m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00308)

Target Name	Thymidine kinase, cytosolic (TK1)
Gene Name	TK1
Chromosomal Location	17q25.3
Family	thymidine kinase family
Function	Cell-cycle-regulated enzyme of importance in nucleotide metabolism (PubMed:9575153). Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate (PubMed:22385435). Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration (Probable). Also important for the activation of anticancer and antiviral nucleoside analog prodrugs such as 1-b-d-arabinofuranosylcytosine (AraC) and 3c-azido-3c-deoxythymidine (AZT) (PubMed:22385435). Click to Show/Hide
Gene ID	7083
Uniprot ID	KITH_HUMAN
HGNC ID	HGNC:11830
KEGG ID	hsa:7083

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

TK1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) [READER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by IGF2BP1*
Cell Line	MV3 cell line	Homo sapiens
Treatment: siIGF2BP1 MV3 cells Control: siControl MV3 cells		GSE146803
Regulation		logFC: -6.03E-01 p-value: 6.27E-08
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	In contrast to the mRNA-decay-promoting function of YTH domain-containing family protein 2, IGF2BPs promote the stability and storage of their target mRNAs (for example, MYC) in an m6A-dependent manner under normal and stress conditions and therefore affect gene expression output. Four representative high confidence targets, including MYC, FSCN1, Thymidine kinase, cytosolic (TK1), and MARCKSL1, exhibit strong binding with IGF2BPs around their m6A motifs in control cells. Knocking down of each individual IGF2BPs in Hela (cervical cancer) and HepG2 (liver cancer) cells significantly repressed MYC expression.
Responsed Disease	Hepatocellular carcinoma		ICD-11: 2C12.02	Disease Info
Cell Process	RNA decay
In-vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	HEK293T	Normal	Homo sapiens	CVCL_0063
	HeLa	Endocervical adenocarcinoma	Homo sapiens	CVCL_0030
	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027

Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) [READER]

Regulator Info

In total 2 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	In contrast to the mRNA-decay-promoting function of YTH domain-containing family protein 2, IGF2BPs promote the stability and storage of their target mRNAs (for example, MYC) in an m6A-dependent manner under normal and stress conditions and therefore affect gene expression output. Four representative high confidence targets, including MYC, FSCN1, Thymidine kinase, cytosolic (TK1), and MARCKSL1, exhibit strong binding with IGF2BPs around their m6A motifs in control cells. Knocking down of each individual IGF2BPs in Hela (cervical cancer) and HepG2 (liver cancer) cells significantly repressed MYC expression.
Responsed Disease	Hepatocellular carcinoma		ICD-11: 2C12.02	Disease Info
Cell Process	RNA decay
In-vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	HEK293T	Normal	Homo sapiens	CVCL_0063
	HeLa	Endocervical adenocarcinoma	Homo sapiens	CVCL_0030
	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
Experiment 2 Reporting the m6A Methylation Regulator of This Target Gene				[3]
Response Summary	In lung cancer, IGF2BP2 modified m6A to increase the expression of Thymidine kinase, cytosolic (TK1), thus promoting angiogenesis.
Target Regulation	Up regulation
Responsed Disease	Lung cancer		ICD-11: 2C25	Disease Info
In-vitro Model	NHBE (Normal bronchial epithelial cells)
	NCI-H460	Lung large cell carcinoma	Homo sapiens	CVCL_0459
	NCI-H1299	Lung large cell carcinoma	Homo sapiens	CVCL_0060
	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
In-vivo Model	Suspension of H1299 cells (5.0 × 10⁵) was subcutaneously injected into the right flanks of the mice.

Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) [READER]

Regulator Info

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	In contrast to the mRNA-decay-promoting function of YTH domain-containing family protein 2, IGF2BPs promote the stability and storage of their target mRNAs (for example, MYC) in an m6A-dependent manner under normal and stress conditions and therefore affect gene expression output. Four representative high confidence targets, including MYC, FSCN1, Thymidine kinase, cytosolic (TK1), and MARCKSL1, exhibit strong binding with IGF2BPs around their m6A motifs in control cells. Knocking down of each individual IGF2BPs in Hela (cervical cancer) and HepG2 (liver cancer) cells significantly repressed MYC expression.
Responsed Disease	Hepatocellular carcinoma		ICD-11: 2C12.02	Disease Info
Cell Process	RNA decay
In-vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	HEK293T	Normal	Homo sapiens	CVCL_0063
	HeLa	Endocervical adenocarcinoma	Homo sapiens	CVCL_0030
	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027

