m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00658)

Target Name	DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Synonyms	Dnmt3b; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB; M.HsaIIIB Click to Show/Hide
Gene Name	DNMT3B
Chromosomal Location	20q11.21
Family	Class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family
Function	Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells. Click to Show/Hide
Gene ID	1789
Uniprot ID	DNM3B_HUMAN
HGNC ID	HGNC:2979
KEGG ID	hsa:1789

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

DNMT3B can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

RNA demethylase ALKBH5 (ALKBH5) [ERASER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by ALKBH5*
Cell Line	143B cell line	Homo sapiens
Treatment: siALKBH5 transfected 143B cells Control: siControl 143B cells		GSE154528
Regulation		logFC: 1.42E+00 p-value: 9.24E-11
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene			[1]
Response Summary	Theses findings reveal an epigenetic interplay mechanism in NPC senescence and IVD degeneration, presenting a critical pro-senescence role of ALKBH5 and m6A hypomethylation, highlighting the therapeutic potential of targeting the m6A/DNA (cytosine-5)-methyltransferase 3B (DNMT3B)/E4F1 axis for treating IVD degeneration.
Target Regulation	Down regulation
Responsed Disease	Intervertebral disc degeneration	ICD-11: FA80	Disease Info
In-vitro Model	Nucleus pulposus cell (The NP tissues were cut into pieces after collection during surgery)

Intervertebral disc degeneration [ICD-11: FA80]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response			[1]
Response Summary	Theses findings reveal an epigenetic interplay mechanism in NPC senescence and IVD degeneration, presenting a critical pro-senescence role of ALKBH5 and m6A hypomethylation, highlighting the therapeutic potential of targeting the m6A/DNA (cytosine-5)-methyltransferase 3B (DNMT3B)/E4F1 axis for treating IVD degeneration.
Responsed Disease	Intervertebral disc degeneration [ICD-11: FA80]
Target Regulator	RNA demethylase ALKBH5 (ALKBH5)	ERASER	Regulator Info
Target Regulation	Down regulation
In-vitro Model	Nucleus pulposus cell (The NP tissues were cut into pieces after collection during surgery)

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

DNA modification

m6A Regulator: RNA demethylase ALKBH5 (ALKBH5)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02025		Crosstalk Info
Epigenetic Regulator	DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target	Transcription factor E4F1 (E4F1)
Crosstalk relationship	m6A → DNA modification
Disease	Intervertebral disc degeneration	Disease Info

m6A Regulator: YTH domain-containing family protein 2 (YTHDF2)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02026		Crosstalk Info
Epigenetic Regulator	DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target	Transcription factor E4F1 (E4F1)
Crosstalk relationship	m6A → DNA modification
Disease	Intervertebral disc degeneration	Disease Info

m6A Regulator: ELAV-like protein 1 (ELAVL1)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02072		Crosstalk Info
Epigenetic Regulator	DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Crosstalk relationship	m6A → DNA modification
Drug	Cisplatin	Drug Info
Crosstalk ID: M6ACROT02073		Crosstalk Info
Epigenetic Regulator	DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target	Serine/threonine-protein kinase PINK1, mitochondrial (PINK1)
Crosstalk relationship	m6A → DNA modification
Disease	Acute ischemic stroke	Disease Info

m6A Regulator: YTH domain-containing family protein 1 (YTHDF1)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02074		Crosstalk Info
Epigenetic Regulator	DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Crosstalk relationship	m6A → DNA modification
Disease	Gastric cancer	Disease Info

Histone modification

m6A Regulator: RNA demethylase ALKBH5 (ALKBH5)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03005		Crosstalk Info
Epigenetic Regulator	Lysine-specific demethylase 4A (KDM4A)
Regulated Target	Histone H3 lysine 9 trimethylation (H3K9me3)
Crosstalk relationship	Histone modification → m6A
Disease	Intervertebral disc degeneration	Disease Info

m6A Regulator: YTH domain-containing family protein 2 (YTHDF2)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03006		Crosstalk Info
Epigenetic Regulator	Lysine-specific demethylase 4A (KDM4A)
Regulated Target	Histone H3 lysine 9 trimethylation (H3K9me3)
Crosstalk relationship	Histone modification → m6A
Disease	Intervertebral disc degeneration	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00658)

DNA (cytosine-5)-methyltransferase 3B (DNMT3B)

