m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00461)

Target Name	Serum response factor (SRF)
Synonyms	SRF Click to Show/Hide
Gene Name	SRF
Chromosomal Location	6p21.1
Function	SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. {ECO:0000250\|UniProtKB:Q9JM73}. Click to Show/Hide
Gene ID	5395
Uniprot ID	SRF_HUMAN
HGNC ID	HGNC:11291
KEGG ID	hsa:6722

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

SRF can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) [READER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by IGF2BP1*
Cell Line	MV3 cell line	Homo sapiens
Treatment: siIGF2BP1 MV3 cells Control: siControl MV3 cells		GSE146803
Regulation		logFC: -9.12E-01 p-value: 4.27E-10
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	IGF2BP1 promotes Serum response factor (SRF) and SRF target genes at the post-transcriptional level suggesting it as a post-transcriptional enhancer of SRF itself as well as SRF-dependent gene expression in cancer cells.
Target Regulation	Up regulation
Responsed Disease	Solid tumour/cancer		ICD-11: 2A00-2F9Z	Disease Info
Cell Process	Cell growth
Cell Process	Cell invasion
In-vitro Model	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	K-562	Chronic myelogenous leukemia	Homo sapiens	CVCL_0004

Solid tumour/cancer [ICD-11: 2A00-2F9Z]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	IGF2BP1 promotes Serum response factor (SRF) and SRF target genes at the post-transcriptional level suggesting it as a post-transcriptional enhancer of SRF itself as well as SRF-dependent gene expression in cancer cells.
Responsed Disease	Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Target Regulator	Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)		READER	Regulator Info
Target Regulation	Up regulation
Cell Process	Cell growth
Cell Process	Cell invasion
In-vitro Model	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	K-562	Chronic myelogenous leukemia	Homo sapiens	CVCL_0004

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Histone modification

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03305		Crosstalk Info
Epigenetic Regulator	Histone-lysine N-methyltransferase EZH2 (EZH2)
Regulated Target	Histone H3 lysine 27 acetylation (H3K27ac)
Crosstalk relationship	Histone modification → m6A
Disease	Brain cancer	Disease Info
Drug	Tislelizumab	Drug Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00461)

Serum response factor (SRF)

Adenosine-to-Inosine editing (A-to-I)

In total 3 m6A sequence/site(s) in this target gene
mod ID: A2ISITE001497		Click to Show/Hide the Full List
mod site	chr6:43174902-43174903:+		[3]
Sequence	AGTTTCCTTCTTCCCCTTCTAAGAACGAAGTCTTCCTTAGG
Transcript ID List	ENST00000265354.6
External Link	RMBase: RNA-editing_site_116407
mod ID: A2ISITE001498		Click to Show/Hide the Full List
mod site	chr6:43177571-43177572:+		[3]
Sequence	TTCCCATATAATGCACGTTAACATTTGAGAAGTGCTTGTTT
Transcript ID List	ENST00000265354.6; rmsk_1933560
External Link	RMBase: RNA-editing_site_116408
mod ID: A2ISITE001499		Click to Show/Hide the Full List
mod site	chr6:43177608-43177609:+		[3]
Sequence	GTTTGAAAGATGAATTTGTTAGCTGTGCATTAAGAAGGAGA
Transcript ID List	ENST00000265354.6
External Link	RMBase: RNA-editing_site_116409

5-methylcytidine (m5C)

