H-imidazol-1-yl)ethoxy)-2H-chromen-2-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-(2-(1H-imidazol-1-yl)ethoxy)-2H-chromen-2-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(2-(1H-imidazol-1-yl)ethoxy)-2H-chromen-2-one through regulating the expression of Aromatase (CYP19A1). [53], [71]
4-(3,4,5-Trimethoxyphenethyl)aniline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-(3,4,5-Trimethoxyphenethyl)aniline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(3,4,5-Trimethoxyphenethyl)aniline through regulating the expression of Aromatase (CYP19A1). [53], [82]
4-(3,4-Dimethoxyphenethyl)aniline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-(3,4-Dimethoxyphenethyl)aniline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(3,4-Dimethoxyphenethyl)aniline through regulating the expression of Aromatase (CYP19A1). [53], [82]
4-(3,5-Dimethoxyphenethyl)benzenamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-(3,5-Dimethoxyphenethyl)benzenamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(3,5-Dimethoxyphenethyl)benzenamine through regulating the expression of Aromatase (CYP19A1). [53], [82]
4-ANDROSTENE-3-17-DIONE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-ANDROSTENE-3-17-DIONE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-ANDROSTENE-3-17-DIONE through regulating the expression of Aromatase (CYP19A1). [53], [88]
4-Bromo-1-imidazol-1-ylmethyl-xanthen-9-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-Bromo-1-imidazol-1-ylmethyl-xanthen-9-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Bromo-1-imidazol-1-ylmethyl-xanthen-9-one through regulating the expression of Aromatase (CYP19A1). [53], [88]
4-Fluoren-9-ylidenemethyl-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-Fluoren-9-ylidenemethyl-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Fluoren-9-ylidenemethyl-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
4-Imidazol-1-yl-2-phenyl-chroman-7-ol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-Imidazol-1-yl-2-phenyl-chroman-7-ol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Imidazol-1-yl-2-phenyl-chroman-7-ol through regulating the expression of Aromatase (CYP19A1). [53], [95]
4-Imidazol-1-ylmethyl-1-nitro-xanthen-9-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-Imidazol-1-ylmethyl-1-nitro-xanthen-9-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Imidazol-1-ylmethyl-1-nitro-xanthen-9-one through regulating the expression of Aromatase (CYP19A1). [53], [74]
4-Imidazol-1-ylmethyl-1-nitrothioxanthen-9-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-Imidazol-1-ylmethyl-1-nitrothioxanthen-9-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Imidazol-1-ylmethyl-1-nitrothioxanthen-9-one through regulating the expression of Aromatase (CYP19A1). [53], [72]
4-Imidazol-1-ylmethyl-2-nitroxanthen-9-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-Imidazol-1-ylmethyl-2-nitroxanthen-9-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Imidazol-1-ylmethyl-2-nitroxanthen-9-one through regulating the expression of Aromatase (CYP19A1). [53], [72]
4-Imidazol-1-ylmethyl-3-nitroxanthen-9-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-Imidazol-1-ylmethyl-3-nitroxanthen-9-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Imidazol-1-ylmethyl-3-nitroxanthen-9-one through regulating the expression of Aromatase (CYP19A1). [53], [72]
4-Imidazol-1-ylmethylthioxanthen-9-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-Imidazol-1-ylmethylthioxanthen-9-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Imidazol-1-ylmethylthioxanthen-9-one through regulating the expression of Aromatase (CYP19A1). [53], [72]
4-Imidazol-1-ylmethylxanthen-9-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-Imidazol-1-ylmethylxanthen-9-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Imidazol-1-ylmethylxanthen-9-one through regulating the expression of Aromatase (CYP19A1). [53], [72]
4-Indan-(1E)-ylidenemethyl-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-Indan-(1E)-ylidenemethyl-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Indan-(1E)-ylidenemethyl-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
4-Indan-(1Z)-ylidenemethyl-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-Indan-(1Z)-ylidenemethyl-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Indan-(1Z)-ylidenemethyl-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
4-[(3'-Hydroxybiphenyl-4-yl)methyl]pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-[(3'-Hydroxybiphenyl-4-yl)methyl]pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[(3'-Hydroxybiphenyl-4-yl)methyl]pyridine through regulating the expression of Aromatase (CYP19A1). [53], [81]
4-[(4'-Hydroxybiphenyl-4-yl)methyl]pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-[(4'-Hydroxybiphenyl-4-yl)methyl]pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[(4'-Hydroxybiphenyl-4-yl)methyl]pyridine through regulating the expression of Aromatase (CYP19A1). [53], [96]
4-[5-Bromo-indan-(1Z)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-[5-Bromo-indan-(1Z)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[5-Bromo-indan-(1Z)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [59]
4-[5-Chloro-indan-(1E)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-[5-Chloro-indan-(1E)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[5-Chloro-indan-(1E)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
4-[5-Chloro-indan-(1Z)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-[5-Chloro-indan-(1Z)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[5-Chloro-indan-(1Z)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
4-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
4-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
4-[5-Methoxy-indan-(1E)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-[5-Methoxy-indan-(1E)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[5-Methoxy-indan-(1E)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
4-[5-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-[5-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[5-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [74]
4-[6-Methoxy-indan-(1E)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-[6-Methoxy-indan-(1E)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[6-Methoxy-indan-(1E)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
4-[6-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-[6-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[6-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
4-[6-Methyl-indan-(1E)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-[6-Methyl-indan-(1E)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[6-Methyl-indan-(1E)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
4-[6-Methyl-indan-(1Z)-ylidenemethyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 4-[6-Methyl-indan-(1Z)-ylidenemethyl]-pyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[6-Methyl-indan-(1Z)-ylidenemethyl]-pyridine through regulating the expression of Aromatase (CYP19A1). [53], [88]
5-((1H-imidazol-1-yl)methyl)-7,8-dihydroquinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 5-((1H-imidazol-1-yl)methyl)-7,8-dihydroquinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-((1H-imidazol-1-yl)methyl)-7,8-dihydroquinoline through regulating the expression of Aromatase (CYP19A1). [53], [71]
5-(2-(1H-imidazol-1-yl)ethyl)quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 5-(2-(1H-imidazol-1-yl)ethyl)quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-(2-(1H-imidazol-1-yl)ethyl)quinoline through regulating the expression of Aromatase (CYP19A1). [53], [71]
5-Bromo-8-imidazol-1-ylmethyl-chromen-4-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 5-Bromo-8-imidazol-1-ylmethyl-chromen-4-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-Bromo-8-imidazol-1-ylmethyl-chromen-4-one through regulating the expression of Aromatase (CYP19A1). [53], [74]
5-Indan-(1E)-ylidenemethyl-1H-imidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 5-Indan-(1E)-ylidenemethyl-1H-imidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-Indan-(1E)-ylidenemethyl-1H-imidazole through regulating the expression of Aromatase (CYP19A1). [53], [92]
5-Indan-(1Z)-ylidenemethyl-1H-imidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 5-Indan-(1Z)-ylidenemethyl-1H-imidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-Indan-(1Z)-ylidenemethyl-1H-imidazole through regulating the expression of Aromatase (CYP19A1). [53], [92]
5-Pyridin-3-yl-1,3-dihydro-2H-indol-2-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 5-Pyridin-3-yl-1,3-dihydro-2H-indol-2-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-Pyridin-3-yl-1,3-dihydro-2H-indol-2-one through regulating the expression of Aromatase (CYP19A1). [53], [97]
5-Pyridin-3-yl-2,3-dihydro-1H-inden-1-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 5-Pyridin-3-yl-2,3-dihydro-1H-inden-1-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-Pyridin-3-yl-2,3-dihydro-1H-inden-1-one through regulating the expression of Aromatase (CYP19A1). [53], [77]
5-[5-Bromo-indan-(1E)-ylidenemethyl]-1H-imidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 5-[5-Bromo-indan-(1E)-ylidenemethyl]-1H-imidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-[5-Bromo-indan-(1E)-ylidenemethyl]-1H-imidazole through regulating the expression of Aromatase (CYP19A1). [53], [92]
5-[5-Bromo-indan-(1Z)-ylidenemethyl]-1H-imidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 5-[5-Bromo-indan-(1Z)-ylidenemethyl]-1H-imidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-[5-Bromo-indan-(1Z)-ylidenemethyl]-1H-imidazole through regulating the expression of Aromatase (CYP19A1). [53], [59]
5-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyrimidine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 5-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyrimidine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyrimidine through regulating the expression of Aromatase (CYP19A1). [53], [88]
5-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyrimidine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 5-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyrimidine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyrimidine through regulating the expression of Aromatase (CYP19A1). [53], [88]
5-[5-Methoxy-indan-(1E)-ylidenemethyl]-thiazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 5-[5-Methoxy-indan-(1E)-ylidenemethyl]-thiazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-[5-Methoxy-indan-(1E)-ylidenemethyl]-thiazole through regulating the expression of Aromatase (CYP19A1). [53], [88]
5-[5-Methoxy-indan-(1Z)-ylidenemethyl]-thiazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 5-[5-Methoxy-indan-(1Z)-ylidenemethyl]-thiazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-[5-Methoxy-indan-(1Z)-ylidenemethyl]-thiazole through regulating the expression of Aromatase (CYP19A1). [53], [88]
6-((1H-imidazol-1-yl)methyl)-2H-chromene-2-thione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 6-((1H-imidazol-1-yl)methyl)-2H-chromene-2-thione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-((1H-imidazol-1-yl)methyl)-2H-chromene-2-thione through regulating the expression of Aromatase (CYP19A1). [53], [71]
6-Imidazol-1-yl-isoquinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 6-Imidazol-1-yl-isoquinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-Imidazol-1-yl-isoquinoline through regulating the expression of Aromatase (CYP19A1). [53], [72]
7,4'-Dihydroxyflavone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 7,4'-Dihydroxyflavone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 7,4'-Dihydroxyflavone through regulating the expression of Aromatase (CYP19A1). [53], [59]
7-((1H-imidazol-1-yl)methyl)-2H-chromen-2-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 7-((1H-imidazol-1-yl)methyl)-2H-chromen-2-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 7-((1H-imidazol-1-yl)methyl)-2H-chromen-2-one through regulating the expression of Aromatase (CYP19A1). [53], [98]
7-((1H-imidazol-1-yl)methyl)-4H-chromen-4-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 7-((1H-imidazol-1-yl)methyl)-4H-chromen-4-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 7-((1H-imidazol-1-yl)methyl)-4H-chromen-4-one through regulating the expression of Aromatase (CYP19A1). [53], [74]
7-((1H-imidazol-1-yl)methyl)isoquinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 7-((1H-imidazol-1-yl)methyl)isoquinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 7-((1H-imidazol-1-yl)methyl)isoquinoline through regulating the expression of Aromatase (CYP19A1). [53], [71]
7-(2-(1H-imidazol-1-yl)ethoxy)-2H-chromen-2-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 7-(2-(1H-imidazol-1-yl)ethoxy)-2H-chromen-2-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 7-(2-(1H-imidazol-1-yl)ethoxy)-2H-chromen-2-one through regulating the expression of Aromatase (CYP19A1). [53], [71]
7-hydroxy-2-(3-hydroxyphenyl)chroman-4-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 7-hydroxy-2-(3-hydroxyphenyl)chroman-4-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 7-hydroxy-2-(3-hydroxyphenyl)chroman-4-one through regulating the expression of Aromatase (CYP19A1). [53], [83]
7-hydroxy-2-phenylchroman-4-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 7-hydroxy-2-phenylchroman-4-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 7-hydroxy-2-phenylchroman-4-one through regulating the expression of Aromatase (CYP19A1). [53], [75]
7-[1,2,4]Triazol-4-ylmethyl-chromen-4-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 7-[1,2,4]Triazol-4-ylmethyl-chromen-4-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 7-[1,2,4]Triazol-4-ylmethyl-chromen-4-one through regulating the expression of Aromatase (CYP19A1). [53], [75]
8-Imidazol-1-ylmethyl-5-nitro-chromen-4-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 8-Imidazol-1-ylmethyl-5-nitro-chromen-4-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 8-Imidazol-1-ylmethyl-5-nitro-chromen-4-one through regulating the expression of Aromatase (CYP19A1). [53], [59]
9-Hydroxy-7,8-benzoflavone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for 9-Hydroxy-7,8-benzoflavone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 9-Hydroxy-7,8-benzoflavone through regulating the expression of Aromatase (CYP19A1). [53], [59]
ALBANOL A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for ALBANOL A. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ALBANOL A through regulating the expression of Aromatase (CYP19A1). [53], [69]
ALPHA-NAPHTHOFLAVONE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for ALPHA-NAPHTHOFLAVONE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ALPHA-NAPHTHOFLAVONE through regulating the expression of Aromatase (CYP19A1). [53], [80]
ANDROSTENEDONE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for ANDROSTENEDONE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ANDROSTENEDONE through regulating the expression of Aromatase (CYP19A1). [53], [90]
APIGENIN [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for APIGENIN. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of APIGENIN through regulating the expression of Aromatase (CYP19A1). [53], [59]
Benzyl-biphenyl-4-ylmethyl-imidazol-1-yl-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for Benzyl-biphenyl-4-ylmethyl-imidazol-1-yl-amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Benzyl-biphenyl-4-ylmethyl-imidazol-1-yl-amine through regulating the expression of Aromatase (CYP19A1). [53], [82]
biochanin A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for biochanin A. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of biochanin A through regulating the expression of Aromatase (CYP19A1). [53], [88]
Broussoflavonol F [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for Broussoflavonol F. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Broussoflavonol F through regulating the expression of Aromatase (CYP19A1). [53], [69]
CGS-18320B [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for CGS-18320B. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CGS-18320B through regulating the expression of Aromatase (CYP19A1). [53], [99]
Chrysin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for Chrysin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Chrysin through regulating the expression of Aromatase (CYP19A1). [53], [88]
DEHYDROLEUCODIN [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for DEHYDROLEUCODIN. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of DEHYDROLEUCODIN through regulating the expression of Aromatase (CYP19A1). [53], [59]
Docosapentaenoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for Docosapentaenoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Docosapentaenoic acid through regulating the expression of Aromatase (CYP19A1). [53], [100]
flavone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for flavone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of flavone through regulating the expression of Aromatase (CYP19A1). [53], [74]
Gamma-mangostin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for Gamma-mangostin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Gamma-mangostin through regulating the expression of Aromatase (CYP19A1). [53], [59]
GARCINONE D [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for GARCINONE D. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GARCINONE D through regulating the expression of Aromatase (CYP19A1). [53], [97]
GOSSYPETIN [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for GOSSYPETIN. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GOSSYPETIN through regulating the expression of Aromatase (CYP19A1). [53], [70]
Isogemichalcone C [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for Isogemichalcone C. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Isogemichalcone C through regulating the expression of Aromatase (CYP19A1). [53], [85]
ISOLICOFLAVONOL [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for ISOLICOFLAVONOL. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISOLICOFLAVONOL through regulating the expression of Aromatase (CYP19A1). [53], [69]
LIQUIRTIGENIN [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for LIQUIRTIGENIN. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LIQUIRTIGENIN through regulating the expression of Aromatase (CYP19A1). [53], [83]
LUDARTIN [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for LUDARTIN. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LUDARTIN through regulating the expression of Aromatase (CYP19A1). [53], [59]
MDL-18962 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for MDL-18962. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MDL-18962 through regulating the expression of Aromatase (CYP19A1). [53], [101]
MONODICTYOCHROMONE B [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for MONODICTYOCHROMONE B. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MONODICTYOCHROMONE B through regulating the expression of Aromatase (CYP19A1). [53], [72]
MORACHALCONE A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for MORACHALCONE A. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MORACHALCONE A through regulating the expression of Aromatase (CYP19A1). [53], [69]
MR-16089 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for MR-16089. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MR-16089 through regulating the expression of Aromatase (CYP19A1). [53], [59]
MR-20492 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for MR-20492. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MR-20492 through regulating the expression of Aromatase (CYP19A1). [53], [91]
MR-20494 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for MR-20494. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MR-20494 through regulating the expression of Aromatase (CYP19A1). [53], [59]
MR-20496 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for MR-20496. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MR-20496 through regulating the expression of Aromatase (CYP19A1). [53], [73]
MR-20814 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for MR-20814. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MR-20814 through regulating the expression of Aromatase (CYP19A1). [53], [83]
N-(2-benzyloxy-4-nitrophenyl)methanesulfonamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for N-(2-benzyloxy-4-nitrophenyl)methanesulfonamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(2-benzyloxy-4-nitrophenyl)methanesulfonamide through regulating the expression of Aromatase (CYP19A1). [53], [87]
N-(2-hexyloxy-4-nitrophenyl)methanesulfonamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for N-(2-hexyloxy-4-nitrophenyl)methanesulfonamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(2-hexyloxy-4-nitrophenyl)methanesulfonamide through regulating the expression of Aromatase (CYP19A1). [53], [76]
N-(2-nonyloxy-4-nitrophenyl)methanesulfonamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for N-(2-nonyloxy-4-nitrophenyl)methanesulfonamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(2-nonyloxy-4-nitrophenyl)methanesulfonamide through regulating the expression of Aromatase (CYP19A1). [53], [76]
N-(2-Propyloxy-4-nitrophenyl)methanesulfonamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for N-(2-Propyloxy-4-nitrophenyl)methanesulfonamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(2-Propyloxy-4-nitrophenyl)methanesulfonamide through regulating the expression of Aromatase (CYP19A1). [53], [102]
N-[2-(4'-Nitrophenyl)ethyl]-imidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for N-[2-(4'-Nitrophenyl)ethyl]-imidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-[2-(4'-Nitrophenyl)ethyl]-imidazole through regulating the expression of Aromatase (CYP19A1). [53], [59]
NSC-122427 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for NSC-122427. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NSC-122427 through regulating the expression of Aromatase (CYP19A1). [53], [84]
NSC-12999 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for NSC-12999. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NSC-12999 through regulating the expression of Aromatase (CYP19A1). [53], [71]
NSC-131736 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for NSC-131736. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NSC-131736 through regulating the expression of Aromatase (CYP19A1). [53], [71]
NSC-289311 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for NSC-289311. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NSC-289311 through regulating the expression of Aromatase (CYP19A1). [53], [71]
NSC-356483 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for NSC-356483. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NSC-356483 through regulating the expression of Aromatase (CYP19A1). [53], [71]
NSC-356781 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for NSC-356781. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NSC-356781 through regulating the expression of Aromatase (CYP19A1). [53], [71]
NSC-368272 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for NSC-368272. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NSC-368272 through regulating the expression of Aromatase (CYP19A1). [53], [71]
NSC-368280 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for NSC-368280. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NSC-368280 through regulating the expression of Aromatase (CYP19A1). [53], [71]
NSC-369087 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for NSC-369087. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NSC-369087 through regulating the expression of Aromatase (CYP19A1). [53], [81]
NSC-613604 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for NSC-613604. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NSC-613604 through regulating the expression of Aromatase (CYP19A1). [53], [84]
NSC-625409 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for NSC-625409. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NSC-625409 through regulating the expression of Aromatase (CYP19A1). [53], [71]
NSC-666292 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for NSC-666292. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NSC-666292 through regulating the expression of Aromatase (CYP19A1). [53], [71]
NSC-683634 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for NSC-683634. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NSC-683634 through regulating the expression of Aromatase (CYP19A1). [53], [71]
NSC-75308 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for NSC-75308. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NSC-75308 through regulating the expression of Aromatase (CYP19A1). [53], [71]
NSC-93358 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for NSC-93358. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NSC-93358 through regulating the expression of Aromatase (CYP19A1). [53], [67]
NSC-94258 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for NSC-94258. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NSC-94258 through regulating the expression of Aromatase (CYP19A1). [53], [69]
NSC-94891 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for NSC-94891. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NSC-94891 through regulating the expression of Aromatase (CYP19A1). [53], [84]
Org-33201 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for Org-33201. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Org-33201 through regulating the expression of Aromatase (CYP19A1). [53], [103]
FINROZOLE [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for FINROZOLE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of FINROZOLE through regulating the expression of Aromatase (CYP19A1). [53], [104]
FORMESTANE [Withdrawn from market]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for FORMESTANE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of FORMESTANE through regulating the expression of Aromatase (CYP19A1). [53], [105]
MINAMESTANE [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for MINAMESTANE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MINAMESTANE through regulating the expression of Aromatase (CYP19A1). [53], [106]
NKS-01 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for NKS-01. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NKS-01 through regulating the expression of Aromatase (CYP19A1). [53], [107]
Rogletimide [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for Rogletimide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Rogletimide through regulating the expression of Aromatase (CYP19A1). [53], [108]
VOROZOLE [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for VOROZOLE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of VOROZOLE through regulating the expression of Aromatase (CYP19A1). [53], [109]
YM-511 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Aromatase (CYP19A1) is a therapeutic target for YM-511. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of YM-511 through regulating the expression of Aromatase (CYP19A1). [53], [110]
Beta-catenin (CTNNB1)
Recombinant human endostatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Beta-catenin (CTNNB1) is a therapeutic target for Recombinant human endostatin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Recombinant human endostatin through regulating the expression of Beta-catenin (CTNNB1). [111], [112]
C 82 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Beta-catenin (CTNNB1) is a therapeutic target for C 82. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C 82 through regulating the expression of Beta-catenin (CTNNB1). [111], [113]
CEQ-508 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Beta-catenin (CTNNB1) is a therapeutic target for CEQ-508. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CEQ-508 through regulating the expression of Beta-catenin (CTNNB1). [111], [114]
C-X-C chemokine receptor type 4 (CXCR4)
Plerixafor [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Plerixafor. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Plerixafor through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [116]
AMD-070 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for AMD-070. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AMD-070 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [117]
Balixafortide [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Balixafortide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Balixafortide through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [28], [115]
BL-8040 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for BL-8040. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BL-8040 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [118]
Ulocuplumab [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Ulocuplumab. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ulocuplumab through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [119]
CTCE-9908 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for CTCE-9908. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CTCE-9908 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [38], [115]
POL-6326 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for POL-6326. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of POL-6326 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [120]
TG-0054 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for TG-0054. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TG-0054 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [121]
USL311 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for USL311. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of USL311 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [122]
ALX-0651 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for ALX-0651. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ALX-0651 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [123]
BMS-936564 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for BMS-936564. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BMS-936564 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [118]
CTCE-0214 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for CTCE-0214. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CTCE-0214 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [124]
GMI-1359 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for GMI-1359. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GMI-1359 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [125]
LY2624587 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for LY2624587. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LY2624587 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [126]
MSX-122 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for MSX-122. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MSX-122 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [127]
PF-06747143 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for PF-06747143. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PF-06747143 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [128]
MAb173 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for MAb173. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MAb173 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [129]
AT-009 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for AT-009. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AT-009 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [130]
ATI-2341 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for ATI-2341. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ATI-2341 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [130]
CTCE-0324 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for CTCE-0324. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CTCE-0324 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [131]
CX-02 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for CX-02. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CX-02 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [130]
CXCL8 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for CXCL8. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CXCL8 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [132]
CXCR4 gene disrupted T cells [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for CXCR4 gene disrupted T cells. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CXCR4 gene disrupted T cells through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [130]
Cyclo(-D-Ala-D-Arg-L-Arg-L-Nal-Gly-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Ala-D-Arg-L-Arg-L-Nal-Gly-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Ala-D-Arg-L-Arg-L-Nal-Gly-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
Cyclo(-D-MeTyr-D-Arg-L-Arg-L-Nal-Gly-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-MeTyr-D-Arg-L-Arg-L-Nal-Gly-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-MeTyr-D-Arg-L-Arg-L-Nal-Gly-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
Cyclo(-D-MeTyr-L-Arg-L-Arg-L-Nal-Gly-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-MeTyr-L-Arg-L-Arg-L-Nal-Gly-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-MeTyr-L-Arg-L-Arg-L-Nal-Gly-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
Cyclo(-D-Tyr-Arg-Arg-Nal-Gly-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-Arg-Arg-Nal-Gly-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Tyr-Arg-Arg-Nal-Gly-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [134]
Cyclo(-D-Tyr-D-Ala-L-Arg-L-Nal-Gly-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-D-Ala-L-Arg-L-Nal-Gly-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Tyr-D-Ala-L-Arg-L-Nal-Gly-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
Cyclo(-D-Tyr-D-Arg-L-Arg-L-MeNal-Gly-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-D-Arg-L-Arg-L-MeNal-Gly-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Tyr-D-Arg-L-Arg-L-MeNal-Gly-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-beta-Ala-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-beta-Ala-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-beta-Ala-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-D-Ala-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-D-Ala-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-D-Ala-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-Gly-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-Gly-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-Gly-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [135]
Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-L-Ala-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-L-Ala-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-L-Ala-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-L-Pic-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-L-Pic-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-L-Pic-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-Sar-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-Sar-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-Sar-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
Cyclo(-D-Tyr-D-Arg-L-MeArg-L-Nal-Gly-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-D-Arg-L-MeArg-L-Nal-Gly-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Tyr-D-Arg-L-MeArg-L-Nal-Gly-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
Cyclo(-D-Tyr-D-MeArg-L-Arg-L-Nal-Gly-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-D-MeArg-L-Arg-L-Nal-Gly-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Tyr-D-MeArg-L-Arg-L-Nal-Gly-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
Cyclo(-D-Tyr-L-Ala-L-Arg-L-Nal-Gly-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-L-Ala-L-Arg-L-Nal-Gly-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Tyr-L-Ala-L-Arg-L-Nal-Gly-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
Cyclo(-D-Tyr-L-Arg-L-Arg-L-Ala-Sar-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-L-Arg-L-Arg-L-Ala-Sar-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Tyr-L-Arg-L-Arg-L-Ala-Sar-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
Cyclo(-D-Tyr-L-Arg-L-Arg-L-MeNal-Gly-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-L-Arg-L-Arg-L-MeNal-Gly-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Tyr-L-Arg-L-Arg-L-MeNal-Gly-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
Cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-beta-Ala-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-beta-Ala-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-beta-Ala-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
Cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-D-Ala-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-D-Ala-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-D-Ala-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
Cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-Gly-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-Gly-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-Gly-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
Cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-L-Ala-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-L-Ala-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-L-Ala-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
Cyclo(-D-Tyr-L-Arg-L-MeArg-L-Nal-Gly-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-L-Arg-L-MeArg-L-Nal-Gly-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Tyr-L-Arg-L-MeArg-L-Nal-Gly-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
Cyclo(-D-Tyr-L-MeArg-L-Arg-L-Nal-Gly-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-L-MeArg-L-Arg-L-Nal-Gly-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Tyr-L-MeArg-L-Arg-L-Nal-Gly-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
GSK-812397 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for GSK-812397. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GSK-812397 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [130]
isothiourea-1a [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for isothiourea-1a. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of isothiourea-1a through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [131]
isothiourea-1t [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for isothiourea-1t. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of isothiourea-1t through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [136]
KUR-CXCR4 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for KUR-CXCR4. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of KUR-CXCR4 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [130]
LP-0067 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for LP-0067. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LP-0067 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [130]
NB-325 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for NB-325. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NB-325 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [130]
ND-401 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for ND-401. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ND-401 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [130]
T134 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for T134. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of T134 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [136]
T140 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for T140. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of T140 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [136]
T22 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for T22. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of T22 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [137]
TN-14003 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for TN-14003. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TN-14003 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [133]
viral macrophage inflammatory protein-II [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for viral macrophage inflammatory protein-II. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of viral macrophage inflammatory protein-II through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [138]
Garnocestim [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Garnocestim. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Garnocestim through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [139]
KRH-2731 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for KRH-2731. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of KRH-2731 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [140]
SURADISTA [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for SURADISTA. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SURADISTA through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [115], [141]
cAMP-dependent protein kinase A type I (PRKAR1A)
5-(2-methylpiperazin-1-ylsulfonyl)isoquinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary cAMP-dependent protein kinase A type I (PRKAR1A) is a therapeutic target for 5-(2-methylpiperazin-1-ylsulfonyl)isoquinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-(2-methylpiperazin-1-ylsulfonyl)isoquinoline through regulating the expression of cAMP-dependent protein kinase A type I (PRKAR1A). [142], [143]
AdcAhxArg4Lys(biotin)-PEG-OMe [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary cAMP-dependent protein kinase A type I (PRKAR1A) is a therapeutic target for AdcAhxArg4Lys(biotin)-PEG-OMe. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AdcAhxArg4Lys(biotin)-PEG-OMe through regulating the expression of cAMP-dependent protein kinase A type I (PRKAR1A). [142], [144]
AdcAhxArg4Lys-PEGOMe [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary cAMP-dependent protein kinase A type I (PRKAR1A) is a therapeutic target for AdcAhxArg4Lys-PEGOMe. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AdcAhxArg4Lys-PEGOMe through regulating the expression of cAMP-dependent protein kinase A type I (PRKAR1A). [142], [145]
AdcAhxArg4NH(CH2)6NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary cAMP-dependent protein kinase A type I (PRKAR1A) is a therapeutic target for AdcAhxArg4NH(CH2)6NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AdcAhxArg4NH(CH2)6NH2 through regulating the expression of cAMP-dependent protein kinase A type I (PRKAR1A). [142], [144]
AdcAhxArg6 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary cAMP-dependent protein kinase A type I (PRKAR1A) is a therapeutic target for AdcAhxArg6. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AdcAhxArg6 through regulating the expression of cAMP-dependent protein kinase A type I (PRKAR1A). [142], [144]
AdoC(Ahx)Arg6 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary cAMP-dependent protein kinase A type I (PRKAR1A) is a therapeutic target for AdoC(Ahx)Arg6. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AdoC(Ahx)Arg6 through regulating the expression of cAMP-dependent protein kinase A type I (PRKAR1A). [142], [145]
AdoC(Aoc)Arg6 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary cAMP-dependent protein kinase A type I (PRKAR1A) is a therapeutic target for AdoC(Aoc)Arg6. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AdoC(Aoc)Arg6 through regulating the expression of cAMP-dependent protein kinase A type I (PRKAR1A). [142], [145]
AdoC(Aun)Arg6 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary cAMP-dependent protein kinase A type I (PRKAR1A) is a therapeutic target for AdoC(Aun)Arg6. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AdoC(Aun)Arg6 through regulating the expression of cAMP-dependent protein kinase A type I (PRKAR1A). [142], [145]
AdoC(beta-Ala)2AlaArg6 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary cAMP-dependent protein kinase A type I (PRKAR1A) is a therapeutic target for AdoC(beta-Ala)2AlaArg6. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AdoC(beta-Ala)2AlaArg6 through regulating the expression of cAMP-dependent protein kinase A type I (PRKAR1A). [142], [146]
AdoC(beta-Ala)Arg6 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary cAMP-dependent protein kinase A type I (PRKAR1A) is a therapeutic target for AdoC(beta-Ala)Arg6. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AdoC(beta-Ala)Arg6 through regulating the expression of cAMP-dependent protein kinase A type I (PRKAR1A). [142], [145]
AdoC(betaAsp)2AlaArg6 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary cAMP-dependent protein kinase A type I (PRKAR1A) is a therapeutic target for AdoC(betaAsp)2AlaArg6. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AdoC(betaAsp)2AlaArg6 through regulating the expression of cAMP-dependent protein kinase A type I (PRKAR1A). [142], [145]
AdoC(Dpr)2AlaArg6 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary cAMP-dependent protein kinase A type I (PRKAR1A) is a therapeutic target for AdoC(Dpr)2AlaArg6. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AdoC(Dpr)2AlaArg6 through regulating the expression of cAMP-dependent protein kinase A type I (PRKAR1A). [142], [145]
AdoC(GABA)Arg6 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary cAMP-dependent protein kinase A type I (PRKAR1A) is a therapeutic target for AdoC(GABA)Arg6. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AdoC(GABA)Arg6 through regulating the expression of cAMP-dependent protein kinase A type I (PRKAR1A). [142], [145]
AdoCGlyArg6 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary cAMP-dependent protein kinase A type I (PRKAR1A) is a therapeutic target for AdoCGlyArg6. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AdoCGlyArg6 through regulating the expression of cAMP-dependent protein kinase A type I (PRKAR1A). [142], [145]
Cyclic Guanosine Monophosphate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary cAMP-dependent protein kinase A type I (PRKAR1A) is a therapeutic target for Cyclic Guanosine Monophosphate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclic Guanosine Monophosphate through regulating the expression of cAMP-dependent protein kinase A type I (PRKAR1A). [142], [147]
RO-316233 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary cAMP-dependent protein kinase A type I (PRKAR1A) is a therapeutic target for RO-316233. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RO-316233 through regulating the expression of cAMP-dependent protein kinase A type I (PRKAR1A). [142], [144]
Sp-Adenosine-3',5'-Cyclic-Monophosphorothioate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary cAMP-dependent protein kinase A type I (PRKAR1A) is a therapeutic target for Sp-Adenosine-3',5'-Cyclic-Monophosphorothioate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Sp-Adenosine-3',5'-Cyclic-Monophosphorothioate through regulating the expression of cAMP-dependent protein kinase A type I (PRKAR1A). [142], [148]
[3H]cAMP [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary cAMP-dependent protein kinase A type I (PRKAR1A) is a therapeutic target for [3H]cAMP. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of [3H]cAMP through regulating the expression of cAMP-dependent protein kinase A type I (PRKAR1A). [142], [148]
Cathepsin B (CTSB)
CA-074Me [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for CA-074Me. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CA-074Me through regulating the expression of Cathepsin B (CTSB). [149], [150]
L-006235-1 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for L-006235-1. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-006235-1 through regulating the expression of Cathepsin B (CTSB). [149], [151]
SD1002 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for SD1002. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SD1002 through regulating the expression of Cathepsin B (CTSB). [149], [150]
SD1003 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for SD1003. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SD1003 through regulating the expression of Cathepsin B (CTSB). [149], [150]
Z-Phe-Ala-diazomethylketone [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for Z-Phe-Ala-diazomethylketone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Z-Phe-Ala-diazomethylketone through regulating the expression of Cathepsin B (CTSB). [149], [152]
(S)-1-benzylcyclopentyl 1-oxohexan-2-ylcarbamate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for (S)-1-benzylcyclopentyl 1-oxohexan-2-ylcarbamate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (S)-1-benzylcyclopentyl 1-oxohexan-2-ylcarbamate through regulating the expression of Cathepsin B (CTSB). [149], [153]
1-(phenyl(p-tolyl)methylene)thiosemicarbazide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for 1-(phenyl(p-tolyl)methylene)thiosemicarbazide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-(phenyl(p-tolyl)methylene)thiosemicarbazide through regulating the expression of Cathepsin B (CTSB). [149], [154]
2-Aminoethanimidic Acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for 2-Aminoethanimidic Acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-Aminoethanimidic Acid through regulating the expression of Cathepsin B (CTSB). [148], [149]
2-Pyridinethiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for 2-Pyridinethiol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-Pyridinethiol through regulating the expression of Cathepsin B (CTSB). [148], [149]
3-Amino-4-Oxybenzyl-2-Butanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for 3-Amino-4-Oxybenzyl-2-Butanone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Amino-4-Oxybenzyl-2-Butanone through regulating the expression of Cathepsin B (CTSB). [148], [149]
3-Methylphenylalanine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for 3-Methylphenylalanine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Methylphenylalanine through regulating the expression of Cathepsin B (CTSB). [149], [155]
Ac-hPhe-Leu-Ala-LeuVSMe [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for Ac-hPhe-Leu-Ala-LeuVSMe. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-hPhe-Leu-Ala-LeuVSMe through regulating the expression of Cathepsin B (CTSB). [149], [156]
Ac-hPhe-Leu-Phe-LeuVSMe [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for Ac-hPhe-Leu-Phe-LeuVSMe. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-hPhe-Leu-Phe-LeuVSMe through regulating the expression of Cathepsin B (CTSB). [149], [153]
Bis(3-bromophenyl)(4-hydroxy)thiosemicarbazone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for Bis(3-bromophenyl)(4-hydroxy)thiosemicarbazone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Bis(3-bromophenyl)(4-hydroxy)thiosemicarbazone through regulating the expression of Cathepsin B (CTSB). [149], [157]