N4-acetylcytidine (ac4C)

In total 2 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000049		Click to Show/Hide the Full List
mod site	chr20:32780363-32780364:+		[5]
Sequence	TCTCAATGGAGAGGAGGACGCCGGCGGGAGGGAAGACTCGA
Cell/Tissue List	H1
Seq Type List	ac4C-seq
Transcript ID List	ENST00000443239.7; ENST00000456297.6; ENST00000201963.3; ENST00000348286.6; ENST00000328111.6; ENST00000353855.6
External Link	RMBase: ac4C_site_1202
mod ID: AC4SITE000050		Click to Show/Hide the Full List
mod site	chr20:32784777-32784778:+		[5]
Sequence	GACTTGACAGGCGATGGCGACGGGGAAGATGGGGATGGCTC
Cell/Tissue List	H1
Seq Type List	ac4C-seq
Transcript ID List	ENST00000201963.3; ENST00000443239.7; ENST00000348286.6; ENST00000328111.6; ENST00000353855.6; ENST00000456297.6
External Link	RMBase: ac4C_site_1203

N1-methyladenosine (m1A)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M1ASITE000081		Click to Show/Hide the Full List
mod site	chr20:32762384-32762385:+		[6]
Sequence	GTCGGCACCGCCCCCTCCCCACCCACTCCCGCTGCCCCGTC
Cell/Tissue List	HEK293T
Seq Type List	m1A-MAP-seq
Transcript ID List	ENST00000328111.6
External Link	RMBase: m1A_site_624

5-methylcytidine (m5C)

In total 2 m6A sequence/site(s) in this target gene
mod ID: M5CSITE002665		Click to Show/Hide the Full List
mod site	chr20:32762517-32762518:+		[7]
Sequence	CTCCCTGGCGGTCGGGCGAGCGGGCGGCAACGCTGCCCGGC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000328111.6; rmsk_5100896; ENST00000348286.6; ENST00000353855.6
External Link	RMBase: m5C_site_28677
mod ID: M5CSITE002666		Click to Show/Hide the Full List
mod site	chr20:32784774-32784775:+		[7]
Sequence	AAGGACTTGACAGGCGATGGCGACGGGGAAGATGGGGATGG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000456297.6; ENST00000348286.6; ENST00000353855.6; ENST00000328111.6; ENST00000201963.3; ENST00000443239.7
External Link	RMBase: m5C_site_28678

N6-methyladenosine (m6A)

