m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG00822)
Name
NB-325
Synonyms
PEHMB; Polyethylene hexamethylene biguanide
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Status
Investigative
Structure
3D MOL
2D MOL
Formula
C16H36Cl2N14
InChI
1S/C16H34N14.2ClH/c17-5-8-27-15(22)29-13(20)25-6-3-1-2-4-7-26-14(21)30-16(23)28-10-9-24-12(19)11-18;;/h1-10,17H2,(H2,19,24)(H5,20,22,25,27,29)(H5,21,23,26,28,30);2*1H
InChIKey
CNGBVJCBMLEXDO-UHFFFAOYSA-N
PubChem CID
15954275
TTD Drug ID
D0R4WT
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
C-X-C chemokine receptor type 4 (CXCR4)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for NB-325. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NB-325 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [1], [2]
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for NB-325. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of NB-325 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [2], [3]
YTH domain-containing family protein 2 (YTHDF2)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for NB-325. The YTH domain-containing family protein 2 (YTHDF2) has potential in affecting the response of NB-325 through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [1], [2]
References
Ref 1 m(6)A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade. Nat Commun. 2019 Jun 25;10(1):2782. doi: 10.1038/s41467-019-10669-0.
Ref 2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 71).
Ref 3 LNC942 promoting METTL14-mediated m(6)A methylation in breast cancer cell proliferation and progression. Oncogene. 2020 Jul;39(31):5358-5372. doi: 10.1038/s41388-020-1338-9. Epub 2020 Jun 23.