Liver cancer [ICD-11: 2C12]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	In contrast to the mRNA-decay-promoting function of YTH domain-containing family protein 2, IGF2BPs promote the stability and storage of their target mRNAs (for example, MYC) in an m6A-dependent manner under normal and stress conditions and therefore affect gene expression output. Four representative high confidence targets, including MYC, FSCN1, Thymidine kinase, cytosolic (TK1), and MARCKSL1, exhibit strong binding with IGF2BPs around their m6A motifs in control cells. Knocking down of each individual IGF2BPs in Hela (cervical cancer) and HepG2 (liver cancer) cells significantly repressed MYC expression.
Responsed Disease	Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator	Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)		READER	Regulator Info
Cell Process	RNA decay
In-vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	HEK293T	Normal	Homo sapiens	CVCL_0063
	HeLa	Endocervical adenocarcinoma	Homo sapiens	CVCL_0030
	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027

Lung cancer [ICD-11: 2C25]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[3]
Response Summary	In lung cancer, IGF2BP2 modified m6A to increase the expression of Thymidine kinase, cytosolic (TK1), thus promoting angiogenesis.
Responsed Disease	Lung cancer [ICD-11: 2C25]
Target Regulator	Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)		READER	Regulator Info
Target Regulation	Up regulation
In-vitro Model	NHBE (Normal bronchial epithelial cells)
	NCI-H460	Lung large cell carcinoma	Homo sapiens	CVCL_0459
	NCI-H1299	Lung large cell carcinoma	Homo sapiens	CVCL_0060
	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
In-vivo Model	Suspension of H1299 cells (5.0 × 10⁵) was subcutaneously injected into the right flanks of the mice.

Cervical cancer [ICD-11: 2C77]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	In contrast to the mRNA-decay-promoting function of YTH domain-containing family protein 2, IGF2BPs promote the stability and storage of their target mRNAs (for example, MYC) in an m6A-dependent manner under normal and stress conditions and therefore affect gene expression output. Four representative high confidence targets, including MYC, FSCN1, Thymidine kinase, cytosolic (TK1), and MARCKSL1, exhibit strong binding with IGF2BPs around their m6A motifs in control cells. Knocking down of each individual IGF2BPs in Hela (cervical cancer) and HepG2 (liver cancer) cells significantly repressed MYC expression.
Responsed Disease	Cervical cancer [ICD-11: 2C77]
Target Regulator	Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)		READER	Regulator Info
Cell Process	RNA decay
In-vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	HEK293T	Normal	Homo sapiens	CVCL_0063
	HeLa	Endocervical adenocarcinoma	Homo sapiens	CVCL_0030
	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

DNA modification

m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02193		Crosstalk Info
Epigenetic Regulator	Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target	Protein tyrosine phosphatase non-receptor type 13 (PTPN13)
Crosstalk relationship	DNA modification → m6A
Disease	Liver cancer	Disease Info

Histone modification

m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03467		Crosstalk Info
Epigenetic Regulator	Histone-lysine N-methyltransferase SETD1A (SETD1A)
Regulated Target	Histone H3 lysine 4 trimethylation (H3K4me3)
Crosstalk relationship	Histone modification → m6A
Disease	Lung cancer	Disease Info

Non-coding RNA

m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05011		Crosstalk Info
Epigenetic Regulator	DARS1 antisense RNA 1 (DARS1-AS1)
Regulated Target	Insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3)
Crosstalk relationship	ncRNA → m6A
Disease	Cervical cancer	Disease Info

m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05367		Crosstalk Info
Epigenetic Regulator	hsa-miR-320b
Regulated Target	Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2)
Crosstalk relationship	ncRNA → m6A
Disease	Lung cancer	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00308)

Thymidine kinase, cytosolic (TK1)

Adenosine-to-Inosine editing (A-to-I)