In total 50 m6A sequence/site(s) in this target gene
mod ID: M6ASITE052149		Click to Show/Hide the Full List
mod site	chr20:32762492-32762493:+		[8]
Sequence	AGCGCCCCCCGACGGACGGGACCGGCTCCCTGGCGGTCGGG
Motif Score	3.622404762
Cell/Tissue List	U2OS; hESCs; HEK293T
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000353855.6; rmsk_5100896; ENST00000328111.6; ENST00000348286.6
External Link	RMBase: m6A_site_527298
mod ID: M6ASITE052150		Click to Show/Hide the Full List
mod site	chr20:32762569-32762570:+		[9]
Sequence	GGGTTAAGTGGCCCAAGTAAACCTAGCTCGGCGATCGGCGC
Motif Score	2.185083333
Cell/Tissue List	HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000348286.6; ENST00000353855.6; ENST00000328111.6
External Link	RMBase: m6A_site_527299
mod ID: M6ASITE052151		Click to Show/Hide the Full List
mod site	chr20:32779866-32779867:+		[9]
Sequence	GAGGGGAAGGGAGAGAGCAAACAAAGGGGTCAGGAGGGAAA
Motif Score	2.20572619
Cell/Tissue List	HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000348286.6; ENST00000328111.6; ENST00000353855.6; ENST00000456297.6; ENST00000201963.3; ENST00000443239.7
External Link	RMBase: m6A_site_527300
mod ID: M6ASITE052152		Click to Show/Hide the Full List
mod site	chr20:32780333-32780334:+		[10]
Sequence	ACAGGAAAGCATGAAGGGAGACACCAGGCATCTCAATGGAG
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T; NB4
Seq Type List	MAZTER-seq; m6A-seq
Transcript ID List	ENST00000456297.6; ENST00000443239.7; ENST00000328111.6; ENST00000348286.6; ENST00000201963.3; ENST00000353855.6
External Link	RMBase: m6A_site_527301
mod ID: M6ASITE052153		Click to Show/Hide the Full List
mod site	chr20:32780378-32780379:+		[11]
Sequence	GGACGCCGGCGGGAGGGAAGACTCGATCCTCGTCAACGGGG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; U2OS; peripheral-blood; HEK293T; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000328111.6; ENST00000201963.3; ENST00000353855.6; ENST00000443239.7; ENST00000456297.6; ENST00000348286.6
External Link	RMBase: m6A_site_527302
mod ID: M6ASITE052154		Click to Show/Hide the Full List
mod site	chr20:32781406-32781407:+		[10]
Sequence	GGTGTCCAGTCTGCTAAGCTACACACAGGTATGGTCTCTGC
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000328111.6; ENST00000348286.6; ENST00000456297.6; ENST00000201963.3; ENST00000443239.7; ENST00000353855.6
External Link	RMBase: m6A_site_527303
mod ID: M6ASITE052155		Click to Show/Hide the Full List
mod site	chr20:32784800-32784801:+		[12]
Sequence	GGAAGATGGGGATGGCTCTGACACCCCAGTCATGCCAAAGC
Motif Score	2.859755952
Cell/Tissue List	HEK293; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000201963.3; ENST00000456297.6; ENST00000348286.6; ENST00000353855.6; ENST00000328111.6; ENST00000443239.7
External Link	RMBase: m6A_site_527304
mod ID: M6ASITE052156		Click to Show/Hide the Full List
mod site	chr20:32784832-32784833:+		[11]
Sequence	TGCCAAAGCTCTTCCGGGAAACCAGGACTCGTTCAGAAAGC
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; HEK293T; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000348286.6; ENST00000456297.6; ENST00000353855.6; ENST00000201963.3; ENST00000328111.6; ENST00000443239.7
External Link	RMBase: m6A_site_527305
mod ID: M6ASITE052157		Click to Show/Hide the Full List
mod site	chr20:32784838-32784839:+		[11]
Sequence	AGCTCTTCCGGGAAACCAGGACTCGTTCAGAAAGCCCAGCT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000353855.6; ENST00000201963.3; ENST00000456297.6; ENST00000348286.6; ENST00000443239.7; ENST00000328111.6
External Link	RMBase: m6A_site_527306
mod ID: M6ASITE052158		Click to Show/Hide the Full List
mod site	chr20:32786507-32786508:+		[11]
Sequence	TCTCTTGCTTCTAGGTCCGAACTCGAAATAACAACAGTGTC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000353855.6; ENST00000443239.7; ENST00000328111.6; ENST00000456297.6; ENST00000348286.6; ENST00000201963.3
External Link	RMBase: m6A_site_527307
mod ID: M6ASITE052159		Click to Show/Hide the Full List
mod site	chr20:32786517-32786518:+		[10]
Sequence	CTAGGTCCGAACTCGAAATAACAACAGTGTCTCCAGCCGGG
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000353855.6; ENST00000443239.7; ENST00000456297.6; ENST00000328111.6; ENST00000201963.3; ENST00000348286.6
External Link	RMBase: m6A_site_527308
mod ID: M6ASITE052160		Click to Show/Hide the Full List
mod site	chr20:32787323-32787324:+		[11]
Sequence	CCTCACAGACGACACAGAGGACACACATGGGACGCCCCAGA
Motif Score	3.643047619
Cell/Tissue List	HeLa; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000443239.7; ENST00000348286.6; ENST00000328111.6; ENST00000456297.6; ENST00000353855.6; ENST00000201963.3
