m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00137)
Target Name microRNA 126 (MIR126)
Synonyms
MIR126; MIRN126; hsa-mir-126
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Gene Name MIR126
Chromosomal Location 9q34.3
Family MicroRNAs
Gene ID 406913
HGNC ID
HGNC:31508
miRBase ID
MI0000471
Ensembl Gene ID
ENSG00000199161
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MIR126 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary The METTL3/m6A/miR126 pathway, whose inhibition contributes to endometriosis development by enhancing cellular migration and invasion.
Target Regulation Up regulation
Responsed Disease Endometriosis ICD-11: GA10
 Disease Info 
In-vitro Model HESC (Human endometrial stromal cells)
Idiopathic interstitial pneumonitis [ICD-11: CB03]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response []
Response Summary m6A modification of pri-miRNA-126 and its binding with DGCR8 decreases blocked microRNA 126 (MIR126) maturation, and then activated the PI3K/AKT/mTOR pathway, which drove the fibro genesis in the lung after CB exposure.
Responsed Disease Pulmonary Fibrosis [ICD-11: CB03.4]
Pathway Response MAPK signaling pathway hsa04010
PI3K-Akt signaling pathway hsa04151
Cell Process RNA maturation
In-vitro Model ()
In-vivo Model Rats inhaled CB at dose of 0, 5 or 30 mg/m3 for 28 days, 6 h/day, respectively. The rats inhaled CB at dose of 0 or 30 mg/m3 for 14 days, 28 days and 90 days, respectively. In vitro experiments, the normal human bronchial epithelial cell line (16HBE) was treated with CB (0, 50, 100 and 200 ug/mL) for 24 h.
Endometriosis [ICD-11: GA10]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary The METTL3/m6A/miR126 pathway, whose inhibition contributes to endometriosis development by enhancing cellular migration and invasion.
Responsed Disease Endometriosis [ICD-11: GA10]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model HESC (Human endometrial stromal cells)
References
Ref 1 Inhibition of METTL3/m6A/miR126 promotes the migration and invasion of endometrial stromal cells in endometriosis?. Biol Reprod. 2021 Nov 15;105(5):1221-1233. doi: 10.1093/biolre/ioab152.