m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00763)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
eIF2AK2
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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YTH domain-containing family protein 3 (YTHDF3) [READER]
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
Response Summary | YTHDF3 was highly expressed in oxaliplatin-resistant (OXAR) CRC tissues and cells. YTHDF3 as a novel hallmark and revealed the molecular mechanism of YTHDF3 on gene translation via coordination with Tyrosine-protein kinase EIF2AK2 (eIF2AK2/p68) in OXAR CRC cells. | |||
Responsed Disease | Colorectal cancer | ICD-11: 2B91 | ||
In-vitro Model | HCT 116 | Colon carcinoma | Homo sapiens | CVCL_0291 |
HCT 8 | Colon adenocarcinoma | Homo sapiens | CVCL_2478 | |
Caco-2 | Colon adenocarcinoma | Homo sapiens | CVCL_0025 | |
RKO | Colon carcinoma | Homo sapiens | CVCL_0504 | |
HCoEpiC (Healthy colon epithelial HCoEpiC cells) | ||||
FHC | Normal | Homo sapiens | CVCL_3688 | |
Colorectal cancer [ICD-11: 2B91]
In total 1 item(s) under this disease | ||||
Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
Response Summary | YTHDF3 was highly expressed in oxaliplatin-resistant (OXAR) CRC tissues and cells. YTHDF3 as a novel hallmark and revealed the molecular mechanism of YTHDF3 on gene translation via coordination with Tyrosine-protein kinase EIF2AK2 (eIF2AK2/p68) in OXAR CRC cells. | |||
Responsed Disease | Colorectal cancer [ICD-11: 2B91] | |||
Target Regulator | YTH domain-containing family protein 3 (YTHDF3) | READER | ||
In-vitro Model | HCT 116 | Colon carcinoma | Homo sapiens | CVCL_0291 |
HCT 8 | Colon adenocarcinoma | Homo sapiens | CVCL_2478 | |
Caco-2 | Colon adenocarcinoma | Homo sapiens | CVCL_0025 | |
RKO | Colon carcinoma | Homo sapiens | CVCL_0504 | |
HCoEpiC (Healthy colon epithelial HCoEpiC cells) | ||||
FHC | Normal | Homo sapiens | CVCL_3688 | |