External Link	RMBase: m6A_site_527309
mod ID: M6ASITE052161		Click to Show/Hide the Full List
mod site	chr20:32787377-32787378:+		[11]
Sequence	CTACGCCCGCCTAGCCCAGGACAGCCAGCAGGGGGGCATGG
Motif Score	3.643047619
Cell/Tissue List	HeLa; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000201963.3; ENST00000353855.6; ENST00000443239.7; ENST00000456297.6; ENST00000348286.6; ENST00000328111.6
External Link	RMBase: m6A_site_527310
mod ID: M6ASITE052162		Click to Show/Hide the Full List
mod site	chr20:32787419-32787420:+		[11]
Sequence	GTCCCCGCAGGTGGAGGCAGACAGTGGAGATGGAGACAGTT
Motif Score	2.897386905
Cell/Tissue List	HeLa; peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000353855.6; ENST00000443239.7; ENST00000201963.3; ENST00000348286.6; ENST00000328111.6; ENST00000456297.6
External Link	RMBase: m6A_site_527311
mod ID: M6ASITE052163		Click to Show/Hide the Full List
mod site	chr20:32787434-32787435:+		[11]
Sequence	GGCAGACAGTGGAGATGGAGACAGTTCAGAGTATCAGGTAT
Motif Score	2.897386905
Cell/Tissue List	HeLa; peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000353855.6; ENST00000456297.6; ENST00000443239.7; ENST00000348286.6; ENST00000328111.6; ENST00000201963.3
External Link	RMBase: m6A_site_527312
mod ID: M6ASITE052164		Click to Show/Hide the Full List
mod site	chr20:32788878-32788879:+		[11]
Sequence	GAAGGAGTTTGGAATAGGGGACCTCGTGTGGGGAAAGATCA
Motif Score	3.622404762
Cell/Tissue List	HeLa; peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000456297.6; ENST00000443239.7; ENST00000328111.6; ENST00000353855.6; ENST00000201963.3; ENST00000348286.6
External Link	RMBase: m6A_site_527313
mod ID: M6ASITE052165		Click to Show/Hide the Full List
mod site	chr20:32791610-32791611:+		[10]
Sequence	TCTCTTTTAGGTCTCTGCAGACAAACTGGTGGCACTGGGGC
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000443239.7; ENST00000348286.6; ENST00000353855.6; ENST00000328111.6; ENST00000201963.3; ENST00000456297.6
External Link	RMBase: m6A_site_527314
mod ID: M6ASITE052166		Click to Show/Hide the Full List
mod site	chr20:32792649-32792650:+		[11]
Sequence	CTAGGGTGCGAGCTGGCAAGACCTTCCCCAGCAGCCCTGGA
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000201963.3; ENST00000443239.7; ENST00000348286.6; ENST00000353855.6; ENST00000328111.6; ENST00000456297.6
External Link	RMBase: m6A_site_527315
mod ID: M6ASITE052167		Click to Show/Hide the Full List
mod site	chr20:32792671-32792672:+		[11]
Sequence	CTTCCCCAGCAGCCCTGGAGACTCATTGGAGGACCAGCTGA
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000348286.6; ENST00000443239.7; ENST00000353855.6; ENST00000201963.3; ENST00000456297.6; ENST00000328111.6
External Link	RMBase: m6A_site_527316
mod ID: M6ASITE052168		Click to Show/Hide the Full List
mod site	chr20:32792683-32792684:+		[11]
Sequence	CCCTGGAGACTCATTGGAGGACCAGCTGAAGCCCATGTTGG
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000201963.3; ENST00000353855.6; ENST00000456297.6; ENST00000328111.6; ENST00000443239.7; ENST00000348286.6
External Link	RMBase: m6A_site_527317
mod ID: M6ASITE052169		Click to Show/Hide the Full List
mod site	chr20:32792750-32792751:+		[11]
Sequence	ACTGGGATCGAGGGCCTCAAACCCAACAACACGCAACCAGG
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000456297.6; ENST00000443239.7; ENST00000328111.6; ENST00000353855.6; ENST00000201963.3; ENST00000348286.6
External Link	RMBase: m6A_site_527318
mod ID: M6ASITE052170		Click to Show/Hide the Full List
mod site	chr20:32792758-32792759:+		[10]
Sequence	CGAGGGCCTCAAACCCAACAACACGCAACCAGGTGGGAATG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000348286.6; ENST00000353855.6; ENST00000456297.6; ENST00000328111.6; ENST00000201963.3; ENST00000443239.7
External Link	RMBase: m6A_site_527319
mod ID: M6ASITE052171		Click to Show/Hide the Full List
mod site	chr20:32795411-32795412:+		[11]
Sequence	CTAATTACCTTTCACAGAGAACAAGACTCGAAGACGCACAG
Motif Score	2.951386905
Cell/Tissue List	HeLa; hESC-HEK293T; MT4
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000443239.7; ENST00000201963.3; ENST00000456297.6; ENST00000348286.6; ENST00000328111.6; ENST00000353855.6
External Link	RMBase: m6A_site_527320
mod ID: M6ASITE052172		Click to Show/Hide the Full List
mod site	chr20:32795416-32795417:+		[11]
Sequence	TACCTTTCACAGAGAACAAGACTCGAAGACGCACAGCTGAC
Motif Score	3.319380952
Cell/Tissue List	HeLa; MT4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000328111.6; ENST00000201963.3; ENST00000456297.6; ENST00000443239.7; ENST00000353855.6; ENST00000348286.6
