m6A-centered Drug Response Information
General Information of the Drug (ID: M6ADRUG0218)
| Name |
US9650366, 12
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| Synonyms |
Cystadane
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| Structure |
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3D MOL
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| Formula |
C25H19F4N7O2
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| InChI |
1S/C25H19F4N7O2/c26-21-9-6-19(25(27,28)29)13-22(21)32-24(38)31-20-7-4-16(5-8-20)2-3-17-12-18(15-30-14-17)23-33-35-36(34-23)10-1-11-37/h4-9,12-15,37H,1,10-11H2,(H2,31,32,38)
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| InChIKey |
LOBSULBGQKFHGX-UHFFFAOYSA-N
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Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Drug
| In total 7 item(s) under this drug | ||
| Crosstalk ID: M6ACROT00003 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Tyrosine-protein kinase EIF2AK2 (eIF2AK2/p68) | |
| Epigenetic Regulator | Interferon-inducible protein 4 (ADAR1) | |
| Regulated Target | Tyrosine-protein kinase EIF2AK2 (eIF2AK2/p68) | |
| Crosstalk relationship | m6A → A-to-I | |
| Crosstalk ID: M6ACROT00061 | ||
| m6A Regulator | YTH domain-containing family protein 1 (YTHDF1) | |
| m6A Target | Interferon-inducible protein 4 (ADAR1) | |
| Epigenetic Regulator | Interferon-inducible protein 4 (ADAR1) | |
| Regulated Target | Tyrosine-protein kinase EIF2AK2 (eIF2AK2/p68) | |
| Crosstalk relationship | m6A → A-to-I | |
| Crosstalk ID: M6ACROT00087 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Interferon-inducible protein 4 (ADAR1) | |
| Epigenetic Regulator | Interferon-inducible protein 4 (ADAR1) | |
| Regulated Target | Tyrosine-protein kinase EIF2AK2 (eIF2AK2/p68) | |
| Crosstalk relationship | m6A → A-to-I | |
| Crosstalk ID: M6ACROT03411 | ||
| m6A Regulator | YTH domain-containing family protein 2 (YTHDF2) | |
| m6A Target | Interleukin-11 (IL11) | |
| Regulated Target | Histone H3 lysine 4 trimethylation (H3K4me3) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Liver cancer | |
| Crosstalk ID: M6ACROT03412 | ||
| m6A Regulator | YTH domain-containing family protein 2 (YTHDF2) | |
| m6A Target | Glia-derived nexin (SERPINE2) | |
| Regulated Target | Histone H3 lysine 4 trimethylation (H3K4me3) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Liver cancer | |
| Crosstalk ID: M6ACROT03422 | ||
| m6A Regulator | YTH domain-containing family protein 2 (YTHDF2) | |
| m6A Target | Interleukin-11 (IL11) | |
| Regulated Target | Histone H3 lysine 27 acetylation (H3K27ac) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Liver cancer | |
| Crosstalk ID: M6ACROT03423 | ||
| m6A Regulator | YTH domain-containing family protein 2 (YTHDF2) | |
| m6A Target | Glia-derived nexin (SERPINE2) | |
| Regulated Target | Histone H3 lysine 27 acetylation (H3K27ac) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Liver cancer | |