In total 2 m6A sequence/site(s) in this target gene
mod ID: A2ISITE008523		Click to Show/Hide the Full List
mod site	chr17:78178149-78178150:-		[4]
Sequence	GGCTGGGCACGGTGGCTCACACCTGTAATCCCAGCACTTTG
Transcript ID List	ENST00000586613.1; ENST00000590430.5; ENST00000301634.12; ENST00000588734.5; ENST00000592126.1; rmsk_4772170; ENST00000590862.5
External Link	RMBase: RNA-editing_site_61364
mod ID: A2ISITE008524		Click to Show/Hide the Full List
mod site	chr17:78181905-78181906:-		[4]
Sequence	AGAAATTAGCCAGTCATAGCAGCGCACACCTGTGGTCCCTG
Transcript ID List	rmsk_4772178; ENST00000590862.5; ENST00000590430.5; ENST00000586613.1; ENST00000301634.12; ENST00000592126.1; ENST00000588734.5
External Link	RMBase: RNA-editing_site_61365

N1-methyladenosine (m1A)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M1ASITE000060		Click to Show/Hide the Full List
mod site	chr17:78174262-78174263:-		[5]
Sequence	CTTGTTTCCTTTTGGGCTCAAAGCCCTTCCTACCTCTGGTG
Cell/Tissue List	HEK293T
Seq Type List	m1A-seq
Transcript ID List	ENST00000588734.5; ENST00000301634.12
External Link	RMBase: m1A_site_487

5-methylcytidine (m5C)

