m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01620)
Target Name 5-hydroxytryptamine receptor 3A (HTR3A)
Synonyms
5-HT3-A; 5-HT3A; 5-hydroxytryptamine receptor 3; 5-HT-3; 5-HT3R; Serotonin receptor 3A; Serotonin-gated ion channel receptor
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Gene Name Htr3a
Chromosomal Location 11q23.2
Family Ligand-gated ion channel (TC 1.A.9) family, 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily, HTR3A sub-subfamily
Function
Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
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Gene ID 3359
Uniprot ID
5HT3A_HUMAN
HGNC ID
HGNC:5297
KEGG ID
hsa:3359
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Histone modification
m6A Regulator: RNA demethylase ALKBH5 (ALKBH5)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03129
 Crosstalk Info 
Epigenetic Regulator Histone deacetylase 11 (HDAC11)
Regulated Target Histone H3 lysine 27 acetylation (H3K27ac)
Crosstalk relationship Histone modification → m6A
Disease Neuropathic pain
 Disease Info 
m6A Regulator: YTH domain-containing family protein 2 (YTHDF2)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03130
 Crosstalk Info 
Epigenetic Regulator Histone deacetylase 11 (HDAC11)
Regulated Target Histone H3 lysine 27 acetylation (H3K27ac)
Crosstalk relationship Histone modification → m6A
Disease Neuropathic pain
 Disease Info 
Non-coding RNA
m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05021
 Crosstalk Info 
Epigenetic Regulator Long intergenic non-protein coding RNA 1305 (LINC01305)
Regulated Target Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2)
Crosstalk relationship ncRNA → m6A
Disease Esophageal Squamous Cell Carcinoma
 Disease Info 
m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05022
 Crosstalk Info 
Epigenetic Regulator Long intergenic non-protein coding RNA 1305 (LINC01305)
Regulated Target Insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3)
Crosstalk relationship ncRNA → m6A
Disease Esophageal Squamous Cell Carcinoma
 Disease Info 
References
Ref 1 Clinical pipeline report, company report or official report of Actinium Pharmaceuticals.
Ref 2 A novel asymmetrical anti-HER2/CD3 bispecific antibody exhibits potent cytotoxicity for HER2-positive tumor cells. J Exp Clin Cancer Res. 2019 Aug 14;38(1):355. doi: 10.1186/s13046-019-1354-1.