Cbz-Ile-Leu-Ala-LeuVSMe [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for Cbz-Ile-Leu-Ala-LeuVSMe. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cbz-Ile-Leu-Ala-LeuVSMe through regulating the expression of Cathepsin B (CTSB). [149], [153]
Cbz-Ile-t-ButylhomoGlu-Ala-LeuVSMe [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for Cbz-Ile-t-ButylhomoGlu-Ala-LeuVSMe. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cbz-Ile-t-ButylhomoGlu-Ala-LeuVSMe through regulating the expression of Cathepsin B (CTSB). [149], [153]
Diphenylacetic Acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for Diphenylacetic Acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Diphenylacetic Acid through regulating the expression of Cathepsin B (CTSB). [149], [158]
GNF-PF-5434 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for GNF-PF-5434. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GNF-PF-5434 through regulating the expression of Cathepsin B (CTSB). [149], [159]
Gold trichloride sodium chloride [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for Gold trichloride sodium chloride. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Gold trichloride sodium chloride through regulating the expression of Cathepsin B (CTSB). [149], [160]
L-873724 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for L-873724. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-873724 through regulating the expression of Cathepsin B (CTSB). [149], [161]
PTosyl-Glu(OtBu)-Ala-LeuVSMe [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for PTosyl-Glu(OtBu)-Ala-LeuVSMe. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PTosyl-Glu(OtBu)-Ala-LeuVSMe through regulating the expression of Cathepsin B (CTSB). [149], [153]
Z-Ala-Leu-His-Agly-Ile-Val-OMe [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for Z-Ala-Leu-His-Agly-Ile-Val-OMe. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Z-Ala-Leu-His-Agly-Ile-Val-OMe through regulating the expression of Cathepsin B (CTSB). [149], [160]
Z-Ala-Leu-lle-Agly-Ile-Val-NHBzl [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for Z-Ala-Leu-lle-Agly-Ile-Val-NHBzl. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Z-Ala-Leu-lle-Agly-Ile-Val-NHBzl through regulating the expression of Cathepsin B (CTSB). [149], [160]
Z-Ala-Leu-lle-Agly-Ile-Val-OMe [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for Z-Ala-Leu-lle-Agly-Ile-Val-OMe. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Z-Ala-Leu-lle-Agly-Ile-Val-OMe through regulating the expression of Cathepsin B (CTSB). [149], [160]
Z-Ala-Leu-Nal-Agly-Ile-Val-OMe [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for Z-Ala-Leu-Nal-Agly-Ile-Val-OMe. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Z-Ala-Leu-Nal-Agly-Ile-Val-OMe through regulating the expression of Cathepsin B (CTSB). [149], [160]
Z-Ala-Leu-Phe-Agly-Ile-Val-OMe [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for Z-Ala-Leu-Phe-Agly-Ile-Val-OMe. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Z-Ala-Leu-Phe-Agly-Ile-Val-OMe through regulating the expression of Cathepsin B (CTSB). [149], [160]
Z-Ala-Leu-Tyr(Me)-Agly-Ile-Val-OMe [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for Z-Ala-Leu-Tyr(Me)-Agly-Ile-Val-OMe. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Z-Ala-Leu-Tyr(Me)-Agly-Ile-Val-OMe through regulating the expression of Cathepsin B (CTSB). [149], [160]
Z-Arg-Leu-Val-Agly-Ala-Gly-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for Z-Arg-Leu-Val-Agly-Ala-Gly-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Z-Arg-Leu-Val-Agly-Ala-Gly-NH2 through regulating the expression of Cathepsin B (CTSB). [149], [160]
Z-Arg-Leu-Val-Agly-Ile-Val-OMe [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for Z-Arg-Leu-Val-Agly-Ile-Val-OMe. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Z-Arg-Leu-Val-Agly-Ile-Val-OMe through regulating the expression of Cathepsin B (CTSB). [148], [149]
Z-Arg-Leu-Val-Agly-Ile-Val-Trp-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for Z-Arg-Leu-Val-Agly-Ile-Val-Trp-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Z-Arg-Leu-Val-Agly-Ile-Val-Trp-NH2 through regulating the expression of Cathepsin B (CTSB). [149], [160]
Z-Arg-Leu-Val-Agly-Ileu-Val-OMe [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for Z-Arg-Leu-Val-Agly-Ileu-Val-OMe. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Z-Arg-Leu-Val-Agly-Ileu-Val-OMe through regulating the expression of Cathepsin B (CTSB). [149], [160]
Z-Arg-Leu-Val-Agly-Trp-Val-Ala-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for Z-Arg-Leu-Val-Agly-Trp-Val-Ala-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Z-Arg-Leu-Val-Agly-Trp-Val-Ala-NH2 through regulating the expression of Cathepsin B (CTSB). [149], [160]
Z-Arg-Leu-Val-Agly-Val-Ala-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for Z-Arg-Leu-Val-Agly-Val-Ala-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Z-Arg-Leu-Val-Agly-Val-Ala-NH2 through regulating the expression of Cathepsin B (CTSB). [149], [162]
Z-leu-Val-Agly-Val-OBzl [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for Z-leu-Val-Agly-Val-OBzl. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Z-leu-Val-Agly-Val-OBzl through regulating the expression of Cathepsin B (CTSB). [149], [160]
[(3-Bromophenyl)-p-tolyl-ketone]thiosemicarbazone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cathepsin B (CTSB) is a therapeutic target for [(3-Bromophenyl)-p-tolyl-ketone]thiosemicarbazone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of [(3-Bromophenyl)-p-tolyl-ketone]thiosemicarbazone through regulating the expression of Cathepsin B (CTSB). [149], [163]
CEBPA messenger RNA (CEBPA mRNA)
MTL-CEPBA [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary CEBPA messenger RNA (CEBPA mRNA) is a therapeutic target for MTL-CEPBA. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MTL-CEPBA through regulating the expression of CEBPA messenger RNA (CEBPA mRNA). [24], [164]
Cellular tumor antigen p53 (TP53)
Contusugene ladenovec [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for Contusugene ladenovec. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Contusugene ladenovec through regulating the expression of Cellular tumor antigen p53 (TP53). [165], [166]
QPI-1002 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for QPI-1002. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of QPI-1002 through regulating the expression of Cellular tumor antigen p53 (TP53). [165], [167]
Thymoquinone [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for Thymoquinone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Thymoquinone through regulating the expression of Cellular tumor antigen p53 (TP53). [165], [168]
Ad-p53 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for Ad-p53. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ad-p53 through regulating the expression of Cellular tumor antigen p53 (TP53). [165], [169]
ALT-801 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for ALT-801. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ALT-801 through regulating the expression of Cellular tumor antigen p53 (TP53). [165], [170]
APG-115 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for APG-115. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of APG-115 through regulating the expression of Cellular tumor antigen p53 (TP53). [165], [171]
APR-246 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for APR-246. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of APR-246 through regulating the expression of Cellular tumor antigen p53 (TP53). [78], [165]
Cenersen [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for Cenersen. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cenersen through regulating the expression of Cellular tumor antigen p53 (TP53). [165], [172]
INGN-225 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for INGN-225. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of INGN-225 through regulating the expression of Cellular tumor antigen p53 (TP53). [38], [165]
ISA-P53-01 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for ISA-P53-01. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISA-P53-01 through regulating the expression of Cellular tumor antigen p53 (TP53). [165], [173]
Kevetrin [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for Kevetrin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Kevetrin through regulating the expression of Cellular tumor antigen p53 (TP53). [22], [165]
OPI-1002 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for OPI-1002. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of OPI-1002 through regulating the expression of Cellular tumor antigen p53 (TP53). [165], [174]
SGT-53 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for SGT-53. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SGT-53 through regulating the expression of Cellular tumor antigen p53 (TP53). [38], [165]
CGM097 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for CGM097. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CGM097 through regulating the expression of Cellular tumor antigen p53 (TP53). [38], [165]
COTI-2 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for COTI-2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of COTI-2 through regulating the expression of Cellular tumor antigen p53 (TP53). [165], [175]
Dendritic cell vaccine [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for Dendritic cell vaccine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Dendritic cell vaccine through regulating the expression of Cellular tumor antigen p53 (TP53). [165], [176]
HDM201 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for HDM201. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of HDM201 through regulating the expression of Cellular tumor antigen p53 (TP53). [165], [177]
ONYX-015 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for ONYX-015. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ONYX-015 through regulating the expression of Cellular tumor antigen p53 (TP53). [165], [178]
SAR-405838 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for SAR-405838. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SAR-405838 through regulating the expression of Cellular tumor antigen p53 (TP53). [165], [166]
1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine through regulating the expression of Cellular tumor antigen p53 (TP53). [165], [179]
AHL [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for AHL. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AHL through regulating the expression of Cellular tumor antigen p53 (TP53). [165], [180]
NU-8231 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for NU-8231. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NU-8231 through regulating the expression of Cellular tumor antigen p53 (TP53). [165], [181]
NUTLIN-3 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for NUTLIN-3. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NUTLIN-3 through regulating the expression of Cellular tumor antigen p53 (TP53). [165], [182]
INGN-234 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for INGN-234. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of INGN-234 through regulating the expression of Cellular tumor antigen p53 (TP53). [165], [183]
Pifithrin-alpha [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for Pifithrin-alpha. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Pifithrin-alpha through regulating the expression of Cellular tumor antigen p53 (TP53). [165], [184]
TAR-1 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for TAR-1. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TAR-1 through regulating the expression of Cellular tumor antigen p53 (TP53). [165], [185]
Cyclin A2 (CCNA2)
2,5-dichloro-N-p-tolylthiophene-3-sulfonamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin A2 (CCNA2) is a therapeutic target for 2,5-dichloro-N-p-tolylthiophene-3-sulfonamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2,5-dichloro-N-p-tolylthiophene-3-sulfonamide through regulating the expression of Cyclin A2 (CCNA2). [186], [187]
4-(phenyldiazenyl)-1H-pyrazole-3,5-diamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin A2 (CCNA2) is a therapeutic target for 4-(phenyldiazenyl)-1H-pyrazole-3,5-diamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(phenyldiazenyl)-1H-pyrazole-3,5-diamine through regulating the expression of Cyclin A2 (CCNA2). [186], [188]
6-(3-Amino-benzyloxy)-9H-purin-2-ylamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin A2 (CCNA2) is a therapeutic target for 6-(3-Amino-benzyloxy)-9H-purin-2-ylamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-(3-Amino-benzyloxy)-9H-purin-2-ylamine through regulating the expression of Cyclin A2 (CCNA2). [186], [189]
6-(3-Methyl-benzyloxy)-9H-purin-2-ylamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin A2 (CCNA2) is a therapeutic target for 6-(3-Methyl-benzyloxy)-9H-purin-2-ylamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-(3-Methyl-benzyloxy)-9H-purin-2-ylamine through regulating the expression of Cyclin A2 (CCNA2). [186], [190]
6-(Cyclohex-3-enylmethoxy)-9H-purin-2-ylamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin A2 (CCNA2) is a therapeutic target for 6-(Cyclohex-3-enylmethoxy)-9H-purin-2-ylamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-(Cyclohex-3-enylmethoxy)-9H-purin-2-ylamine through regulating the expression of Cyclin A2 (CCNA2). [186], [190]
6-Cyclohexylmethoxy-pyrimidine-2,4,5-triamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin A2 (CCNA2) is a therapeutic target for 6-Cyclohexylmethoxy-pyrimidine-2,4,5-triamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-Cyclohexylmethoxy-pyrimidine-2,4,5-triamine through regulating the expression of Cyclin A2 (CCNA2). [186], [191]
6-O-Cyclohexylmethyl Guanine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin A2 (CCNA2) is a therapeutic target for 6-O-Cyclohexylmethyl Guanine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-O-Cyclohexylmethyl Guanine through regulating the expression of Cyclin A2 (CCNA2). [186], [190]
aloisine A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin A2 (CCNA2) is a therapeutic target for aloisine A. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of aloisine A through regulating the expression of Cyclin A2 (CCNA2). [186], [192]
GW-8510 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin A2 (CCNA2) is a therapeutic target for GW-8510. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GW-8510 through regulating the expression of Cyclin A2 (CCNA2). [186], [193]
MERIOLIN 1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin A2 (CCNA2) is a therapeutic target for MERIOLIN 1. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MERIOLIN 1 through regulating the expression of Cyclin A2 (CCNA2). [186], [194]
MERIOLIN 2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin A2 (CCNA2) is a therapeutic target for MERIOLIN 2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MERIOLIN 2 through regulating the expression of Cyclin A2 (CCNA2). [186], [194]
MERIOLIN 3 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin A2 (CCNA2) is a therapeutic target for MERIOLIN 3. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MERIOLIN 3 through regulating the expression of Cyclin A2 (CCNA2). [186], [194]
MERIOLIN 4 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin A2 (CCNA2) is a therapeutic target for MERIOLIN 4. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MERIOLIN 4 through regulating the expression of Cyclin A2 (CCNA2). [186], [194]
MERIOLIN 5 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin A2 (CCNA2) is a therapeutic target for MERIOLIN 5. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MERIOLIN 5 through regulating the expression of Cyclin A2 (CCNA2). [186], [194]
MERIOLIN 6 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin A2 (CCNA2) is a therapeutic target for MERIOLIN 6. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MERIOLIN 6 through regulating the expression of Cyclin A2 (CCNA2). [186], [194]
MERIOLIN 7 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin A2 (CCNA2) is a therapeutic target for MERIOLIN 7. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MERIOLIN 7 through regulating the expression of Cyclin A2 (CCNA2). [186], [195]
MERIOLIN 8 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin A2 (CCNA2) is a therapeutic target for MERIOLIN 8. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MERIOLIN 8 through regulating the expression of Cyclin A2 (CCNA2). [186], [194]
NU-6027 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin A2 (CCNA2) is a therapeutic target for NU-6027. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NU-6027 through regulating the expression of Cyclin A2 (CCNA2). [186], [194]
Purvalanol A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin A2 (CCNA2) is a therapeutic target for Purvalanol A. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Purvalanol A through regulating the expression of Cyclin A2 (CCNA2). [186], [196]
RESCOVITINE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin A2 (CCNA2) is a therapeutic target for RESCOVITINE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RESCOVITINE through regulating the expression of Cyclin A2 (CCNA2). [186], [197]
PD-0183812 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin A2 (CCNA2) is a therapeutic target for PD-0183812. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PD-0183812 through regulating the expression of Cyclin A2 (CCNA2). [186], [198]
Cyclin-dependent kinase 2 (CDK2)
PHA848125 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for PHA848125. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PHA848125 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [199]
Ro 31-7453 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for Ro 31-7453. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ro 31-7453 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [200]
Roscovitine [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for Roscovitine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Roscovitine through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [201]
TG02 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for TG02. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TG02 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [202]
AG-024322 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for AG-024322. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AG-024322 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [203]
AT7519 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for AT7519. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AT7519 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [204]
AZD-5438 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for AZD-5438. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AZD-5438 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [205]
CYC065 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for CYC065. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CYC065 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [206]
FN-1501 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for FN-1501. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of FN-1501 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [207]
PF-07104091 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for PF-07104091. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PF-07104091 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [208]
PHA-793887 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for PHA-793887. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PHA-793887 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [209]
RGB-286638 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for RGB-286638. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RGB-286638 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [202]
SNS-032 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for SNS-032. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SNS-032 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [38], [186]
INOC-005 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for INOC-005. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of INOC-005 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [199]
L-751250 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for L-751250. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-751250 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [202]
1-Amino-6-Cyclohex-3-Enylmethyloxypurine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for 1-Amino-6-Cyclohex-3-Enylmethyloxypurine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-Amino-6-Cyclohex-3-Enylmethyloxypurine through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [148], [186]
10Z-Hymenialdisine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for 10Z-Hymenialdisine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 10Z-Hymenialdisine through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [199]
2-Amino-6-Chloropyrazine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for 2-Amino-6-Chloropyrazine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-Amino-6-Chloropyrazine through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [148], [186]
2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for 2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [78], [186]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [210]
3,4-diphenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for 3,4-diphenyl-1H-pyrrole-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,4-diphenyl-1H-pyrrole-2,5-dione through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [211]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [212]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [210]
4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for 4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamine through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [148], [186]
4-[(6-chloropyrazin-2-yl)amino]benzenesulfonamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for 4-[(6-chloropyrazin-2-yl)amino]benzenesulfonamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[(6-chloropyrazin-2-yl)amino]benzenesulfonamide through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [78], [186]
4-[3-Hydroxyanilino]-6,7-Dimethoxyquinazoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for 4-[3-Hydroxyanilino]-6,7-Dimethoxyquinazoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[3-Hydroxyanilino]-6,7-Dimethoxyquinazoline through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [148], [186]
5-hydroxynaphthalene-1-sulfonamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for 5-hydroxynaphthalene-1-sulfonamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-hydroxynaphthalene-1-sulfonamide through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [78], [186]
6-(3-Amino-benzyloxy)-9H-purin-2-ylamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for 6-(3-Amino-benzyloxy)-9H-purin-2-ylamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-(3-Amino-benzyloxy)-9H-purin-2-ylamine through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [189]
6-(3-Methyl-benzyloxy)-9H-purin-2-ylamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for 6-(3-Methyl-benzyloxy)-9H-purin-2-ylamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-(3-Methyl-benzyloxy)-9H-purin-2-ylamine through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [190]
6-(Cyclohex-3-enylmethoxy)-9H-purin-2-ylamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for 6-(Cyclohex-3-enylmethoxy)-9H-purin-2-ylamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-(Cyclohex-3-enylmethoxy)-9H-purin-2-ylamine through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [190]
6-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO) PURINE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for 6-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO) PURINE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO) PURINE through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [199]
6-Cyclohexylmethoxy-pyrimidine-2,4,5-triamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for 6-Cyclohexylmethoxy-pyrimidine-2,4,5-triamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-Cyclohexylmethoxy-pyrimidine-2,4,5-triamine through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [190]
6-cyclohexylmethyloxy-2-(4'-hydroxyanilino)purine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for 6-cyclohexylmethyloxy-2-(4'-hydroxyanilino)purine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-cyclohexylmethyloxy-2-(4'-hydroxyanilino)purine through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [78], [186]
6-O-Cyclohexylmethyl Guanine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for 6-O-Cyclohexylmethyl Guanine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-O-Cyclohexylmethyl Guanine through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [148], [186]
9-Nitropaullone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for 9-Nitropaullone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 9-Nitropaullone through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [199]
aloisine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for aloisine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of aloisine through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [191]
aloisine A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for aloisine A. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of aloisine A through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [213]
aminopurvalanol A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for aminopurvalanol A. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of aminopurvalanol A through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [214]
Benzyl-(9-isopropyl-9H-purin-6-yl)-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for Benzyl-(9-isopropyl-9H-purin-6-yl)-amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Benzyl-(9-isopropyl-9H-purin-6-yl)-amine through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [148], [186]
BMS 536924 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for BMS 536924. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BMS 536924 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [193]
BMS-265246 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for BMS-265246. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BMS-265246 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [215]
BOHEMINE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for BOHEMINE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BOHEMINE through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [78], [186]
BX-795 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for BX-795. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BX-795 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [215]
BX-912 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for BX-912. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BX-912 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [216]
Cdk4 inhibitor III [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for Cdk4 inhibitor III. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cdk4 inhibitor III through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [217]
CVT-313 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for CVT-313. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CVT-313 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [218]
Double Oxidized Cysteine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for Double Oxidized Cysteine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Double Oxidized Cysteine through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [217]
GW-8510 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for GW-8510. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GW-8510 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [193]
Indirubin-3'-monoxime [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for Indirubin-3'-monoxime. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Indirubin-3'-monoxime through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [199]
Indirubin-5-sulfonate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for Indirubin-5-sulfonate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Indirubin-5-sulfonate through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [199]
JNJ 7706621 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for JNJ 7706621. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of JNJ 7706621 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [210]
K00024 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for K00024. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of K00024 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [219]
Lysine Nz-Carboxylic Acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for Lysine Nz-Carboxylic Acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Lysine Nz-Carboxylic Acid through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [78], [186]
MERIOLIN 1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for MERIOLIN 1. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MERIOLIN 1 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [210]
MERIOLIN 2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for MERIOLIN 2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MERIOLIN 2 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [194]
MERIOLIN 3 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for MERIOLIN 3. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MERIOLIN 3 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [194]
MERIOLIN 4 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for MERIOLIN 4. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MERIOLIN 4 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [194]
MERIOLIN 5 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for MERIOLIN 5. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MERIOLIN 5 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [194]
MERIOLIN 6 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for MERIOLIN 6. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MERIOLIN 6 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [194]
MERIOLIN 8 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for MERIOLIN 8. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MERIOLIN 8 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [194]
N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [148], [186]
N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [220]
N-(4-sulfamoylphenyl)-1H-indazole-3-carboxamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for N-(4-sulfamoylphenyl)-1H-indazole-3-carboxamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(4-sulfamoylphenyl)-1H-indazole-3-carboxamide through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [78], [186]
N-(5-Cyclopropyl-1h-Pyrazol-3-Yl)Benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for N-(5-Cyclopropyl-1h-Pyrazol-3-Yl)Benzamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(5-Cyclopropyl-1h-Pyrazol-3-Yl)Benzamide through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [155], [186]
N-phenyl-1H-pyrazole-3-carboxamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for N-phenyl-1H-pyrazole-3-carboxamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-phenyl-1H-pyrazole-3-carboxamide through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [78], [186]
NSC-625987 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for NSC-625987. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NSC-625987 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [221]
NU-6027 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for NU-6027. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NU-6027 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [194]
NU-6102 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for NU-6102. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NU-6102 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [195]
NU6140 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for NU6140. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NU6140 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [222]
Oxindole 95 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for Oxindole 95. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Oxindole 95 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [199]
PF-228 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for PF-228. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PF-228 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [196]
PHA-690509 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for PHA-690509. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PHA-690509 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [223]
PHENYLAMINOIMIDAZO(1,2-ALPHA)PYRIDINE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for PHENYLAMINOIMIDAZO(1,2-ALPHA)PYRIDINE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PHENYLAMINOIMIDAZO(1,2-ALPHA)PYRIDINE through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [78], [186]
Purvalanol A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for Purvalanol A. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Purvalanol A through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [224]
PYRAZOLOPYRIDAZINE 1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for PYRAZOLOPYRIDAZINE 1. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PYRAZOLOPYRIDAZINE 1 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [225]
PYRAZOLOPYRIDAZINE 2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for PYRAZOLOPYRIDAZINE 2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PYRAZOLOPYRIDAZINE 2 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [226]
RESCOVITINE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for RESCOVITINE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RESCOVITINE through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [211]
SCH-546909 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for SCH-546909. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SCH-546909 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [227]
SU9516 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for SU9516. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SU9516 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [225]
TRIAZOLOPYRIMIDINE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for TRIAZOLOPYRIMIDINE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TRIAZOLOPYRIMIDINE through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [78], [186]
VER-54505 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for VER-54505. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of VER-54505 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [223]
BAY 10-00394 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for BAY 10-00394. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BAY 10-00394 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [228]
Olomoucine [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for Olomoucine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Olomoucine through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [229]
PD-0183812 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for PD-0183812. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PD-0183812 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [230]
R547 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for R547. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of R547 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [202]
SCH 727965 [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for SCH 727965. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SCH 727965 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [231]
ZK 304709 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 2 (CDK2) is a therapeutic target for ZK 304709. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ZK 304709 through regulating the expression of Cyclin-dependent kinase 2 (CDK2). [186], [202]
Cyclin-dependent kinase 6 (CDK6)
Apremilast [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for Apremilast. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Apremilast through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [166], [232]
LY2835219 [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for LY2835219. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LY2835219 through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [232], [233]
Palbociclib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for Palbociclib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Palbociclib through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [232], [234]
Ribociclib Succinate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for Ribociclib Succinate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ribociclib Succinate through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [229], [232]
Trilaciclib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for Trilaciclib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Trilaciclib through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [232], [235]
LEE011 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for LEE011. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LEE011 through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [232], [236]
FCN-437 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for FCN-437. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of FCN-437 through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [232], [237]
G1T38 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for G1T38. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of G1T38 through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [232], [238]
GLR2007 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for GLR2007. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GLR2007 through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [38], [232]
FN-1501 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for FN-1501. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of FN-1501 through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [232], [239]
G1T28-1 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for G1T28-1. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of G1T28-1 through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [208], [232]
INOC-005 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for INOC-005. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of INOC-005 through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [166], [232]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [210], [232]
3,4-diphenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for 3,4-diphenyl-1H-pyrrole-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,4-diphenyl-1H-pyrrole-2,5-dione through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [210], [232]
3,7,3',4'-TETRAHYDROXYFLAVONE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for 3,7,3',4'-TETRAHYDROXYFLAVONE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,7,3',4'-TETRAHYDROXYFLAVONE through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [199], [232]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [232], [240]
APIGENIN [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for APIGENIN. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of APIGENIN through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [232], [241]
Chrysin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for Chrysin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Chrysin through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [210], [232]
Deschloroflavopiridol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for Deschloroflavopiridol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Deschloroflavopiridol through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [199], [232]
Fascaplysin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for Fascaplysin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Fascaplysin through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [232], [241]
RGB-286147 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for RGB-286147. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RGB-286147 through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [78], [232]
CYC-103 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for CYC-103. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CYC-103 through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [199], [232]
PD-0183812 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for PD-0183812. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PD-0183812 through regulating the expression of Cyclin-dependent kinase 6 (CDK6). [230], [232]
Cytochrome P450 2C8 (CYP2C8)
Almotriptan malate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Almotriptan malate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Almotriptan malate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [243]
Aminophenazone [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Aminophenazone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Aminophenazone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [244]
Amiodarone hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Amiodarone hydrochloride. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Amiodarone hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [245]
Amitriptyline hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Amitriptyline hydrochloride. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Amitriptyline hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [246]
Amodiaquine [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Amodiaquine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Amodiaquine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [247]
Anastrozole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Anastrozole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Anastrozole through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [248]
Apalutamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Apalutamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Apalutamide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [249]
Apixaban [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Apixaban. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Apixaban through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [250]
Atorvastatin calcium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Atorvastatin calcium. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Atorvastatin calcium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [251]
Azelastine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Azelastine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Azelastine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [252]
Benzyl alcohol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Benzyl alcohol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Benzyl alcohol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [253]
Beraprost [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Beraprost. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Beraprost through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [254]
Brigatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Brigatinib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Brigatinib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [255]
Bromfenac [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Bromfenac. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Bromfenac through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [256]
Buprenorphine hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Buprenorphine hydrochloride. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Buprenorphine hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [257]
Cabazitaxel [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cabazitaxel. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cabazitaxel through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [258]
Caffeine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Caffeine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Caffeine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [259]
Capsaicin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Capsaicin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Capsaicin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [260]
Carbamazepine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Carbamazepine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Carbamazepine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [261]
Cefaloridine [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cefaloridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cefaloridine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [262]
Celecoxib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Celecoxib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Celecoxib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [263]
Cerivastatin sodium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cerivastatin sodium. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cerivastatin sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [251]
Cisapride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cisapride. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cisapride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [264]
Clozapine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Clozapine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Clozapine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [265]
Cyclophosphamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cyclophosphamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclophosphamide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [266]
Dabrafenib mesylate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Dabrafenib mesylate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Dabrafenib mesylate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [251]
Dapsone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Dapsone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Dapsone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [267]
Desloratadine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Desloratadine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Desloratadine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [268]
Dexibuprofen [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Dexibuprofen. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Dexibuprofen through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [269]
Diazepam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Diazepam. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Diazepam through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [270]
Diclofenac sodium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Diclofenac sodium. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Diclofenac sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [271]
Diethylstilbestrol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Diethylstilbestrol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Diethylstilbestrol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [272]
Diltiazem hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Diltiazem hydrochloride. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Diltiazem hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [273]
Eltrombopag olamine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Eltrombopag olamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Eltrombopag olamine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [274]
Enasidenib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Enasidenib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Enasidenib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [275]
Enzalutamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Enzalutamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Enzalutamide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [251]
Estradiol acetate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Estradiol acetate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Estradiol acetate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [251]
Estradiol cypionate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Estradiol cypionate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Estradiol cypionate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [276]
Estradiol valerate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Estradiol valerate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Estradiol valerate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [276]
Eszopiclone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Eszopiclone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Eszopiclone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [277]
Ethinyl estradiol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ethinyl estradiol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ethinyl estradiol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [278]
Fluvastatin sodium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Fluvastatin sodium. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Fluvastatin sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [279]
Glasdegib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Glasdegib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Glasdegib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [280]
Halofantrine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Halofantrine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Halofantrine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [281]
Ibuprofen [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ibuprofen. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ibuprofen through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [269]
Ifosfamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ifosfamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ifosfamide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [266]
Imatinib mesylate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Imatinib mesylate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Imatinib mesylate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [251]
Irbesartan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Irbesartan. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Irbesartan through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [278]
