General Information of the Drug (ID: M6APDG02891)
Name
p-nitrophenyl glutamyl anilide
Synonyms
gamma-glutamyl-p-nitroanilide; p-nitrophenyl glutamyl anilide; AC1OF0UB; GTPL4508; (2S)-2-azaniumyl-5-(4-nitroanilino)-5-oxopentanoate
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Status
Investigative
Structure
Formula
C11H13N3O5
InChI
1S/C11H13N3O5/c12-9(11(16)17)5-6-10(15)13-7-1-3-8(4-2-7)14(18)19/h1-4,9H,5-6,12H2,(H,13,15)(H,16,17)/t9-/m0/s1
InChIKey
WMZTYIRRBCGARG-VIFPVBQESA-N
PubChem CID
7090494
TTD Drug ID
D00IWH
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Alanine/serine/cysteine/threonine transporter 2 (SLC1A5)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
Response Summary Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) is a therapeutic target for p-nitrophenyl glutamyl anilide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of p-nitrophenyl glutamyl anilide through regulating the expression of Alanine/serine/cysteine/threonine transporter 2 (SLC1A5). [1], [2]
References
Ref 1 The m(6)A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor. Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21441-21449. doi: 10.1073/pnas.2000516117. Epub 2020 Aug 19.
Ref 2 New inhibitors for the neutral amino acid transporter ASCT2 reveal its Na+-dependent anion leak. J Physiol. 2004 Jun 15;557(Pt 3):747-59. doi: 10.1113/jphysiol.2004.062521. Epub 2004 Apr 23.