m6A-centered Disease Response Information | M6AREG

General Information of the Disease (ID: M6ADIS0144)

Name	Endometriosis
ICD	ICD-11: GA10

Full List of Target Gene(s) of This m6A-centered Disease Response

microRNA 126 (MIR126)

Target Info

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[1]
Response Summary	The METTL3/m6A/miR126 pathway, whose inhibition contributes to endometriosis development by enhancing cellular migration and invasion.
Responsed Disease	Endometriosis [ICD-11: GA10]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Up regulation
In-vitro Model	HESC (Human endometrial stromal cells)

References

Ref 1	Inhibition of METTL3/m6A/miR126 promotes the migration and invasion of endometrial stromal cells in endometriosis?. Biol Reprod. 2021 Nov 15;105(5):1221-1233. doi: 10.1093/biolre/ioab152.

Cite M6AREG

S. P. Liu, L. Chen, Y. T. Zhang, Y. Zhou, Y. He, Z. Chen, S. S. Qi, J. Y. Zhu, X. D. Chen, H. Zhang, Y. C. Luo, Y. Q. Qiu, L. Tao*, F. Zhu*. M6AREG: m6A-centered regulation of disease development and drug response. Nucleic Acids Research. 2022 Sep 22;gkac801. PMID: 36134713

Correspondence

Prof. Feng ZHU

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

Prof. Shuiping Liu

School of Pharmacy, Hangzhou Normal University, Hangzhou, China

Visitor Map

Back to top