General Information of the Disease (ID: M6ADIS0144)
Name
Endometriosis
ICD
ICD-11: GA10
Full List of Target Gene(s) of This m6A-centered Disease Response
microRNA 126 (MIR126)
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary The METTL3/m6A/miR126 pathway, whose inhibition contributes to endometriosis development by enhancing cellular migration and invasion.
Responsed Disease Endometriosis [ICD-11: GA10]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
Target Regulation Up regulation
In-vitro Model HESC (Human endometrial stromal cells)
References
Ref 1 Inhibition of METTL3/m6A/miR126 promotes the migration and invasion of endometrial stromal cells in endometriosis?. Biol Reprod. 2021 Nov 15;105(5):1221-1233. doi: 10.1093/biolre/ioab152.