General Information of the Drug (ID: M6APDG01282)
Name
Dichloroacetate
Synonyms
2,2-dichloroacetate; Dichloracetate; Dichloroacetate ion; 13425-80-4; Dichloroacetic acid ion(1-); DCA; BRN 3903873; 2q8h; ACETIC ACID, DICHLORO-, ION(1-); 2,2-bis(chloranyl)ethanoate; GTPL4518; CHEBI:28240; DTXSID40158610; STL483470; NCGC00241105-01; 68626-EP2292227A2; 68626-EP2292628A2; 68626-EP2298776A1; 68626-EP2308861A1; 68626-EP2374454A1; A839686; Q27077050
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Status
Phase 4
Structure
Formula
C2HCl2O2-
InChI
1S/C2H2Cl2O2/c3-1(4)2(5)6/h1H,(H,5,6)/p-1
InChIKey
JXTHNDFMNIQAHM-UHFFFAOYSA-M
PubChem CID
25975
TTD Drug ID
D7I9JH
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Pyruvate dehydrogenase kinase 1 (PDHK1)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
Response Summary Pyruvate dehydrogenase kinase 1 (PDHK1) is a therapeutic target for Dichloroacetate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Dichloroacetate through regulating the expression of Pyruvate dehydrogenase kinase 1 (PDHK1). [1], [2]
References
Ref 1 Long noncoding RNA just proximal to X-inactive specific transcript facilitates aerobic glycolysis and temozolomide chemoresistance by promoting stability of PDK1 mRNA in an m6A-dependent manner in glioblastoma multiforme cells. Cancer Sci. 2021 Nov;112(11):4543-4552. doi: 10.1111/cas.15072. Epub 2021 Aug 30.
Ref 2 PDK1 disruptors and modulators: a patent review. Expert Opin Ther Pat. 2015 May;25(5):513-37. doi: 10.1517/13543776.2015.1014801. Epub 2015 Feb 15.