m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG02974)
Name
Glycine
Synonyms
(1-13c)glycinato; (15N)Glycine; 2,2-dialkylglycines; 2-Aminoacetic acid; AB-131/40217813; AMINOACETIC ACID 1.5% IN PLASTIC CONTAINER; Acide aminoacetique; Acide aminoacetique [INN-French]; Acido aminoacetico; Acido aminoacetico [INN-Spanish]; Acidum aminoaceticum; Acidum aminoaceticum [INN-Latin]; Aciport; Aminoacetic acid; Aminoazijnzuur; Aminoessigsaeure; Aminoethanoic acid; Amitone; An alpha amino acid ester; Corilin; GLY (IUPAC abbrev); GLYCINE 1.5% IN PLASTIC CONTAINER; GLYCINE, ACS; Glicina; Glicina [INN-Spanish]; Glicoamin; Gly; Glycin; Glycine (JP15/USP); Glycine [INN]; Glycine iron sulphate (1:1); Glycine, homopolymer (VAN); Glycine, labeled with carbon-14; Glycine, non-medical; Glycine-UL-14C hydrochloride; Glycinum; Glycinum [INN-Latin]; Glycocoll; Glycolixir; Glycosthene; Glykokoll; Glyzin; Gyn-hydralin; H-Gly-OH; H2N-CH2-COOH; Hampshire glycine; Hgly; L-Glycine; L-alpha-amino acids; Leimzucker; Padil; Polyglycine; Polyglycine II; S04-0135; Sucre de gelatine
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Status
Approved
Structure
Formula
C2H5NO2
InChI
1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKey
DHMQDGOQFOQNFH-UHFFFAOYSA-N
PubChem CID
750
VARIDT Drug ID
DR00242
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Alanine/serine/cysteine/threonine transporter 2 (SLC1A5)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) is a therapeutic target for Glycine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Glycine through regulating the expression of Alanine/serine/cysteine/threonine transporter 2 (SLC1A5). [1], [2]
References
Ref 1 The m(6)A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor. Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21441-21449. doi: 10.1073/pnas.2000516117. Epub 2020 Aug 19.
Ref 2 Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+). Am J Physiol Gastrointest Liver Physiol. 2007 Nov;293(5):G1046-53. doi: 10.1152/ajpgi.00233.2007. Epub 2007 Sep 13.