m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00061
 [1]
m6A modification ADAR1 ADAR1 YTHDF1 : m6A sites Direct Enhancement RNA modification eIF2AK2 eIF2AK2 ADAR1 Methylation : modification sites
m6A Modification:
m6A Regulator YTH domain-containing family protein 1 (YTHDF1) READER
 Regulator Info 
m6A Target Interferon-inducible protein 4 (ADAR1)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator Interferon-inducible protein 4 (ADAR1) WRITER View Details
Regulated Target Tyrosine-protein kinase EIF2AK2 (eIF2AK2/p68) View Details
Crosstalk Relationship m6A  →  A-to-I Enhancement
Crosstalk Mechanism m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator
Crosstalk Summary The A-to-I RNA editing activity of Interferon-inducible protein 4 (ADAR1) plays important roles in the YTHDF1-dependent IFN responses. Therefore, m6A and YTHDF1 affect innate immune responses through modulating the ADAR1-mediated A-to-I RNA editing of mRNA (TNKS; Tyrosine-protein kinase EIF2AK2 (eIF2AK2/p68) and PSMB2).
Responsed Drug US9650366, 12
 Drug Info 
In-vitro Model
 A-172 Glioblastoma Homo sapiens CVCL_0131
LN-229 Glioblastoma Homo sapiens CVCL_0393
Vero Normal Chlorocebus sabaeus CVCL_0059
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Tyrosine-protein kinase EIF2AK2 (eIF2AK2/p68) 6 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name US9650366, 12 Patented [2]
Synonyms
SCHEMBL17669987; BDBM308061
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 121268883
TTD: D05GPF
 Compound Name US9650366, 2 Patented [2]
Synonyms
SCHEMBL17669993; LHUVPYZTQHNXRU-UHFFFAOYSA-N; BDBM308050; 1-{2-[2-amino-5-(2H-tetrazol-5-yl)pyridin-3-yl]-1-benzothien-5-yl}-3-[4-chloro-3-(trifluoromethyl)phenyl]urea; 1-(2-(2-amino-5-(2H-tetrazol-5-yl)pyridin-3-yl)benzo[b]thiophen-5-yl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea
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MOA Inhibitor
External Link
CID: 121268887
TTD: D0QZ4B
 Compound Name US9650366, 9 Patented [2]
Synonyms
SCHEMBL17670002; OGVARLFWIBVKET-UHFFFAOYSA-N; BDBM308058; N-[3-({5-[2-(3-hydroxypropyl)-2H-tetrazol-5-yl]pyridin-3-yl}ethynyl)phenyl]-3-methyl-2-furamide
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MOA Inhibitor
External Link
CID: 121268893
TTD: D0Z0BQ
 Compound Name ASN-11124542 Investigative [3]
Synonyms
AC1O5VPR; ASN 11124542
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MOA Inhibitor
External Link
CID: 6490494
TTD: D0C1DQ
 Compound Name indirubin derivative E804 Investigative [4]
Synonyms
indirubin E804; compound 2 [PMID: 21632247]
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MOA Inhibitor
External Link
CID: 6419764
TTD: D0N9DU
 Compound Name NU6140 Investigative [4]
Synonyms
Cdk2 Inhibitor IV, NU6140; 444723-13-1; NU 6140; CHEMBL1802728; 4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide; 4-{[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino}-N,N-diethylbenzamide; Cdk2 inhibitor IV; SCHEMBL2169233; GTPL5949; CTK8E7940; DTXSID30436732; MolPort-023-276-742; MolPort-044-561-419; HMS3229E18; IN1369; ZINC22309248; BDBM50347924; AKOS024457537; CCG-206836; NCGC00370819-01; NU6140, > RT-011957; 4-(6-cyclohexylmethoxy-9hpurin-2-ylamino)-N,N-diethyl-benzamide
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MOA Inhibitor
Activity IC50 = 2000 nM
External Link
CID: 10202471
TTD: D04WFN
References
Ref 1 N6-methyladenosine promotes induction of ADAR1-mediated A-to-I RNA editing to suppress aberrant antiviral innate immune responses. PLoS Biol. 2021 Jul 29;19(7):e3001292. doi: 10.1371/journal.pbio.3001292. eCollection 2021 Jul.
Ref 2 Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors. US9650366.
Ref 3 Small molecule inhibitors of the RNA-dependent protein kinase. Biochem Biophys Res Commun. 2003 Aug 15;308(1):50-7.
Ref 4 Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4108-14. doi: 10.1016/j.bmcl.2011.04.149. Epub 2011 May 13.