m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00450)
Target Name Wnt inhibitory factor 1 (WIF1)
Synonyms
WIF-1; UNQ191/PRO217
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Gene Name WIF1
Chromosomal Location 12q14.3
Function
Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
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Gene ID 11197
Uniprot ID
WIF1_HUMAN
HGNC ID
HGNC:18081
Ensembl Gene ID
ENSG00000156076
KEGG ID
hsa:11197
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
WIF1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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RNA demethylase ALKBH5 (ALKBH5) [ERASER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary ALKBH5 overexpression sensitizes Pancreatic cancer cells to gemcitabine treatment, and it represses PDAC tumorigenesis by reducing m6A levels of Wnt inhibitory factor 1 (WIF1) and hindering activation of Wnt signaling.
Target Regulation Up regulation
Responsed Disease Pancreatic cancer ICD-11: 2C10
 Disease Info 
Responsed Drug Gemcitabine Approved
 Drug Info 
Pathway Response Wnt signaling pathway hsa04310
In-vitro Model AsPC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0152
BxPC-3 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0186
Capan-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0237
Capan-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0026
CFPAC-1 Cystic fibrosis Homo sapiens CVCL_1119
HPDE6c7 Normal Homo sapiens CVCL_0P38
MIA PaCa-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0428
PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0480
Pancreatic cancer [ICD-11: 2C10]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary ALKBH5 overexpression sensitizes Pancreatic cancer cells to gemcitabine treatment, and it represses PDAC tumorigenesis by reducing m6A levels of Wnt inhibitory factor 1 (WIF1) and hindering activation of Wnt signaling.
Responsed Disease Pancreatic cancer [ICD-11: 2C10]
Target Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
Target Regulation Up regulation
Responsed Drug Gemcitabine Approved
 Drug Info 
Pathway Response Wnt signaling pathway hsa04310
In-vitro Model AsPC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0152
BxPC-3 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0186
Capan-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0237
Capan-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0026
CFPAC-1 Cystic fibrosis Homo sapiens CVCL_1119
HPDE6c7 Normal Homo sapiens CVCL_0P38
MIA PaCa-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0428
PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0480
Gemcitabine [Approved]
 Drug Info 
In total 1 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response [1]
Response Summary ALKBH5 overexpression sensitizes Pancreatic cancer cells to gemcitabine treatment, and it represses PDAC tumorigenesis by reducing m6A levels of Wnt inhibitory factor 1 (WIF1) and hindering activation of Wnt signaling.
Target Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
Target Regulation Up regulation
Responsed Disease Pancreatic cancer ICD-11: 2C10
 Disease Info 
Pathway Response Wnt signaling pathway hsa04310
In-vitro Model AsPC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0152
BxPC-3 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0186
Capan-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0237
Capan-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0026
CFPAC-1 Cystic fibrosis Homo sapiens CVCL_1119
HPDE6c7 Normal Homo sapiens CVCL_0P38
MIA PaCa-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0428
PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0480
References
Ref 1 m(6)A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling. Mol Cancer. 2020 Jan 6;19(1):3. doi: 10.1186/s12943-019-1128-6.