Istradefylline [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Istradefylline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Istradefylline through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [282]
Ixazomib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ixazomib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ixazomib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [283]
Ketobemidone [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ketobemidone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ketobemidone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [284]
Ketorolac [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ketorolac. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ketorolac through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [285]
Lansoprazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Lansoprazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Lansoprazole through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [286]
Lapatinib ditosylate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Lapatinib ditosylate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Lapatinib ditosylate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [287]
Levomilnacipran [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Levomilnacipran. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Levomilnacipran through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [288]
Lidocaine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Lidocaine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Lidocaine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [289]
Loperamide hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Loperamide hydrochloride. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Loperamide hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [290]
Loratadine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Loratadine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Loratadine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [251]
Lorlatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Lorlatinib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Lorlatinib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [291]
Losartan potassium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Losartan potassium. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Losartan potassium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [292]
Lovastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Lovastatin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Lovastatin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [293]
Mefenamic acid [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Mefenamic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Mefenamic acid through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [251]
Meloxicam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Meloxicam. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Meloxicam through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [294]
Mephenytoin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Mephenytoin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Mephenytoin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [295]
Mestranol [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Mestranol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Mestranol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [296]
Methadone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Methadone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Methadone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [297]
Mirtazapine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Mirtazapine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Mirtazapine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [289]
Montelukast sodium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Montelukast sodium. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Montelukast sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [298]
Morphine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Morphine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Morphine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [299]
Mycophenolate mofetil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Mycophenolate mofetil. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Mycophenolate mofetil through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [300]
Naloxone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Naloxone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Naloxone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [257]
Naproxen [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Naproxen. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Naproxen through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [301]
Nicardipine hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Nicardipine hydrochloride. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Nicardipine hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [289]
Nicotine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Nicotine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Nicotine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [302]
Nilotinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Nilotinib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Nilotinib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [251]
Ombitasvir [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ombitasvir. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ombitasvir through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [303]
Omeprazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Omeprazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Omeprazole through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [304]
Pazopanib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Pazopanib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Pazopanib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [305]
Pentamidine isethionate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Pentamidine isethionate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Pentamidine isethionate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [306]
Perphenazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Perphenazine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Perphenazine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [307]
Phenobarbital [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Phenobarbital. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Phenobarbital through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [308]
Phenprocoumon [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Phenprocoumon. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Phenprocoumon through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [309]
Phenytoin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Phenytoin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Phenytoin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [289]
Pioglitazone hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Pioglitazone hydrochloride. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Pioglitazone hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [310]
Piroxicam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Piroxicam. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Piroxicam through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [311]
Pitavastatin calcium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Pitavastatin calcium. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Pitavastatin calcium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [312]
Propofol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Propofol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Propofol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [313]
Quinidine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Quinidine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Quinidine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [251]
Quinine sulfate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Quinine sulfate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Quinine sulfate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [251]
Repaglinide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Repaglinide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Repaglinide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [314]
Riociguat [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Riociguat. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Riociguat through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [315]
Rofecoxib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Rofecoxib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Rofecoxib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [251]
Rosiglitazone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Rosiglitazone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Rosiglitazone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [316]
Selegiline hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Selegiline hydrochloride. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Selegiline hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [317]
Selexipag [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Selexipag. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Selexipag through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [318]
Simvastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Simvastatin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Simvastatin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [319]
Sitagliptin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Sitagliptin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Sitagliptin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [320]
Sulfadiazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Sulfadiazine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Sulfadiazine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [321]
Sulfamethoxazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Sulfamethoxazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Sulfamethoxazole through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [322]
Sulfinpyrazone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Sulfinpyrazone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Sulfinpyrazone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [289]
Tazarotene [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Tazarotene. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Tazarotene through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [323]
Tegafur [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Tegafur. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Tegafur through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [324]
Temazepam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Temazepam. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Temazepam through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [325]
Terbinafine hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Terbinafine hydrochloride. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Terbinafine hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [277]
Testosterone cypionate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Testosterone cypionate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Testosterone cypionate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [251]
Testosterone enanthate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Testosterone enanthate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Testosterone enanthate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [251]
Testosterone undecanoate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Testosterone undecanoate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Testosterone undecanoate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [251]
Thalidomide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Thalidomide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Thalidomide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [326]
Tolbutamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Tolbutamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Tolbutamide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [327]
Torasemide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Torasemide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Torasemide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [328]
Treprostinil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Treprostinil. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Treprostinil through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [329]
Trifarotene [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Trifarotene. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Trifarotene through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [330]
Trimethadione [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Trimethadione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Trimethadione through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [331]
Trimethoprim [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Trimethoprim. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Trimethoprim through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [332]
Troglitazone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Troglitazone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Troglitazone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [333]
Velpatasvir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Velpatasvir. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Velpatasvir through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [334]
Verapamil hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Verapamil hydrochloride. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Verapamil hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [335]
Vortioxetine hydrobromide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Vortioxetine hydrobromide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Vortioxetine hydrobromide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [336]
Voxilaprevir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Voxilaprevir. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Voxilaprevir through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [334]
Warfarin sodium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Warfarin sodium. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Warfarin sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [301]
Zafirlukast [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Zafirlukast. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Zafirlukast through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [332]
Zidovudine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Zidovudine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Zidovudine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [289]
Zopiclone [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Zopiclone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Zopiclone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [337]
BMS-298585 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for BMS-298585. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BMS-298585 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [338]
BNP-1350 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for BNP-1350. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BNP-1350 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [339]
CKD-501 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for CKD-501. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CKD-501 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [340]
CYT-387 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for CYT-387. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CYT-387 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [341]
Dasabuvir [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Dasabuvir. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Dasabuvir through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [342]
Domperidone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Domperidone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Domperidone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [343]
DRF-2593 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for DRF-2593. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of DRF-2593 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [340]
EMD-128130 [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for EMD-128130. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of EMD-128130 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [344]
Estradiol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Estradiol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Estradiol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [251]
LAS-17177 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for LAS-17177. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LAS-17177 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [345]
LAU-7b [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for LAU-7b. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LAU-7b through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [346]
LY-2484595 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for LY-2484595. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LY-2484595 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [347]
NSC-122758 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for NSC-122758. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NSC-122758 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [348]
QLT-091001 [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for QLT-091001. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of QLT-091001 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [348]
Rivoglitazone [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Rivoglitazone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Rivoglitazone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [349]
AZD-2014 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for AZD-2014. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AZD-2014 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [350]
GSK-1278863 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for GSK-1278863. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GSK-1278863 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [351]
TAK-652 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for TAK-652. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TAK-652 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [352]
AG-1549 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for AG-1549. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AG-1549 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [353]
AZD-9496 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for AZD-9496. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AZD-9496 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [354]
H3B-6545 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for H3B-6545. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of H3B-6545 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [355]
M-813 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for M-813. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of M-813 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [356]
MK-0822 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for MK-0822. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MK-0822 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [357]
Antipyrine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Antipyrine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Antipyrine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [277]
Cyamemazine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cyamemazine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyamemazine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [358]
Paraoxon [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Paraoxon. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Paraoxon through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [359]
ABT-001 [Discontinued]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for ABT-001. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ABT-001 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [360]
ADD-3878 [Discontinued]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for ADD-3878. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ADD-3878 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [340]
Aleglitazar [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Aleglitazar. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Aleglitazar through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [361]
ML-3000 [Discontinued]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for ML-3000. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ML-3000 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [242], [277]
Dehydrogenase/reductase retSDR2 (HSD17B11)
Hombreol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Dehydrogenase/reductase retSDR2 (HSD17B11) is a therapeutic target for Hombreol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Hombreol through regulating the expression of Dehydrogenase/reductase retSDR2 (HSD17B11). [362], [363]
Diacylglycerol O-acyltransferase 2 (DGAT2)
Vitamin B3 [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Diacylglycerol O-acyltransferase 2 (DGAT2) is a therapeutic target for Vitamin B3. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Vitamin B3 through regulating the expression of Diacylglycerol O-acyltransferase 2 (DGAT2). [364], [365]
ARI-3037MO [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Diacylglycerol O-acyltransferase 2 (DGAT2) is a therapeutic target for ARI-3037MO. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ARI-3037MO through regulating the expression of Diacylglycerol O-acyltransferase 2 (DGAT2). [364], [366]
ION 224 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Diacylglycerol O-acyltransferase 2 (DGAT2) is a therapeutic target for ION 224. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ION 224 through regulating the expression of Diacylglycerol O-acyltransferase 2 (DGAT2). [364], [367]
PF-06427878 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Diacylglycerol O-acyltransferase 2 (DGAT2) is a therapeutic target for PF-06427878. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PF-06427878 through regulating the expression of Diacylglycerol O-acyltransferase 2 (DGAT2). [364], [368]
Dickkopf-related protein 1 (DKK1)
BHQ880 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Dickkopf-related protein 1 (DKK1) is a therapeutic target for BHQ880. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BHQ880 through regulating the expression of Dickkopf-related protein 1 (DKK1). [369], [370]
DKN-01 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Dickkopf-related protein 1 (DKK1) is a therapeutic target for DKN-01. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of DKN-01 through regulating the expression of Dickkopf-related protein 1 (DKK1). [369], [371]
PF-04840082 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Dickkopf-related protein 1 (DKK1) is a therapeutic target for PF-04840082. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PF-04840082 through regulating the expression of Dickkopf-related protein 1 (DKK1). [369], [372]
E2F transcription factor 1 (E2F1)
ARQ-171 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary E2F transcription factor 1 (E2F1) is a therapeutic target for ARQ-171. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ARQ-171 through regulating the expression of E2F transcription factor 1 (E2F1). [373], [374]
ISIS 113019 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary E2F transcription factor 1 (E2F1) is a therapeutic target for ISIS 113019. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 113019 through regulating the expression of E2F transcription factor 1 (E2F1). [373], [375]
ISIS 113020 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary E2F transcription factor 1 (E2F1) is a therapeutic target for ISIS 113020. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 113020 through regulating the expression of E2F transcription factor 1 (E2F1). [373], [375]
ISIS 113021 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary E2F transcription factor 1 (E2F1) is a therapeutic target for ISIS 113021. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 113021 through regulating the expression of E2F transcription factor 1 (E2F1). [373], [375]
ISIS 113022 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary E2F transcription factor 1 (E2F1) is a therapeutic target for ISIS 113022. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 113022 through regulating the expression of E2F transcription factor 1 (E2F1). [373], [375]
ISIS 113048 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary E2F transcription factor 1 (E2F1) is a therapeutic target for ISIS 113048. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 113048 through regulating the expression of E2F transcription factor 1 (E2F1). [373], [376]
Endostatin (COL18A1)
RetinoStat [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Endostatin (COL18A1) is a therapeutic target for RetinoStat. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RetinoStat through regulating the expression of Endostatin (COL18A1). [149], [377]
Endo-CD [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Endostatin (COL18A1) is a therapeutic target for Endo-CD. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Endo-CD through regulating the expression of Endostatin (COL18A1). [149], [378]
Ephrin type-B receptor 2 (EPHB2)
BVD-523 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-B receptor 2 (EPHB2) is a therapeutic target for BVD-523. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BVD-523 through regulating the expression of Ephrin type-B receptor 2 (EPHB2). [379], [380]
SEphB4-HSA [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-B receptor 2 (EPHB2) is a therapeutic target for SEphB4-HSA. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SEphB4-HSA through regulating the expression of Ephrin type-B receptor 2 (EPHB2). [379], [381]
KO-947 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-B receptor 2 (EPHB2) is a therapeutic target for KO-947. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of KO-947 through regulating the expression of Ephrin type-B receptor 2 (EPHB2). [38], [379]
MK-8353 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-B receptor 2 (EPHB2) is a therapeutic target for MK-8353. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MK-8353 through regulating the expression of Ephrin type-B receptor 2 (EPHB2). [38], [379]
AMP-PNP [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-B receptor 2 (EPHB2) is a therapeutic target for AMP-PNP. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AMP-PNP through regulating the expression of Ephrin type-B receptor 2 (EPHB2). [379], [382]
SNEWIQPRLPQH [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-B receptor 2 (EPHB2) is a therapeutic target for SNEWIQPRLPQH. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SNEWIQPRLPQH through regulating the expression of Ephrin type-B receptor 2 (EPHB2). [38], [379]
Erbb2 tyrosine kinase receptor (HER2)
Afatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Afatinib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Afatinib through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [384]
Dacomitinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Dacomitinib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Dacomitinib through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [233], [383]
Lapatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Lapatinib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Lapatinib through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [31], [383]
Margetuximab [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Margetuximab. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Margetuximab through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [385]
Masoprocol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Masoprocol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Masoprocol through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [386]
Merimepodib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Merimepodib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Merimepodib through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [387]
NERATINIB MALEATE [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for NERATINIB MALEATE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NERATINIB MALEATE through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [388]
Pertuzumab [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Pertuzumab. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Pertuzumab through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [389]
Trastuzumab [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Trastuzumab. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Trastuzumab through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [390]
HKI-272 [Phase 3]
In total 2 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for HKI-272. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of HKI-272 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [38], [383]
Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for HKI-272. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of HKI-272 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [391]
Nelipepimut S [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Nelipepimut S. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Nelipepimut S through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [392]
NeuVax [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for NeuVax. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NeuVax through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [201], [383]
PF-05280014 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for PF-05280014. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PF-05280014 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [29], [383]
Trastuzumab-DM1 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Trastuzumab-DM1. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Trastuzumab-DM1 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [393]
Varlitinib [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Varlitinib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Varlitinib through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [31], [383]
A166 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for A166. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of A166 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [394]
ABY-025 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for ABY-025. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ABY-025 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [395]
AGN-208397 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for AGN-208397. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AGN-208397 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [396]
Anti-HER2 CAR-T [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Anti-HER2 CAR-T. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Anti-HER2 CAR-T through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [397]
AU105 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for AU105. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AU105 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [38], [383]
AVX901 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for AVX901. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AVX901 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [398]
AZD8931 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for AZD8931. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AZD8931 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [390]
BDTX-189 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for BDTX-189. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BDTX-189 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [399]
BMS-599626 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for BMS-599626. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BMS-599626 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [201], [383]
BMS-690514 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for BMS-690514. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BMS-690514 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [400]
CART-HER-2 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for CART-HER-2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CART-HER-2 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [401]
CI-1033 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for CI-1033. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CI-1033 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [38], [383]
CP-724714 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for CP-724714. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CP-724714 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [402]
DN24-02 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for DN24-02. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of DN24-02 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [403]
Ertumaxomab [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Ertumaxomab. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ertumaxomab through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [201], [383]
HER-2 Protein AutoVac [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for HER-2 Protein AutoVac. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of HER-2 Protein AutoVac through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [404]
HER-2-targeting CAR T Cells [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for HER-2-targeting CAR T Cells. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of HER-2-targeting CAR T Cells through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [118], [383]
Her2-targeted autologous T-cell therapy [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Her2-targeted autologous T-cell therapy. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Her2-targeted autologous T-cell therapy through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [405]
HM-78136B [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for HM-78136B. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of HM-78136B through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [406]
ISB 1302 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for ISB 1302. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISB 1302 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [407]
KN026 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for KN026. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of KN026 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [408]
MCLA-128 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for MCLA-128. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MCLA-128 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [409]
MGAH22 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for MGAH22. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MGAH22 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [410]
MM-111 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for MM-111. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MM-111 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [411]
MRG002 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for MRG002. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MRG002 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [412]
Sym013 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Sym013. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Sym013 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [413]
Tarloxotinib [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Tarloxotinib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Tarloxotinib through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [166], [383]
TAS-0728 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for TAS-0728. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TAS-0728 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [414]
Zenocutuzomab [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Zenocutuzomab. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Zenocutuzomab through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [415]
AIP-303 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for AIP-303. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AIP-303 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [416]
ARRY-380 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for ARRY-380. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ARRY-380 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [166], [383]
BAY 2701439 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for BAY 2701439. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BAY 2701439 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [417]
CAR-T Cells targeting HER2 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for CAR-T Cells targeting HER2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CAR-T Cells targeting HER2 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [418]
CAR-T cells targeting HER2 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for CAR-T cells targeting HER2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CAR-T cells targeting HER2 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [419]
Cipatinib [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Cipatinib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cipatinib through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [420]
CUDC-101 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for CUDC-101. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CUDC-101 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [421]
DZD1516 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for DZD1516. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of DZD1516 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [422]
GBR1302 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for GBR1302. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GBR1302 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [423]
GQ1001 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for GQ1001. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GQ1001 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [424]
HER2-CAR T Cells [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for HER2-CAR T Cells. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of HER2-CAR T Cells through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [38], [383]
HER2-specific CAR T cell [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for HER2-specific CAR T cell. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of HER2-specific CAR T cell through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [425]
HER2-specific T cells [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for HER2-specific T cells. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of HER2-specific T cells through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [426]
HER2p63-71 peptide vaccine [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for HER2p63-71 peptide vaccine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of HER2p63-71 peptide vaccine through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [427]
JNJ-26483327 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for JNJ-26483327. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of JNJ-26483327 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [428]
M802 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for M802. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of M802 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [429]
MB-103 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for MB-103. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MB-103 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [430]
MBS301 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for MBS301. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MBS301 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [431]
MEDI4276 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for MEDI4276. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MEDI4276 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [432]
MM-302 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for MM-302. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MM-302 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [433]
MT-5111 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for MT-5111. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MT-5111 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [434]
MVA HER-2 AutoVac [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for MVA HER-2 AutoVac. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MVA HER-2 AutoVac through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [435]
NJH395 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for NJH395. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NJH395 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [436]
Recombinant human Erbb3 fragment therapeutic tumor vaccine [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Recombinant human Erbb3 fragment therapeutic tumor vaccine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Recombinant human Erbb3 fragment therapeutic tumor vaccine through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [437]
S-222611 [Phase 1b]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for S-222611. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of S-222611 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [438]
SBT6050 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for SBT6050. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SBT6050 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [439]
TAK-285 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for TAK-285. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TAK-285 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [440]
TrasGEX [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for TrasGEX. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TrasGEX through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [441]
VM-206 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for VM-206. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of VM-206 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [442]
Zemab [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Zemab. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Zemab through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [443]
ZW49 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for ZW49. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ZW49 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [444]
227Th-labelled HER2-TTC [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for 227Th-labelled HER2-TTC. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 227Th-labelled HER2-TTC through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [201], [383]
(1-Benzyl-1H-indazol-5-yl)-quinazolin-4-yl-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for (1-Benzyl-1H-indazol-5-yl)-quinazolin-4-yl-amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (1-Benzyl-1H-indazol-5-yl)-quinazolin-4-yl-amine through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [445]
(1-Benzyl-1H-indol-5-yl)-quinazolin-4-yl-amine [Investigative]
In total 2 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for (1-Benzyl-1H-indol-5-yl)-quinazolin-4-yl-amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (1-Benzyl-1H-indol-5-yl)-quinazolin-4-yl-amine through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [446]
Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for (1-Benzyl-1H-indol-5-yl)-quinazolin-4-yl-amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (1-Benzyl-1H-indol-5-yl)-quinazolin-4-yl-amine through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [447]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [210], [383]
3,4-diphenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for 3,4-diphenyl-1H-pyrrole-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,4-diphenyl-1H-pyrrole-2,5-dione through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [448]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [449]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [210], [383]
4-(3-phenoxylphenyl)-5-cyano-2H-1,2,3-triazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for 4-(3-phenoxylphenyl)-5-cyano-2H-1,2,3-triazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(3-phenoxylphenyl)-5-cyano-2H-1,2,3-triazole through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [447]
4-(4-bromophenyl)-5-cyano-2H-1,2,3-triazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for 4-(4-bromophenyl)-5-cyano-2H-1,2,3-triazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(4-bromophenyl)-5-cyano-2H-1,2,3-triazole through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [447]
4-(4-chlorophenyl)-5-cyano-2H-1,2,3-triazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for 4-(4-chlorophenyl)-5-cyano-2H-1,2,3-triazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(4-chlorophenyl)-5-cyano-2H-1,2,3-triazole through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [447]
4-(4-isopropylphenyl)-5-cyano-2H-1,2,3-triazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for 4-(4-isopropylphenyl)-5-cyano-2H-1,2,3-triazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(4-isopropylphenyl)-5-cyano-2H-1,2,3-triazole through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [210], [383]
4-(Bis(2-chloroethyl)amino)-N-p-tolylbenzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for 4-(Bis(2-chloroethyl)amino)-N-p-tolylbenzamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(Bis(2-chloroethyl)amino)-N-p-tolylbenzamide through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [450]
4557W [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for 4557W. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4557W through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [449]
AG-213 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for AG-213. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AG-213 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [451]
BMS 536924 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for BMS 536924. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BMS 536924 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [452]
CL-387785 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for CL-387785. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CL-387785 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [210], [383]
Geldanamycin-estradiol hybrid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Geldanamycin-estradiol hybrid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Geldanamycin-estradiol hybrid through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [453]
HDS-029 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for HDS-029. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of HDS-029 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [454]
ISIS 12882 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for ISIS 12882. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 12882 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [455]
ISIS 12883 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for ISIS 12883. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 12883 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [455]
ISIS 12884 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for ISIS 12884. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 12884 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [226], [383]
ISIS 9002 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for ISIS 9002. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 9002 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [455]
ISIS 9003 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for ISIS 9003. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 9003 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [455]
ISIS 9005 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for ISIS 9005. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 9005 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [455]
N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [446]
PD-168393 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for PD-168393. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PD-168393 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [453]
PF 5208766 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for PF 5208766. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PF 5208766 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [456]
PNT-500 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for PNT-500. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PNT-500 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [446]
Redoxal [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Redoxal. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Redoxal through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [446]
TA1-RTA [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for TA1-RTA. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TA1-RTA through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [457]
GW-974 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for GW-974. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GW-974 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [458]
Her-2-Bi-armed ATC [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for Her-2-Bi-armed ATC. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Her-2-Bi-armed ATC through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [459]
TAK165 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Erbb2 tyrosine kinase receptor (HER2) is a therapeutic target for TAK165. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TAK165 through regulating the expression of Erbb2 tyrosine kinase receptor (HER2). [383], [460]