In total 20 m6A sequence/site(s) in this target gene
mod ID: M5CSITE003990		Click to Show/Hide the Full List
mod site	chr6:43177635-43177636:+
Sequence	CATTAAGAAGGAGAGAGAGGCCGGGTGCGGTGGCTCACGTC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000265354.6; rmsk_1933561
External Link	RMBase: m5C_site_38120
mod ID: M5CSITE003991		Click to Show/Hide the Full List
mod site	chr6:43177636-43177637:+
Sequence	ATTAAGAAGGAGAGAGAGGCCGGGTGCGGTGGCTCACGTCT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	rmsk_1933561; ENST00000265354.6
External Link	RMBase: m5C_site_38121
mod ID: M5CSITE003992		Click to Show/Hide the Full List
mod site	chr6:43177642-43177643:+
Sequence	AAGGAGAGAGAGGCCGGGTGCGGTGGCTCACGTCTGTAATC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	rmsk_1933561; ENST00000265354.6
External Link	RMBase: m5C_site_38122
mod ID: M5CSITE003993		Click to Show/Hide the Full List
mod site	chr6:43177662-43177663:+
Sequence	CGGTGGCTCACGTCTGTAATCCCAGCGCTTTGGGAGGCCGA
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	rmsk_1933561; ENST00000265354.6
External Link	RMBase: m5C_site_38123
mod ID: M5CSITE003994		Click to Show/Hide the Full List
mod site	chr6:43177663-43177664:+
Sequence	GGTGGCTCACGTCTGTAATCCCAGCGCTTTGGGAGGCCGAG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000265354.6; rmsk_1933561
External Link	RMBase: m5C_site_38124
mod ID: M5CSITE003995		Click to Show/Hide the Full List
mod site	chr6:43177664-43177665:+
Sequence	GTGGCTCACGTCTGTAATCCCAGCGCTTTGGGAGGCCGAGG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	rmsk_1933561; ENST00000265354.6
External Link	RMBase: m5C_site_38125
mod ID: M5CSITE003996		Click to Show/Hide the Full List
mod site	chr6:43177667-43177668:+
Sequence	GCTCACGTCTGTAATCCCAGCGCTTTGGGAGGCCGAGGGGG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	rmsk_1933561; ENST00000265354.6
External Link	RMBase: m5C_site_38126
mod ID: M5CSITE003997		Click to Show/Hide the Full List
mod site	chr6:43177669-43177670:+
Sequence	TCACGTCTGTAATCCCAGCGCTTTGGGAGGCCGAGGGGGGC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	rmsk_1933561; ENST00000265354.6
External Link	RMBase: m5C_site_38127
mod ID: M5CSITE003998		Click to Show/Hide the Full List
mod site	chr6:43177679-43177680:+
Sequence	AATCCCAGCGCTTTGGGAGGCCGAGGGGGGCAGATCACGAG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	rmsk_1933561; ENST00000265354.6
External Link	RMBase: m5C_site_38128
mod ID: M5CSITE003999		Click to Show/Hide the Full List
mod site	chr6:43177680-43177681:+
Sequence	ATCCCAGCGCTTTGGGAGGCCGAGGGGGGCAGATCACGAGG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000265354.6; rmsk_1933561
External Link	RMBase: m5C_site_38129
mod ID: M5CSITE004001		Click to Show/Hide the Full List
mod site	chr6:43177689-43177690:+
Sequence	CTTTGGGAGGCCGAGGGGGGCAGATCACGAGGTCAGGAGAT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	rmsk_1933561; ENST00000265354.6
External Link	RMBase: m5C_site_38130
mod ID: M5CSITE004002		Click to Show/Hide the Full List
mod site	chr6:43177694-43177695:+
Sequence	GGAGGCCGAGGGGGGCAGATCACGAGGTCAGGAGATTGAGA
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	rmsk_1933561; ENST00000265354.6
External Link	RMBase: m5C_site_38131
mod ID: M5CSITE004003		Click to Show/Hide the Full List
mod site	chr6:43177696-43177697:+
Sequence	AGGCCGAGGGGGGCAGATCACGAGGTCAGGAGATTGAGATC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000265354.6; rmsk_1933561
External Link	RMBase: m5C_site_38132
mod ID: M5CSITE004004		Click to Show/Hide the Full List
mod site	chr6:43177702-43177703:+
Sequence	AGGGGGGCAGATCACGAGGTCAGGAGATTGAGATCATCCTG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000265354.6; rmsk_1933561
External Link	RMBase: m5C_site_38133
mod ID: M5CSITE004005		Click to Show/Hide the Full List
mod site	chr6:43180018-43180019:+
Sequence	AACTCCCCTTCCCTGGGGAGCCCTCAGGCTCCCCAGAACTG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m5C_site_38134
mod ID: M5CSITE004006		Click to Show/Hide the Full List
mod site	chr6:43180026-43180027:+		[4]
Sequence	TTCCCTGGGGAGCCCTCAGGCTCCCCAGAACTGGCTGGGCC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m5C_site_38135
mod ID: M5CSITE004007		Click to Show/Hide the Full List
mod site	chr6:43180028-43180029:+		[4]
Sequence	CCCTGGGGAGCCCTCAGGCTCCCCAGAACTGGCTGGGCCCC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m5C_site_38136
mod ID: M5CSITE004008		Click to Show/Hide the Full List
mod site	chr6:43180029-43180030:+		[4]
Sequence	CCTGGGGAGCCCTCAGGCTCCCCAGAACTGGCTGGGCCCCT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m5C_site_38137
mod ID: M5CSITE004009		Click to Show/Hide the Full List
mod site	chr6:43180030-43180031:+		[4]
Sequence	CTGGGGAGCCCTCAGGCTCCCCAGAACTGGCTGGGCCCCTG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m5C_site_38138
mod ID: M5CSITE004010		Click to Show/Hide the Full List
mod site	chr6:43180031-43180032:+		[4]
Sequence	TGGGGAGCCCTCAGGCTCCCCAGAACTGGCTGGGCCCCTGG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m5C_site_38139