External Link	RMBase: m6A_site_527321
mod ID: M6ASITE052173		Click to Show/Hide the Full List
mod site	chr20:32795482-32795483:+		[11]
Sequence	CCGCACCCAAGCGCCTCAAGACAAATTGCTATAACAACGGC
Motif Score	2.897386905
Cell/Tissue List	HeLa; hESC-HEK293T; hNPCs
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000353855.6; ENST00000348286.6; ENST00000443239.7; ENST00000328111.6; ENST00000201963.3; ENST00000456297.6
External Link	RMBase: m6A_site_527322
mod ID: M6ASITE052174		Click to Show/Hide the Full List
mod site	chr20:32795495-32795496:+		[10]
Sequence	CCTCAAGACAAATTGCTATAACAACGGCAAAGACCGAGGGG
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000328111.6; ENST00000201963.3; ENST00000348286.6; ENST00000443239.7; ENST00000456297.6; ENST00000353855.6
External Link	RMBase: m6A_site_527323
mod ID: M6ASITE052175		Click to Show/Hide the Full List
mod site	chr20:32795507-32795508:+		[13]
Sequence	TTGCTATAACAACGGCAAAGACCGAGGGGATGAAGATCAGA
Motif Score	2.876744048
Cell/Tissue List	hNPCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000348286.6; ENST00000456297.6; ENST00000353855.6; ENST00000328111.6; ENST00000201963.3; ENST00000443239.7
External Link	RMBase: m6A_site_527324
mod ID: M6ASITE052176		Click to Show/Hide the Full List
mod site	chr20:32795676-32795677:+		[10]
Sequence	GGCTTCAGATGTTGCCAACAACAAGAGCAGCCTGGAAGGTA
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000456297.6; ENST00000443239.7; ENST00000348286.6; ENST00000353855.6; ENST00000201963.3; ENST00000328111.6
External Link	RMBase: m6A_site_527325
mod ID: M6ASITE052177		Click to Show/Hide the Full List
mod site	chr20:32796816-32796817:+		[11]
Sequence	TTTGTCTTGTGGCAGGAAAAACCCCGTGTCCTTCCACCCTC
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000353855.6; ENST00000456297.6; ENST00000443239.7; ENST00000328111.6; ENST00000348286.6; ENST00000201963.3
External Link	RMBase: m6A_site_527326
mod ID: M6ASITE052178		Click to Show/Hide the Full List
mod site	chr20:32796860-32796861:+		[11]
Sequence	TTGAGGGGGGGCTCTGTCAGACATGCCGGGTAAGTCCTCCT
Motif Score	2.897386905
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000348286.6; ENST00000328111.6; ENST00000443239.7; ENST00000456297.6; ENST00000353855.6; ENST00000201963.3
External Link	RMBase: m6A_site_527327
mod ID: M6ASITE052179		Click to Show/Hide the Full List
mod site	chr20:32797208-32797209:+		[10]
Sequence	TCGCTTCCTTGAGCTGTTTTACATGTATGATGACGATGGCT
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000456297.6; ENST00000201963.3; ENST00000443239.7; ENST00000328111.6; ENST00000353855.6; ENST00000348286.6
External Link	RMBase: m6A_site_527328
mod ID: M6ASITE052180		Click to Show/Hide the Full List
mod site	chr20:32797283-32797284:+		[10]
Sequence	AGAGCTGCTGCTTTGCAGCAACACGAGCTGCTGCCGGTGAG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000456297.6; ENST00000348286.6; ENST00000353855.6; ENST00000328111.6; ENST00000443239.7; ENST00000201963.3
External Link	RMBase: m6A_site_527329
mod ID: M6ASITE052181		Click to Show/Hide the Full List
mod site	chr20:32798542-32798543:+		[10]
Sequence	TCAGGAGCCCTGGAGCTGTTACATGTGTCTCCCGCAGCGCT
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000328111.6; ENST00000443239.7; ENST00000201963.3; ENST00000353855.6; ENST00000456297.6; ENST00000348286.6
External Link	RMBase: m6A_site_527330
mod ID: M6ASITE052182		Click to Show/Hide the Full List
mod site	chr20:32798626-32798627:+		[10]
Sequence	GCAGGCCTTCTTCACCAGTGACACGGGGCTTGAATATGTAA
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000353855.6; ENST00000443239.7; ENST00000348286.6; ENST00000456297.6; ENST00000328111.6; ENST00000201963.3
External Link	RMBase: m6A_site_527331
mod ID: M6ASITE052183		Click to Show/Hide the Full List
mod site	chr20:32801397-32801398:+		[10]
Sequence	TGTAGCCATGAAGGTTGGCGACAAGAGGGACATCTCACGGT
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000353855.6; ENST00000328111.6; ENST00000456297.6; ENST00000443239.7; ENST00000348286.6; ENST00000201963.3
External Link	RMBase: m6A_site_527332
mod ID: M6ASITE052184		Click to Show/Hide the Full List
mod site	chr20:32801406-32801407:+		[10]
Sequence	GAAGGTTGGCGACAAGAGGGACATCTCACGGTTCCTGGAGG
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000201963.3; ENST00000348286.6; ENST00000443239.7; ENST00000353855.6; ENST00000328111.6; ENST00000456297.6
External Link	RMBase: m6A_site_527333
mod ID: M6ASITE052185		Click to Show/Hide the Full List
mod site	chr20:32807799-32807800:+		[10]
