m6A-centered Drug Response Information | M6AREG

General Information of the Drug (ID: M6ADRUG0111)

Name	Tislelizumab
DrugBank ID	DB14922

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Drug

In total 2 item(s) under this drug
Crosstalk ID: M6ACROT03304		Crosstalk Info
m6A Regulator	Methyltransferase-like 3 (METTL3)	Regulator Info
m6A Target	Aryl hydrocarbon receptor (AHR)	Target Gene
Epigenetic Regulator	Histone-lysine N-methyltransferase EZH2 (EZH2)
Regulated Target	Histone H3 lysine 27 acetylation (H3K27ac)
Crosstalk relationship	Histone modification → m6A
Disease	Brain cancer	Disease Info
Crosstalk ID: M6ACROT03305		Crosstalk Info
m6A Regulator	Methyltransferase-like 3 (METTL3)	Regulator Info
m6A Target	Serum response factor (SRF)	Target Gene
Epigenetic Regulator	Histone-lysine N-methyltransferase EZH2 (EZH2)
Regulated Target	Histone H3 lysine 27 acetylation (H3K27ac)
Crosstalk relationship	Histone modification → m6A
Disease	Brain cancer	Disease Info

References

Ref 1	Interaction of enrofloxacin with breast cancer resistance protein (BCRP/ABCG2): influence of flavonoids and role in milk secretion in sheep. J Vet Pharmacol Ther. 2006 Aug;29(4):279-87.

Cite M6AREG

S. P. Liu, L. Chen, Y. T. Zhang, Y. Zhou, Y. He, Z. Chen, S. S. Qi, J. Y. Zhu, X. D. Chen, H. Zhang, Y. C. Luo, Y. Q. Qiu, L. Tao*, F. Zhu*. M6AREG: m6A-centered regulation of disease development and drug response. Nucleic Acids Research. 2022 Sep 22;gkac801. PMID: 36134713

Correspondence

Prof. Feng ZHU

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

Prof. Shuiping Liu

School of Pharmacy, Hangzhou Normal University, Hangzhou, China

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