In total 32 m6A sequence/site(s) in this target gene
mod ID: M5CSITE001288		Click to Show/Hide the Full List
mod site	chr17:78174186-78174187:-		[6]
Sequence	GATGGGTGGCACCAACCTTGCTGGGACTTGGATCCCAGGGG
Cell/Tissue List	HeLa; T24
Seq Type List	m5C-RIP-seq; Bisulfite-seq
Transcript ID List	ENST00000588734.5; ENST00000301634.12
External Link	RMBase: m5C_site_20105
mod ID: M5CSITE001289		Click to Show/Hide the Full List
mod site	chr17:78175613-78175614:-		[6]
Sequence	CACGTGCCCTTTCCAGTTCCCTGACATCGTGGAGTTCTGCG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000590430.5; ENST00000301634.12; ENST00000588734.5; ENST00000590862.5; ENST00000586613.1; ENST00000592126.1
External Link	RMBase: m5C_site_20106
mod ID: M5CSITE001290		Click to Show/Hide the Full List
mod site	chr17:78178762-78178763:-
Sequence	AATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000586613.1; ENST00000301634.12; ENST00000590430.5; rmsk_4772171; ENST00000588734.5; ENST00000592126.1; ENST00000590862.5
External Link	RMBase: m5C_site_20107
mod ID: M5CSITE001291		Click to Show/Hide the Full List
mod site	chr17:78178771-78178772:-
Sequence	CATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	rmsk_4772171; ENST00000301634.12; ENST00000590862.5; ENST00000586613.1; ENST00000592126.1; ENST00000588734.5; ENST00000590430.5
External Link	RMBase: m5C_site_20108
mod ID: M5CSITE001292		Click to Show/Hide the Full List
mod site	chr17:78178774-78178775:-
Sequence	GCGCATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000592126.1; ENST00000590862.5; ENST00000586613.1; ENST00000301634.12; ENST00000588734.5; ENST00000590430.5; rmsk_4772171
External Link	RMBase: m5C_site_20109
mod ID: M5CSITE001293		Click to Show/Hide the Full List
mod site	chr17:78178777-78178778:-
Sequence	GTGGCGCATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	rmsk_4772171; ENST00000590430.5; ENST00000590862.5; ENST00000588734.5; ENST00000592126.1; ENST00000301634.12; ENST00000586613.1
External Link	RMBase: m5C_site_20110
mod ID: M5CSITE001294		Click to Show/Hide the Full List
mod site	chr17:78179820-78179821:-
Sequence	TGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000586613.1; ENST00000592126.1; ENST00000588734.5; ENST00000301634.12; ENST00000590430.5; ENST00000590862.5
External Link	RMBase: m5C_site_20111
mod ID: M5CSITE001295		Click to Show/Hide the Full List
mod site	chr17:78179827-78179828:-
Sequence	ATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000586613.1; ENST00000592126.1; ENST00000590430.5; ENST00000590862.5; ENST00000588734.5; ENST00000301634.12
External Link	RMBase: m5C_site_20112
mod ID: M5CSITE001296		Click to Show/Hide the Full List
mod site	chr17:78179828-78179829:-
Sequence	GATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000592126.1; ENST00000301634.12; ENST00000590430.5; ENST00000586613.1; ENST00000590862.5; ENST00000588734.5
External Link	RMBase: m5C_site_20113
mod ID: M5CSITE001297		Click to Show/Hide the Full List
mod site	chr17:78179829-78179830:-
Sequence	TGATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000590862.5; ENST00000301634.12; ENST00000588734.5; ENST00000590430.5; ENST00000592126.1; ENST00000586613.1
External Link	RMBase: m5C_site_20114
mod ID: M5CSITE001298		Click to Show/Hide the Full List
mod site	chr17:78180978-78180979:-
Sequence	GGGATTACAGGCGTGAGCCACCACGCCTGGTCTTGATCTTG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000586613.1; ENST00000590862.5; ENST00000588734.5; ENST00000301634.12; ENST00000590430.5; ENST00000592126.1
External Link	RMBase: m5C_site_20115
mod ID: M5CSITE001299		Click to Show/Hide the Full List
mod site	chr17:78180980-78180981:-
Sequence	CTGGGATTACAGGCGTGAGCCACCACGCCTGGTCTTGATCT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000301634.12; ENST00000590862.5; ENST00000590430.5; ENST00000588734.5; ENST00000586613.1; ENST00000592126.1
External Link	RMBase: m5C_site_20116
mod ID: M5CSITE001300		Click to Show/Hide the Full List
mod site	chr17:78180981-78180982:-
Sequence	GCTGGGATTACAGGCGTGAGCCACCACGCCTGGTCTTGATC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000592126.1; ENST00000586613.1; ENST00000590430.5; ENST00000590862.5; ENST00000301634.12; ENST00000588734.5
External Link	RMBase: m5C_site_20117
mod ID: M5CSITE001301		Click to Show/Hide the Full List
mod site	chr17:78180987-78180988:-
Sequence	CAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCTGGTC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000590862.5; ENST00000586613.1; ENST00000592126.1; ENST00000301634.12; ENST00000590430.5; ENST00000588734.5
External Link	RMBase: m5C_site_20118
mod ID: M5CSITE001302		Click to Show/Hide the Full List
mod site	chr17:78180991-78180992:-
Sequence	CTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000590862.5; ENST00000590430.5; ENST00000586613.1; ENST00000301634.12; ENST00000588734.5; ENST00000592126.1
External Link	RMBase: m5C_site_20119
mod ID: M5CSITE001303		Click to Show/Hide the Full List
mod site	chr17:78181466-78181467:-
Sequence	CGGCTCACTGCAACCTCTGCCACCCGGATTCAAGCGATTTT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000592126.1; ENST00000301634.12; ENST00000590862.5; ENST00000590430.5; ENST00000588734.5; ENST00000586613.1
External Link	RMBase: m5C_site_20120
mod ID: M5CSITE001304		Click to Show/Hide the Full List
mod site	chr17:78181467-78181468:-