Sequence	GCACTACACAGACGTGTCCAACATGGGCCGTGGTGCCCGCC
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000201963.3; ENST00000328111.6; ENST00000353855.6; ENST00000456297.6; ENST00000443239.7; ENST00000348286.6
External Link	RMBase: m6A_site_527334
mod ID: M6ASITE052186		Click to Show/Hide the Full List
mod site	chr20:32807860-32807861:+		[10]
Sequence	TGGAGCGTGCCTGTCATCCGACACCTCTTCGCCCCTCTGAA
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000443239.7; ENST00000456297.6; ENST00000201963.3; ENST00000348286.6; ENST00000328111.6; ENST00000353855.6
External Link	RMBase: m6A_site_527335
mod ID: M6ASITE052187		Click to Show/Hide the Full List
mod site	chr20:32808107-32808108:+		[13]
Sequence	CCTCCTTGTGCACAAATCAGACCTGGCTGCTTGGAGCAGCC
Motif Score	2.876744048
Cell/Tissue List	A549
Seq Type List	m6A-seq
Transcript ID List	ENST00000353855.6; ENST00000328111.6; ENST00000201963.3; ENST00000348286.6; ENST00000443239.7
External Link	RMBase: m6A_site_527336
mod ID: M6ASITE052188		Click to Show/Hide the Full List
mod site	chr20:32808130-32808131:+		[10]
Sequence	TGGCTGCTTGGAGCAGCCTAACACGGTGCTCATTTTTTCTT
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000328111.6; ENST00000443239.7; ENST00000348286.6; ENST00000353855.6; ENST00000201963.3
External Link	RMBase: m6A_site_527337
mod ID: M6ASITE052189		Click to Show/Hide the Full List
mod site	chr20:32808229-32808230:+		[10]
Sequence	TGGGTCTACCACTCAGAGAAACAATGGCTAAGATACCAAAA
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000201963.3; ENST00000353855.6; ENST00000328111.6; ENST00000443239.7; ENST00000348286.6
External Link	RMBase: m6A_site_527338
mod ID: M6ASITE052190		Click to Show/Hide the Full List
mod site	chr20:32808359-32808360:+		[14]
Sequence	CTACTGCTCTGTGTTTACAGACGTGTGCAGTTGTAGGCATG
Motif Score	2.871321429
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000353855.6; ENST00000348286.6; ENST00000328111.6; ENST00000201963.3
External Link	RMBase: m6A_site_527339
mod ID: M6ASITE052191		Click to Show/Hide the Full List
mod site	chr20:32808712-32808713:+		[10]
Sequence	AGCTGCCATATATTTTGTAGACAAGTATGGCTCCTCCATAT
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000353855.6; ENST00000201963.3; ENST00000328111.6; ENST00000348286.6
External Link	RMBase: m6A_site_527340
mod ID: M6ASITE052192		Click to Show/Hide the Full List
mod site	chr20:32808780-32808781:+		[10]
Sequence	AAGCAAGGAGCTTAGATAAGACACCCCCTCAAACCCATTCC
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000201963.3; ENST00000328111.6; ENST00000348286.6; ENST00000353855.6
External Link	RMBase: m6A_site_527341
mod ID: M6ASITE052193		Click to Show/Hide the Full List
mod site	chr20:32809084-32809085:+		[10]
Sequence	TGCTGTCATAATGGTTTTTAACACCTTTTACTCTTCTTACT
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000353855.6; ENST00000201963.3; ENST00000328111.6; ENST00000348286.6
External Link	RMBase: m6A_site_527342
mod ID: M6ASITE052194		Click to Show/Hide the Full List
mod site	chr20:32809128-32809129:+		[10]
Sequence	GCTATTTTGTAGAATAAGGAACAACGTTGACAAGTTTTGTG
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000348286.6; ENST00000201963.3; ENST00000328111.6; ENST00000353855.6
External Link	RMBase: m6A_site_527343
mod ID: M6ASITE052195		Click to Show/Hide the Full List
mod site	chr20:32809137-32809138:+		[14]
Sequence	TAGAATAAGGAACAACGTTGACAAGTTTTGTGGGGCTTTTT
Motif Score	2.859755952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000353855.6; ENST00000201963.3; ENST00000328111.6; ENST00000348286.6
External Link	RMBase: m6A_site_527344
mod ID: M6ASITE052196		Click to Show/Hide the Full List
mod site	chr20:32809160-32809161:+		[10]
Sequence	AGTTTTGTGGGGCTTTTTATACACTTTTTAAAATCTCAAAC
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000328111.6; ENST00000348286.6; ENST00000201963.3; ENST00000353855.6
External Link	RMBase: m6A_site_527345
mod ID: M6ASITE052197		Click to Show/Hide the Full List
mod site	chr20:32809224-32809225:+		[14]
Sequence	TCATTAAAATTTTTTTTGTAACTGGAGCCACGACGTAACAA
Motif Score	2.590089286
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000353855.6; ENST00000201963.3; ENST00000328111.6; ENST00000348286.6
External Link	RMBase: m6A_site_527346
mod ID: M6ASITE052198		Click to Show/Hide the Full List
mod site	chr20:32809241-32809242:+		[10]
Sequence	GTAACTGGAGCCACGACGTAACAAATATGGGGAAAAAACTG
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000348286.6; ENST00000328111.6; ENST00000353855.6; ENST00000201963.3
External Link	RMBase: m6A_site_527347