Fatty acid synthase (FASN)
Cerulenin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for Cerulenin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cerulenin through regulating the expression of Fatty acid synthase (FASN). [461], [462]
TVB-2640 [Phase 2]
In total 2 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for TVB-2640. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TVB-2640 through regulating the expression of Fatty acid synthase (FASN). [461], [463]
Fatty acid synthase (FASN) is a therapeutic target for TVB-2640. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TVB-2640 through regulating the expression of Fatty acid synthase (FASN). [461], [464]
FAS1 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for FAS1. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of FAS1 through regulating the expression of Fatty acid synthase (FASN). [461], [462]
FSA2 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for FSA2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of FSA2 through regulating the expression of Fatty acid synthase (FASN). [461], [465]
(-)-CATECHINGALLATE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for (-)-CATECHINGALLATE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (-)-CATECHINGALLATE through regulating the expression of Fatty acid synthase (FASN). [461], [466]
2-Hexadecynoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for 2-Hexadecynoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-Hexadecynoic acid through regulating the expression of Fatty acid synthase (FASN). [461], [462]
3,7,3',4'-TETRAHYDROXYFLAVONE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for 3,7,3',4'-TETRAHYDROXYFLAVONE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,7,3',4'-TETRAHYDROXYFLAVONE through regulating the expression of Fatty acid synthase (FASN). [461], [464]
4-hydroxy-6-nitro-3-phenylquinolin-2(1H)-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for 4-hydroxy-6-nitro-3-phenylquinolin-2(1H)-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-hydroxy-6-nitro-3-phenylquinolin-2(1H)-one through regulating the expression of Fatty acid synthase (FASN). [461], [464]
4-hydroxy-8-nitro-3-phenylquinolin-2(1H)-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for 4-hydroxy-8-nitro-3-phenylquinolin-2(1H)-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-hydroxy-8-nitro-3-phenylquinolin-2(1H)-one through regulating the expression of Fatty acid synthase (FASN). [461], [467]
Anti-Fas mabs [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for Anti-Fas mabs. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Anti-Fas mabs through regulating the expression of Fatty acid synthase (FASN). [461], [468]
biochanin A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for biochanin A. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of biochanin A through regulating the expression of Fatty acid synthase (FASN). [461], [464]
C75 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for C75. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C75 through regulating the expression of Fatty acid synthase (FASN). [461], [464]
FAS-031 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for FAS-031. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of FAS-031 through regulating the expression of Fatty acid synthase (FASN). [461], [468]
GALLOCATECHIN GALLATE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for GALLOCATECHIN GALLATE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GALLOCATECHIN GALLATE through regulating the expression of Fatty acid synthase (FASN). [461], [466]
GSK2194069 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for GSK2194069. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GSK2194069 through regulating the expression of Fatty acid synthase (FASN). [461], [469]
MG-28 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for MG-28. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MG-28 through regulating the expression of Fatty acid synthase (FASN). [461], [470]
MORIN [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for MORIN. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MORIN through regulating the expression of Fatty acid synthase (FASN). [461], [464]
MT-061 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for MT-061. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MT-061 through regulating the expression of Fatty acid synthase (FASN). [461], [468]
Follicle-stimulating hormone receptor (FSHR)
Follitropin beta [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Follicle-stimulating hormone receptor (FSHR) is a therapeutic target for Follitropin beta. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Follitropin beta through regulating the expression of Follicle-stimulating hormone receptor (FSHR). [53], [471]
Menotropins [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Follicle-stimulating hormone receptor (FSHR) is a therapeutic target for Menotropins. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Menotropins through regulating the expression of Follicle-stimulating hormone receptor (FSHR). [53], [472]
Urofollitropin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Follicle-stimulating hormone receptor (FSHR) is a therapeutic target for Urofollitropin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Urofollitropin through regulating the expression of Follicle-stimulating hormone receptor (FSHR). [53], [473]
Suramin [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Follicle-stimulating hormone receptor (FSHR) is a therapeutic target for Suramin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Suramin through regulating the expression of Follicle-stimulating hormone receptor (FSHR). [53], [474]
FSHR NAM [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Follicle-stimulating hormone receptor (FSHR) is a therapeutic target for FSHR NAM. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of FSHR NAM through regulating the expression of Follicle-stimulating hormone receptor (FSHR). [53], [475]
Long-acting FSH conjugate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Follicle-stimulating hormone receptor (FSHR) is a therapeutic target for Long-acting FSH conjugate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Long-acting FSH conjugate through regulating the expression of Follicle-stimulating hormone receptor (FSHR). [53], [474]
PRX-111 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Follicle-stimulating hormone receptor (FSHR) is a therapeutic target for PRX-111. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PRX-111 through regulating the expression of Follicle-stimulating hormone receptor (FSHR). [53], [474]
Recombinant follicle stimulating hormone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Follicle-stimulating hormone receptor (FSHR) is a therapeutic target for Recombinant follicle stimulating hormone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Recombinant follicle stimulating hormone through regulating the expression of Follicle-stimulating hormone receptor (FSHR). [53], [476]
Forkhead box protein O1A (FOXO1)
AS-1708727 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Forkhead box protein O1A (FOXO1) is a therapeutic target for AS-1708727. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AS-1708727 through regulating the expression of Forkhead box protein O1A (FOXO1). [364], [477]
ISIS 188755 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Forkhead box protein O1A (FOXO1) is a therapeutic target for ISIS 188755. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 188755 through regulating the expression of Forkhead box protein O1A (FOXO1). [143], [364]
ISIS 188757 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Forkhead box protein O1A (FOXO1) is a therapeutic target for ISIS 188757. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 188757 through regulating the expression of Forkhead box protein O1A (FOXO1). [143], [364]
ISIS 188759 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Forkhead box protein O1A (FOXO1) is a therapeutic target for ISIS 188759. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 188759 through regulating the expression of Forkhead box protein O1A (FOXO1). [143], [364]
ISIS 188761 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Forkhead box protein O1A (FOXO1) is a therapeutic target for ISIS 188761. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 188761 through regulating the expression of Forkhead box protein O1A (FOXO1). [143], [364]
ISIS 188763 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Forkhead box protein O1A (FOXO1) is a therapeutic target for ISIS 188763. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 188763 through regulating the expression of Forkhead box protein O1A (FOXO1). [143], [364]
ISIS 188778 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Forkhead box protein O1A (FOXO1) is a therapeutic target for ISIS 188778. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 188778 through regulating the expression of Forkhead box protein O1A (FOXO1). [143], [364]
ISIS 188780 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Forkhead box protein O1A (FOXO1) is a therapeutic target for ISIS 188780. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 188780 through regulating the expression of Forkhead box protein O1A (FOXO1). [143], [364]
ISIS 188781 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Forkhead box protein O1A (FOXO1) is a therapeutic target for ISIS 188781. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 188781 through regulating the expression of Forkhead box protein O1A (FOXO1). [143], [364]
ISIS 188782 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Forkhead box protein O1A (FOXO1) is a therapeutic target for ISIS 188782. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 188782 through regulating the expression of Forkhead box protein O1A (FOXO1). [226], [364]
Frizzled-10 (FZD10)
OTSA-101-DTPA-90Y [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Frizzled-10 (FZD10) is a therapeutic target for OTSA-101-DTPA-90Y. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of OTSA-101-DTPA-90Y through regulating the expression of Frizzled-10 (FZD10). [166], [478]
G1/S-specific cyclin-D1 (CCND1)
ABT-263 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary G1/S-specific cyclin-D1 (CCND1) is a therapeutic target for ABT-263. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ABT-263 through regulating the expression of G1/S-specific cyclin-D1 (CCND1). [479], [480]
Briciclib [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary G1/S-specific cyclin-D1 (CCND1) is a therapeutic target for Briciclib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Briciclib through regulating the expression of G1/S-specific cyclin-D1 (CCND1). [38], [479]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary G1/S-specific cyclin-D1 (CCND1) is a therapeutic target for 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione through regulating the expression of G1/S-specific cyclin-D1 (CCND1). [210], [479]
3,4-diphenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary G1/S-specific cyclin-D1 (CCND1) is a therapeutic target for 3,4-diphenyl-1H-pyrrole-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,4-diphenyl-1H-pyrrole-2,5-dione through regulating the expression of G1/S-specific cyclin-D1 (CCND1). [210], [479]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary G1/S-specific cyclin-D1 (CCND1) is a therapeutic target for 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione through regulating the expression of G1/S-specific cyclin-D1 (CCND1). [479], [481]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary G1/S-specific cyclin-D1 (CCND1) is a therapeutic target for 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione through regulating the expression of G1/S-specific cyclin-D1 (CCND1). [210], [479]
7-hydroxycoumarin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary G1/S-specific cyclin-D1 (CCND1) is a therapeutic target for 7-hydroxycoumarin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 7-hydroxycoumarin through regulating the expression of G1/S-specific cyclin-D1 (CCND1). [195], [479]
Ghrelin (GHRL)
Unacylated ghrelin [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Ghrelin (GHRL) is a therapeutic target for Unacylated ghrelin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Unacylated ghrelin through regulating the expression of Ghrelin (GHRL). [482], [483]
Glutamate receptor ionotropic NMDA 1 (NMDAR1)
Cycloserine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for Cycloserine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cycloserine through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [485]
D-serine [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for D-serine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of D-serine through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [486]
ELIPRODIL [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for ELIPRODIL. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ELIPRODIL through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [148], [484]
NBQX [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for NBQX. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NBQX through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [487]
(D)-Ala-Pro-Glu [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for (D)-Ala-Pro-Glu. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (D)-Ala-Pro-Glu through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [488]
(R)-2-Amino-5-phosphono-pentanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for (R)-2-Amino-5-phosphono-pentanoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (R)-2-Amino-5-phosphono-pentanoic acid through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [489]
(R)-2-Amino-7-phosphono-heptanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for (R)-2-Amino-7-phosphono-heptanoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (R)-2-Amino-7-phosphono-heptanoic acid through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [490]
(RS)-(tetrazol-5-yl)glycine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for (RS)-(tetrazol-5-yl)glycine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (RS)-(tetrazol-5-yl)glycine through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [78], [484]
1,3-ditolylguanidine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 1,3-ditolylguanidine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1,3-ditolylguanidine through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [491]
2-(4-Phenoxy-benzyl)-1H-benzoimidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 2-(4-Phenoxy-benzyl)-1H-benzoimidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-(4-Phenoxy-benzyl)-1H-benzoimidazole through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [492]
2-(4-Phenoxy-benzyl)-3H-benzoimidazol-4-ol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 2-(4-Phenoxy-benzyl)-3H-benzoimidazol-4-ol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-(4-Phenoxy-benzyl)-3H-benzoimidazol-4-ol through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [492]
2-(4-Phenoxy-benzyl)-3H-benzoimidazol-5-ol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 2-(4-Phenoxy-benzyl)-3H-benzoimidazol-5-ol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-(4-Phenoxy-benzyl)-3H-benzoimidazol-5-ol through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [492]
2-(4-Phenoxy-benzyl)-3H-benzoimidazol-5-ylamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 2-(4-Phenoxy-benzyl)-3H-benzoimidazol-5-ylamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-(4-Phenoxy-benzyl)-3H-benzoimidazol-5-ylamine through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [492]
2-Methylamino-succinic acid(NMDA) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 2-Methylamino-succinic acid(NMDA). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-Methylamino-succinic acid(NMDA) through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [493]
2-Pyridin-4-yl-1,2,3,4-tetrahydro-isoquinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 2-Pyridin-4-yl-1,2,3,4-tetrahydro-isoquinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-Pyridin-4-yl-1,2,3,4-tetrahydro-isoquinoline through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [494]
3-Carbamoyl-6-chloro-1H-indole-2-carboxylic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 3-Carbamoyl-6-chloro-1H-indole-2-carboxylic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Carbamoyl-6-chloro-1H-indole-2-carboxylic acid through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [488]
3-Hydroxy-1H-benzo[b]azepine-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 3-Hydroxy-1H-benzo[b]azepine-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Hydroxy-1H-benzo[b]azepine-2,5-dione through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [495]
3-Hydroxy-6-methyl-1H-benzo[b]azepine-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 3-Hydroxy-6-methyl-1H-benzo[b]azepine-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Hydroxy-6-methyl-1H-benzo[b]azepine-2,5-dione through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [495]
3-Hydroxy-7-nitro-1H-benzo[b]azepine-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 3-Hydroxy-7-nitro-1H-benzo[b]azepine-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Hydroxy-7-nitro-1H-benzo[b]azepine-2,5-dione through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [489]
3-Hydroxy-8-methyl-1H-benzo[b]azepine-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 3-Hydroxy-8-methyl-1H-benzo[b]azepine-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Hydroxy-8-methyl-1H-benzo[b]azepine-2,5-dione through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [496]
3-phenyl-4-hydroxyquinolin-2(1H)-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 3-phenyl-4-hydroxyquinolin-2(1H)-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-phenyl-4-hydroxyquinolin-2(1H)-one through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [494]
4,5,7-Trichloro-3-hydroxy-1H-quinolin-2-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 4,5,7-Trichloro-3-hydroxy-1H-quinolin-2-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4,5,7-Trichloro-3-hydroxy-1H-quinolin-2-one through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [497]
4,6-Dichloro-1H-indole-2-carboxylic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 4,6-Dichloro-1H-indole-2-carboxylic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4,6-Dichloro-1H-indole-2-carboxylic acid through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [498]
4-(3,4-Dihydro-1H-isoquinolin-2-yl)-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 4-(3,4-Dihydro-1H-isoquinolin-2-yl)-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(3,4-Dihydro-1H-isoquinolin-2-yl)-quinoline through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [488]
4-Benzyl-1-(2-phenoxy-ethyl)-piperidine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 4-Benzyl-1-(2-phenoxy-ethyl)-piperidine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Benzyl-1-(2-phenoxy-ethyl)-piperidine through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [499]
4-Benzyl-1-phenethyl-piperidine hydrochloride [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 4-Benzyl-1-phenethyl-piperidine hydrochloride. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Benzyl-1-phenethyl-piperidine hydrochloride through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [490]
4-Bromo-3-hydroxy-1H-quinolin-2-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 4-Bromo-3-hydroxy-1H-quinolin-2-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Bromo-3-hydroxy-1H-quinolin-2-one through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [497]
4-Bromo-5,7-dichloro-3-hydroxy-1H-quinolin-2-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 4-Bromo-5,7-dichloro-3-hydroxy-1H-quinolin-2-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Bromo-5,7-dichloro-3-hydroxy-1H-quinolin-2-one through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [497]
4-Chloro-3-hydroxy-1H-quinolin-2-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 4-Chloro-3-hydroxy-1H-quinolin-2-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Chloro-3-hydroxy-1H-quinolin-2-one through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [500]
4-hydroxy-5-phenylthieno[2,3-b]pyridin-6(7H)-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 4-hydroxy-5-phenylthieno[2,3-b]pyridin-6(7H)-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-hydroxy-5-phenylthieno[2,3-b]pyridin-6(7H)-one through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [490]
4-[2-(3-Phenyl-propylamino)-ethyl]-phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 4-[2-(3-Phenyl-propylamino)-ethyl]-phenol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[2-(3-Phenyl-propylamino)-ethyl]-phenol through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [501]
4-[2-(4-Benzyl-piperidin-1-yl)-ethoxy]-phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 4-[2-(4-Benzyl-piperidin-1-yl)-ethoxy]-phenol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[2-(4-Benzyl-piperidin-1-yl)-ethoxy]-phenol through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [502]
4-[2-(4-Phenyl-butoxy)-ethyl]-phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 4-[2-(4-Phenyl-butoxy)-ethyl]-phenol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[2-(4-Phenyl-butoxy)-ethyl]-phenol through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [490]
4-[2-(4-Phenyl-butylamino)-ethyl]-phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 4-[2-(4-Phenyl-butylamino)-ethyl]-phenol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[2-(4-Phenyl-butylamino)-ethyl]-phenol through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [490]
4-[2-(4-Phenyl-piperidin-1-yl)-ethoxy]-phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 4-[2-(4-Phenyl-piperidin-1-yl)-ethoxy]-phenol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[2-(4-Phenyl-piperidin-1-yl)-ethoxy]-phenol through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [503]
4-[2-(5-Phenyl-pentylamino)-ethyl]-phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 4-[2-(5-Phenyl-pentylamino)-ethyl]-phenol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[2-(5-Phenyl-pentylamino)-ethyl]-phenol through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [490]
4-[2-(6-Phenyl-hexylamino)-ethyl]-phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 4-[2-(6-Phenyl-hexylamino)-ethyl]-phenol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[2-(6-Phenyl-hexylamino)-ethyl]-phenol through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [490]
4-[3-(4-Phenyl-butylamino)-propyl]-phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 4-[3-(4-Phenyl-butylamino)-propyl]-phenol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[3-(4-Phenyl-butylamino)-propyl]-phenol through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [504]
4-[3-(5-Phenyl-pentylamino)-propyl]-phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 4-[3-(5-Phenyl-pentylamino)-propyl]-phenol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-[3-(5-Phenyl-pentylamino)-propyl]-phenol through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [487]
4-{2-[Ethyl-(4-phenyl-butyl)-amino]-ethyl}-phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 4-{2-[Ethyl-(4-phenyl-butyl)-amino]-ethyl}-phenol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-{2-[Ethyl-(4-phenyl-butyl)-amino]-ethyl}-phenol through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [490]
5,6,7-Trichloro-1,4-dihydro-quinoxaline-2,3-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 5,6,7-Trichloro-1,4-dihydro-quinoxaline-2,3-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5,6,7-Trichloro-1,4-dihydro-quinoxaline-2,3-dione through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [505]
5,7-Dibromo-1,4-dihydro-quinoxaline-2,3-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 5,7-Dibromo-1,4-dihydro-quinoxaline-2,3-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5,7-Dibromo-1,4-dihydro-quinoxaline-2,3-dione through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [505]
5,7-Dichloro-1,4-dihydro-quinoxaline-2,3-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 5,7-Dichloro-1,4-dihydro-quinoxaline-2,3-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5,7-Dichloro-1,4-dihydro-quinoxaline-2,3-dione through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [505]
5,7-Dichloro-3-hydroxy-1H-quinazoline-2,4-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 5,7-Dichloro-3-hydroxy-1H-quinazoline-2,4-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5,7-Dichloro-3-hydroxy-1H-quinazoline-2,4-dione through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [505]
5,7-Dichloro-4-hydroxy-3-phenyl-1H-quinolin-2-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 5,7-Dichloro-4-hydroxy-3-phenyl-1H-quinolin-2-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5,7-Dichloro-4-hydroxy-3-phenyl-1H-quinolin-2-one through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [501]
5,7-Dichlorokynurenic Acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 5,7-Dichlorokynurenic Acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5,7-Dichlorokynurenic Acid through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [506]
5,7-Dinitro-1,4-dihydro-quinoxaline-2,3-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 5,7-Dinitro-1,4-dihydro-quinoxaline-2,3-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5,7-Dinitro-1,4-dihydro-quinoxaline-2,3-dione through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [501]
6,7-Dichloro-1,4-dihydro-quinoxaline-2,3-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 6,7-Dichloro-1,4-dihydro-quinoxaline-2,3-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6,7-Dichloro-1,4-dihydro-quinoxaline-2,3-dione through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [507]
6,7-Dichloro-3-hydroxy-1H-quinazoline-2,4-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 6,7-Dichloro-3-hydroxy-1H-quinazoline-2,4-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6,7-Dichloro-3-hydroxy-1H-quinazoline-2,4-dione through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [508]
6-Chloro-1,4-dihydro-quinoxaline-2,3-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 6-Chloro-1,4-dihydro-quinoxaline-2,3-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-Chloro-1,4-dihydro-quinoxaline-2,3-dione through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [509]
6-Methoxy-2-(4-phenoxy-benzyl)-1H-benzoimidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 6-Methoxy-2-(4-phenoxy-benzyl)-1H-benzoimidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-Methoxy-2-(4-phenoxy-benzyl)-1H-benzoimidazole through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [492]
6-Nitro-1,4-dihydro-quinoxaline-2,3-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 6-Nitro-1,4-dihydro-quinoxaline-2,3-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-Nitro-1,4-dihydro-quinoxaline-2,3-dione through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [490]
6-Nitro-2-(4-phenoxy-benzyl)-1H-benzoimidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 6-Nitro-2-(4-phenoxy-benzyl)-1H-benzoimidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-Nitro-2-(4-phenoxy-benzyl)-1H-benzoimidazole through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [508]
7-chloro-3-hydroxyquinazoline-2,4-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 7-chloro-3-hydroxyquinazoline-2,4-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 7-chloro-3-hydroxyquinazoline-2,4-dione through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [510]
8-Bromo-3-hydroxy-1H-benzo[b]azepine-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 8-Bromo-3-hydroxy-1H-benzo[b]azepine-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 8-Bromo-3-hydroxy-1H-benzo[b]azepine-2,5-dione through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [495]
8-Chloro-3-hydroxy-1H-benzo[b]azepine-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 8-Chloro-3-hydroxy-1H-benzo[b]azepine-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 8-Chloro-3-hydroxy-1H-benzo[b]azepine-2,5-dione through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [495]
8-Ethyl-3-hydroxy-1H-benzo[b]azepine-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 8-Ethyl-3-hydroxy-1H-benzo[b]azepine-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 8-Ethyl-3-hydroxy-1H-benzo[b]azepine-2,5-dione through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [495]
8-Fluoro-3-hydroxy-1H-benzo[b]azepine-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for 8-Fluoro-3-hydroxy-1H-benzo[b]azepine-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 8-Fluoro-3-hydroxy-1H-benzo[b]azepine-2,5-dione through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [495]
Ala-Pro-Glu [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for Ala-Pro-Glu. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ala-Pro-Glu through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [495]
AP-7 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for AP-7. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AP-7 through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [507]
Benzyl 4-aminobutyl(3-aminopropyl)carbamate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for Benzyl 4-aminobutyl(3-aminopropyl)carbamate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Benzyl 4-aminobutyl(3-aminopropyl)carbamate through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [511]
CGP61594 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for CGP61594. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CGP61594 through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [489]
Cycloleucine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for Cycloleucine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cycloleucine through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [492]
D-aspartic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for D-aspartic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of D-aspartic acid through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [489]
DNQX [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for DNQX. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of DNQX through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [495]
Gly-Amp-Glu [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for Gly-Amp-Glu. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Gly-Amp-Glu through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [512]
Gly-b7Pro-Glu [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for Gly-b7Pro-Glu. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Gly-b7Pro-Glu through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [488]
Gly-Hyp-Glu [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for Gly-Hyp-Glu. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Gly-Hyp-Glu through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [488]
Gly-Pip-Glu [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for Gly-Pip-Glu. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Gly-Pip-Glu through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [488]
H-Gly-D-dmP-Glu-OH [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for H-Gly-D-dmP-Glu-OH. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of H-Gly-D-dmP-Glu-OH through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [510]
H-Gly-dmP-Glu-OH [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for H-Gly-dmP-Glu-OH. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of H-Gly-dmP-Glu-OH through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [513]
homoquinolinic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for homoquinolinic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of homoquinolinic acid through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [489]
L-aspartic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for L-aspartic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-aspartic acid through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [489]
N,N'-Bis-(4-butoxy-phenyl)-guanidine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for N,N'-Bis-(4-butoxy-phenyl)-guanidine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N,N'-Bis-(4-butoxy-phenyl)-guanidine through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [508]
N,N'-Bis-(4-butyl-phenyl)-guanidine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for N,N'-Bis-(4-butyl-phenyl)-guanidine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N,N'-Bis-(4-butyl-phenyl)-guanidine through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [508]
N,N'-Bis-(4-ethyl-phenyl)-guanidine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for N,N'-Bis-(4-ethyl-phenyl)-guanidine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N,N'-Bis-(4-ethyl-phenyl)-guanidine through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [508]
N,N'-Bis-(4-hexyl-phenyl)-guanidine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for N,N'-Bis-(4-hexyl-phenyl)-guanidine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N,N'-Bis-(4-hexyl-phenyl)-guanidine through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [508]
N,N'-Bis-(4-isopropyl-phenyl)-guanidine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for N,N'-Bis-(4-isopropyl-phenyl)-guanidine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N,N'-Bis-(4-isopropyl-phenyl)-guanidine through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [508]
N,N'-Bis-(4-sec-butyl-phenyl)-guanidine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for N,N'-Bis-(4-sec-butyl-phenyl)-guanidine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N,N'-Bis-(4-sec-butyl-phenyl)-guanidine through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [487]
N-(2-methoxybenzyl)cinnamamidine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for N-(2-methoxybenzyl)cinnamamidine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(2-methoxybenzyl)cinnamamidine through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [503]
Nle-Pro-Glu [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for Nle-Pro-Glu. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Nle-Pro-Glu through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [488]
Phe-Pro-Glu [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for Phe-Pro-Glu. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Phe-Pro-Glu through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [488]
PHENCYCLIDINE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for PHENCYCLIDINE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PHENCYCLIDINE through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [509]
Phenethyl-(3-phenyl-propyl)-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for Phenethyl-(3-phenyl-propyl)-amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Phenethyl-(3-phenyl-propyl)-amine through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [487]
Phenethyl-(4-phenyl-butyl)-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for Phenethyl-(4-phenyl-butyl)-amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Phenethyl-(4-phenyl-butyl)-amine through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [490]
RPR-118723 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for RPR-118723. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RPR-118723 through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [497]
TRANSTORINE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for TRANSTORINE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TRANSTORINE through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [513]
[3H]CGP39653 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for [3H]CGP39653. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of [3H]CGP39653 through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [489]
[3H]CGS19755 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for [3H]CGS19755. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of [3H]CGS19755 through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [489]
[3H]CPP [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for [3H]CPP. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of [3H]CPP through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [489]
[3H]dizocilpine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for [3H]dizocilpine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of [3H]dizocilpine through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [489]
[3H]MDL105519 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for [3H]MDL105519. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of [3H]MDL105519 through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [489]
AM-92016 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for AM-92016. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AM-92016 through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [514]
DIZOCILPINE [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for DIZOCILPINE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of DIZOCILPINE through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [501]
L-687414 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for L-687414. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-687414 through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [501]
L-689560 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for L-689560. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-689560 through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [515]
L-695902 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for L-695902. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-695902 through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [78], [484]
L-698532 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for L-698532. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-698532 through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [503]
L-698544 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for L-698544. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-698544 through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [503]
L-701324 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for L-701324. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-701324 through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [516]
MDL-105519 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for MDL-105519. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MDL-105519 through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [501]
RPR-104632 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for RPR-104632. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RPR-104632 through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [517]
SPERMINE [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for SPERMINE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SPERMINE through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [496]
YM-90K [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for YM-90K. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of YM-90K through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [484], [518]
Glycogen synthase kinase-3 beta (GSK-3B)
AMO-02 [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for AMO-02. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AMO-02 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [520]
9-ING-41 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for 9-ING-41. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 9-ING-41 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [521]
Lithium [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for Lithium. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Lithium through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [522]
LY2090314 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for LY2090314. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LY2090314 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [523]
Neu-120 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for Neu-120. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Neu-120 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [524]
Tideglusib [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for Tideglusib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Tideglusib through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [525]
(E)-N-(6-(prop-1-enyl)-1H-indazol-3-yl)butyramide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for (E)-N-(6-(prop-1-enyl)-1H-indazol-3-yl)butyramide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (E)-N-(6-(prop-1-enyl)-1H-indazol-3-yl)butyramide through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [526]
12,13-DEHYDRO-8-O-ACETYLMANZAMINE A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for 12,13-DEHYDRO-8-O-ACETYLMANZAMINE A. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 12,13-DEHYDRO-8-O-ACETYLMANZAMINE A through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [527]
12,13-DEHYDROMANZAMINE A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for 12,13-DEHYDROMANZAMINE A. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 12,13-DEHYDROMANZAMINE A through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [527]
3-(6-(phenylamino)-9H-purin-8-yl)benzonitrile [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for 3-(6-(phenylamino)-9H-purin-8-yl)benzonitrile. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(6-(phenylamino)-9H-purin-8-yl)benzonitrile through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [528]
3-phenyl-4-(phenylamino)-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for 3-phenyl-4-(phenylamino)-1H-pyrrole-2,5-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-phenyl-4-(phenylamino)-1H-pyrrole-2,5-dione through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [529]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [530]
4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for 4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [531]
6-deoxymanzamine X [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for 6-deoxymanzamine X. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-deoxymanzamine X through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [527]
8-O-(4-bromobenzenesulfonyl)manzamine F [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for 8-O-(4-bromobenzenesulfonyl)manzamine F. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 8-O-(4-bromobenzenesulfonyl)manzamine F through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [527]
8-O-(4-chlorobenzenesulfonyl)manzamine F [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for 8-O-(4-chlorobenzenesulfonyl)manzamine F. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 8-O-(4-chlorobenzenesulfonyl)manzamine F through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [532]
8-O-(4-toluenesulfonyl)manzamine A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for 8-O-(4-toluenesulfonyl)manzamine A. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 8-O-(4-toluenesulfonyl)manzamine A through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [532]
8-OH-MANZAMINE A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for 8-OH-MANZAMINE A. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 8-OH-MANZAMINE A through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [188], [519]
9-N-ETHYL-8-ETHOXY-MANZAMINE A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for 9-N-ETHYL-8-ETHOXY-MANZAMINE A. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 9-N-ETHYL-8-ETHOXY-MANZAMINE A through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [527]
9-N-METHYL-8-METHOXY-MANZAMINE A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for 9-N-METHYL-8-METHOXY-MANZAMINE A. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 9-N-METHYL-8-METHOXY-MANZAMINE A through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [527]
alsterpaullone 2-cyanoethyl [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for alsterpaullone 2-cyanoethyl. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of alsterpaullone 2-cyanoethyl through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [215], [519]
AMP-PNP [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for AMP-PNP. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AMP-PNP through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [225], [519]
AS-601245 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for AS-601245. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AS-601245 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [533]
AZAKENPAULLONE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for AZAKENPAULLONE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AZAKENPAULLONE through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [534]
Bisindolylmaleimide-I [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for Bisindolylmaleimide-I. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Bisindolylmaleimide-I through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [534]
BX-795 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for BX-795. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BX-795 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [215], [519]
BX-912 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for BX-912. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BX-912 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [213], [519]
CHIR-98014 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for CHIR-98014. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CHIR-98014 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [148], [519]
CHIR-98023 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for CHIR-98023. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CHIR-98023 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [535]
CI-1040 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for CI-1040. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CI-1040 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [536]
CP-70949 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for CP-70949. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CP-70949 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [537]
CT-98024 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for CT-98024. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CT-98024 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [538]
DM-204 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for DM-204. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of DM-204 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [521]
ELLAGIC ACID [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for ELLAGIC ACID. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ELLAGIC ACID through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [528]
GSK-3beta inhibitor II [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for GSK-3beta inhibitor II. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GSK-3beta inhibitor II through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [539]
GSK-3beta inhibitor XI [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for GSK-3beta inhibitor XI. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GSK-3beta inhibitor XI through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [227], [519]
I-5 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for I-5. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of I-5 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [78], [519]
IM-12 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for IM-12. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of IM-12 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [540]
indirubin deriv. 8a [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for indirubin deriv. 8a. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of indirubin deriv. 8a through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [541]
K00244 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for K00244. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of K00244 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [542]
L-779450 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for L-779450. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-779450 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [543]
LEUCETTAMINE B [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for LEUCETTAMINE B. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LEUCETTAMINE B through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [544]
MANZAMINE A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for MANZAMINE A. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MANZAMINE A through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [527]
Manzamine E [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for Manzamine E. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Manzamine E through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [527]
Manzamine Y [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for Manzamine Y. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Manzamine Y through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [532]
N,8-diphenyl-9H-purin-6-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for N,8-diphenyl-9H-purin-6-amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N,8-diphenyl-9H-purin-6-amine through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [532]
N-(6-(2-chlorophenyl)-1H-indazol-3-yl)butyramide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for N-(6-(2-chlorophenyl)-1H-indazol-3-yl)butyramide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(6-(2-chlorophenyl)-1H-indazol-3-yl)butyramide through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [535]
N-(6-(3-hydroxyphenyl)-1H-indazol-3-yl)butyramide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for N-(6-(3-hydroxyphenyl)-1H-indazol-3-yl)butyramide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(6-(3-hydroxyphenyl)-1H-indazol-3-yl)butyramide through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [535]
N-(6-(4-aminophenyl)-1H-indazol-3-yl)butyramide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for N-(6-(4-aminophenyl)-1H-indazol-3-yl)butyramide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(6-(4-aminophenyl)-1H-indazol-3-yl)butyramide through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [535]