N6-methyladenosine (m6A)

In total 58 m6A sequence/site(s) in this target gene
mod ID: M6ASITE075150		Click to Show/Hide the Full List
mod site	chr6:43171270-43171271:+		[5]
Sequence	CGGCCTCGCCATAAAAGGAAACATTGTATCTCTTTATATGG
Motif Score	2.20572619
Cell/Tissue List	HeLa; hESC-HEK293T; HEK293A-TOA; MSC; TREX
Seq Type List	MeRIP-seq; MAZTER-seq; m6A-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717975
mod ID: M6ASITE075151		Click to Show/Hide the Full List
mod site	chr6:43171426-43171427:+		[6]
Sequence	CGCGCCGCCCTAGCAGACGGACAGGGGGCGCTGCGCGCGGC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; A549; U2OS; H1B; Jurkat; CD4T; GSC-11; HEK293A-TOA; MSC; TREX; iSLK; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717976
mod ID: M6ASITE075152		Click to Show/Hide the Full List
mod site	chr6:43171723-43171724:+		[6]
Sequence	GGCCCTGGGGGGCAGCCTGAACCGGACCCCGACGGGGCGGC
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; HepG2; A549; U2OS; LCLs; Jurkat; CD4T; GSC-11; HEK293T; HEK293A-TOA; TREX; iSLK; MSC; TIME; endometrial; HEC-1-A; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717977
mod ID: M6ASITE075153		Click to Show/Hide the Full List
mod site	chr6:43171728-43171729:+		[6]
Sequence	TGGGGGGCAGCCTGAACCGGACCCCGACGGGGCGGCCGGGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; A549; U2OS; LCLs; Jurkat; CD4T; GSC-11; HEK293T; HEK293A-TOA; TREX; iSLK; MSC; TIME; endometrial; HEC-1-A; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717978
mod ID: M6ASITE075154		Click to Show/Hide the Full List
mod site	chr6:43171761-43171762:+		[6]
Sequence	GGCCGGGCGGCGGCGGCGGGACACGCGGGGCTAACGGGGGC
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; A549; hESC-HEK293T; U2OS; H1A; LCLs; Jurkat; CD4T; GSC-11; TREX; iSLK; MSC; TIME; endometrial; HEC-1-A; NB4; MM6; AML
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; miCLIP
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717979
mod ID: M6ASITE075155		Click to Show/Hide the Full List
mod site	chr6:43172073-43172074:+		[6]
Sequence	GGGCCAAGCCGGGTAAGAAGACCCGGGGCCGCGTGAAGATC
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HepG2; U2OS; MT4; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717980
mod ID: M6ASITE075156		Click to Show/Hide the Full List
mod site	chr6:43172128-43172129:+		[7]
Sequence	CGACAACAAGCTGCGGCGCTACACGACCTTCAGCAAGAGGA
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717981
mod ID: M6ASITE075157		Click to Show/Hide the Full List
mod site	chr6:43173873-43173874:+		[6]
Sequence	AGCTGTCCACGCTGACAGGGACACAGGTGCTGTTGCTGGTG
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; U2OS; MT4; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717982
mod ID: M6ASITE075158		Click to Show/Hide the Full List
mod site	chr6:43173903-43173904:+		[6]
Sequence	TGTTGCTGGTGGCCAGTGAGACAGGCCATGTGTATACCTTT
Motif Score	2.897386905
Cell/Tissue List	HeLa; CD34; HepG2; MT4; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717983
mod ID: M6ASITE075159		Click to Show/Hide the Full List
mod site	chr6:43173935-43173936:+		[6]
Sequence	TATACCTTTGCCACCCGAAAACTGCAGCCCATGATCACCAG
Motif Score	2.627720238
Cell/Tissue List	HeLa; CD34; HepG2; MT4; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717984
mod ID: M6ASITE075160		Click to Show/Hide the Full List
