m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00627)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
DIAPH1-AS1
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) [READER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | WTAP-mediated m6A modification of DIAPH1 antisense RNA 1 (DIAPH1-AS1) enhanced its stability relying on the m6A reader IGF2BP2-dependent pathway. Furthermore, DIAPH1-AS1 acted as a molecular adaptor that promoted MTDH-LASP1 complex formation and upregulated LASP1 expression, ultimately facilitating NPC growth and metastasis. | |||
| Target Regulation | Up regulation | |||
| Responsed Disease | Nasopharyngeal carcinoma | ICD-11: 2B6B | ||
Wilms tumor 1-associating protein (WTAP) [WRITER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | WTAP-mediated m6A modification of DIAPH1 antisense RNA 1 (DIAPH1-AS1) enhanced its stability relying on the m6A reader IGF2BP2-dependent pathway. Furthermore, DIAPH1-AS1 acted as a molecular adaptor that promoted MTDH-LASP1 complex formation and upregulated LASP1 expression, ultimately facilitating NPC growth and metastasis. | |||
| Target Regulation | Up regulation | |||
| Responsed Disease | Nasopharyngeal carcinoma | ICD-11: 2B6B | ||
Nasopharyngeal carcinoma [ICD-11: 2B6B]
| In total 2 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | WTAP-mediated m6A modification of DIAPH1 antisense RNA 1 (DIAPH1-AS1) enhanced its stability relying on the m6A reader IGF2BP2-dependent pathway. Furthermore, DIAPH1-AS1 acted as a molecular adaptor that promoted MTDH-LASP1 complex formation and upregulated LASP1 expression, ultimately facilitating NPC growth and metastasis. | |||
| Responsed Disease | Nasopharyngeal carcinoma [ICD-11: 2B6B] | |||
| Target Regulator | Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) | READER | ||
| Target Regulation | Up regulation | |||
| Experiment 2 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | WTAP-mediated m6A modification of DIAPH1 antisense RNA 1 (DIAPH1-AS1) enhanced its stability relying on the m6A reader IGF2BP2-dependent pathway. Furthermore, DIAPH1-AS1 acted as a molecular adaptor that promoted MTDH-LASP1 complex formation and upregulated LASP1 expression, ultimately facilitating NPC growth and metastasis. | |||
| Responsed Disease | Nasopharyngeal carcinoma [ICD-11: 2B6B] | |||
| Target Regulator | Wilms tumor 1-associating protein (WTAP) | WRITER | ||
| Target Regulation | Up regulation | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Histone modification
m6A Regulator: Wilms tumor 1-associating protein (WTAP)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT03065 | ||
| Epigenetic Regulator | CREB-binding protein (CREBBP) | |
| Regulated Target | Histone H3 lysine 27 acetylation (H3K27ac) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Nasopharyngeal carcinoma | |
Non-coding RNA
m6A Regulator: Wilms tumor 1-associating protein (WTAP)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05601 | ||
| Epigenetic Regulator | DIAPH1 antisense RNA 1 (DIAPH1-AS1) | |
| Regulated Target | LIM and SH3 domain protein 1 (LASP1) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Nasopharyngeal carcinoma | |
m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05602 | ||
| Epigenetic Regulator | DIAPH1 antisense RNA 1 (DIAPH1-AS1) | |
| Regulated Target | LIM and SH3 domain protein 1 (LASP1) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Nasopharyngeal carcinoma | |