N-(6-(4-fluorophenyl)-1H-indazol-3-yl)butyramide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for N-(6-(4-fluorophenyl)-1H-indazol-3-yl)butyramide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(6-(4-fluorophenyl)-1H-indazol-3-yl)butyramide through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [535]
N-(6-(4-hydroxyphenyl)-1H-indazol-3-yl)butyramide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for N-(6-(4-hydroxyphenyl)-1H-indazol-3-yl)butyramide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(6-(4-hydroxyphenyl)-1H-indazol-3-yl)butyramide through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [535]
N-(6-(furan-3-yl)-1H-indazol-3-yl)butyramide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for N-(6-(furan-3-yl)-1H-indazol-3-yl)butyramide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(6-(furan-3-yl)-1H-indazol-3-yl)butyramide through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [535]
N-(6-(pyridin-3-yl)-1H-indazol-3-yl)butyramide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for N-(6-(pyridin-3-yl)-1H-indazol-3-yl)butyramide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(6-(pyridin-3-yl)-1H-indazol-3-yl)butyramide through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [545]
N-(6-(pyridin-4-yl)-1H-indazol-3-yl)butyramide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for N-(6-(pyridin-4-yl)-1H-indazol-3-yl)butyramide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(6-(pyridin-4-yl)-1H-indazol-3-yl)butyramide through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [544]
N-(6-(thiophen-3-yl)-1H-indazol-3-yl)butyramide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for N-(6-(thiophen-3-yl)-1H-indazol-3-yl)butyramide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(6-(thiophen-3-yl)-1H-indazol-3-yl)butyramide through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [526]
N-(6-(trifluoromethyl)-1H-indazol-3-yl)butyramide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for N-(6-(trifluoromethyl)-1H-indazol-3-yl)butyramide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(6-(trifluoromethyl)-1H-indazol-3-yl)butyramide through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [535]
N-(6-benzyl-1H-indazol-3-yl)butyramide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for N-(6-benzyl-1H-indazol-3-yl)butyramide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(6-benzyl-1H-indazol-3-yl)butyramide through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [535]
N-(6-bromo-1H-indazol-3-yl)butyramide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for N-(6-bromo-1H-indazol-3-yl)butyramide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(6-bromo-1H-indazol-3-yl)butyramide through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [535]
N-(6-chloro-1H-indazol-3-yl)butyramide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for N-(6-chloro-1H-indazol-3-yl)butyramide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(6-chloro-1H-indazol-3-yl)butyramide through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [535]
N-(6-chloro-5-p-tolyl-1H-indazol-3-yl)butyramide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for N-(6-chloro-5-p-tolyl-1H-indazol-3-yl)butyramide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(6-chloro-5-p-tolyl-1H-indazol-3-yl)butyramide through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [535]
N-(6-chloro-5-phenyl-1H-indazol-3-yl)butyramide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for N-(6-chloro-5-phenyl-1H-indazol-3-yl)butyramide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(6-chloro-5-phenyl-1H-indazol-3-yl)butyramide through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [535]
N-(6-phenethyl-1H-indazol-3-yl)butyramide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for N-(6-phenethyl-1H-indazol-3-yl)butyramide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(6-phenethyl-1H-indazol-3-yl)butyramide through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [526]
N-(6-phenyl-1H-indazol-3-yl)butyramide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for N-(6-phenyl-1H-indazol-3-yl)butyramide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(6-phenyl-1H-indazol-3-yl)butyramide through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [535]
N-(8-(3-cyanophenyl)-9H-purin-6-yl)pentanamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for N-(8-(3-cyanophenyl)-9H-purin-6-yl)pentanamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(8-(3-cyanophenyl)-9H-purin-6-yl)pentanamide through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [528]
Neo-kauluamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for Neo-kauluamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Neo-kauluamine through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [224], [519]
NU-6102 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for NU-6102. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NU-6102 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [195], [519]
PAULLONE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for PAULLONE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PAULLONE through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [520]
PF-228 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for PF-228. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PF-228 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [535]
PYRAZOLOPYRIDAZINE 1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for PYRAZOLOPYRIDAZINE 1. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PYRAZOLOPYRIDAZINE 1 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [225], [519]
PYRAZOLOPYRIDAZINE 2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for PYRAZOLOPYRIDAZINE 2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PYRAZOLOPYRIDAZINE 2 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [544]
Quinoxaline1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for Quinoxaline1. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Quinoxaline1 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [546]
RGB-286147 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for RGB-286147. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RGB-286147 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [213], [519]
Ro31-8220 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for Ro31-8220. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ro31-8220 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [547]
SB-415286 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for SB-415286. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SB-415286 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [531]
STAUROSPORINONE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for STAUROSPORINONE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of STAUROSPORINONE through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [548]
Thieno analogue of kenpaullone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for Thieno analogue of kenpaullone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Thieno analogue of kenpaullone through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [549]
TWS-119 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for TWS-119. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TWS-119 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [550]
AZD-1080 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for AZD-1080. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AZD-1080 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [551]
RO-320432 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for RO-320432. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RO-320432 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [229], [519]
SAN-61 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Glycogen synthase kinase-3 beta (GSK-3B) is a therapeutic target for SAN-61. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SAN-61 through regulating the expression of Glycogen synthase kinase-3 beta (GSK-3B). [519], [552]
Heat shock protein 90 alpha (HSP90A)
Amlexanox [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for Amlexanox. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Amlexanox through regulating the expression of Heat shock protein 90 alpha (HSP90A). [78], [553]
Cromoglicate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for Cromoglicate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cromoglicate through regulating the expression of Heat shock protein 90 alpha (HSP90A). [78], [553]
BIIB-021 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for BIIB-021. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BIIB-021 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [554]
Efungumab [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for Efungumab. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Efungumab through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [555]
KW-2478 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for KW-2478. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of KW-2478 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [556]
NVP-AUY922 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for NVP-AUY922. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NVP-AUY922 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [557]
SNX-5422 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for SNX-5422. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SNX-5422 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [555]
Tanespimycin [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for Tanespimycin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Tanespimycin through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [558]
VER 50589 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for VER 50589. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of VER 50589 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [559]
Alvespimycin hydrochloride [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for Alvespimycin hydrochloride. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Alvespimycin hydrochloride through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [560]
AT13387 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for AT13387. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AT13387 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [555]
BIIB 028 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for BIIB 028. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BIIB 028 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [522], [553]
Debio 0932 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for Debio 0932. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Debio 0932 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [561]
PU-AD [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for PU-AD. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PU-AD through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [556]
PU3 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for PU3. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PU3 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [562]
RTA-901 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for RTA-901. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RTA-901 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [563]
CCT-018159 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for CCT-018159. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CCT-018159 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [405], [553]
KOS-2484 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for KOS-2484. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of KOS-2484 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [555]
17-desmethoxy-17-aminogeldanamycin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for 17-desmethoxy-17-aminogeldanamycin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 17-desmethoxy-17-aminogeldanamycin through regulating the expression of Heat shock protein 90 alpha (HSP90A). [376], [553]
2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for 2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol through regulating the expression of Heat shock protein 90 alpha (HSP90A). [78], [553]
2-Methyl-2,4-Pentanediol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for 2-Methyl-2,4-Pentanediol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-Methyl-2,4-Pentanediol through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [555]
4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for 4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [555]
6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for 6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE through regulating the expression of Heat shock protein 90 alpha (HSP90A). [78], [553]
8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H- [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H-. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H- through regulating the expression of Heat shock protein 90 alpha (HSP90A). [78], [553]
9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for 9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine through regulating the expression of Heat shock protein 90 alpha (HSP90A). [78], [553]
9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for 9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine through regulating the expression of Heat shock protein 90 alpha (HSP90A). [78], [553]
Geldanamycin-estradiol hybrid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for Geldanamycin-estradiol hybrid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Geldanamycin-estradiol hybrid through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [564]
GNF-PF-67 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for GNF-PF-67. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GNF-PF-67 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [376], [553]
KOSN1559 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for KOSN1559. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of KOSN1559 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [555]
Macbecin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for Macbecin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Macbecin through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [565]
PU24S [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for PU24S. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PU24S through regulating the expression of Heat shock protein 90 alpha (HSP90A). [148], [553]
Radicicol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for Radicicol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Radicicol through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [566]
RHEIN [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for RHEIN. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RHEIN through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [567]
SNX-2112 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for SNX-2112. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SNX-2112 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [564]
VER-49009 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for VER-49009. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of VER-49009 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [452], [553]
ZEARALANONE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for ZEARALANONE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ZEARALANONE through regulating the expression of Heat shock protein 90 alpha (HSP90A). [376], [553]
EC-154 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for EC-154. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of EC-154 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [568]
Geldanamycin [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for Geldanamycin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Geldanamycin through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [569]
HBP-347 [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for HBP-347. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of HBP-347 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [570]
IPI-493 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for IPI-493. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of IPI-493 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [553], [571]
Herpesvirus ubiquitin-specific protease (HAUSP)
ADC-01 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Herpesvirus ubiquitin-specific protease (HAUSP) is a therapeutic target for ADC-01. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ADC-01 through regulating the expression of Herpesvirus ubiquitin-specific protease (HAUSP). [572], [573]
ADC-03 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Herpesvirus ubiquitin-specific protease (HAUSP) is a therapeutic target for ADC-03. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ADC-03 through regulating the expression of Herpesvirus ubiquitin-specific protease (HAUSP). [572], [574]
HBX19818 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Herpesvirus ubiquitin-specific protease (HAUSP) is a therapeutic target for HBX19818. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of HBX19818 through regulating the expression of Herpesvirus ubiquitin-specific protease (HAUSP). [572], [575]
P22077 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Herpesvirus ubiquitin-specific protease (HAUSP) is a therapeutic target for P22077. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of P22077 through regulating the expression of Herpesvirus ubiquitin-specific protease (HAUSP). [572], [576]
Histone-lysine N-methyltransferase EHMT2 (EHMT2)
A-366 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone-lysine N-methyltransferase EHMT2 (EHMT2) is a therapeutic target for A-366. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of A-366 through regulating the expression of Histone-lysine N-methyltransferase EHMT2 (EHMT2). [577], [578]
BIX-01294 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone-lysine N-methyltransferase EHMT2 (EHMT2) is a therapeutic target for BIX-01294. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BIX-01294 through regulating the expression of Histone-lysine N-methyltransferase EHMT2 (EHMT2). [577], [579]
MS012 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone-lysine N-methyltransferase EHMT2 (EHMT2) is a therapeutic target for MS012. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MS012 through regulating the expression of Histone-lysine N-methyltransferase EHMT2 (EHMT2). [577], [580]
BRD9539 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone-lysine N-methyltransferase EHMT2 (EHMT2) is a therapeutic target for BRD9539. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BRD9539 through regulating the expression of Histone-lysine N-methyltransferase EHMT2 (EHMT2). [577], [581]
UNC0321 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone-lysine N-methyltransferase EHMT2 (EHMT2) is a therapeutic target for UNC0321. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of UNC0321 through regulating the expression of Histone-lysine N-methyltransferase EHMT2 (EHMT2). [577], [582]
UNC0638 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone-lysine N-methyltransferase EHMT2 (EHMT2) is a therapeutic target for UNC0638. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of UNC0638 through regulating the expression of Histone-lysine N-methyltransferase EHMT2 (EHMT2). [577], [583]
UNC0642 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone-lysine N-methyltransferase EHMT2 (EHMT2) is a therapeutic target for UNC0642. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of UNC0642 through regulating the expression of Histone-lysine N-methyltransferase EHMT2 (EHMT2). [577], [584]
Integrin beta-1 (ITGB1)
131I-radretumab [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Integrin beta-1 (ITGB1) is a therapeutic target for 131I-radretumab. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 131I-radretumab through regulating the expression of Integrin beta-1 (ITGB1). [585], [586]
JSM 6427 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Integrin beta-1 (ITGB1) is a therapeutic target for JSM 6427. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of JSM 6427 through regulating the expression of Integrin beta-1 (ITGB1). [585], [587]
OS2966 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Integrin beta-1 (ITGB1) is a therapeutic target for OS2966. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of OS2966 through regulating the expression of Integrin beta-1 (ITGB1). [585], [588]
C(-GRGDfL-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Integrin beta-1 (ITGB1) is a therapeutic target for C(-GRGDfL-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C(-GRGDfL-) through regulating the expression of Integrin beta-1 (ITGB1). [585], [589]
MK-0668 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Integrin beta-1 (ITGB1) is a therapeutic target for MK-0668. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MK-0668 through regulating the expression of Integrin beta-1 (ITGB1). [585], [590]
SB-265123 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Integrin beta-1 (ITGB1) is a therapeutic target for SB-265123. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SB-265123 through regulating the expression of Integrin beta-1 (ITGB1). [585], [591]
Intercellular adhesion molecule ICAM-1 (ICAM1)
ISIS 1570 [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for ISIS 1570. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 1570 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [593]
lifitegrast [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for lifitegrast. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of lifitegrast through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [594]
Alicaforsen [Phase 3]
In total 2 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for Alicaforsen. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Alicaforsen through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [595]
Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for Alicaforsen. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Alicaforsen through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [596]
APC-8015F [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for APC-8015F. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of APC-8015F through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [597]
BI-505 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for BI-505. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BI-505 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [598]
AIC100 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for AIC100. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AIC100 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [599]
A-286982 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for A-286982. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of A-286982 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [600]
Dehydropipernonaline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for Dehydropipernonaline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Dehydropipernonaline through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [600]
ISIS 11158 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for ISIS 11158. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 11158 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [601]
ISIS 11159 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for ISIS 11159. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 11159 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [602]
ISIS 11665 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for ISIS 11665. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 11665 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [602]
ISIS 1931 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for ISIS 1931. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 1931 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [595]
ISIS 2974 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for ISIS 2974. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 2974 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [602]
ISIS 3067 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for ISIS 3067. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 3067 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [602]
ISIS 3224 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for ISIS 3224. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 3224 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [602]
ISIS-1939 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for ISIS-1939. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS-1939 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [603]
Pellitorin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for Pellitorin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Pellitorin through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [600]
PIPERNONALINE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for PIPERNONALINE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PIPERNONALINE through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [604]
PIPERROLEIN B [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for PIPERROLEIN B. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PIPERROLEIN B through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [600]
A-252444.0 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for A-252444.0. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of A-252444.0 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [605]
GI-270384X [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for GI-270384X. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GI-270384X through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [606]
INXC-ICAM1 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for INXC-ICAM1. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of INXC-ICAM1 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [595]
MOR-102 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for MOR-102. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MOR-102 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [592], [607]
Janus kinase 2 (JAK-2)
Baricitinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for Baricitinib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Baricitinib through regulating the expression of Janus kinase 2 (JAK-2). [608], [609]
Fedratinib [Approved]
In total 2 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for Fedratinib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Fedratinib through regulating the expression of Janus kinase 2 (JAK-2). [608], [610]
Janus kinase 2 (JAK-2) is a therapeutic target for Fedratinib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Fedratinib through regulating the expression of Janus kinase 2 (JAK-2). [608], [628]
Ruxolitinib [Approved]
In total 2 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for Ruxolitinib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ruxolitinib through regulating the expression of Janus kinase 2 (JAK-2). [608], [611]
Janus kinase 2 (JAK-2) is a therapeutic target for Ruxolitinib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ruxolitinib through regulating the expression of Janus kinase 2 (JAK-2). [114], [608]
CYT-387 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for CYT-387. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CYT-387 through regulating the expression of Janus kinase 2 (JAK-2). [608], [612]
ITF2357 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for ITF2357. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ITF2357 through regulating the expression of Janus kinase 2 (JAK-2). [608], [613]
Pacritinib [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for Pacritinib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Pacritinib through regulating the expression of Janus kinase 2 (JAK-2). [608], [614]
XL019 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for XL019. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of XL019 through regulating the expression of Janus kinase 2 (JAK-2). [608], [615]
AZD1480 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for AZD1480. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AZD1480 through regulating the expression of Janus kinase 2 (JAK-2). [608], [616]
BMS-911543 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for BMS-911543. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BMS-911543 through regulating the expression of Janus kinase 2 (JAK-2). [608], [617]
Cerdulatinib [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for Cerdulatinib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cerdulatinib through regulating the expression of Janus kinase 2 (JAK-2). [608], [618]
CTP-543 [Phase 2]
In total 2 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for CTP-543. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CTP-543 through regulating the expression of Janus kinase 2 (JAK-2). [608], [619]
Janus kinase 2 (JAK-2) is a therapeutic target for CTP-543. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CTP-543 through regulating the expression of Janus kinase 2 (JAK-2). [608], [615]
INCB039110 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for INCB039110. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of INCB039110 through regulating the expression of Janus kinase 2 (JAK-2). [608], [620]
LY2784544 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for LY2784544. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LY2784544 through regulating the expression of Janus kinase 2 (JAK-2). [608], [621]
NS-018 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for NS-018. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NS-018 through regulating the expression of Janus kinase 2 (JAK-2). [608], [619]
AC430 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for AC430. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AC430 through regulating the expression of Janus kinase 2 (JAK-2). [608], [622]
Peginterferon beta [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for Peginterferon beta. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Peginterferon beta through regulating the expression of Janus kinase 2 (JAK-2). [608], [611]
SB-1578 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for SB-1578. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SB-1578 through regulating the expression of Janus kinase 2 (JAK-2). [608], [623]
1,2,3,4,5,6-hexabromocyclohexane [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for 1,2,3,4,5,6-hexabromocyclohexane. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1,2,3,4,5,6-hexabromocyclohexane through regulating the expression of Janus kinase 2 (JAK-2). [608], [624]
5-phenyl-1H-indazol-3-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for 5-phenyl-1H-indazol-3-amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-phenyl-1H-indazol-3-amine through regulating the expression of Janus kinase 2 (JAK-2). [608], [625]
AMG-JAK2-01 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for AMG-JAK2-01. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AMG-JAK2-01 through regulating the expression of Janus kinase 2 (JAK-2). [608], [619]
Atropisomer 1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for Atropisomer 1. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Atropisomer 1 through regulating the expression of Janus kinase 2 (JAK-2). [376], [608]
AZ960 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for AZ960. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AZ960 through regulating the expression of Janus kinase 2 (JAK-2). [78], [608]
BVB-808 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for BVB-808. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BVB-808 through regulating the expression of Janus kinase 2 (JAK-2). [608], [626]
CMP-6 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for CMP-6. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CMP-6 through regulating the expression of Janus kinase 2 (JAK-2). [608], [627]
K-454 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for K-454. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of K-454 through regulating the expression of Janus kinase 2 (JAK-2). [608], [629]
NSC-1771 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for NSC-1771. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NSC-1771 through regulating the expression of Janus kinase 2 (JAK-2). [608], [630]
ON-044580 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for ON-044580. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ON-044580 through regulating the expression of Janus kinase 2 (JAK-2). [608], [619]
SGI-1252 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for SGI-1252. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SGI-1252 through regulating the expression of Janus kinase 2 (JAK-2). [608], [631]
WHI-P154 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for WHI-P154. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of WHI-P154 through regulating the expression of Janus kinase 2 (JAK-2). [608], [632]
AG490 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for AG490. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AG490 through regulating the expression of Janus kinase 2 (JAK-2). [608], [611]
Leukocyte immunoglobulin-like receptor B4 (LILRB4)
IO-202 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Leukocyte immunoglobulin-like receptor B4 (LILRB4) is a therapeutic target for IO-202. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of IO-202 through regulating the expression of Leukocyte immunoglobulin-like receptor B4 (LILRB4). [633], [634]
Mammalian target of rapamycin complex 1 (mTORC1)
RBT-101 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for RBT-101. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RBT-101 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [635], [636]
AZD-2014 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for AZD-2014. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AZD-2014 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [635], [637]
ME-344 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for ME-344. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ME-344 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [38], [635]
NV-5138 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for NV-5138. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NV-5138 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [635], [638]
Palomid-529 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for Palomid-529. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Palomid-529 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [38], [635]
VS-5584 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for VS-5584. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of VS-5584 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [635], [639]
Matrix metalloproteinase-13 (MMP-13)
Curcumin [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for Curcumin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Curcumin through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [641]
Apratastat [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for Apratastat. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Apratastat through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [642]
PMID17935984C1 [Clinical trial]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for PMID17935984C1. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PMID17935984C1 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [643]
1-(4-Methoxy-benzenesulfonyl)-heptane-3-thiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 1-(4-Methoxy-benzenesulfonyl)-heptane-3-thiol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-(4-Methoxy-benzenesulfonyl)-heptane-3-thiol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [644]
1-Methyloxy-4-Sulfone-Benzene [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 1-Methyloxy-4-Sulfone-Benzene. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-Methyloxy-4-Sulfone-Benzene through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [645]
2-(2-(biphenyl-4-yl)ethylsulfonyl)acetic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 2-(2-(biphenyl-4-yl)ethylsulfonyl)acetic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-(2-(biphenyl-4-yl)ethylsulfonyl)acetic acid through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [646]
2-(biphenyl-4-ylsulfonamido)pentanedioic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 2-(biphenyl-4-ylsulfonamido)pentanedioic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-(biphenyl-4-ylsulfonamido)pentanedioic acid through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [642]
2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [647]
3-(4-Methoxy-benzenesulfonyl)-cyclohexanethiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 3-(4-Methoxy-benzenesulfonyl)-cyclohexanethiol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-Methoxy-benzenesulfonyl)-cyclohexanethiol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [648]
3-(4-Methoxy-benzenesulfonyl)-cyclopentanethiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 3-(4-Methoxy-benzenesulfonyl)-cyclopentanethiol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-Methoxy-benzenesulfonyl)-cyclopentanethiol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [649]
3-(4-Methoxy-benzenesulfonyl)-hexane-1-thiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 3-(4-Methoxy-benzenesulfonyl)-hexane-1-thiol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-Methoxy-benzenesulfonyl)-hexane-1-thiol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [650]
3-(4-Methoxy-benzenesulfonyl)-pentane-1-thiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 3-(4-Methoxy-benzenesulfonyl)-pentane-1-thiol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-Methoxy-benzenesulfonyl)-pentane-1-thiol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [644]
3-(4-Methoxy-benzenesulfonyl)-propane-1-thiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 3-(4-Methoxy-benzenesulfonyl)-propane-1-thiol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-Methoxy-benzenesulfonyl)-propane-1-thiol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [651]
3-(4-Phenoxy-benzenesulfonyl)-cyclohexanethiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 3-(4-Phenoxy-benzenesulfonyl)-cyclohexanethiol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-Phenoxy-benzenesulfonyl)-cyclohexanethiol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [644]
3-(4-Phenoxy-benzenesulfonyl)-propane-1-thiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 3-(4-Phenoxy-benzenesulfonyl)-propane-1-thiol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-Phenoxy-benzenesulfonyl)-propane-1-thiol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [644]
3-Benzenesulfonyl-heptanoic acid hydroxyamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 3-Benzenesulfonyl-heptanoic acid hydroxyamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Benzenesulfonyl-heptanoic acid hydroxyamide through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [645]
3-Cyclohexanesulfonyl-heptanoic acid hydroxyamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 3-Cyclohexanesulfonyl-heptanoic acid hydroxyamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Cyclohexanesulfonyl-heptanoic acid hydroxyamide through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [651]
3-Methylpyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 3-Methylpyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Methylpyridine through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [148], [640]
4-(2,2'-bithiophen-5-ylmethyleneamino)phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 4-(2,2'-bithiophen-5-ylmethyleneamino)phenol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(2,2'-bithiophen-5-ylmethyleneamino)phenol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [652]
4-(4-Methoxy-benzenesulfonyl)-butane-2-thiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 4-(4-Methoxy-benzenesulfonyl)-butane-2-thiol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(4-Methoxy-benzenesulfonyl)-butane-2-thiol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [651]
4-(methyl(4-phenylthiazol-2-yl)amino)phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 4-(methyl(4-phenylthiazol-2-yl)amino)phenol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(methyl(4-phenylthiazol-2-yl)amino)phenol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [653]
4-amino-3-(4-(hexyloxy)phenyl)-4-oxobutanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 4-amino-3-(4-(hexyloxy)phenyl)-4-oxobutanoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-amino-3-(4-(hexyloxy)phenyl)-4-oxobutanoic acid through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [642]
5-(4'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 5-(4'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-(4'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [654]
CL82198 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for CL82198. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CL82198 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [655]
Ethyl 2-cyano-2-(quinoxalin-2(1H)-ylidene)acetate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for Ethyl 2-cyano-2-(quinoxalin-2(1H)-ylidene)acetate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ethyl 2-cyano-2-(quinoxalin-2(1H)-ylidene)acetate through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [653]
Hydroxyaminovaline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for Hydroxyaminovaline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Hydroxyaminovaline through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [148], [640]
IK-862 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for IK-862. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of IK-862 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [644]
MMI270 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for MMI270. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MMI270 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [656]
N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [646]
N1,N3-bis(3-methoxybenzyl)isophthalamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for N1,N3-bis(3-methoxybenzyl)isophthalamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N1,N3-bis(3-methoxybenzyl)isophthalamide through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [657]
N4,N6-dibenzylpyrimidine-4,6-dicarboxamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for N4,N6-dibenzylpyrimidine-4,6-dicarboxamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N4,N6-dibenzylpyrimidine-4,6-dicarboxamide through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [642]
PD-156 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for PD-156. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PD-156 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [658]
PKF-242-484 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for PKF-242-484. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PKF-242-484 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [659]
Ro-37-9790 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for Ro-37-9790. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ro-37-9790 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [644]
SL422 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for SL422. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SL422 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [660]
SR-973 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for SR-973. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SR-973 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [647]
UK-356618 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for UK-356618. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of UK-356618 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [148], [640]
WAY-151693 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for WAY-151693. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of WAY-151693 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [148], [640]
WAY170523 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for WAY170523. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of WAY170523 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [660]
[2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for [2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of [2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [647]
GM6001 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for GM6001. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GM6001 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [661]
RS-130830 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for RS-130830. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RS-130830 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [640], [662]
Melanocortin receptor 4 (MC4R)
Amylin [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Amylin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Amylin through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [664]
Bremelanotide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Bremelanotide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Bremelanotide through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [665]
Methylnaltrexone bromide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Methylnaltrexone bromide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Methylnaltrexone bromide through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [666]
Setmelanotide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Setmelanotide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Setmelanotide through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [667]
AMG 386 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for AMG 386. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AMG 386 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [668]
AP-1030 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for AP-1030. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AP-1030 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [669]
PF-446687 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for PF-446687. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PF-446687 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [670]
PMX-53 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for PMX-53. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PMX-53 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [667]
IDDBCP-150101 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for IDDBCP-150101. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of IDDBCP-150101 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [667]
Melanotetan II [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Melanotetan II. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Melanotetan II through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [667]
Ro-27-3225 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ro-27-3225. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ro-27-3225 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [671]
1-Benzyl-4-methyl-piperazine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for 1-Benzyl-4-methyl-piperazine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-Benzyl-4-methyl-piperazine through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [672]
1-Methyl-4-(1-phenyl-ethyl)-piperazine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for 1-Methyl-4-(1-phenyl-ethyl)-piperazine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-Methyl-4-(1-phenyl-ethyl)-piperazine through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [673]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [667]
Ac-dR[CEHdFRWC]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ac-dR[CEHdFRWC]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-dR[CEHdFRWC]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [674]
Ac-His-D-Phe-Arg-2-Nal-NHCH3 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ac-His-D-Phe-Arg-2-Nal-NHCH3. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-His-D-Phe-Arg-2-Nal-NHCH3 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [675]
Ac-His-DPhe-Arg-Trp-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ac-His-DPhe-Arg-Trp-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-His-DPhe-Arg-Trp-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [676]
Ac-Nle-c[Asp-His-DNaI(2')-Pro-Trp-Lys]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ac-Nle-c[Asp-His-DNaI(2')-Pro-Trp-Lys]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-Nle-c[Asp-His-DNaI(2')-Pro-Trp-Lys]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [677]
Ac-Nle-c[Asp-His-DNal(2')-Pro-Trp-Lys]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ac-Nle-c[Asp-His-DNal(2')-Pro-Trp-Lys]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-Nle-c[Asp-His-DNal(2')-Pro-Trp-Lys]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [678]
AC-Nle-c[Asp-His-DPhe-Pro-Trp-Lys]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for AC-Nle-c[Asp-His-DPhe-Pro-Trp-Lys]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AC-Nle-c[Asp-His-DPhe-Pro-Trp-Lys]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [679]
Ac-R[CEHdFRWC]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ac-R[CEHdFRWC]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-R[CEHdFRWC]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [673]
Ac-Tyr-D-Phe-Arg-2-Nal-NHCH3 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ac-Tyr-D-Phe-Arg-2-Nal-NHCH3. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-Tyr-D-Phe-Arg-2-Nal-NHCH3 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [680]
Ac-YCit[CEHdFRWC]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ac-YCit[CEHdFRWC]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-YCit[CEHdFRWC]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [673]
Ac-YK[CEHdFRWC]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ac-YK[CEHdFRWC]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-YK[CEHdFRWC]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [673]
Ac-YRC(Me)*EHdFRWC(Me)NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ac-YRC(Me)*EHdFRWC(Me)NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-YRC(Me)*EHdFRWC(Me)NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [673]
Ac-YRMEHdFRWG-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ac-YRMEHdFRWG-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-YRMEHdFRWG-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [673]
