Name	Liver disease
ICD	ICD-11: DB9Z

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[1]
Response Summary	METTL14 promotes DNA damage-inducible transcript 3 protein (DDIT3/CHOP) mRNA decay through its 3' UTR N6-methyladenosine (m6A) to inhibit its downstream pro-apoptotic target gene expression, suppress ER proteotoxic liver disease. UPR induces METTL14 expression by competing against the HRD1-ER-associated degradation (ERAD) machinery to block METTL14 ubiquitination and degradation.
Responsed Disease	Liver disease [ICD-11: DB9Z]
Target Regulator	Methyltransferase-like 14 (METTL14)		WRITER	Regulator Info
Target Regulation	Down regulation
Pathway Response	Ubiquitin mediated proteolysis			hsa04120
Cell Process	Cell apoptosis
	Ubiquitination degradation
In-vitro Model	HEK293	Normal	Homo sapiens	CVCL_0045
	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[2]
Response Summary	ALKBH5-dependent High mobility group protein B1 (HMGB1) expression mediates STING-interferon regulatory factor 3 innate immune response in radiation-induced liver diseases.
Responsed Disease	Liver disease [ICD-11: DB9Z]
Target Regulator	RNA demethylase ALKBH5 (ALKBH5)		ERASER	Regulator Info
Target Regulation	Down regulation
Cell Process	Immune Response
	Cell apoptosis

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[3]
Response Summary	Mammalian target of rapamycin complex 1 (mTORC1) pathway is highly activated in rbm15-deficient hepatocytes. Rapamycin treatment partially restored normal hepatic gene expression as well as the nuclear location of the transcription factor Hnf4a. Taken together, these results reveal an unexpected role of Rbm15 in liver maturation.
Responsed Disease	Liver disease [ICD-11: DB9Z]
Target Regulator	RNA-binding motif protein 15 (RBM15)		WRITER	Regulator Info
Target Regulation	Down regulation
Pathway Response	mTOR signaling pathway			hsa04150
Cell Process	Cell proliferation and apoptosis
In-vivo Model	Zebrafish (Danio rerio) AB strain-derived Tg(lfabp:Dendra2-NTR)cq1 was used as WT, and rbm15cq96 mutant was generated by ENU treatment.

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[2]
Response Summary	ALKBH5-dependent HMGB1 expression mediates Stimulator of interferon genes protein (STING1)-interferon regulatory factor 3 innate immune response in radiation-induced liver diseases.
Responsed Disease	Liver disease [ICD-11: DB9Z]
Target Regulator	RNA demethylase ALKBH5 (ALKBH5)		ERASER	Regulator Info
Target Regulation	Down regulation
Cell Process	Immune Response
	Cell apoptosis

Ref 1	HRD1-mediated METTL14 degradation regulates m(6)A mRNA modification to suppress ER proteotoxic liver disease. Mol Cell. 2021 Dec 16;81(24):5052-5065.e6. doi: 10.1016/j.molcel.2021.10.028. Epub 2021 Nov 29.
Ref 2	ALKBH5-Modified HMGB1-STING Activation Contributes to Radiation Induced Liver Disease via Innate Immune Response. Int J Radiat Oncol Biol Phys. 2021 Oct 1;111(2):491-501. doi: 10.1016/j.ijrobp.2021.05.115. Epub 2021 May 24.
Ref 3	Loss of the RNA-binding protein Rbm15 disrupts liver maturation in zebrafish. J Biol Chem. 2020 Aug 14;295(33):11466-11472. doi: 10.1074/jbc.RA120.014080. Epub 2020 Jun 9.