Sequence	TCGGCTCACTGCAACCTCTGCCACCCGGATTCAAGCGATTT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000588734.5; ENST00000301634.12; ENST00000590862.5; ENST00000592126.1; ENST00000586613.1; ENST00000590430.5
External Link	RMBase: m5C_site_20121
mod ID: M5CSITE001305		Click to Show/Hide the Full List
mod site	chr17:78181470-78181471:-
Sequence	ATCTCGGCTCACTGCAACCTCTGCCACCCGGATTCAAGCGA
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000590430.5; ENST00000590862.5; ENST00000301634.12; ENST00000588734.5; ENST00000586613.1; ENST00000592126.1
External Link	RMBase: m5C_site_20122
mod ID: M5CSITE001306		Click to Show/Hide the Full List
mod site	chr17:78181472-78181473:-
Sequence	TGATCTCGGCTCACTGCAACCTCTGCCACCCGGATTCAAGC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000301634.12; ENST00000590862.5; ENST00000590430.5; ENST00000586613.1; ENST00000592126.1; ENST00000588734.5
External Link	RMBase: m5C_site_20123
mod ID: M5CSITE001307		Click to Show/Hide the Full List
mod site	chr17:78181473-78181474:-
Sequence	GTGATCTCGGCTCACTGCAACCTCTGCCACCCGGATTCAAG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000590430.5; ENST00000590862.5; ENST00000588734.5; ENST00000301634.12; ENST00000592126.1; ENST00000586613.1
External Link	RMBase: m5C_site_20124
mod ID: M5CSITE001308		Click to Show/Hide the Full List
mod site	chr17:78181476-78181477:-
Sequence	GGCGTGATCTCGGCTCACTGCAACCTCTGCCACCCGGATTC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000590430.5; ENST00000301634.12; ENST00000590862.5; ENST00000592126.1; ENST00000586613.1; ENST00000588734.5
External Link	RMBase: m5C_site_20125
mod ID: M5CSITE001309		Click to Show/Hide the Full List
mod site	chr17:78181479-78181480:-
Sequence	AATGGCGTGATCTCGGCTCACTGCAACCTCTGCCACCCGGA
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000590430.5; ENST00000301634.12; ENST00000590862.5; ENST00000588734.5; ENST00000592126.1; ENST00000586613.1
External Link	RMBase: m5C_site_20126
mod ID: M5CSITE001310		Click to Show/Hide the Full List
mod site	chr17:78181481-78181482:-
Sequence	GCAATGGCGTGATCTCGGCTCACTGCAACCTCTGCCACCCG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000590430.5; ENST00000301634.12; ENST00000590862.5; ENST00000586613.1; ENST00000588734.5; ENST00000592126.1
External Link	RMBase: m5C_site_20127
mod ID: M5CSITE001311		Click to Show/Hide the Full List
mod site	chr17:78181483-78181484:-
Sequence	GTGCAATGGCGTGATCTCGGCTCACTGCAACCTCTGCCACC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000590430.5; ENST00000592126.1; ENST00000301634.12; ENST00000586613.1; ENST00000588734.5; ENST00000590862.5
External Link	RMBase: m5C_site_20128
mod ID: M5CSITE001312		Click to Show/Hide the Full List
mod site	chr17:78181486-78181487:-
Sequence	GGAGTGCAATGGCGTGATCTCGGCTCACTGCAACCTCTGCC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000590430.5; ENST00000592126.1; ENST00000588734.5; ENST00000301634.12; ENST00000590862.5; ENST00000586613.1
External Link	RMBase: m5C_site_20129
mod ID: M5CSITE001313		Click to Show/Hide the Full List
mod site	chr17:78181494-78181495:-
Sequence	CCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTCACTGCAA
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000590862.5; ENST00000301634.12; ENST00000586613.1; ENST00000590430.5; ENST00000592126.1; ENST00000588734.5
External Link	RMBase: m5C_site_20130
mod ID: M5CSITE001314		Click to Show/Hide the Full List
mod site	chr17:78181500-78181501:-
Sequence	CTGTCGCCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTCA
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000590862.5; ENST00000301634.12; ENST00000586613.1; ENST00000592126.1; ENST00000590430.5; ENST00000588734.5
External Link	RMBase: m5C_site_20131
mod ID: M5CSITE001315		Click to Show/Hide the Full List
mod site	chr17:78181508-78181509:-
Sequence	GTCTTACTCTGTCGCCCAGGCTGGAGTGCAATGGCGTGATC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000588734.5; ENST00000592126.1; ENST00000586613.1; ENST00000590862.5; ENST00000590430.5; ENST00000301634.12
External Link	RMBase: m5C_site_20132
mod ID: M5CSITE001316		Click to Show/Hide the Full List
mod site	chr17:78181512-78181513:-
Sequence	CGGAGTCTTACTCTGTCGCCCAGGCTGGAGTGCAATGGCGT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000588734.5; ENST00000590862.5; ENST00000301634.12; ENST00000590430.5; ENST00000586613.1; ENST00000592126.1
External Link	RMBase: m5C_site_20133
mod ID: M5CSITE001317		Click to Show/Hide the Full List
mod site	chr17:78181513-78181514:-
Sequence	ACGGAGTCTTACTCTGTCGCCCAGGCTGGAGTGCAATGGCG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000590862.5; ENST00000588734.5; ENST00000590430.5; ENST00000592126.1; ENST00000586613.1; ENST00000301634.12
External Link	RMBase: m5C_site_20134
mod ID: M5CSITE001318		Click to Show/Hide the Full List
mod site	chr17:78181514-78181515:-
Sequence	GACGGAGTCTTACTCTGTCGCCCAGGCTGGAGTGCAATGGC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000592126.1; ENST00000301634.12; ENST00000590430.5; ENST00000586613.1; ENST00000588734.5; ENST00000590862.5
External Link	RMBase: m5C_site_20135
mod ID: M5CSITE001319		Click to Show/Hide the Full List
mod site	chr17:78187064-78187065:-		[6]
Sequence	CCGTGGTTTAAAGCGGTCGGCGCGGGAACCAGGGGCTTACT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000588734.5
External Link	RMBase: m5C_site_20136

