m6A-centered Drug Response Information
General Information of the Drug (ID: M6ADRUG0259)
| Name |
Triptonide
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| Synonyms |
(-)-triptonide; NSC 165677; Triptolide, 14-deoxy-14-oxo-; CHEBI:132267; (1S,2S,4S,5S,7S,9S,11S,13S)-1-methyl-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-ene-8,17-dione; (3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-6a-isopropyl-8b-methyl-3b,4,4a,7a,7b,8b,9,10-octahydrotrisoxireno[6,7:8a,9:4b,5]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione; (1S,2S,4S,5S,7S,9S,11S,13S)-1-methyl-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo(11.7.0.02,4.02,9.05,7.09,11.014,18)icos-14(18)-ene-8,17-dione
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| Structure |
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3D MOL
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| Formula |
C20H22O6
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| InChI |
InChI=1S/C20H22O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14H,4-7H2,1-3H3/t11-,12-,13-,14-,17-,18-,19+,20+/m0/s1
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| InChIKey |
SWOVVKGLGOOUKI-ZHGGVEMFSA-N
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| PubChem CID | |||||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Drug
| In total 3 item(s) under this drug | ||
| Crosstalk ID: M6ACROT05891 | ||
| m6A Regulator | Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) | |
| m6A Target | Myc proto-oncogene protein (MYC) | |
| Epigenetic Regulator | Testis associated oncogenic lncRNA (THORLNC) | |
| Regulated Target | Insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1) | |
| Crosstalk relationship | ncRNA → m6A | |
| Disease | Nasopharyngeal carcinoma | |
| Crosstalk ID: M6ACROT05892 | ||
| m6A Regulator | Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) | |
| m6A Target | Insulin-like growth factor 2 (IGF2) | |
| Epigenetic Regulator | Testis associated oncogenic lncRNA (THORLNC) | |
| Regulated Target | Insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1) | |
| Crosstalk relationship | ncRNA → m6A | |
| Disease | Nasopharyngeal carcinoma | |
| Crosstalk ID: M6ACROT05893 | ||
| m6A Regulator | Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) | |
| m6A Target | Zinc finger protein GLI1 (GLI1) | |
| Epigenetic Regulator | Testis associated oncogenic lncRNA (THORLNC) | |
| Regulated Target | Insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1) | |
| Crosstalk relationship | ncRNA → m6A | |
| Disease | Nasopharyngeal carcinoma | |