Ref 1	m6A hypomethylation of DNMT3B regulated by ALKBH5 promotes intervertebral disc degeneration via E4F1 deficiency. Clin Transl Med. 2022 Mar;12(3):e765. doi: 10.1002/ctm2.765.
Ref 2	Antitumor activity of SRI 62-834, a cyclic ether analog of ET-18-OCH3. Lipids. 1987 Nov;22(11):884-90. doi: 10.1007/BF02535549.
Ref 3	Antidiabetic and hypolipidemic effects of a novel dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist, E3030, in db/db mice and beagle dogs. J Pharmacol Sci. 2008 Sep;108(1):40-8. doi: 10.1254/jphs.fp0072346. Epub 2008 Sep 6.
Ref 4	Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. doi: 10.1093/nar/gkr797. Epub 2011 Sep 24.
Ref 5	NAT10-mediated N4-acetylcytidine mRNA modification regulates self-renewal in human embryonic stem cells. Nucleic Acids Res. 2023 Sep 8;51(16):8514-8531. doi: 10.1093/nar/gkad628.
Ref 6	Base-Resolution Mapping Reveals Distinct m(1)A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts. Mol Cell. 2017 Dec 7;68(5):993-1005.e9. doi: 10.1016/j.molcel.2017.10.019. Epub 2017 Nov 5.
Ref 7	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 8	RNA-methylation-dependent RNA processing controls the speed of the circadian clock. Cell. 2013 Nov 7;155(4):793-806. doi: 10.1016/j.cell.2013.10.026.
Ref 9	Dynamics of Human and Viral RNA Methylation during Zika Virus Infection. Cell Host Microbe. 2016 Nov 9;20(5):666-673. doi: 10.1016/j.chom.2016.10.002. Epub 2016 Oct 20.
Ref 10	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 11	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 12	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 13	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 14	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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