General Information of the Disease (ID: M6ADIS0311)
Name
Preeclampsia
ICD
ICD-11: JA23
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
In total 4 item(s) under this disease
Crosstalk ID: M6ACROT03216
m6A Regulator RNA-binding motif protein 15 (RBM15)
m6A Target Tripartite motif-containing protein 72 (TRIM72)
Epigenetic Regulator Histone-lysine N-methyltransferase 2A (KMT2A)
Regulated Target Histone H3 lysine 4 trimethylation (H3K4me3)
Crosstalk relationship Histone modification → m6A
Drug Actinomycin D
Crosstalk ID: M6ACROT03217
m6A Regulator YTH domain-containing family protein 2 (YTHDF2)
m6A Target Tripartite motif-containing protein 72 (TRIM72)
Epigenetic Regulator Histone-lysine N-methyltransferase 2A (KMT2A)
Regulated Target Histone H3 lysine 4 trimethylation (H3K4me3)
Crosstalk relationship Histone modification → m6A
Drug Actinomycin D
Crosstalk ID: M6ACROT03237
m6A Regulator RNA demethylase ALKBH5 (ALKBH5)
m6A Target Peroxisome proliferator-activated receptor gamma (PPARG)
Epigenetic Regulator Lysine-specific demethylase 3B (KDM3B)
Regulated Target Histone H3 lysine 9 dimethylation (H3K9me2)
Crosstalk relationship m6A → Histone modification
Crosstalk ID: M6ACROT05162
m6A Regulator Methyltransferase-like 3 (METTL3)
m6A Target Tumor necrosis factor receptor superfamily member 6 (FAS)
Epigenetic Regulator Long intergenic non-protein coding RNA 1410 (LINC01410)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship ncRNA → m6A
References
Ref 1 A high-affinity fully human anti-IL-6 mAb (OP-R003-1, 1339) for the treatment of Multiple Myeloma
Ref 2 A patent review of arginine methyltransferase inhibitors (2010-2018). Expert Opin Ther Pat. 2019 Feb;29(2):97-114. doi: 10.1080/13543776.2019.1567711.
Ref 3 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023753)