mod site	chr6:43173960-43173961:+		[6]
Sequence	AGCCCATGATCACCAGTGAGACCGGCAAGGCACTGATTCAG
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HepG2; MT4; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717985
mod ID: M6ASITE075161		Click to Show/Hide the Full List
mod site	chr6:43173981-43173982:+		[6]
Sequence	CCGGCAAGGCACTGATTCAGACCTGCCTCAACTCGCCAGAC
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HepG2; MT4; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717986
mod ID: M6ASITE075162		Click to Show/Hide the Full List
mod site	chr6:43174000-43174001:+		[6]
Sequence	GACCTGCCTCAACTCGCCAGACTCTCCACCCCGTTCAGACC
Motif Score	3.319380952
Cell/Tissue List	HeLa; CD34; HepG2; MT4; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717987
mod ID: M6ASITE075163		Click to Show/Hide the Full List
mod site	chr6:43174018-43174019:+		[6]
Sequence	AGACTCTCCACCCCGTTCAGACCCCACAACAGACCAGAGAA
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HepG2; MT4; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717988
mod ID: M6ASITE075164		Click to Show/Hide the Full List
mod site	chr6:43174023-43174024:+		[7]
Sequence	CTCCACCCCGTTCAGACCCCACAACAGACCAGAGAATGAGT
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717989
mod ID: M6ASITE075165		Click to Show/Hide the Full List
mod site	chr6:43174030-43174031:+		[6]
Sequence	CCGTTCAGACCCCACAACAGACCAGAGAATGAGTGCCACTG
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HepG2; MT4; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717990
mod ID: M6ASITE075166		Click to Show/Hide the Full List
mod site	chr6:43174062-43174063:+		[6]
Sequence	GTGCCACTGGCTTTGAAGAGACAGATCTCACCTACCAGGTG
Motif Score	2.897386905
Cell/Tissue List	HeLa; CD34; HepG2; MT4; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717991
mod ID: M6ASITE075167		Click to Show/Hide the Full List
mod site	chr6:43174107-43174108:+		[6]
Sequence	AGTCTGACAGCAGTGGGGAGACCAAGGTGTGTTTGGGTTGC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; MT4; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717992
mod ID: M6ASITE075168		Click to Show/Hide the Full List
mod site	chr6:43175765-43175766:+		[8]
Sequence	GTACAACCTCCACCATCCAAACAGCACCTAGCACCTCTACC
Motif Score	2.20572619
Cell/Tissue List	HepG2; HeLa; MT4; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717993
mod ID: M6ASITE075169		Click to Show/Hide the Full List
mod site	chr6:43176637-43176638:+		[9]
Sequence	CTCCCGTGACAGCAGCACAGACCTCACGCAGACCTCCTCCA
Motif Score	2.876744048
Cell/Tissue List	HeLa; MT4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717994
mod ID: M6ASITE075170		Click to Show/Hide the Full List
mod site	chr6:43176648-43176649:+		[10]
Sequence	GCAGCACAGACCTCACGCAGACCTCCTCCAGCGGGACAGGT
Motif Score	2.876744048
Cell/Tissue List	CD34; HeLa; MT4; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717995
mod ID: M6ASITE075171		Click to Show/Hide the Full List
mod site	chr6:43176663-43176664:+		[10]
Sequence	CGCAGACCTCCTCCAGCGGGACAGGTATAGCTCGCAGCCCT
Motif Score	3.643047619
Cell/Tissue List	CD34; HeLa; MT4; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717996
mod ID: M6ASITE075172		Click to Show/Hide the Full List
mod site	chr6:43178331-43178332:+		[7]
Sequence	TCATGACGTCATCCGTGCCCACAACTGTGGGTGGCCACATG
