Name	Kaposi's sarcoma
ICD	ICD-11: 2B57

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[1]
Response Summary	This modification recruits the m6A reader YTHDC2 and found that YTHDC2 is necessary for the escape of the IL-6 transcript. m6A modification is essential to confer SOX resistance to the Interleukin-6 (IL-6) mRNA. These results shed light on how the host cell has evolved to use RNA modifications to circumvent viral manipulation of RNA fate during KSHV infection Kaposi's sarcoma.
Responsed Disease	Kaposi's sarcoma [ICD-11: 2B57]
Target Regulator	YTH domain-containing protein 2 (YTHDC2)		READER	Regulator Info
In-vitro Model	iSLK.219	Clear cell renal cell carcinoma	Homo sapiens	CVCL_B6YV
	HEK293T	Normal	Homo sapiens	CVCL_0063
	HEK293	Normal	Homo sapiens	CVCL_0045

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[2]
Response Summary	Kaposi's sarcoma-associated herpesvirus(KSHV) productive lytic replication plays a pivotal role in the initiation and progression of Kaposi's sarcoma tumors. m6A sites in RTA pre-mRNA crucial for splicing through interactions with YTHDC1, SRSF3 and Serine/arginine-rich splicing factor 10 (SRSF10). m6A in regulating RTA pre-mRNA splicing but also suggest that KSHV has evolved a mechanism to manipulate the host m6A machinery to its advantage in promoting lytic replication.
Responsed Disease	Kaposi's sarcoma [ICD-11: 2B57]
Target Regulator	YTH domain-containing protein 1 (YTHDC1)		READER	Regulator Info
Target Regulation	Up regulation
Pathway Response	Spliceosome			hsa03040
In-vitro Model	TIVE-KSHV (KSHV-infected telomerase-immortalized human umbilical vein endothelial cells (TIVE-KSHV cells))
	iSLK-BAC16 cells (Kaposi's sarcoma cells carrying the recombinant KSHV bacterial artificial chromosome 16 (BAC16) (iSLK-BAC16 cells))
	HUVEC-C	Normal	Homo sapiens	CVCL_2959

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[2]
Response Summary	Kaposi's sarcoma-associated herpesvirus(KSHV) productive lytic replication plays a pivotal role in the initiation and progression of Kaposi's sarcoma tumors. m6A sites in RTA pre-mRNA crucial for splicing through interactions with YTHDC1, Serine/arginine-rich splicing factor 3 (SRSF3) and SRSF10. m6A in regulating RTA pre-mRNA splicing but also suggest that KSHV has evolved a mechanism to manipulate the host m6A machinery to its advantage in promoting lytic replication.
Responsed Disease	Kaposi's sarcoma [ICD-11: 2B57]
Target Regulator	YTH domain-containing protein 1 (YTHDC1)		READER	Regulator Info
Target Regulation	Up regulation
Pathway Response	Spliceosome			hsa03040
In-vitro Model	TIVE-KSHV (KSHV-infected telomerase-immortalized human umbilical vein endothelial cells (TIVE-KSHV cells))
	iSLK-BAC16 cells (Kaposi's sarcoma cells carrying the recombinant KSHV bacterial artificial chromosome 16 (BAC16) (iSLK-BAC16 cells))
	HUVEC-C	Normal	Homo sapiens	CVCL_2959

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[3]
Response Summary	Staphylococcal nuclease domain-containing protein 1 (SND1) depletion leads to inhibition of KSHV early gene expression showing that SND1 is essential for Kaposi's sarcoma associated herpesvirus(KSHV) lytic replication.
Responsed Disease	Kaposi's sarcoma [ICD-11: 2B57]
In-vitro Model	HEK293T	Normal	Homo sapiens	CVCL_0063
	HEK293	Normal	Homo sapiens	CVCL_0045
	BCBL-1	Primary effusion lymphoma	Homo sapiens	CVCL_0165

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[1]
Response Summary	This modification recruits the m6A reader YTHDC2 and found that YTHDC2 is necessary for the escape of the IL-6 transcript. m6A modification is essential to confer SOX (SOX) resistance to the IL-6 mRNA. These results shed light on how the host cell has evolved to use RNA modifications to circumvent viral manipulation of RNA fate during KSHV infection Kaposi's sarcoma.
Responsed Disease	Kaposi's sarcoma [ICD-11: 2B57]
Target Regulator	YTH domain-containing protein 2 (YTHDC2)		READER	Regulator Info
In-vitro Model	iSLK.219	Clear cell renal cell carcinoma	Homo sapiens	CVCL_B6YV
	HEK293T	Normal	Homo sapiens	CVCL_0063
	HEK293	Normal	Homo sapiens	CVCL_0045

Ref 1	The m(6)A reader YTHDC2 is essential for escape from KSHV SOX-induced RNA decay. Proc Natl Acad Sci U S A. 2022 Feb 22;119(8):e2116662119. doi: 10.1073/pnas.2116662119.
Ref 2	Kaposi's Sarcoma-Associated Herpesvirus Utilizes and Manipulates RNA N(6)-Adenosine Methylation To Promote Lytic Replication. J Virol. 2017 Jul 27;91(16):e00466-17. doi: 10.1128/JVI.00466-17. Print 2017 Aug 15.
Ref 3	The Tudor SND1 protein is an m(6)A RNA reader essential for replication of Kaposi's sarcoma-associated herpesvirus. Elife. 2019 Oct 24;8:e47261. doi: 10.7554/eLife.47261.