N6-methyladenosine (m6A)

In total 28 m6A sequence/site(s) in this target gene
mod ID: M6ASITE035559		Click to Show/Hide the Full List
mod site	chr17:78174105-78174106:-		[7]
Sequence	TGCTGTAGCTTATGAAATTAACTAATTGAAAATTCACTGGT
Motif Score	2.590089286
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000301634.12
External Link	RMBase: m6A_site_385169
mod ID: M6ASITE035560		Click to Show/Hide the Full List
mod site	chr17:78174181-78174182:-		[8]
Sequence	GTGGCACCAACCTTGCTGGGACTTGGATCCCAGGGGCTTAT
Motif Score	4.065041667
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000588734.5; ENST00000301634.12
External Link	RMBase: m6A_site_385170
mod ID: M6ASITE035561		Click to Show/Hide the Full List
mod site	chr17:78174226-78174227:-		[8]
Sequence	TGGTGATGGTTTCCACAGGAACAACAGCATCTTTCACCAAG
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000301634.12; ENST00000588734.5
External Link	RMBase: m6A_site_385171
mod ID: M6ASITE035562		Click to Show/Hide the Full List
mod site	chr17:78174232-78174233:-		[9]
Sequence	TACCTCTGGTGATGGTTTCCACAGGAACAACAGCATCTTTC
Motif Score	2.053113095
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000588734.5; ENST00000301634.12
External Link	RMBase: m6A_site_385172
mod ID: M6ASITE035563		Click to Show/Hide the Full List
mod site	chr17:78174289-78174290:-		[7]
Sequence	CCTGAGGATGGCCTGGATTCACGCCCTCTTGTTTCCTTTTG
Motif Score	2.021232143
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000301634.12; ENST00000588734.5
External Link	RMBase: m6A_site_385173
mod ID: M6ASITE035564		Click to Show/Hide the Full List
mod site	chr17:78174353-78174354:-		[7]
Sequence	ACCTTTGAGCCTTGGCCCACACTGAGGCTTAGGCCTCTCTG
Motif Score	2.506922619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000588734.5; ENST00000301634.12
External Link	RMBase: m6A_site_385174
mod ID: M6ASITE035565		Click to Show/Hide the Full List
mod site	chr17:78174355-78174356:-		[10]
Sequence	GCACCTTTGAGCCTTGGCCCACACTGAGGCTTAGGCCTCTC
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000588734.5; ENST00000301634.12
External Link	RMBase: m6A_site_385175
mod ID: M6ASITE035566		Click to Show/Hide the Full List
mod site	chr17:78174446-78174447:-		[7]
Sequence	GACAGAGCCCCACGCTGTTGACATCAGCCTGCTTCTTCCCC
Motif Score	2.859755952
Cell/Tissue List	HEK293T; hESC-HEK293T; AML
Seq Type List	DART-seq; MAZTER-seq; miCLIP
Transcript ID List	ENST00000301634.12; ENST00000588734.5
External Link	RMBase: m6A_site_385176
mod ID: M6ASITE035567		Click to Show/Hide the Full List
mod site	chr17:78174465-78174466:-		[8]
Sequence	CCCTCTCCTTGGGGTGAGGGACAGAGCCCCACGCTGTTGAC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; hESCs; LCLs; H1299; MM6; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000301634.12; ENST00000588734.5
External Link	RMBase: m6A_site_385177
mod ID: M6ASITE035568		Click to Show/Hide the Full List
mod site	chr17:78174490-78174491:-		[10]
Sequence	TTGGTGGCCTGGGATCTGGCACACTCCCTCTCCTTGGGGTG
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000588734.5; ENST00000301634.12
External Link	RMBase: m6A_site_385178
mod ID: M6ASITE035569		Click to Show/Hide the Full List
mod site	chr17:78174628-78174629:-		[8]
Sequence	CACACCTTGGCCTTCTGGGAACTCTCCTTTGTGTGGCTGCC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; hESCs; fibroblasts; LCLs; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000588734.5; ENST00000301634.12
External Link	RMBase: m6A_site_385179
mod ID: M6ASITE035570		Click to Show/Hide the Full List
mod site	chr17:78174647-78174648:-		[10]
Sequence	GGGAGGCGTGGAGGGTGACCACACCTTGGCCTTCTGGGAAC
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000301634.12; ENST00000588734.5