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717997
mod ID: M6ASITE075173		Click to Show/Hide the Full List
mod site	chr6:43178347-43178348:+		[7]
Sequence	GCCCACAACTGTGGGTGGCCACATGATGTACCCTAGCCCGC
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717998
mod ID: M6ASITE075174		Click to Show/Hide the Full List
mod site	chr6:43178462-43178463:+		[7]
Sequence	CCATCCACCATGCAGGTGTCACACAGCCAGGTCCAGGAGCC
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_717999
mod ID: M6ASITE075176		Click to Show/Hide the Full List
mod site	chr6:43178843-43178844:+		[6]
Sequence	TCCTGACAGCATCATCTGGGACAGTGCAGATCCCTGTTTCA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; NB4; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718000
mod ID: M6ASITE075177		Click to Show/Hide the Full List
mod site	chr6:43179155-43179156:+		[6]
Sequence	CACCGAGCTACAGGTGGTGAACCTGGACACCGCCCACAGCA
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; MM6; Huh7; peripheral-blood; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718001
mod ID: M6ASITE075178		Click to Show/Hide the Full List
mod site	chr6:43179161-43179162:+		[6]
Sequence	GCTACAGGTGGTGAACCTGGACACCGCCCACAGCACCAAGA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; MM6; Huh7; peripheral-blood; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718002
mod ID: M6ASITE075179		Click to Show/Hide the Full List
mod site	chr6:43179207-43179208:+		[6]
Sequence	TGATCCGCCCGCCGCCCTGGACAGATGGCCCAAGGGATGGC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; MM6; Huh7; peripheral-blood; HEK293A-TOA; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718003
mod ID: M6ASITE075180		Click to Show/Hide the Full List
mod site	chr6:43179264-43179265:+		[7]
Sequence	TGCCTTTTCACGTTTTCTTTACACACACGTTGACGGGCCGC
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718004
mod ID: M6ASITE075181		Click to Show/Hide the Full List
mod site	chr6:43179276-43179277:+		[11]
Sequence	TTTTCTTTACACACACGTTGACGGGCCGCAGGAGGGAGGCG
Motif Score	2.833690476
Cell/Tissue List	CD8T
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718005
mod ID: M6ASITE075182		Click to Show/Hide the Full List
mod site	chr6:43179307-43179308:+		[11]
Sequence	GAGGGAGGCGGGGAGGAGGAACGGGCAGCCACAGGACTGAG
Motif Score	2.925321429
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718006
mod ID: M6ASITE075183		Click to Show/Hide the Full List
mod site	chr6:43179317-43179318:+		[12]
Sequence	GGGAGGAGGAACGGGCAGCCACAGGACTGAGCCCTCTCACT
Motif Score	2.053113095
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718007
mod ID: M6ASITE075184		Click to Show/Hide the Full List
mod site	chr6:43179322-43179323:+		[6]
Sequence	GAGGAACGGGCAGCCACAGGACTGAGCCCTCTCACTCCAGC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; CD8T; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718008
mod ID: M6ASITE075185		Click to Show/Hide the Full List
mod site	chr6:43179447-43179448:+		[6]
Sequence	GGGCTGTCCTCCTTCCTGGGACCCCCTCGCCAGCTTGGCTC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718009
mod ID: M6ASITE075186		Click to Show/Hide the Full List
mod site	chr6:43179502-43179503:+		[6]
Sequence	GTATTAGCTTACCCAATGGGACCGTGCCCCACCTCCCCACA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; MM6; Huh7; peripheral-blood; MSC; TIME; TREX; iSLK; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718010
