m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00591)
Target Name SOX (SOX)
Gene Name SOX
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
SOX can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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YTH domain-containing protein 2 (YTHDC2) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary This modification recruits the m6A reader YTHDC2 and found that YTHDC2 is necessary for the escape of the IL-6 transcript. m6A modification is essential to confer SOX (SOX) resistance to the IL-6 mRNA. These results shed light on how the host cell has evolved to use RNA modifications to circumvent viral manipulation of RNA fate during KSHV infection Kaposi's sarcoma.
Responsed Disease Kaposi's sarcoma ICD-11: 2B57
 Disease Info 
In-vitro Model iSLK.219 Clear cell renal cell carcinoma Homo sapiens CVCL_B6YV
HEK293T Normal Homo sapiens CVCL_0063
HEK293 Normal Homo sapiens CVCL_0045
Kaposi's sarcoma [ICD-11: 2B57]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary This modification recruits the m6A reader YTHDC2 and found that YTHDC2 is necessary for the escape of the IL-6 transcript. m6A modification is essential to confer SOX (SOX) resistance to the IL-6 mRNA. These results shed light on how the host cell has evolved to use RNA modifications to circumvent viral manipulation of RNA fate during KSHV infection Kaposi's sarcoma.
Responsed Disease Kaposi's sarcoma [ICD-11: 2B57]
Target Regulator YTH domain-containing protein 2 (YTHDC2) READER
 Regulator Info 
In-vitro Model iSLK.219 Clear cell renal cell carcinoma Homo sapiens CVCL_B6YV
HEK293T Normal Homo sapiens CVCL_0063
HEK293 Normal Homo sapiens CVCL_0045
References
Ref 1 The m(6)A reader YTHDC2 is essential for escape from KSHV SOX-induced RNA decay. Proc Natl Acad Sci U S A. 2022 Feb 22;119(8):e2116662119. doi: 10.1073/pnas.2116662119.