External Link	RMBase: m6A_site_385180
mod ID: M6ASITE035571		Click to Show/Hide the Full List
mod site	chr17:78174708-78174709:-		[7]
Sequence	CTGCCACTGCCGCCTACTGGACGCTGCCCTGCATGCTGCCC
Motif Score	3.616982143
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000588734.5; ENST00000590862.5; ENST00000301634.12
External Link	RMBase: m6A_site_385182
mod ID: M6ASITE035572		Click to Show/Hide the Full List
mod site	chr17:78174754-78174755:-		[8]
Sequence	GCAGCCCTGCCAACTGAGGGACCTGCGAGGGCCGCCCGCTC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; DART-seq
Transcript ID List	ENST00000590862.5; ENST00000588734.5; ENST00000301634.12
External Link	RMBase: m6A_site_385183
mod ID: M6ASITE035573		Click to Show/Hide the Full List
mod site	chr17:78174849-78174850:-		[8]
Sequence	CGGGCCGGACAACAAAGAGAACTGCCCAGTGCCAGGAAAGC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; A549; HEK293T; H1A; H1B; hNPCs; hESCs; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000590862.5; ENST00000588734.5; ENST00000301634.12; ENST00000590430.5
External Link	RMBase: m6A_site_385184
mod ID: M6ASITE035574		Click to Show/Hide the Full List
mod site	chr17:78174858-78174859:-		[10]
Sequence	CCAGCCTGCCGGGCCGGACAACAAAGAGAACTGCCCAGTGC
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000588734.5; ENST00000590862.5; ENST00000590430.5; ENST00000301634.12
External Link	RMBase: m6A_site_385185
mod ID: M6ASITE035575		Click to Show/Hide the Full List
mod site	chr17:78174861-78174862:-		[8]
Sequence	AGGCCAGCCTGCCGGGCCGGACAACAAAGAGAACTGCCCAG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; A549; hESC-HEK293T; H1A; H1B; hNPCs; hESCs; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000590430.5; ENST00000590862.5; ENST00000588734.5; ENST00000301634.12
External Link	RMBase: m6A_site_385186
mod ID: M6ASITE035576		Click to Show/Hide the Full List
mod site	chr17:78174927-78174928:-		[8]
Sequence	CGAGGTGATTGGGGGAGCAGACAAGTACCACTCCGTGTGTC
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; hESC-HEK293T; H1A; H1B; A549; MM6; peripheral-blood; GSC-11; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000590430.5; ENST00000588734.5; ENST00000586613.1; ENST00000301634.12; ENST00000590862.5
External Link	RMBase: m6A_site_385187
mod ID: M6ASITE035577		Click to Show/Hide the Full List
mod site	chr17:78175149-78175150:-		[11]
Sequence	GCCATTTGGGGCCATCCTGAACCTGGTGCCGCTGGCCGAGA
Motif Score	2.930744048
Cell/Tissue List	HepG2; HeLa; peripheral-blood; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000586613.1; ENST00000590430.5; ENST00000592126.1; ENST00000590862.5; ENST00000301634.12; ENST00000588734.5
External Link	RMBase: m6A_site_385188
mod ID: M6ASITE035578		Click to Show/Hide the Full List
mod site	chr17:78175542-78175543:-		[11]
Sequence	TTGTGGCTGCACTGGATGGGACCTTCCAGAGGAAGGTAAGG
Motif Score	3.622404762
Cell/Tissue List	HepG2; HeLa; peripheral-blood; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000592126.1; ENST00000586613.1; ENST00000301634.12; ENST00000590862.5; ENST00000590430.5; ENST00000588734.5
External Link	RMBase: m6A_site_385189
mod ID: M6ASITE035579		Click to Show/Hide the Full List
mod site	chr17:78175569-78175570:-		[11]
Sequence	CCATGGCCAACGCCGGGAAGACCGTAATTGTGGCTGCACTG
Motif Score	2.876744048
Cell/Tissue List	HepG2; HeLa; peripheral-blood; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000590862.5; ENST00000590430.5; ENST00000588734.5; ENST00000301634.12; ENST00000592126.1; ENST00000586613.1
External Link	RMBase: m6A_site_385190
mod ID: M6ASITE035580		Click to Show/Hide the Full List
mod site	chr17:78175610-78175611:-		[10]