mod ID: M6ASITE075187		Click to Show/Hide the Full List
mod site	chr6:43179794-43179795:+		[6]
Sequence	TGCCTTGCCGCTCCCCTTGGACCTCCAGGGGCTCCTGGGTT
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718011
mod ID: M6ASITE075188		Click to Show/Hide the Full List
mod site	chr6:43179822-43179823:+		[6]
Sequence	GGGCTCCTGGGTTGGAGGGAACCACCAGCGTTCCCTTCTCC
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718012
mod ID: M6ASITE075189		Click to Show/Hide the Full List
mod site	chr6:43179825-43179826:+		[12]
Sequence	CTCCTGGGTTGGAGGGAACCACCAGCGTTCCCTTCTCCCCC
Motif Score	2.032470238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718013
mod ID: M6ASITE075190		Click to Show/Hide the Full List
mod site	chr6:43179877-43179878:+		[12]
Sequence	CCTCTCCTCCCAGCTGCTTTACTTAAAGTTGATTTTGAACT
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718014
mod ID: M6ASITE075191		Click to Show/Hide the Full List
mod site	chr6:43179895-43179896:+		[6]
Sequence	TTACTTAAAGTTGATTTTGAACTTTTTATTTGAGGAGACGA
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718015
mod ID: M6ASITE075192		Click to Show/Hide the Full List
mod site	chr6:43179912-43179913:+		[12]
Sequence	TGAACTTTTTATTTGAGGAGACGAAGTGAAAACAAATCTAT
Motif Score	2.871321429
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718016
mod ID: M6ASITE075193		Click to Show/Hide the Full List
mod site	chr6:43179923-43179924:+		[6]
Sequence	TTTGAGGAGACGAAGTGAAAACAAATCTATAAATATATATT
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718017
mod ID: M6ASITE075194		Click to Show/Hide the Full List
mod site	chr6:43180249-43180250:+		[13]
Sequence	TAGGGAGAGGGAAGAGGGAGACCAAATGTCGGGGTTGGGGT
Motif Score	2.876744048
Cell/Tissue List	MT4
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718018
mod ID: M6ASITE075195		Click to Show/Hide the Full List
mod site	chr6:43180527-43180528:+		[12]
Sequence	TGTAACTTTTTTAAATTAAGACAAAAAGCCTTGAAGAAAAT
Motif Score	2.897386905
Cell/Tissue List	HEK293T; hESC-HEK293T; MT4
Seq Type List	DART-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718019
mod ID: M6ASITE075196		Click to Show/Hide the Full List
mod site	chr6:43180592-43180593:+		[12]
Sequence	TCAGTATTTATGTAATTTGTACAGGGGCCATGCCCCACCCC
Motif Score	2.856142857
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718020
mod ID: M6ASITE075197		Click to Show/Hide the Full List
mod site	chr6:43180729-43180730:+		[13]
Sequence	GAAGGGGAGCTTTTTCAGAAACAGGGCAGCAGTGGGGTGAA
Motif Score	2.20572619
Cell/Tissue List	MT4
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718021
mod ID: M6ASITE075198		Click to Show/Hide the Full List
mod site	chr6:43180768-43180769:+		[13]
Sequence	AAATTTTCTTAACCCCTAAGACTGCCTTCAGTAGGAACAAG
Motif Score	3.319380952
Cell/Tissue List	MT4
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718022
mod ID: M6ASITE075199		Click to Show/Hide the Full List
mod site	chr6:43180784-43180785:+		[7]
Sequence	TAAGACTGCCTTCAGTAGGAACAAGCTGGCTTCTGTGATTA
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T; MT4
Seq Type List	MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718023
mod ID: M6ASITE075200		Click to Show/Hide the Full List
mod site	chr6:43180864-43180865:+		[12]
Sequence	ATCAAGGGGATGATTTGCCGACATGTTTGAGAACCCCCTAA
Motif Score	2.865571429