Ac-YRMEHdFRWGSPPKD-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ac-YRMEHdFRWGSPPKD-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-YRMEHdFRWGSPPKD-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [673]
Ac-YR[CE(1-Me-H)dFRWC]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ac-YR[CE(1-Me-H)dFRWC]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-YR[CE(1-Me-H)dFRWC]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [673]
Ac-YR[CEH(d-2alpha-Nal)RWC]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ac-YR[CEH(d-2alpha-Nal)RWC]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-YR[CEH(d-2alpha-Nal)RWC]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [673]
Ac-YR[CEH(pCl-dF)RWC]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ac-YR[CEH(pCl-dF)RWC]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-YR[CEH(pCl-dF)RWC]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [673]
Ac-YR[CEH(pF-dF)RWC]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ac-YR[CEH(pF-dF)RWC]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-YR[CEH(pF-dF)RWC]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [673]
Ac-YR[CEHdFRWC]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ac-YR[CEHdFRWC]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-YR[CEHdFRWC]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [673]
Ac-YR[CEHdFRWC]SPPKD-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ac-YR[CEHdFRWC]SPPKD-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-YR[CEHdFRWC]SPPKD-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [673]
Ac-YR[CEHFRWC]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ac-YR[CEHFRWC]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-YR[CEHFRWC]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [673]
Ac-[CEHdFRWC]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ac-[CEHdFRWC]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ac-[CEHdFRWC]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [673]
AEKKDEGPYRMEHFRWGSPPKD [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for AEKKDEGPYRMEHFRWGSPPKD. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AEKKDEGPYRMEHFRWGSPPKD through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [673]
AMSH [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for AMSH. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AMSH through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [681]
BL-6020 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for BL-6020. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BL-6020 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [682]
C(his-D-phe-arg-trp-Abu) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C(his-D-phe-arg-trp-Abu). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C(his-D-phe-arg-trp-Abu) through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [683]
C(his-D-phe-arg-trp-Ahp) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C(his-D-phe-arg-trp-Ahp). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C(his-D-phe-arg-trp-Ahp) through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [683]
C(his-D-phe-arg-trp-Ahx) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C(his-D-phe-arg-trp-Ahx). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C(his-D-phe-arg-trp-Ahx) through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [683]
C(his-D-phe-arg-trp-Aoc) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C(his-D-phe-arg-trp-Aoc). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C(his-D-phe-arg-trp-Aoc) through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [684]
C(his-L-phe-arg-trp-Aoc) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C(his-L-phe-arg-trp-Aoc). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C(his-L-phe-arg-trp-Aoc) through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [685]
C[CO-(CH2)2-CO-Nle-D-Nal(2)-Arg-Trp-Lys]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C[CO-(CH2)2-CO-Nle-D-Nal(2)-Arg-Trp-Lys]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C[CO-(CH2)2-CO-Nle-D-Nal(2)-Arg-Trp-Lys]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [676]
C[CO-(CH2)2-CO-Nle-D-Phe-Arg-Trp-Lys]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C[CO-(CH2)2-CO-Nle-D-Phe-Arg-Trp-Lys]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C[CO-(CH2)2-CO-Nle-D-Phe-Arg-Trp-Lys]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [676]
C[CO-(CH2)3-CO-Pro-D-Nal(2)-Arg-Trp-Lys]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C[CO-(CH2)3-CO-Pro-D-Nal(2)-Arg-Trp-Lys]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C[CO-(CH2)3-CO-Pro-D-Nal(2)-Arg-Trp-Lys]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [676]
C[CO-o-C6H4-CO-Pro-D-Nal(2)-Arg-Trp-Lys]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C[CO-o-C6H4-CO-Pro-D-Nal(2)-Arg-Trp-Lys]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C[CO-o-C6H4-CO-Pro-D-Nal(2)-Arg-Trp-Lys]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [676]
C[CO-o-C6H4-CO-Pro-D-Phe-Arg-Trp-Lys]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C[CO-o-C6H4-CO-Pro-D-Phe-Arg-Trp-Lys]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C[CO-o-C6H4-CO-Pro-D-Phe-Arg-Trp-Lys]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [677]
C[Nle-Arg-D-Nal(2')-Arg-Trp-Glu]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C[Nle-Arg-D-Nal(2')-Arg-Trp-Glu]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C[Nle-Arg-D-Nal(2')-Arg-Trp-Glu]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [675]
C[Nle-Arg-D-Phe-Arg-Trp-Glu]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C[Nle-Arg-D-Phe-Arg-Trp-Glu]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C[Nle-Arg-D-Phe-Arg-Trp-Glu]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [670]
C[Nle-Asp-D-Nal(2')-Arg-Trp-Glu]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C[Nle-Asp-D-Nal(2')-Arg-Trp-Glu]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C[Nle-Asp-D-Nal(2')-Arg-Trp-Glu]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [675]
C[Nle-Asp-D-Phe-Arg-Trp-Glu]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C[Nle-Asp-D-Phe-Arg-Trp-Glu]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C[Nle-Asp-D-Phe-Arg-Trp-Glu]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [686]
C[Nle-Gln-D-Nal(2')-Arg-Trp-Glu]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C[Nle-Gln-D-Nal(2')-Arg-Trp-Glu]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C[Nle-Gln-D-Nal(2')-Arg-Trp-Glu]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [675]
C[Nle-Glu-D-Nal(2')-Arg-Trp-Glu]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C[Nle-Glu-D-Nal(2')-Arg-Trp-Glu]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C[Nle-Glu-D-Nal(2')-Arg-Trp-Glu]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [675]
C[Nle-His-D-Nal(2')-Arg-Trp-Glu]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C[Nle-His-D-Nal(2')-Arg-Trp-Glu]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C[Nle-His-D-Nal(2')-Arg-Trp-Glu]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [675]
C[Nle-His-D-Phe-Arg-Trp-Glu]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C[Nle-His-D-Phe-Arg-Trp-Glu]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C[Nle-His-D-Phe-Arg-Trp-Glu]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [675]
C[Nle-Nle-D-Nal(2')-Arg-Trp-Glu]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C[Nle-Nle-D-Nal(2')-Arg-Trp-Glu]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C[Nle-Nle-D-Nal(2')-Arg-Trp-Glu]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [675]
C[Nle-Nle-D-Phe-Arg-Trp-Glu]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C[Nle-Nle-D-Phe-Arg-Trp-Glu]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C[Nle-Nle-D-Phe-Arg-Trp-Glu]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [675]
C[Nle-Pro-D-Nal(2')-Arg-Trp-Glu]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C[Nle-Pro-D-Nal(2')-Arg-Trp-Glu]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C[Nle-Pro-D-Nal(2')-Arg-Trp-Glu]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [675]
C[Nle-Pro-D-Phe-Arg-Trp-Glu]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C[Nle-Pro-D-Phe-Arg-Trp-Glu]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C[Nle-Pro-D-Phe-Arg-Trp-Glu]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [675]
C[Nle-Val-D-Nal(2')-Arg-Trp-Glu]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C[Nle-Val-D-Nal(2')-Arg-Trp-Glu]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C[Nle-Val-D-Nal(2')-Arg-Trp-Glu]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [675]
C[Nle-Val-D-Phe-Arg-Trp-Glu]-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C[Nle-Val-D-Phe-Arg-Trp-Glu]-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C[Nle-Val-D-Phe-Arg-Trp-Glu]-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [675]
C[Ser-Tyr-Thr-His-Dphe-Arg-Trp-Thr-Ile-Pro] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C[Ser-Tyr-Thr-His-Dphe-Arg-Trp-Thr-Ile-Pro]. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C[Ser-Tyr-Thr-His-Dphe-Arg-Trp-Thr-Ile-Pro] through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [683]
C[Thr-Tyr-Thr-His-DNaf-Arg-Trp-Thr-Ile-Pro] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for C[Thr-Tyr-Thr-His-DNaf-Arg-Trp-Thr-Ile-Pro]. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C[Thr-Tyr-Thr-His-DNaf-Arg-Trp-Thr-Ile-Pro] through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [684]
D-Phe-Arg-2-Nal-NHCH3 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for D-Phe-Arg-2-Nal-NHCH3. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of D-Phe-Arg-2-Nal-NHCH3 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [677]
GPYRMEHFRWGSPPKD-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for GPYRMEHFRWGSPPKD-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GPYRMEHFRWGSPPKD-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [672]
His-DPhe-Arg-Trp [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for His-DPhe-Arg-Trp. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of His-DPhe-Arg-Trp through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [686]
Hoo-Phe-Orn-Pro-hle-Pff-Phe-NH2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Hoo-Phe-Orn-Pro-hle-Pff-Phe-NH2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Hoo-Phe-Orn-Pro-hle-Pff-Phe-NH2 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [675]
HS014 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for HS014. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of HS014 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [687]
MCL-129 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for MCL-129. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MCL-129 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [684]
MCL0129 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for MCL0129. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MCL0129 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [688]
Melanocortin-4 Receptor antagonist [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Melanocortin-4 Receptor antagonist. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Melanocortin-4 Receptor antagonist through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [689]
MK-10 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for MK-10. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MK-10 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [690]
MK-11 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for MK-11. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MK-11 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [674]
ML-253764 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for ML-253764. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ML-253764 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [673]
MT-II [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for MT-II. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MT-II through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [691]
NDP-alpha-MSH [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for NDP-alpha-MSH. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NDP-alpha-MSH through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [692]
NDP-SYSMEHFRWGKPVG [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for NDP-SYSMEHFRWGKPVG. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NDP-SYSMEHFRWGKPVG through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [673]
Ser-Tyr-Ser-Nle-Glu-His-Dphe-Arg [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Ser-Tyr-Ser-Nle-Glu-His-Dphe-Arg. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ser-Tyr-Ser-Nle-Glu-His-Dphe-Arg through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [678]
THIQ [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for THIQ. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of THIQ through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [691]
Tic-D-Phe-Arg-2-Nal-NHCH3 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for Tic-D-Phe-Arg-2-Nal-NHCH3. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Tic-D-Phe-Arg-2-Nal-NHCH3 through regulating the expression of Melanocortin receptor 4 (MC4R). [663], [683]
PT-14 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Melanocortin receptor 4 (MC4R) is a therapeutic target for PT-14. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PT-14 through regulating the expression of Melanocortin receptor 4 (MC4R). [166], [663]
Methylenetetrahydrofolate reductase (MTHFR)
Benazepril [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Methylenetetrahydrofolate reductase (MTHFR) is a therapeutic target for Benazepril. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Benazepril through regulating the expression of Methylenetetrahydrofolate reductase (MTHFR). [149], [693]
Folic acid [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Methylenetetrahydrofolate reductase (MTHFR) is a therapeutic target for Folic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Folic acid through regulating the expression of Methylenetetrahydrofolate reductase (MTHFR). [149], [694]
Menadione [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Methylenetetrahydrofolate reductase (MTHFR) is a therapeutic target for Menadione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Menadione through regulating the expression of Methylenetetrahydrofolate reductase (MTHFR). [149], [695]
Methotrexate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Methylenetetrahydrofolate reductase (MTHFR) is a therapeutic target for Methotrexate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Methotrexate through regulating the expression of Methylenetetrahydrofolate reductase (MTHFR). [149], [696]
ISO-901 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Methylenetetrahydrofolate reductase (MTHFR) is a therapeutic target for ISO-901. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISO-901 through regulating the expression of Methylenetetrahydrofolate reductase (MTHFR). [149], [697]
677T [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Methylenetetrahydrofolate reductase (MTHFR) is a therapeutic target for 677T. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 677T through regulating the expression of Methylenetetrahydrofolate reductase (MTHFR). [149], [698]
EX5 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Methylenetetrahydrofolate reductase (MTHFR) is a therapeutic target for EX5. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of EX5 through regulating the expression of Methylenetetrahydrofolate reductase (MTHFR). [149], [699]
microRNA hsa-miR-155 (MIR155)
Cobomarsen [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary microRNA hsa-miR-155 (MIR155) is a therapeutic target for Cobomarsen. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cobomarsen through regulating the expression of microRNA hsa-miR-155 (MIR155). [700], [701]
MRG-201 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary microRNA hsa-miR-155 (MIR155) is a therapeutic target for MRG-201. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MRG-201 through regulating the expression of microRNA hsa-miR-155 (MIR155). [38], [700]
Multidrug resistance-associated protein 7 (ABCC10)
Docetaxel [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Multidrug resistance-associated protein 7 (ABCC10) is a therapeutic target for Docetaxel. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Docetaxel through regulating the expression of Multidrug resistance-associated protein 7 (ABCC10). [702], [703]
Tenofovir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Multidrug resistance-associated protein 7 (ABCC10) is a therapeutic target for Tenofovir. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Tenofovir through regulating the expression of Multidrug resistance-associated protein 7 (ABCC10). [702], [704]
NAD-dependent deacetylase sirtuin-1 (SIRT1)
GSK2245840 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for GSK2245840. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GSK2245840 through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [705], [706]
MB-12066 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for MB-12066. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MB-12066 through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [705], [707]
SEN-196 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for SEN-196. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SEN-196 through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [705], [708]
SRT2379 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for SRT2379. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SRT2379 through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [705], [709]
SRT3025 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for SRT3025. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SRT3025 through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [705], [710]
(R)-sirtinol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for (R)-sirtinol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (R)-sirtinol through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [705], [711]
(S)-sirtinol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for (S)-sirtinol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (S)-sirtinol through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [705], [711]
2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for 2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [705], [712]
2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for 2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [390], [705]
Meta-sirtinol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for Meta-sirtinol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Meta-sirtinol through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [705], [713]
Para-sirtinol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for Para-sirtinol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Para-sirtinol through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [705], [711]
RO-316233 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for RO-316233. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RO-316233 through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [705], [712]
Ro31-8220 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for Ro31-8220. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ro31-8220 through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [705], [714]
splitomicin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for splitomicin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of splitomicin through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [705], [715]
SRT1720 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for SRT1720. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SRT1720 through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [705], [711]
YK-3237 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for YK-3237. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of YK-3237 through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [705], [714]
GSK184072 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for GSK184072. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GSK184072 through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [705], [716]
Nitric oxide synthase endothelial (NOS3)
Tilarginine acetate [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for Tilarginine acetate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Tilarginine acetate through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [717]
ACCLAIM [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for ACCLAIM. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ACCLAIM through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [718]
L-NAME [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for L-NAME. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-NAME through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [719]
MTR105 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for MTR105. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MTR105 through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [720]
VAS-203 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for VAS-203. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of VAS-203 through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [721]
Autologous cell based gene therapy [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for Autologous cell based gene therapy. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Autologous cell based gene therapy through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [722]
(5-Imino-[1,4]thiazepan-3-yl)-methanol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for (5-Imino-[1,4]thiazepan-3-yl)-methanol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (5-Imino-[1,4]thiazepan-3-yl)-methanol through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [723]
(5S,6R)-[Octahydro-quinolin-(2E)-ylidene]amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for (5S,6R)-[Octahydro-quinolin-(2E)-ylidene]amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (5S,6R)-[Octahydro-quinolin-(2E)-ylidene]amine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [724]
(5S,6S)-[Octahydro-quinolin-(2E)-ylidene]amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for (5S,6S)-[Octahydro-quinolin-(2E)-ylidene]amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (5S,6S)-[Octahydro-quinolin-(2E)-ylidene]amine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [725]
(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for (6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin through regulating the expression of Nitric oxide synthase endothelial (NOS3). [78], [592]
(S)-2-Amino-5-(N-methyl-guanidino)-pentanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for (S)-2-Amino-5-(N-methyl-guanidino)-pentanoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (S)-2-Amino-5-(N-methyl-guanidino)-pentanoic acid through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [724]
(S)-3-Propyl-[1,4]thiazepan-(5E)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for (S)-3-Propyl-[1,4]thiazepan-(5E)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (S)-3-Propyl-[1,4]thiazepan-(5E)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [723]
(S)-6-Amino-2-(2-imino-ethylamino)-hexanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for (S)-6-Amino-2-(2-imino-ethylamino)-hexanoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (S)-6-Amino-2-(2-imino-ethylamino)-hexanoic acid through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [723]
1,2,4-Triazole-Carboxamidine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 1,2,4-Triazole-Carboxamidine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1,2,4-Triazole-Carboxamidine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [148], [592]
1-(2-amino-benzothiazol-5-yl)-2-ethyl-isothiourea [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 1-(2-amino-benzothiazol-5-yl)-2-ethyl-isothiourea. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-(2-amino-benzothiazol-5-yl)-2-ethyl-isothiourea through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [726]
1-(2-amino-benzothiazol-6-yl)-2-ethyl-isothiourea [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 1-(2-amino-benzothiazol-6-yl)-2-ethyl-isothiourea. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-(2-amino-benzothiazol-6-yl)-2-ethyl-isothiourea through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [727]
1400W [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 1400W. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1400W through regulating the expression of Nitric oxide synthase endothelial (NOS3). [148], [592]
2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [148], [592]
2-amino-4-methylpyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 2-amino-4-methylpyridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-amino-4-methylpyridine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [728]
2-Amino-5-(N-nitro-guanidino)-pentanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 2-Amino-5-(N-nitro-guanidino)-pentanoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-Amino-5-(N-nitro-guanidino)-pentanoic acid through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [729]
2-Aminothiazoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 2-Aminothiazoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-Aminothiazoline through regulating the expression of Nitric oxide synthase endothelial (NOS3). [148], [592]
2-Methyl-2,4-Pentanediol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 2-Methyl-2,4-Pentanediol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-Methyl-2,4-Pentanediol through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [729]
2-Methyl-[1,4]thiazepan-(5E)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 2-Methyl-[1,4]thiazepan-(5E)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-Methyl-[1,4]thiazepan-(5E)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [723]
2-Propanol, Isopropanol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 2-Propanol, Isopropanol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-Propanol, Isopropanol through regulating the expression of Nitric oxide synthase endothelial (NOS3). [78], [592]
3,4-Dimethyl-pyrrolidin-(2Z)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 3,4-Dimethyl-pyrrolidin-(2Z)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,4-Dimethyl-pyrrolidin-(2Z)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [730]
3-Bromo-1H-indazole-7-carbonitrile [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 3-Bromo-1H-indazole-7-carbonitrile. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Bromo-1H-indazole-7-carbonitrile through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [731]
3-bromo-7-nitro-1H-indazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 3-bromo-7-nitro-1H-indazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-bromo-7-nitro-1H-indazole through regulating the expression of Nitric oxide synthase endothelial (NOS3). [78], [592]
3-Ethyl-[1,4]thiazepan-(5E)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 3-Ethyl-[1,4]thiazepan-(5E)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Ethyl-[1,4]thiazepan-(5E)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [723]
3-Methyl-pyrrolidin-(2Z)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 3-Methyl-pyrrolidin-(2Z)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Methyl-pyrrolidin-(2Z)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [730]
3-Methyl-[1,4]thiazepan-(5E)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 3-Methyl-[1,4]thiazepan-(5E)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Methyl-[1,4]thiazepan-(5E)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [723]
4,5-Dimethyl-pyrrolidin-(2Z)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 4,5-Dimethyl-pyrrolidin-(2Z)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4,5-Dimethyl-pyrrolidin-(2Z)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [730]
4-Ethyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 4-Ethyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Ethyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [727]
4-Ethyl-5-methyl-pyrrolidin-(2Z)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 4-Ethyl-5-methyl-pyrrolidin-(2Z)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Ethyl-5-methyl-pyrrolidin-(2Z)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [730]
4-Ethyl-pyrrolidin-(2Z)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 4-Ethyl-pyrrolidin-(2Z)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Ethyl-pyrrolidin-(2Z)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [723]
4-Methyl-3,6-dihydro-1H-pyridin-(2Z)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 4-Methyl-3,6-dihydro-1H-pyridin-(2Z)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Methyl-3,6-dihydro-1H-pyridin-(2Z)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [732]
4-Methyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 4-Methyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Methyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [732]
4-methyl-6-propylpyridin-2-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 4-methyl-6-propylpyridin-2-amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-methyl-6-propylpyridin-2-amine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [731]
4-Methyl-piperidin-(2E)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 4-Methyl-piperidin-(2E)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Methyl-piperidin-(2E)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [724]
4-Methyl-pyrrolidin-(2Z)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 4-Methyl-pyrrolidin-(2Z)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Methyl-pyrrolidin-(2Z)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [730]
5,6-Cyclic-Tetrahydropteridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 5,6-Cyclic-Tetrahydropteridine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5,6-Cyclic-Tetrahydropteridine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [148], [592]
5-Ethyl-3-methyl-pyrrolidin-(2Z)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 5-Ethyl-3-methyl-pyrrolidin-(2Z)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-Ethyl-3-methyl-pyrrolidin-(2Z)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [730]
5-Ethyl-4-methyl-pyrrolidin-(2Z)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 5-Ethyl-4-methyl-pyrrolidin-(2Z)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-Ethyl-4-methyl-pyrrolidin-(2Z)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [730]
5-Methyl-pyrrolidin-(2Z)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 5-Methyl-pyrrolidin-(2Z)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-Methyl-pyrrolidin-(2Z)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [730]
5-Nitroindazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 5-Nitroindazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-Nitroindazole through regulating the expression of Nitric oxide synthase endothelial (NOS3). [148], [592]
6-(2-Fluoropropyl)-4-methylpyridin-2-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 6-(2-Fluoropropyl)-4-methylpyridin-2-amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-(2-Fluoropropyl)-4-methylpyridin-2-amine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [726]
6-(3-Fluoropropyl)-4-methylpyridin-2-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 6-(3-Fluoropropyl)-4-methylpyridin-2-amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-(3-Fluoropropyl)-4-methylpyridin-2-amine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [733]
6-isobutyl-4-methylpyridin-2-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 6-isobutyl-4-methylpyridin-2-amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-isobutyl-4-methylpyridin-2-amine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [726]
6-Nitroindazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 6-Nitroindazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-Nitroindazole through regulating the expression of Nitric oxide synthase endothelial (NOS3). [148], [592]
6s-5,6,7,8-Tetrahydrobiopterin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 6s-5,6,7,8-Tetrahydrobiopterin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6s-5,6,7,8-Tetrahydrobiopterin through regulating the expression of Nitric oxide synthase endothelial (NOS3). [148], [592]
7-(2-Nitro-ethyl)-azepan-(2Z)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 7-(2-Nitro-ethyl)-azepan-(2Z)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 7-(2-Nitro-ethyl)-azepan-(2Z)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [732]
7-Methyl-[1,4]thiazepan-(5E)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 7-Methyl-[1,4]thiazepan-(5E)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 7-Methyl-[1,4]thiazepan-(5E)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [723]
7-nitro-1H-indazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 7-nitro-1H-indazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 7-nitro-1H-indazole through regulating the expression of Nitric oxide synthase endothelial (NOS3). [148], [592]
7-Nitroindazole-2-Carboxamidine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 7-Nitroindazole-2-Carboxamidine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 7-Nitroindazole-2-Carboxamidine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [155], [592]
Acetate Ion [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for Acetate Ion. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Acetate Ion through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [734]
AP-Cav [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for AP-Cav. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AP-Cav through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [724]
Azepan-(2Z)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for Azepan-(2Z)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Azepan-(2Z)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [729]
Cacodylate Ion [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for Cacodylate Ion. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cacodylate Ion through regulating the expression of Nitric oxide synthase endothelial (NOS3). [148], [592]
Ethylisothiourea [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for Ethylisothiourea. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ethylisothiourea through regulating the expression of Nitric oxide synthase endothelial (NOS3). [148], [592]
Heme [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for Heme. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Heme through regulating the expression of Nitric oxide synthase endothelial (NOS3). [148], [592]
Hexahydro-cyclopenta[c]pyrrol-(1Z)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for Hexahydro-cyclopenta[c]pyrrol-(1Z)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Hexahydro-cyclopenta[c]pyrrol-(1Z)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [730]
Hydroxydimethylarsine Oxide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for Hydroxydimethylarsine Oxide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Hydroxydimethylarsine Oxide through regulating the expression of Nitric oxide synthase endothelial (NOS3). [78], [592]
L-2-Amino-4-(Guanidinooxy)Butyric Acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for L-2-Amino-4-(Guanidinooxy)Butyric Acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-2-Amino-4-(Guanidinooxy)Butyric Acid through regulating the expression of Nitric oxide synthase endothelial (NOS3). [148], [592]
L-Homoarginine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for L-Homoarginine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-Homoarginine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [148], [592]
L-NIO [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for L-NIO. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-NIO through regulating the expression of Nitric oxide synthase endothelial (NOS3). [155], [592]
N,N-dimethylarginine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for N,N-dimethylarginine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N,N-dimethylarginine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [148], [592]
N-(5-Amino-6-oxo-heptyl)-acetamidine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for N-(5-Amino-6-oxo-heptyl)-acetamidine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(5-Amino-6-oxo-heptyl)-acetamidine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [730]
N-(Chlorophenyl)-N'-Hydroxyguanidine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for N-(Chlorophenyl)-N'-Hydroxyguanidine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-(Chlorophenyl)-N'-Hydroxyguanidine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [735]
N-omega-allyl-L-arginine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for N-omega-allyl-L-arginine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-omega-allyl-L-arginine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [733]
N-Omega-Hydroxy-L-Arginine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for N-Omega-Hydroxy-L-Arginine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-Omega-Hydroxy-L-Arginine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [148], [592]
N-omega-propargyl-L-arginine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for N-omega-propargyl-L-arginine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-omega-propargyl-L-arginine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [736]
N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane through regulating the expression of Nitric oxide synthase endothelial (NOS3). [148], [592]
N5-(1-iminobut-3-enyl)-L-ornithine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for N5-(1-iminobut-3-enyl)-L-ornithine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N5-(1-iminobut-3-enyl)-L-ornithine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [733]
N5-(1-iminobutyl)-L-ornithine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for N5-(1-iminobutyl)-L-ornithine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N5-(1-iminobutyl)-L-ornithine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [733]
N5-(1-iminopropyl)-L-ornithine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for N5-(1-iminopropyl)-L-ornithine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N5-(1-iminopropyl)-L-ornithine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [733]
Nitroarginine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for Nitroarginine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Nitroarginine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [148], [592]
Piperidin-(2E)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for Piperidin-(2E)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Piperidin-(2E)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [737]
Pyrrolidin-(2Z)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for Pyrrolidin-(2Z)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Pyrrolidin-(2Z)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [730]
S-(Dimethylarsenic)Cysteine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for S-(Dimethylarsenic)Cysteine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of S-(Dimethylarsenic)Cysteine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [148], [592]
S-Ethyl-N-Phenyl-Isothiourea [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for S-Ethyl-N-Phenyl-Isothiourea. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of S-Ethyl-N-Phenyl-Isothiourea through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [738]
S-Isopropyl-Isothiourea [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for S-Isopropyl-Isothiourea. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of S-Isopropyl-Isothiourea through regulating the expression of Nitric oxide synthase endothelial (NOS3). [148], [592]
Se-Ethyl-Isoselenourea [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for Se-Ethyl-Isoselenourea. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Se-Ethyl-Isoselenourea through regulating the expression of Nitric oxide synthase endothelial (NOS3). [78], [592]
THIOCITRULLINE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for THIOCITRULLINE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of THIOCITRULLINE through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [730]
[1,3]Oxazinan-(2E)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for [1,3]Oxazinan-(2E)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of [1,3]Oxazinan-(2E)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [729]
[1,3]Thiazinan-(2E)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for [1,3]Thiazinan-(2E)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of [1,3]Thiazinan-(2E)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [78], [592]
[1,4]Oxazepan-(3E)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for [1,4]Oxazepan-(3E)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of [1,4]Oxazepan-(3E)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [723]
[1,4]Thiazepan-(3E)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for [1,4]Thiazepan-(3E)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of [1,4]Thiazepan-(3E)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [723]
[1,4]Thiazepan-(5E)-ylideneamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for [1,4]Thiazepan-(5E)-ylideneamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of [1,4]Thiazepan-(5E)-ylideneamine through regulating the expression of Nitric oxide synthase endothelial (NOS3). [592], [737]
L-NIL [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for L-NIL. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-NIL through regulating the expression of Nitric oxide synthase endothelial (NOS3). [148], [592]
Notch-1 receptor (NOTCH1)
LY3039478 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Notch-1 receptor (NOTCH1) is a therapeutic target for LY3039478. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LY3039478 through regulating the expression of Notch-1 receptor (NOTCH1). [739], [740]
OMP-52M51 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Notch-1 receptor (NOTCH1) is a therapeutic target for OMP-52M51. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of OMP-52M51 through regulating the expression of Notch-1 receptor (NOTCH1). [38], [739]
Nuclear factor erythroid 2-related factor 2 (Nrf2)
ABT-RTA-408 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for ABT-RTA-408. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ABT-RTA-408 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [438], [741]
CXA10 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for CXA10. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CXA10 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [741], [742]
Omaveloxolone [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for Omaveloxolone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Omaveloxolone through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [741], [743]
OT-551 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for OT-551. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of OT-551 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [116], [741]
OT551 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for OT551. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of OT551 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [741], [744]
SFX-01 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for SFX-01. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SFX-01 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [741], [745]
HPP971 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for HPP971. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of HPP971 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [741], [746]
CAT4001 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for CAT4001. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CAT4001 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [741], [747]
M102 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for M102. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of M102 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [741], [748]
TFM735 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for TFM735. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TFM735 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [741], [743]
Nucleophosmin (NPM1)
IPP-204106 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nucleophosmin (NPM1) is a therapeutic target for IPP-204106. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of IPP-204106 through regulating the expression of Nucleophosmin (NPM1). [379], [749]
Oxalosuccinate decarboxylase (IDH1)
Ivosidenib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Oxalosuccinate decarboxylase (IDH1) is a therapeutic target for Ivosidenib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ivosidenib through regulating the expression of Oxalosuccinate decarboxylase (IDH1). [750], [751]
IDH305 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Oxalosuccinate decarboxylase (IDH1) is a therapeutic target for IDH305. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of IDH305 through regulating the expression of Oxalosuccinate decarboxylase (IDH1). [750], [752]
LY3410738 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Oxalosuccinate decarboxylase (IDH1) is a therapeutic target for LY3410738. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LY3410738 through regulating the expression of Oxalosuccinate decarboxylase (IDH1). [750], [753]
Peroxisome proliferator-activated receptor alpha (PPARA)
Bezafibrate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Bezafibrate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Bezafibrate through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [755]
Ciprofibrate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Ciprofibrate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ciprofibrate through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [756]
Fenofibrate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Fenofibrate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Fenofibrate through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [757]
Lobeglitazone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Lobeglitazone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Lobeglitazone through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [758]
Pemafibrate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Pemafibrate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Pemafibrate through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [755]
BMS-298585 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for BMS-298585. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BMS-298585 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [636], [754]
CS-038 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for CS-038. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CS-038 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [759]
GFT-505 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for GFT-505. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GFT-505 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [760]
Imiglitazar [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Imiglitazar. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Imiglitazar through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [761]
Ragaglitazar [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Ragaglitazar. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ragaglitazar through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [762]
TESAGLITAZAR [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for TESAGLITAZAR. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TESAGLITAZAR through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [763]
ZYH-1 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for ZYH-1. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ZYH-1 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [764]
GFT14 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for GFT14. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GFT14 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [765]
LY-518674 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for LY-518674. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LY-518674 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [766]
Naveglitazar [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Naveglitazar. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Naveglitazar through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [166], [754]
ONO-5129 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for ONO-5129. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ONO-5129 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [767]
ZYH7 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for ZYH7. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ZYH7 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [768]
AVE0897 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for AVE0897. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AVE0897 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [769]
CDT-fenofibrate [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for CDT-fenofibrate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CDT-fenofibrate through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [770]
GW-409544 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for GW-409544. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GW-409544 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [771]
Oxeglitazar [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Oxeglitazar. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Oxeglitazar through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [772]
TPST-1120 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for TPST-1120. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TPST-1120 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [773]
MC-3001 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for MC-3001. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MC-3001 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [774]
MC-3002 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for MC-3002. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MC-3002 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [775]
PIRINIXIC ACID [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for PIRINIXIC ACID. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PIRINIXIC ACID through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [776]