Sequence	GTGCCCTTTCCAGTTCCCTGACATCGTGGAGTTCTGCGAGG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000592126.1; ENST00000588734.5; ENST00000586613.1; ENST00000590862.5; ENST00000301634.12; ENST00000590430.5
External Link	RMBase: m6A_site_385191
mod ID: M6ASITE035581		Click to Show/Hide the Full List
mod site	chr17:78182679-78182680:-		[10]
Sequence	CTGGCTTTCTCTTCCCAGGAACACCATGGAGGCACTGCCCG
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T; Huh7; peripheral-blood
Seq Type List	MAZTER-seq; MeRIP-seq; m6A-seq
Transcript ID List	ENST00000586613.1; ENST00000590862.5; ENST00000301634.12; ENST00000590430.5; ENST00000588734.5; ENST00000592126.1
External Link	RMBase: m6A_site_385192
mod ID: M6ASITE035582		Click to Show/Hide the Full List
mod site	chr17:78185090-78185091:-		[12]
Sequence	GGTGATCAAGTATGCCAAAGACACTCGCTACAGCAGCAGCT
Motif Score	2.897386905
Cell/Tissue List	Huh7; peripheral-blood; endometrial; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000590430.5; ENST00000592126.1; ENST00000588734.5; ENST00000590862.5; ENST00000586613.1; ENST00000301634.12
External Link	RMBase: m6A_site_385193
mod ID: M6ASITE035583		Click to Show/Hide the Full List
mod site	chr17:78185120-78185121:-		[10]
Sequence	TCGCTTCCAGATTGCTCAGTACAAGTGCCTGGTGATCAAGT
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000590862.5; ENST00000588734.5; ENST00000592126.1; ENST00000301634.12; ENST00000586613.1; ENST00000590430.5
External Link	RMBase: m6A_site_385194
mod ID: M6ASITE035584		Click to Show/Hide the Full List
mod site	chr17:78186945-78186946:-		[8]
Sequence	TGCCTGGCTCCCCCAGCAAGACCCGGGGGCAGATCCAGGTG
Motif Score	2.876744048
Cell/Tissue List	HeLa; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000588734.5; ENST00000590430.5; ENST00000586613.1; ENST00000592126.1; ENST00000301634.12; ENST00000590862.5
External Link	RMBase: m6A_site_385195
mod ID: M6ASITE035585		Click to Show/Hide the Full List
mod site	chr17:78187009-78187010:-		[8]
Sequence	GAGAGTACTCGGGTTCGTGAACTTCCCGGAGGCGCAATGAG
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000590430.5; ENST00000588734.5; ENST00000592126.1; ENST00000590862.5; ENST00000301634.12; ENST00000586613.1
External Link	RMBase: m6A_site_385196
mod ID: M6ASITE035586		Click to Show/Hide the Full List
mod site	chr17:78187057-78187058:-		[8]
Sequence	TTAAAGCGGTCGGCGCGGGAACCAGGGGCTTACTGCGGGAC
Motif Score	2.930744048
Cell/Tissue List	HeLa; A549; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000588734.5; ENST00000586613.1
External Link	RMBase: m6A_site_385197

Ref 1	Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat Cell Biol. 2018 Mar;20(3):285-295. doi: 10.1038/s41556-018-0045-z. Epub 2018 Feb 23.
Ref 2	DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB09054)
Ref 3	microRNA-320b suppresses HNF4G and IGF2BP2 expression to inhibit angiogenesis and tumor growth of lung cancer. Carcinogenesis. 2021 May 28;42(5):762-771. doi: 10.1093/carcin/bgab023.
Ref 4	Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome. Nat Biotechnol. 2012 Feb 12;30(3):253-60. doi: 10.1038/nbt.2122.
Ref 5	The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution. Nature. 2017 Nov 9;551(7679):251-255. doi: 10.1038/nature24456. Epub 2017 Oct 25.
Ref 6	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 7	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 8	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 9	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 10	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 11	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
Ref 12	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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