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718024
mod ID: M6ASITE075201		Click to Show/Hide the Full List
mod site	chr6:43180876-43180877:+		[13]
Sequence	ATTTGCCGACATGTTTGAGAACCCCCTAACCTCTAACCCTC
Motif Score	2.930744048
Cell/Tissue List	MT4
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718025
mod ID: M6ASITE075202		Click to Show/Hide the Full List
mod site	chr6:43181036-43181037:+		[6]
Sequence	AGAGAGCAGGGGAGCTTGGGACTCAGGTCTGTAACTGCCCA
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; DART-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718026
mod ID: M6ASITE075203		Click to Show/Hide the Full List
mod site	chr6:43181159-43181160:+		[14]
Sequence	GAATTCTTCCTCTCCTTCCCACAAAAGACAGACCCAGTGAG
Motif Score	2.053113095
Cell/Tissue List	brain; kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718027
mod ID: M6ASITE075204		Click to Show/Hide the Full List
mod site	chr6:43181166-43181167:+		[12]
Sequence	TCCTCTCCTTCCCACAAAAGACAGACCCAGTGAGTGAATCA
Motif Score	2.897386905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718028
mod ID: M6ASITE075205		Click to Show/Hide the Full List
mod site	chr6:43181233-43181234:+		[7]
Sequence	GTGAGCGTGGCCTTGGGAGGACATGCGTGTGTCAGGGATGA
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718029
mod ID: M6ASITE075206		Click to Show/Hide the Full List
mod site	chr6:43181421-43181422:+		[7]
Sequence	TGCTGACCCAGGAATAGTGGACATGGTCACAGTCCTATGTA
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718030
mod ID: M6ASITE075207		Click to Show/Hide the Full List
mod site	chr6:43181471-43181472:+		[12]
Sequence	CTTTTGTATTAAAAAAAAATACTCTTTCAATAAATGTATCA
Motif Score	2.53247619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718031
mod ID: M6ASITE075208		Click to Show/Hide the Full List
mod site	chr6:43181501-43181502:+		[7]
Sequence	TAAATGTATCATTTTTGTGCACAGACTGTGGGGTCTTTGGT
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000265354.6
External Link	RMBase: m6A_site_718032

Ref 1	IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A- and miRNA-dependent manner. Nucleic Acids Res. 2019 Jan 10;47(1):375-390. doi: 10.1093/nar/gky1012.
Ref 2	Interaction of enrofloxacin with breast cancer resistance protein (BCRP/ABCG2): influence of flavonoids and role in milk secretion in sheep. J Vet Pharmacol Ther. 2006 Aug;29(4):279-87.
Ref 3	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 4	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 5	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 6	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 7	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 8	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 9	N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014 Jan 2;505(7481):117-20. doi: 10.1038/nature12730. Epub 2013 Nov 27.
Ref 10	Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018 Sep;28(9):904-917. doi: 10.1038/s41422-018-0072-0. Epub 2018 Jul 31.
Ref 11	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 12	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 13	Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells. Nat Microbiol. 2016 Feb 22;1:16011. doi: 10.1038/nmicrobiol.2016.11.
Ref 14	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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