m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00583				[1], [2], [3]
m⁶A modification MIR93 MIR93 HNRNPA2B1 : m⁶A sites Indirect Enhancement RNA modification G3BP1 G3BP1 YBX1 : modification sites
m6A Regulator	Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)			READER	Regulator Info
m6A Target	microRNA 93 (MIR93)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> 5-methylcytidine (m5C)
Epigenetic Regulator	Y-box-binding protein 1 (YBX1)			READER	View Details
Regulated Target	Ras GTPase-activating protein-binding protein 1 (G3BP1)				View Details
Crosstalk Relationship	m6A → m5C			Enhancement
Crosstalk Mechanism	m6A modification indirectly impacts RNA modification through downstream signaling pathways
Crosstalk Summary	HNRNPA2B1 interacts with microRNA 93 (MIR93), reading its m6A level and promoting its physical interaction with Ras GTPase-activating protein-binding protein 1 (G3BP1), which was regulated by YBX1-mediated m5C modification.
In-vitro Model	TE1	N.A.	Mus musculus		CVCL_C6K3

References

Ref 1	The interaction of YBX1 with G3BP1 promotes renal cell carcinoma cell metastasis via YBX1/G3BP1-SPP1- NF-kappaB signaling axis. J Exp Clin Cancer Res. 2019 Sep 3;38(1):386. doi: 10.1186/s13046-019-1347-0.
Ref 2	HNRNPA2B1 Affects the Prognosis of Esophageal Cancer by Regulating the miR-17-92 Cluster. Front Cell Dev Biol. 2021 Jun 30;9:658642. doi: 10.3389/fcell.2021.658642. eCollection 2021.
Ref 3	Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner. Cell Death Dis. 2021 Feb 24;12(2):209. doi: 10.1038/s41419-021-03484-3.