m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00124)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MIR93
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [3] | |||
| Response Summary | METTL3-mediated formation of EV microRNA 93 (MIR93), facilitated by m6A, is implicated in the aberrant cross-talk of epithelium-macrophages, indicating that this process is involved in the smoking-related emphysema. EV miR-93 was used as a novel risk biomarker for CS-induced emphysema. MiR-93 activated the JNK pathway by targeting dual-specificity phosphatase 2 (DUSP2), which elevated the levels of matrix metalloproteinase 9 (MMP9) and matrix metalloproteinase 12 (MMP12) and induced elastin degradation, leading to emphysema. | |||
| Target Regulation | Up regulation | |||
| Responsed Disease | Emphysema | ICD-11: CA21 | ||
| Pathway Response | MAPK signaling pathway | hsa04010 | ||
Emphysema [ICD-11: CA21]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [3] | |||
| Response Summary | METTL3-mediated formation of EV microRNA 93 (MIR93), facilitated by m6A, is implicated in the aberrant cross-talk of epithelium-macrophages, indicating that this process is involved in the smoking-related emphysema. EV miR-93 was used as a novel risk biomarker for CS-induced emphysema. MiR-93 activated the JNK pathway by targeting dual-specificity phosphatase 2 (DUSP2), which elevated the levels of matrix metalloproteinase 9 (MMP9) and matrix metalloproteinase 12 (MMP12) and induced elastin degradation, leading to emphysema. | |||
| Responsed Disease | Emphysema [ICD-11: CA21] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | MAPK signaling pathway | hsa04010 | ||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
RNA modification
m6A Regulator: Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)
| In total 3 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT00581 | ||
| Epigenetic Regulator | Interferon-inducible protein 4 (ADAR1) | |
| Regulated Target | Signal transducer and activator of transcription 3 (STAT3) | |
| Crosstalk relationship | m6A → A-to-I | |
| Crosstalk ID: M6ACROT00582 | ||
| Epigenetic Regulator | Fat mass and obesity-associated protein (FTO) | |
| Regulated Target | Signal transducer and activator of transcription 3 (STAT3) | |
| Crosstalk relationship | m6A → m6Am | |
| Crosstalk ID: M6ACROT00583 | ||
| Epigenetic Regulator | Y-box-binding protein 1 (YBX1) | |
| Regulated Target | Ras GTPase-activating protein-binding protein 1 (G3BP1) | |
| Crosstalk relationship | m6A → m5C | |
Histone modification
m6A Regulator: Methyltransferase-like 14 (METTL14)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT03309 | ||
| Epigenetic Regulator | Lysine-specific demethylase 5B (KDM5B) | |
| Regulated Target | Histone H3 lysine 4 trimethylation (H3K4me3) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Non-small cell lung cancer | |
Non-coding RNA
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05481 | ||
| Epigenetic Regulator | MicroRNA 93 (MIR93) | |
| Regulated Target | Dual specificity protein phosphatase 2 (DUSP2) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Emphysema | |
m6A Regulator: Methyltransferase-like 14 (METTL14)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05770 | ||
| Epigenetic Regulator | MicroRNA 93 (MIR93) | |
| Regulated Target | Thioredoxin-interacting protein (TXNIP) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Non-small cell lung cancer | |
m6A Regulator: Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05811 | ||
| Epigenetic Regulator | MicroRNA 93 (MIR93) | |
| Crosstalk relationship | m6A → ncRNA | |
References