Romazarit [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Romazarit. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Romazarit through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [166], [754]
(9Z,12E)-12-nitrooctadeca-9,12-dienoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for (9Z,12E)-12-nitrooctadeca-9,12-dienoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (9Z,12E)-12-nitrooctadeca-9,12-dienoic acid through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [777]
(E)-12-Nitrooctadec-12-enoic Acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for (E)-12-Nitrooctadec-12-enoic Acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (E)-12-Nitrooctadec-12-enoic Acid through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [778]
(E)-13-Nitrooctadec-12-enoic Acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for (E)-13-Nitrooctadec-12-enoic Acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (E)-13-Nitrooctadec-12-enoic Acid through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [778]
(E)-4-(3,5-dimethoxystyryl)phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for (E)-4-(3,5-dimethoxystyryl)phenol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (E)-4-(3,5-dimethoxystyryl)phenol through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [779]
8S-HETE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for 8S-HETE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 8S-HETE through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [764]
AD-5061 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for AD-5061. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AD-5061 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [780]
BMS-687453 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for BMS-687453. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BMS-687453 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [781]
CP-775146 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for CP-775146. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CP-775146 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [148], [754]
DB-900 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for DB-900. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of DB-900 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [782]
Deoxy-Bigchap [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Deoxy-Bigchap. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Deoxy-Bigchap through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [783]
DRF 2519 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for DRF 2519. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of DRF 2519 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [784]
eicosatetranoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for eicosatetranoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of eicosatetranoic acid through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [785]
Fibrates [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Fibrates. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Fibrates through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [786]
GSK-9578 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for GSK-9578. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GSK-9578 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [778]
GW-2331 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for GW-2331. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GW-2331 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [787]
GW7647 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for GW7647. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GW7647 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [788]
L-165461 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for L-165461. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-165461 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [786]
L-796449 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for L-796449. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-796449 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [755]
LL-6531 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for LL-6531. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LL-6531 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [789]
LY-465608 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for LY-465608. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LY-465608 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [790]
N-oleoylethanolamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for N-oleoylethanolamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N-oleoylethanolamide through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [791]
pristanic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for pristanic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of pristanic acid through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [792]
reglitazar [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for reglitazar. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of reglitazar through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [793]
TZD18 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for TZD18. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TZD18 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [794]
ZY H2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for ZY H2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ZY H2 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [795]
Aleglitazar [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Aleglitazar. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Aleglitazar through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [796]
AR-H049020 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for AR-H049020. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AR-H049020 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [792]
AVE-0847 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for AVE-0847. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AVE-0847 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [797]
AVE-8134 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for AVE-8134. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AVE-8134 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [798]
BM-17.0744 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for BM-17.0744. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BM-17.0744 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [166], [754]
BVT-142 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for BVT-142. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BVT-142 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [799]
CS-204 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for CS-204. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CS-204 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [800]
CS-207 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for CS-207. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CS-207 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [801]
DRF 10945 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for DRF 10945. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of DRF 10945 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [802]
E-3030 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for E-3030. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of E-3030 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [803]
GSK-677954 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for GSK-677954. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GSK-677954 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [804]
Indeglitazar [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Indeglitazar. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Indeglitazar through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [31], [754]
KRP-101 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for KRP-101. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of KRP-101 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [805]
KRP-105 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for KRP-105. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of KRP-105 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [763]
KRP-297 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for KRP-297. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of KRP-297 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [792]
LG-101280 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for LG-101280. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LG-101280 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [806]
LY-929 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for LY-929. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LY-929 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [807]
MP-136 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for MP-136. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MP-136 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [808]
NS-220 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for NS-220. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NS-220 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [809]
Reglixane [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Reglixane. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Reglixane through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [810]
Sipoglitazar [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Sipoglitazar. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Sipoglitazar through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [811]
Sodelglitazar [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Sodelglitazar. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Sodelglitazar through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [754], [812]
Peroxisome proliferator-activated receptor gamma (PPAR-gamma)
Glitazone [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for Glitazone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Glitazone through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [756], [813]
Lobeglitazone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for Lobeglitazone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Lobeglitazone through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [814]
Pioglitazone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for Pioglitazone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Pioglitazone through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [390], [813]
Rosiglitazone XR [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for Rosiglitazone XR. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Rosiglitazone XR through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [815]
Thiazolidinedione [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for Thiazolidinedione. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Thiazolidinedione through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [755], [813]
Troglitazone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for Troglitazone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Troglitazone through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [814]
Bardoxolone methyl [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for Bardoxolone methyl. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Bardoxolone methyl through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [816]
BMS-298585 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for BMS-298585. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BMS-298585 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [636], [813]
CS-038 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for CS-038. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CS-038 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [759], [813]
DRF-2593 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for DRF-2593. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of DRF-2593 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [762], [813]
FARGLITAZAR [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for FARGLITAZAR. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of FARGLITAZAR through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [763], [813]
Imiglitazar [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for Imiglitazar. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Imiglitazar through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [761], [813]
MBX-102 [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for MBX-102. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MBX-102 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [390], [813]
Ragaglitazar [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for Ragaglitazar. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ragaglitazar through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [817]
Rivoglitazone [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for Rivoglitazone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Rivoglitazone through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [760], [813]
TESAGLITAZAR [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for TESAGLITAZAR. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TESAGLITAZAR through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [818]
ZYH-1 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for ZYH-1. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ZYH-1 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [764], [813]
CHS-131 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for CHS-131. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CHS-131 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [819]
FK-614 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for FK-614. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of FK-614 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [820]
GED-0507-34-Levo [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for GED-0507-34-Levo. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GED-0507-34-Levo through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [821]
MBX-2044 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for MBX-2044. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MBX-2044 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [822]
Naveglitazar [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for Naveglitazar. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Naveglitazar through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [166], [813]
Netoglitazone [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for Netoglitazone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Netoglitazone through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [765], [813]
OMS405 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for OMS405. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of OMS405 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [823]
ONO-5129 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for ONO-5129. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ONO-5129 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [114], [813]
T3D-959 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for T3D-959. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of T3D-959 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [819]
CLX-0921 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for CLX-0921. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CLX-0921 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [824]
DSP-8658 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for DSP-8658. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of DSP-8658 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [770], [813]
Englitazone sodium [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for Englitazone sodium. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Englitazone sodium through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [825]
GW-409544 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for GW-409544. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GW-409544 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [826]
Oxeglitazar [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for Oxeglitazar. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Oxeglitazar through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [772], [813]
ADD-3878 [Discontinued]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for ADD-3878. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ADD-3878 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [166], [813]
MC-3002 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for MC-3002. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MC-3002 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [806], [813]
(2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [78], [813]
(2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [78], [813]
(2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [78], [813]
(9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for (9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [78], [813]
(9Z,12E)-12-nitrooctadeca-9,12-dienoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for (9Z,12E)-12-nitrooctadeca-9,12-dienoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (9Z,12E)-12-nitrooctadeca-9,12-dienoic acid through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [778], [813]
(E)-10-Nitrohexadec-9-enoic Acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for (E)-10-Nitrohexadec-9-enoic Acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (E)-10-Nitrohexadec-9-enoic Acid through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [778], [813]
(E)-10-nitrooctadec-9-enoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for (E)-10-nitrooctadec-9-enoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (E)-10-nitrooctadec-9-enoic acid through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [778], [813]
(E)-12-Nitrooctadec-12-enoic Acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for (E)-12-Nitrooctadec-12-enoic Acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (E)-12-Nitrooctadec-12-enoic Acid through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [778], [813]
(E)-13-Nitrooctadec-12-enoic Acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for (E)-13-Nitrooctadec-12-enoic Acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (E)-13-Nitrooctadec-12-enoic Acid through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [778], [813]
(E)-5-Nitrooctadec-5-enoic Acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for (E)-5-Nitrooctadec-5-enoic Acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (E)-5-Nitrooctadec-5-enoic Acid through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [778], [813]
(E)-6-Nitrooctadec-5-enoic Acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for (E)-6-Nitrooctadec-5-enoic Acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (E)-6-Nitrooctadec-5-enoic Acid through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [376], [813]
(E)-9-Nitrohexadec-9-enoicAcid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for (E)-9-Nitrohexadec-9-enoicAcid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (E)-9-Nitrohexadec-9-enoicAcid through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [778], [813]
(E)-9-nitrooctadec-9-enoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for (E)-9-nitrooctadec-9-enoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (E)-9-nitrooctadec-9-enoic acid through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [778], [813]
15-deoxy-Delta(12, 14)-prostaglandin J(2) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for 15-deoxy-Delta(12, 14)-prostaglandin J(2). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 15-deoxy-Delta(12, 14)-prostaglandin J(2) through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [78], [813]
2-chloro-5-nitro-N-phenylbenzamide [Investigative]
In total 2 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for 2-chloro-5-nitro-N-phenylbenzamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-chloro-5-nitro-N-phenylbenzamide through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [778], [813]
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for 2-chloro-5-nitro-N-phenylbenzamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-chloro-5-nitro-N-phenylbenzamide through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [827]
3-(5-methoxy-1H-indol-3-yl)propanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for 3-(5-methoxy-1H-indol-3-yl)propanoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(5-methoxy-1H-indol-3-yl)propanoic acid through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [78], [813]
9-hydroxyoctadecadienoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for 9-hydroxyoctadecadienoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 9-hydroxyoctadecadienoic acid through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [78], [813]
AD-5061 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for AD-5061. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AD-5061 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [828]
BADGE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for BADGE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BADGE through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [829]
BRL-48482 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for BRL-48482. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BRL-48482 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [830]
CHLOROCYCLINONE A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for CHLOROCYCLINONE A. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CHLOROCYCLINONE A through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [830]
CHLOROCYCLINONE B [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for CHLOROCYCLINONE B. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CHLOROCYCLINONE B through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [831]
CHLOROCYCLINONE C [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for CHLOROCYCLINONE C. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CHLOROCYCLINONE C through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [830]
CHLOROCYCLINONE D [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for CHLOROCYCLINONE D. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CHLOROCYCLINONE D through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [830]
COOH [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for COOH. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of COOH through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [832]
DB-900 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for DB-900. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of DB-900 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [833]
DRF 2519 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for DRF 2519. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of DRF 2519 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [834]
GNF-PF-2893 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for GNF-PF-2893. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GNF-PF-2893 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [835]
GNF-PF-3037 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for GNF-PF-3037. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GNF-PF-3037 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [376], [813]
GW-2331 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for GW-2331. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GW-2331 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [787], [813]
GW0072 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for GW0072. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GW0072 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [836]
GW1929 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for GW1929. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GW1929 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [837]
GW7845 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for GW7845. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GW7845 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [781], [813]
ISIS 105987 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for ISIS 105987. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 105987 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [838]
ISIS 105989 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for ISIS 105989. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 105989 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [839]
ISIS 105990 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for ISIS 105990. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 105990 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [838]
ISIS 106008 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for ISIS 106008. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 106008 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [838]
L-165461 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for L-165461. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-165461 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [786], [813]
L-764406 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for L-764406. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-764406 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [840]
L-783483 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for L-783483. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-783483 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [841]
L-796449 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for L-796449. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-796449 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [842]
L-Tryptophan-L-2-aminoadipic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for L-Tryptophan-L-2-aminoadipic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-Tryptophan-L-2-aminoadipic acid through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [831]
L-Tryptophan-L-arginine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for L-Tryptophan-L-arginine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-Tryptophan-L-arginine through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [831]
L-Tryptophan-L-asparagine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for L-Tryptophan-L-asparagine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-Tryptophan-L-asparagine through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [831]
L-Tryptophan-L-aspartic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for L-Tryptophan-L-aspartic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-Tryptophan-L-aspartic acid through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [831]
L-Tryptophan-L-glutamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for L-Tryptophan-L-glutamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-Tryptophan-L-glutamine through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [831]
L-Tryptophan-L-leucine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for L-Tryptophan-L-leucine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of L-Tryptophan-L-leucine through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [831]
LG100754 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for LG100754. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LG100754 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [791], [813]
LY-465608 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for LY-465608. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LY-465608 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [779], [813]
nTzDpa [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for nTzDpa. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of nTzDpa through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [843]
PAT5A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for PAT5A. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PAT5A through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [844]
PD-068235 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for PD-068235. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PD-068235 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [831]
Ploglitazone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for Ploglitazone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ploglitazone through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [786], [813]
reglitazar [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for reglitazar. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of reglitazar through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [764], [813]
SB-213068 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for SB-213068. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SB-213068 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [842]
T0070907 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for T0070907. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of T0070907 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [844]
tagitinin A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for tagitinin A. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of tagitinin A through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [845]
tirotundin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for tirotundin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of tirotundin through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [846]
TZD18 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for TZD18. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TZD18 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [794], [813]
ZY H2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for ZY H2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ZY H2 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [795], [813]
[125I]SB-236636 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for [125I]SB-236636. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of [125I]SB-236636 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [847]
[3H]GW2331 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for [3H]GW2331. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of [3H]GW2331 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [848]
AD-5075 [Terminated]
In total 2 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for AD-5075. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AD-5075 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [763], [813]
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for AD-5075. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AD-5075 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [849]
AKP-320 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for AKP-320. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AKP-320 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [782], [813]
AVE-0847 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for AVE-0847. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AVE-0847 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [797], [813]
BVT-142 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for BVT-142. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BVT-142 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [850]
CS-204 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for CS-204. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CS-204 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [851]
DARGLITAZONE [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for DARGLITAZONE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of DARGLITAZONE through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [852]
DS-6930 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for DS-6930. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of DS-6930 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [808], [813]
E-3030 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for E-3030. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of E-3030 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [853]
Edaglitazone [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for Edaglitazone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Edaglitazone through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [854]
GSK-677954 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for GSK-677954. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GSK-677954 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [166], [813]
Indeglitazar [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for Indeglitazar. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Indeglitazar through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [855]
KRP-297 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for KRP-297. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of KRP-297 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [815]
LY-929 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for LY-929. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LY-929 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [856]
Reglixane [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for Reglixane. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Reglixane through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [810], [813]
SB-219994 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for SB-219994. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SB-219994 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [813], [835]
Sipoglitazar [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for Sipoglitazar. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Sipoglitazar through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [811], [813]
Sodelglitazar [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for Sodelglitazar. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Sodelglitazar through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [812], [813]
YM-440 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for YM-440. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of YM-440 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [803], [813]
Platelet-derived growth factor receptor beta (PDGFRB)
Becaplermin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for Becaplermin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Becaplermin through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [857]
Romiplostim [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for Romiplostim. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Romiplostim through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [233], [379]
E-3810 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for E-3810. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of E-3810 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [858]
Famitinib [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for Famitinib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Famitinib through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [859]
MK-2461 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for MK-2461. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MK-2461 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [860]
SNN-0031 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for SNN-0031. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SNN-0031 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [861]
XL-820 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for XL-820. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of XL-820 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [862]
TAK-593 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for TAK-593. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TAK-593 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [863]
(1H-indol-2-yl)(5-methoxy-1H-indol-2-yl)methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for (1H-indol-2-yl)(5-methoxy-1H-indol-2-yl)methanone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (1H-indol-2-yl)(5-methoxy-1H-indol-2-yl)methanone through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [864]
(1H-indol-2-yl)(5-phenoxy-1H-indol-2-yl)methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for (1H-indol-2-yl)(5-phenoxy-1H-indol-2-yl)methanone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (1H-indol-2-yl)(5-phenoxy-1H-indol-2-yl)methanone through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [864]
(1H-indol-2-yl)(6-methoxy-1H-indol-2-yl)methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for (1H-indol-2-yl)(6-methoxy-1H-indol-2-yl)methanone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (1H-indol-2-yl)(6-methoxy-1H-indol-2-yl)methanone through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [864]
(2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for (2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [865]
(5-fluoro-1H-indol-2-yl)-(1H-indol-2-yl)methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for (5-fluoro-1H-indol-2-yl)-(1H-indol-2-yl)methanone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (5-fluoro-1H-indol-2-yl)-(1H-indol-2-yl)methanone through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [864]
(5-hydroxy-1H-indol-2-yl)(1H-indol-2-yl)methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for (5-hydroxy-1H-indol-2-yl)(1H-indol-2-yl)methanone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (5-hydroxy-1H-indol-2-yl)(1H-indol-2-yl)methanone through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [864]
(benzo[b]furan-2-yl)-(1H-indol-2-yl)methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for (benzo[b]furan-2-yl)-(1H-indol-2-yl)methanone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (benzo[b]furan-2-yl)-(1H-indol-2-yl)methanone through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [866]
1-Phenyl-1H-benzoimidazol-5-ol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 1-Phenyl-1H-benzoimidazol-5-ol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-Phenyl-1H-benzoimidazol-5-ol through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [867]
1-Phenyl-1H-benzoimidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 1-Phenyl-1H-benzoimidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 1-Phenyl-1H-benzoimidazole through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [699]
2-(1H-indazol-3-yl)-1H-benzo[d]imidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 2-(1H-indazol-3-yl)-1H-benzo[d]imidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-(1H-indazol-3-yl)-1H-benzo[d]imidazole through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [868]
3-((E)-Styryl)-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 3-((E)-Styryl)-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-((E)-Styryl)-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [869]
3-(1H-Indol-3-yl)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 3-(1H-Indol-3-yl)-6,7-dimethoxy-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(1H-Indol-3-yl)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
3-(1H-Indol-3-yl)-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 3-(1H-Indol-3-yl)-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(1H-Indol-3-yl)-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
3-(2-Cyclohexyl-ethyl)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 3-(2-Cyclohexyl-ethyl)-6,7-dimethoxy-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(2-Cyclohexyl-ethyl)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [869]
3-(3,4-Dichloro-phenyl)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 3-(3,4-Dichloro-phenyl)-6,7-dimethoxy-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(3,4-Dichloro-phenyl)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
3-(3,4-Difluoro-phenyl)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 3-(3,4-Difluoro-phenyl)-6,7-dimethoxy-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(3,4-Difluoro-phenyl)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
3-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 3-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
3-(3-Fluoro-phenyl)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 3-(3-Fluoro-phenyl)-6,7-dimethoxy-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(3-Fluoro-phenyl)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
3-(4-dimethylamino-benzylidenyl)-2-indolinone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 3-(4-dimethylamino-benzylidenyl)-2-indolinone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-dimethylamino-benzylidenyl)-2-indolinone through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [871]
3-(4-Fluoro-phenyl)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 3-(4-Fluoro-phenyl)-6,7-dimethoxy-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(4-Fluoro-phenyl)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
3-(6,7-Dimethoxy-quinolin-4-yloxy)-phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 3-(6,7-Dimethoxy-quinolin-4-yloxy)-phenol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(6,7-Dimethoxy-quinolin-4-yloxy)-phenol through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [872]
3-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 3-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [872]
3-Benzyloxy-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 3-Benzyloxy-6,7-dimethoxy-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Benzyloxy-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
3-Cyclohexylethynyl-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 3-Cyclohexylethynyl-6,7-dimethoxy-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Cyclohexylethynyl-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
3-Cyclopent-1-enyl-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 3-Cyclopent-1-enyl-6,7-dimethoxy-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Cyclopent-1-enyl-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [869]
3-Cyclopentyl-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 3-Cyclopentyl-6,7-dimethoxy-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Cyclopentyl-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
3-Pyridin-3-yl-quinoline-6,7-diol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 3-Pyridin-3-yl-quinoline-6,7-diol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Pyridin-3-yl-quinoline-6,7-diol through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
3-Pyridin-4-yl-quinolin-7-ol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 3-Pyridin-4-yl-quinolin-7-ol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Pyridin-4-yl-quinolin-7-ol through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [866]
3-Pyridin-4-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 3-Pyridin-4-yl-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Pyridin-4-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
3-Pyridin-4-yl-quinoline-5,7-diol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 3-Pyridin-4-yl-quinoline-5,7-diol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Pyridin-4-yl-quinoline-5,7-diol through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [869]
3-Thiophen-3-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 3-Thiophen-3-yl-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-Thiophen-3-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
4-(2,3-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 4-(2,3-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(2,3-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [872]
4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [873]
4-(3,5-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 4-(3,5-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(3,5-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [872]
4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinazoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinazoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinazoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [872]
4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [872]
4-(3-Ethoxy-phenoxy)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 4-(3-Ethoxy-phenoxy)-6,7-dimethoxy-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(3-Ethoxy-phenoxy)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [872]
4-(3-Ethyl-phenoxy)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 4-(3-Ethyl-phenoxy)-6,7-dimethoxy-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(3-Ethyl-phenoxy)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [872]
4-(3-Fluoro-phenoxy)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 4-(3-Fluoro-phenoxy)-6,7-dimethoxy-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(3-Fluoro-phenoxy)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [872]
4-(5-Methoxy-benzoimidazol-1-yl)-phenylamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 4-(5-Methoxy-benzoimidazol-1-yl)-phenylamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(5-Methoxy-benzoimidazol-1-yl)-phenylamine through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [872]
4-(6,7-Dimethoxy-quinolin-3-yl)-benzoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 4-(6,7-Dimethoxy-quinolin-3-yl)-benzoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(6,7-Dimethoxy-quinolin-3-yl)-benzoic acid through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
4-(6,7-Dimethoxy-quinolin-3-yl)-phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 4-(6,7-Dimethoxy-quinolin-3-yl)-phenol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(6,7-Dimethoxy-quinolin-3-yl)-phenol through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
4-Benzoimidazol-1-yl-phenylamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 4-Benzoimidazol-1-yl-phenylamine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-Benzoimidazol-1-yl-phenylamine through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [871]
5,6,7-Trimethoxy-3-pyridin-4-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 5,6,7-Trimethoxy-3-pyridin-4-yl-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5,6,7-Trimethoxy-3-pyridin-4-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [869]
5,7-Dimethoxy-3-pyridin-4-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 5,7-Dimethoxy-3-pyridin-4-yl-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5,7-Dimethoxy-3-pyridin-4-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
5,7-Dimethoxy-3-thiophen-3-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 5,7-Dimethoxy-3-thiophen-3-yl-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5,7-Dimethoxy-3-thiophen-3-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
5,7-Dimethyl-3-thiophen-3-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 5,7-Dimethyl-3-thiophen-3-yl-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5,7-Dimethyl-3-thiophen-3-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
5-(6,7-Dimethoxy-quinolin-3-yl)-1H-pyridin-2-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 5-(6,7-Dimethoxy-quinolin-3-yl)-1H-pyridin-2-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-(6,7-Dimethoxy-quinolin-3-yl)-1H-pyridin-2-one through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
5-Methoxy-1-phenyl-1H-benzoimidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 5-Methoxy-1-phenyl-1H-benzoimidazole. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 5-Methoxy-1-phenyl-1H-benzoimidazole through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [871]
6,7-Dichloro-3-thiophen-3-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 6,7-Dichloro-3-thiophen-3-yl-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6,7-Dichloro-3-thiophen-3-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
6,7-Difluoro-3-thiophen-3-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 6,7-Difluoro-3-thiophen-3-yl-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6,7-Difluoro-3-thiophen-3-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
6,7-Dimethoxy-3-((E)-styryl)-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 6,7-Dimethoxy-3-((E)-styryl)-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6,7-Dimethoxy-3-((E)-styryl)-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
6,7-Dimethoxy-3-(3-methoxy-phenyl)-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 6,7-Dimethoxy-3-(3-methoxy-phenyl)-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6,7-Dimethoxy-3-(3-methoxy-phenyl)-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
6,7-Dimethoxy-3-(4-methoxy-phenyl)-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 6,7-Dimethoxy-3-(4-methoxy-phenyl)-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6,7-Dimethoxy-3-(4-methoxy-phenyl)-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
6,7-Dimethoxy-3-(4-nitro-phenyl)-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 6,7-Dimethoxy-3-(4-nitro-phenyl)-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6,7-Dimethoxy-3-(4-nitro-phenyl)-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [869]
6,7-Dimethoxy-3-p-tolyl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 6,7-Dimethoxy-3-p-tolyl-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6,7-Dimethoxy-3-p-tolyl-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
6,7-Dimethoxy-3-phenyl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 6,7-Dimethoxy-3-phenyl-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6,7-Dimethoxy-3-phenyl-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
6,7-Dimethoxy-3-phenylethynyl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 6,7-Dimethoxy-3-phenylethynyl-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6,7-Dimethoxy-3-phenylethynyl-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
6,7-Dimethoxy-3-pyridin-3-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 6,7-Dimethoxy-3-pyridin-3-yl-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6,7-Dimethoxy-3-pyridin-3-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
6,7-Dimethoxy-3-pyridin-4-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 6,7-Dimethoxy-3-pyridin-4-yl-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6,7-Dimethoxy-3-pyridin-4-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [869]
6,7-Dimethoxy-3-thiophen-2-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 6,7-Dimethoxy-3-thiophen-2-yl-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6,7-Dimethoxy-3-thiophen-2-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
6,7-Dimethoxy-4-(2-methoxy-phenoxy)-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 6,7-Dimethoxy-4-(2-methoxy-phenoxy)-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6,7-Dimethoxy-4-(2-methoxy-phenoxy)-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [872]
6,7-Dimethoxy-4-(3-methoxy-phenoxy)-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 6,7-Dimethoxy-4-(3-methoxy-phenoxy)-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6,7-Dimethoxy-4-(3-methoxy-phenoxy)-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [866]
6,7-Dimethoxy-4-(3-nitro-phenoxy)-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 6,7-Dimethoxy-4-(3-nitro-phenoxy)-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6,7-Dimethoxy-4-(3-nitro-phenoxy)-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [872]
6,7-Dimethoxy-4-(4-methoxy-phenoxy)-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 6,7-Dimethoxy-4-(4-methoxy-phenoxy)-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6,7-Dimethoxy-4-(4-methoxy-phenoxy)-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [872]
6,7-Dimethoxy-4-m-tolyloxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 6,7-Dimethoxy-4-m-tolyloxy-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6,7-Dimethoxy-4-m-tolyloxy-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [872]
6,7-Dimethoxy-4-phenoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 6,7-Dimethoxy-4-phenoxy-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6,7-Dimethoxy-4-phenoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [872]
6-Methoxy-3-pyridin-4-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 6-Methoxy-3-pyridin-4-yl-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-Methoxy-3-pyridin-4-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [869]
6-Methoxy-3-thiophen-3-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 6-Methoxy-3-thiophen-3-yl-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 6-Methoxy-3-thiophen-3-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
7-Chloro-3-pyridin-4-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 7-Chloro-3-pyridin-4-yl-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 7-Chloro-3-pyridin-4-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [869]
7-Fluoro-3-thiophen-3-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 7-Fluoro-3-thiophen-3-yl-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 7-Fluoro-3-thiophen-3-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
7-Methoxy-3-pyridin-4-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 7-Methoxy-3-pyridin-4-yl-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 7-Methoxy-3-pyridin-4-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
7-Methoxy-3-thiophen-3-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 7-Methoxy-3-thiophen-3-yl-quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 7-Methoxy-3-thiophen-3-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
7-Thiophen-3-yl-[1,3]dioxolo[4,5-g]quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for 7-Thiophen-3-yl-[1,3]dioxolo[4,5-g]quinoline. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 7-Thiophen-3-yl-[1,3]dioxolo[4,5-g]quinoline through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
AGL 2043 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for AGL 2043. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AGL 2043 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [749]
Benzyl-(6,7-dimethoxy-quinolin-3-yl)-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for Benzyl-(6,7-dimethoxy-quinolin-3-yl)-amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Benzyl-(6,7-dimethoxy-quinolin-3-yl)-amine through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
Bis(5-acetoxybenzo[b]furan-2-yl)methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for Bis(5-acetoxybenzo[b]furan-2-yl)methanone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Bis(5-acetoxybenzo[b]furan-2-yl)methanone through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [866]
Bis(5-aminobenzo[b]furan-2-yl)methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for Bis(5-aminobenzo[b]furan-2-yl)methanone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Bis(5-aminobenzo[b]furan-2-yl)methanone through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [866]
Bis(5-hydroxybenzo[b]furan-2-yl)methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for Bis(5-hydroxybenzo[b]furan-2-yl)methanone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Bis(5-hydroxybenzo[b]furan-2-yl)methanone through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [874]
Bis(5-methoxybenzo[b]furan-2-yl)methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for Bis(5-methoxybenzo[b]furan-2-yl)methanone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Bis(5-methoxybenzo[b]furan-2-yl)methanone through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [871]
Bis(6-hydroxybenzo[b]furan-2-yl)methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for Bis(6-hydroxybenzo[b]furan-2-yl)methanone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Bis(6-hydroxybenzo[b]furan-2-yl)methanone through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [866]
Bis(benzo[b]furan-2-yl)methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for Bis(benzo[b]furan-2-yl)methanone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Bis(benzo[b]furan-2-yl)methanone through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [866]
Bis-(5-hydroxy-1H-indol-2-yl)-methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for Bis-(5-hydroxy-1H-indol-2-yl)-methanone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Bis-(5-hydroxy-1H-indol-2-yl)-methanone through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [875]
BMS 536924 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for BMS 536924. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BMS 536924 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [865]
CP-673451 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for CP-673451. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CP-673451 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [876]
Di(1H-indol-2-yl)methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for Di(1H-indol-2-yl)methanone. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Di(1H-indol-2-yl)methanone through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [877]
GTP-14564 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for GTP-14564. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GTP-14564 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [878]
HKI-9924129 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for HKI-9924129. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of HKI-9924129 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [879]
JNJ-10198409 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for JNJ-10198409. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of JNJ-10198409 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [858]
Ki-11502 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for Ki-11502. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ki-11502 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [864]
Ki-20227 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for Ki-20227. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ki-20227 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [880]
PD-0166326 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for PD-0166326. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PD-0166326 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [881]
PD-0173952 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for PD-0173952. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PD-0173952 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [881]
PD-0173955 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for PD-0173955. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PD-0173955 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [864]
PD-0173956 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for PD-0173956. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PD-0173956 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [881]
PD-0173958 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for PD-0173958. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PD-0173958 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [881]
PD-0179483 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for PD-0179483. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PD-0179483 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [881]
PDGF receptor tyrosine kinase inhibitor III [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for PDGF receptor tyrosine kinase inhibitor III. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PDGF receptor tyrosine kinase inhibitor III through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [882]
Ro-4396686 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for Ro-4396686. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ro-4396686 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [881]
RPR-101511 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for RPR-101511. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RPR-101511 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
RPR-108514A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for RPR-108514A. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RPR-108514A through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [870]
SU-11652 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for SU-11652. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SU-11652 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [872]
TG-100435 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for TG-100435. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TG-100435 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [881]
XB-387 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for XB-387. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of XB-387 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [883]
AG1295 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for AG1295. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AG1295 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [884]
CDP-860 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for CDP-860. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CDP-860 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [885]
CEP-2563 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for CEP-2563. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CEP-2563 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [699]
RG-13022 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for RG-13022. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RG-13022 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [866]
SRI-62-834 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor beta (PDGFRB) is a therapeutic target for SRI-62-834. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SRI-62-834 through regulating the expression of Platelet-derived growth factor receptor beta (PDGFRB). [379], [886]
Programmed cell death 1 ligand 1 (PD-L1)
Atezolizumab [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for Atezolizumab. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Atezolizumab through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [887]
Avelumab [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for Avelumab. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Avelumab through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [233], [373]
Bavencio [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for Bavencio. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Bavencio through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [888]
Durvalumab [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for Durvalumab. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Durvalumab through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [889]
RG-7446 [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for RG-7446. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RG-7446 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [890]
CS1001 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for CS1001. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CS1001 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [891]
KN046 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for KN046. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of KN046 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [892]
MEDI4736 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for MEDI4736. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MEDI4736 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [893]
MPDL-3280A [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for MPDL-3280A. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MPDL-3280A through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [894]
BGB-A333 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for BGB-A333. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BGB-A333 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [895]
Bintrafusp alfa [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for Bintrafusp alfa. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Bintrafusp alfa through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [896]
CX-072 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for CX-072. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CX-072 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [897]
GS-4224 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for GS-4224. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GS-4224 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [898]
INCB86550 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for INCB86550. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of INCB86550 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [899]
KN035 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for KN035. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of KN035 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [900]
M7824 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for M7824. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of M7824 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [118], [373]
NM21-1480 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for NM21-1480. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NM21-1480 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [889]
Pidilizumab [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for Pidilizumab. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Pidilizumab through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [38], [373]
ALPN-202 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for ALPN-202. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ALPN-202 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [901]
Anti-PD-L1 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for Anti-PD-L1. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Anti-PD-L1 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [902]
Anti-PD-L1 CSR T cells [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for Anti-PD-L1 CSR T cells. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Anti-PD-L1 CSR T cells through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [38], [373]
BMS-986189 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for BMS-986189. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BMS-986189 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [889]
CA-170 [Phase 1]
In total 2 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for CA-170. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CA-170 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [118], [373]
Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for CA-170. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CA-170 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [903]
Cosibelimab [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for Cosibelimab. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cosibelimab through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [904]
FAZ053 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for FAZ053. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of FAZ053 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [889]
FS118 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for FS118. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of FS118 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [905]
GEN1046 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for GEN1046. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GEN1046 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [906]
IBI318 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for IBI318. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of IBI318 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [907]
INBRX-105 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for INBRX-105. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of INBRX-105 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [908]
KD033 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for KD033. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of KD033 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [909]
LY3300054 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for LY3300054. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LY3300054 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [38], [373]
LY3415244 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for LY3415244. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LY3415244 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [910]
MCLA-145 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for MCLA-145. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MCLA-145 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [911]
MSB2311 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for MSB2311. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MSB2311 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [889]
PD-L1 t-haNK [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for PD-L1 t-haNK. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PD-L1 t-haNK through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [912]
RG6084 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for RG6084. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RG6084 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [118], [373]
TAK-252 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for TAK-252. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TAK-252 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [913]
CA-327 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for CA-327. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CA-327 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [373], [889]
Proto-oncogene c-Myc (MYC)
AVI-5126 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Proto-oncogene c-Myc (MYC) is a therapeutic target for AVI-5126. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AVI-5126 through regulating the expression of Proto-oncogene c-Myc (MYC). [373], [914]
Resten-NG [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Proto-oncogene c-Myc (MYC) is a therapeutic target for Resten-NG. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Resten-NG through regulating the expression of Proto-oncogene c-Myc (MYC). [373], [915]
TWS-119 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Proto-oncogene c-Myc (MYC) is a therapeutic target for TWS-119. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TWS-119 through regulating the expression of Proto-oncogene c-Myc (MYC). [119], [373]
Pyruvate dehydrogenase kinase 1 (PDHK1)
Dichloroacetate [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Pyruvate dehydrogenase kinase 1 (PDHK1) is a therapeutic target for Dichloroacetate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Dichloroacetate through regulating the expression of Pyruvate dehydrogenase kinase 1 (PDHK1). [916], [917]
Pyruvate kinase M2 (PKM)
CAP-232 [Phase 2a]
In total 1 mechanisms lead to this potential drug response
Response Summary Pyruvate kinase M2 (PKM) is a therapeutic target for CAP-232. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CAP-232 through regulating the expression of Pyruvate kinase M2 (PKM). [485], [918]
TP-1454 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Pyruvate kinase M2 (PKM) is a therapeutic target for TP-1454. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TP-1454 through regulating the expression of Pyruvate kinase M2 (PKM). [166], [918]
Retinoic acid receptor alpha (RARA)
Tamibarotene [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Retinoic acid receptor alpha (RARA) is a therapeutic target for Tamibarotene. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Tamibarotene through regulating the expression of Retinoic acid receptor alpha (RARA). [919], [920]
IRX-5183 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Retinoic acid receptor alpha (RARA) is a therapeutic target for IRX-5183. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of IRX-5183 through regulating the expression of Retinoic acid receptor alpha (RARA). [38], [919]
SY-1425 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Retinoic acid receptor alpha (RARA) is a therapeutic target for SY-1425. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SY-1425 through regulating the expression of Retinoic acid receptor alpha (RARA). [919], [921]
AGN193109 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Retinoic acid receptor alpha (RARA) is a therapeutic target for AGN193109. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AGN193109 through regulating the expression of Retinoic acid receptor alpha (RARA). [919], [922]
AGN193836 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Retinoic acid receptor alpha (RARA) is a therapeutic target for AGN193836. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AGN193836 through regulating the expression of Retinoic acid receptor alpha (RARA). [919], [923]
BMS614 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Retinoic acid receptor alpha (RARA) is a therapeutic target for BMS614. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BMS614 through regulating the expression of Retinoic acid receptor alpha (RARA). [919], [924]
BMS753 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Retinoic acid receptor alpha (RARA) is a therapeutic target for BMS753. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BMS753 through regulating the expression of Retinoic acid receptor alpha (RARA). [919], [925]
CD666 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Retinoic acid receptor alpha (RARA) is a therapeutic target for CD666. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CD666 through regulating the expression of Retinoic acid receptor alpha (RARA). [919], [926]
Ro 40-6055 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Retinoic acid receptor alpha (RARA) is a therapeutic target for Ro 40-6055. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ro 40-6055 through regulating the expression of Retinoic acid receptor alpha (RARA). [919], [927]
Ro 41-5253 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Retinoic acid receptor alpha (RARA) is a therapeutic target for Ro 41-5253. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ro 41-5253 through regulating the expression of Retinoic acid receptor alpha (RARA). [919], [928]
Ro-40-0655 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Retinoic acid receptor alpha (RARA) is a therapeutic target for Ro-40-0655. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ro-40-0655 through regulating the expression of Retinoic acid receptor alpha (RARA). [919], [929]
LG100268 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Retinoic acid receptor alpha (RARA) is a therapeutic target for LG100268. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LG100268 through regulating the expression of Retinoic acid receptor alpha (RARA). [919], [930]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2)
Gallopamil [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) is a therapeutic target for Gallopamil. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Gallopamil through regulating the expression of Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2). [931], [932]
Mydicar [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) is a therapeutic target for Mydicar. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Mydicar through regulating the expression of Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2). [931], [933]
Sequestosome-1 p62 (SQSTM1)
IMX-942 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Sequestosome-1 p62 (SQSTM1) is a therapeutic target for IMX-942. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of IMX-942 through regulating the expression of Sequestosome-1 p62 (SQSTM1). [934], [935]
Serine/threonine-protein kinase mTOR (mTOR)
Glasdegib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for Glasdegib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Glasdegib through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [937]
Novolimus [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for Novolimus. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Novolimus through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [522], [936]
Temsirolimus [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for Temsirolimus. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Temsirolimus through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [938]
Zotarolimus [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for Zotarolimus. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Zotarolimus through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [381], [936]
Ridaforolimus [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for Ridaforolimus. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ridaforolimus through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [939]
ABI-009 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for ABI-009. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ABI-009 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [940]
AZD-2014 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for AZD-2014. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AZD-2014 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [381], [936]
BEZ235 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for BEZ235. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BEZ235 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [38], [936]
BGT226 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for BGT226. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BGT226 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [381], [936]
CC-223 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for CC-223. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CC-223 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [941]
INK128 [Phase 2]
In total 2 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for INK128. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of INK128 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [942]
Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for INK128. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of INK128 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [962]
LY3023414 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for LY3023414. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LY3023414 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [943]
ME-344 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for ME-344. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ME-344 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [944]
MM-141 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for MM-141. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MM-141 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [38], [936]
OSI-027 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for OSI-027. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of OSI-027 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [945]
PF-04691502 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for PF-04691502. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PF-04691502 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [946]
PF-05212384 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for PF-05212384. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PF-05212384 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [947]
PQR309 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for PQR309. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PQR309 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [948]
Salirasib [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for Salirasib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Salirasib through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [381], [936]
SAR245409 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for SAR245409. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SAR245409 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [949]
SF1126 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for SF1126. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SF1126 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [38], [936]
BI 860585 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for BI 860585. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of BI 860585 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [950]
DS-3078 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for DS-3078. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of DS-3078 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [951]
DS-7423 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for DS-7423. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of DS-7423 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [952]
GDC-0349 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for GDC-0349. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GDC-0349 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [381], [936]
LAM-001 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for LAM-001. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LAM-001 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [953]
PWT-33597 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for PWT-33597. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PWT-33597 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [954]
VS-5584 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for VS-5584. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of VS-5584 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [955]
(4-(6-morpholino-9H-purin-2-yl)phenyl)methanol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for (4-(6-morpholino-9H-purin-2-yl)phenyl)methanol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of (4-(6-morpholino-9H-purin-2-yl)phenyl)methanol through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [956]
2-(2-Methyl-morpholin-4-yl)-benzo[h]chromen-4-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for 2-(2-Methyl-morpholin-4-yl)-benzo[h]chromen-4-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-(2-Methyl-morpholin-4-yl)-benzo[h]chromen-4-one through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [957]
2-(6-morpholino-9H-purin-2-yl)phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for 2-(6-morpholino-9H-purin-2-yl)phenol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-(6-morpholino-9H-purin-2-yl)phenol through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [956]
2-chloro-N-(6-cyanopyridin-3-yl)propanamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for 2-chloro-N-(6-cyanopyridin-3-yl)propanamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-chloro-N-(6-cyanopyridin-3-yl)propanamide through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [958]
2-Morpholin-4-yl-pyrimido[2,1-a]isoquinolin-4-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for 2-Morpholin-4-yl-pyrimido[2,1-a]isoquinolin-4-one. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-Morpholin-4-yl-pyrimido[2,1-a]isoquinolin-4-one through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [959]
3-(6-morpholino-9H-purin-2-yl)phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for 3-(6-morpholino-9H-purin-2-yl)phenol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3-(6-morpholino-9H-purin-2-yl)phenol through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [956]
4-(2-(1H-indol-6-yl)-9H-purin-6-yl)morpholine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for 4-(2-(1H-indol-6-yl)-9H-purin-6-yl)morpholine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(2-(1H-indol-6-yl)-9H-purin-6-yl)morpholine through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [956]
4-(2-(thiophen-2-yl)-9H-purin-6-yl)morpholine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for 4-(2-(thiophen-2-yl)-9H-purin-6-yl)morpholine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(2-(thiophen-2-yl)-9H-purin-6-yl)morpholine through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [960]
4-(2-(thiophen-3-yl)-9H-purin-6-yl)morpholine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for 4-(2-(thiophen-3-yl)-9H-purin-6-yl)morpholine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(2-(thiophen-3-yl)-9H-purin-6-yl)morpholine through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [956]
4-(6-morpholino-9H-purin-2-yl)phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for 4-(6-morpholino-9H-purin-2-yl)phenol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 4-(6-morpholino-9H-purin-2-yl)phenol through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [956]
AP-21967 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for AP-21967. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AP-21967 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [957]
AR-mTOR-26 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for AR-mTOR-26. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AR-mTOR-26 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [381], [936]
C-16-(S)-3-methylindolerapamycin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for C-16-(S)-3-methylindolerapamycin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C-16-(S)-3-methylindolerapamycin through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [956]
CU-906 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for CU-906. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of CU-906 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [381], [936]
EC-0565 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for EC-0565. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of EC-0565 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [381], [936]
EC-0845 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for EC-0845. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of EC-0845 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [381], [936]
EM-101 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for EM-101. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of EM-101 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [961]
Ethyl 1-[(1H-benzimidazol-2(3H)one-5-yl)sulfonyl]-1H-pyrrole-2-carboxylate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for Ethyl 1-[(1H-benzimidazol-2(3H)one-5-yl)sulfonyl]-1H-pyrrole-2-carboxylate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ethyl 1-[(1H-benzimidazol-2(3H)one-5-yl)sulfonyl]-1H-pyrrole-2-carboxylate through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [959]
HM-5016699 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for HM-5016699. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of HM-5016699 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [381], [936]
OXA-01 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for OXA-01. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of OXA-01 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [381], [936]
P-2281 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for P-2281. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of P-2281 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [381], [936]
P-6915 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for P-6915. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of P-6915 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [381], [936]
PF-03772304 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for PF-03772304. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PF-03772304 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [381], [936]
PF-05094037 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for PF-05094037. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PF-05094037 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [963]
PP-242 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for PP-242. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PP-242 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [964]
PP121 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for PP121. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PP121 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [965]
Rapamycin complexed with immunophilin FKBP12 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for Rapamycin complexed with immunophilin FKBP12. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Rapamycin complexed with immunophilin FKBP12 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [959]
SB-2280 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for SB-2280. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SB-2280 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [381], [936]
SX-MTR1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for SX-MTR1. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SX-MTR1 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [381], [936]
torin 1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for torin 1. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of torin 1 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [965]
Torin2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for Torin2. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Torin2 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [966]
X-387 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for X-387. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of X-387 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [381], [936]
AZD8055 [Discontinued in Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for AZD8055. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of AZD8055 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [967]
SCR-44001 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for SCR-44001. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SCR-44001 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [936], [968]
TAFA-93 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Serine/threonine-protein kinase mTOR (mTOR) is a therapeutic target for TAFA-93. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TAFA-93 through regulating the expression of Serine/threonine-protein kinase mTOR (mTOR). [405], [936]
Signal transducer and activator of transcription 3 (STAT3)
Acitretin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for Acitretin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Acitretin through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [608], [969]
Napabucasin [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for Napabucasin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Napabucasin through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [608], [970]
Atiprimod [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for Atiprimod. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Atiprimod through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [608], [971]
GLG-801 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for GLG-801. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GLG-801 through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [608], [933]
Golotimod [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for Golotimod. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Golotimod through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [38], [608]
IMX-110 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for IMX-110. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of IMX-110 through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [38], [608]
ISIS-STAT3 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for ISIS-STAT3. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS-STAT3 through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [608], [972]
NT219 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for NT219. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NT219 through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [608], [973]
OPB-31121 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for OPB-31121. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of OPB-31121 through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [38], [608]
WP-1066 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for WP-1066. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of WP-1066 through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [38], [608]
C188-9 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for C188-9. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of C188-9 through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [608], [974]
DSP-0337 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for DSP-0337. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of DSP-0337 through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [28], [608]
OPB-111077 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for OPB-111077. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of OPB-111077 through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [608], [975]
OPB-51602 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for OPB-51602. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of OPB-51602 through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [608], [976]
TAK-114 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for TAK-114. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of TAK-114 through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [608], [977]
WP1220 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for WP1220. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of WP1220 through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [608], [978]
GNF-PF-1399 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for GNF-PF-1399. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of GNF-PF-1399 through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [608], [979]
ISIS 113176 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for ISIS 113176. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 113176 through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [608], [972]
ISIS 113187 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for ISIS 113187. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 113187 through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [608], [972]
ISIS 113209 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for ISIS 113209. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 113209 through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [608], [972]
ISIS 113210 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for ISIS 113210. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 113210 through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [38], [608]
ISIS 17148 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for ISIS 17148. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 17148 through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [608], [972]
ISIS 17152 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Signal transducer and activator of transcription 3 (STAT3) is a therapeutic target for ISIS 17152. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 17152 through regulating the expression of Signal transducer and activator of transcription 3 (STAT3). [608], [972]
SRSF protein kinase 2 (SRPK2)
URMC-099 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary SRSF protein kinase 2 (SRPK2) is a therapeutic target for URMC-099. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of URMC-099 through regulating the expression of SRSF protein kinase 2 (SRPK2). [531], [980]
Superoxide dismutase Mn (SOD Mn)
Imisopasem manganese [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Superoxide dismutase Mn (SOD Mn) is a therapeutic target for Imisopasem manganese. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Imisopasem manganese through regulating the expression of Superoxide dismutase Mn (SOD Mn). [22], [981]
Tyrosine-protein kinase Mer (MERTK)
MK-2461 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Tyrosine-protein kinase Mer (MERTK) is a therapeutic target for MK-2461. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MK-2461 through regulating the expression of Tyrosine-protein kinase Mer (MERTK). [149], [982]
ONO-7475 [Phase 1/2]
In total 2 mechanisms lead to this potential drug response
Response Summary Tyrosine-protein kinase Mer (MERTK) is a therapeutic target for ONO-7475. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ONO-7475 through regulating the expression of Tyrosine-protein kinase Mer (MERTK). [149], [374]
Tyrosine-protein kinase Mer (MERTK) is a therapeutic target for ONO-7475. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ONO-7475 through regulating the expression of Tyrosine-protein kinase Mer (MERTK). [149], [984]
INCB81776 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Tyrosine-protein kinase Mer (MERTK) is a therapeutic target for INCB81776. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of INCB81776 through regulating the expression of Tyrosine-protein kinase Mer (MERTK). [149], [863]
MRX-2843 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Tyrosine-protein kinase Mer (MERTK) is a therapeutic target for MRX-2843. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of MRX-2843 through regulating the expression of Tyrosine-protein kinase Mer (MERTK). [149], [983]
PF-07265807 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Tyrosine-protein kinase Mer (MERTK) is a therapeutic target for PF-07265807. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PF-07265807 through regulating the expression of Tyrosine-protein kinase Mer (MERTK). [149], [985]
RXDX-106 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Tyrosine-protein kinase Mer (MERTK) is a therapeutic target for RXDX-106. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RXDX-106 through regulating the expression of Tyrosine-protein kinase Mer (MERTK). [149], [986]
G749 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Tyrosine-protein kinase Mer (MERTK) is a therapeutic target for G749. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of G749 through regulating the expression of Tyrosine-protein kinase Mer (MERTK). [149], [987]
LDC1267 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Tyrosine-protein kinase Mer (MERTK) is a therapeutic target for LDC1267. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of LDC1267 through regulating the expression of Tyrosine-protein kinase Mer (MERTK). [149], [988]
UNC2025 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Tyrosine-protein kinase Mer (MERTK) is a therapeutic target for UNC2025. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of UNC2025 through regulating the expression of Tyrosine-protein kinase Mer (MERTK). [38], [149]
UNC569 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Tyrosine-protein kinase Mer (MERTK) is a therapeutic target for UNC569. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of UNC569 through regulating the expression of Tyrosine-protein kinase Mer (MERTK). [149], [989]
VCAM-1 messenger RNA (VCAM1 mRNA)
ISIS 3792 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary VCAM-1 messenger RNA (VCAM1 mRNA) is a therapeutic target for ISIS 3792. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 3792 through regulating the expression of VCAM-1 messenger RNA (VCAM1 mRNA). [592], [990]
ISIS 3801 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary VCAM-1 messenger RNA (VCAM1 mRNA) is a therapeutic target for ISIS 3801. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 3801 through regulating the expression of VCAM-1 messenger RNA (VCAM1 mRNA). [592], [990]
ISIS 3804 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary VCAM-1 messenger RNA (VCAM1 mRNA) is a therapeutic target for ISIS 3804. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 3804 through regulating the expression of VCAM-1 messenger RNA (VCAM1 mRNA). [592], [991]
ISIS 3805 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary VCAM-1 messenger RNA (VCAM1 mRNA) is a therapeutic target for ISIS 3805. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 3805 through regulating the expression of VCAM-1 messenger RNA (VCAM1 mRNA). [592], [990]
ISIS 5874 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary VCAM-1 messenger RNA (VCAM1 mRNA) is a therapeutic target for ISIS 5874. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 5874 through regulating the expression of VCAM-1 messenger RNA (VCAM1 mRNA). [592], [990]
ISIS 5875 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary VCAM-1 messenger RNA (VCAM1 mRNA) is a therapeutic target for ISIS 5875. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 5875 through regulating the expression of VCAM-1 messenger RNA (VCAM1 mRNA). [592], [990]
ISIS 5876 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary VCAM-1 messenger RNA (VCAM1 mRNA) is a therapeutic target for ISIS 5876. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 5876 through regulating the expression of VCAM-1 messenger RNA (VCAM1 mRNA). [592], [990]
ISIS 5884 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary VCAM-1 messenger RNA (VCAM1 mRNA) is a therapeutic target for ISIS 5884. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of ISIS 5884 through regulating the expression of VCAM-1 messenger RNA (VCAM1 mRNA). [592], [990]
SYMBIOPOLYOL [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary VCAM-1 messenger RNA (VCAM1 mRNA) is a therapeutic target for SYMBIOPOLYOL. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of SYMBIOPOLYOL through regulating the expression of VCAM-1 messenger RNA (VCAM1 mRNA). [592], [992]
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